检索结果-南通市图书馆

Microplastic exposure disturbs sleep structure,reduces lifespan,and decreases ovary size in Drosophila melanogaster

Zoological Research 2024年第4期45卷 805-820页

作者： Wei Yan zi-Jie Li zi-Yi Lin Shu-Qin Ji William ka Fai Tse Zhi-Qiang Meng Chang Liu Lei Li Shenzhen-Hong Kong Institute of Brain Science Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Laboratory of Developmental Disorders and Toxicology Center for Promotion of International Education and ResearchFaculty of AgricultureKyushu UniversityFukuokaFukuoka 819-0395Japan Shenzhen Key Laboratory of Drug Addiction the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518000China

The organ-specific toxicity resulting from microplastic(MP)exposure has been extensively explored,particularly concerning the gut,liver,testis,and ***,under natural conditions,these effects are not restricted to specific organs or *** whether MP exposure presents a systemic threat to an entire organism,impacting factors such as lifespan,sleep,and fecundity,is *** this study,we investigated the effects of dietary exposure to two different doses of MPs(1–5μm)using the terrestrial model organism Drosophila *** indicated that the particles caused gut damage and remained within the digestive *** MP exposure significantly shortened the lifespan of adult *** short-term exposure disrupted sleep patterns,increasing the length of daytime sleep ***,one week of MP exposure reduced ovary size,with a trend towards decreased egg-laying in mated *** MPs did not penetrate the brain or ovaries,transcriptome analysis revealed altered gene expression in these *** the ovary,Gene Ontology(GO)analysis indicated genotoxic effects impacting inflammation,circadian regulation,and metabolic processes,with significant impacts on extracellular structure-related *** the brain,GO analysis identified changes in pathways associated with proteolysis and carbohydrate ***,this study provides compelling evidence of the systemic negative effects of MP exposure,highlighting the urgent need to address and mitigate environmental MP pollution.

关键词： Microplastics Sleep Lifespan Reproduction Risk assessment Drosophila melanogaster

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Role of antispasmodics in the treatment of irritable bowel syndrome

引用

World Journal of Gastroenterology 2014年第20期20卷 6031-6043页

作者： Anita Annaházi Richárd Róka András Rosztóczy Tibor Wittmann First Department of Medicine University of Szeged 6720 Szeged Hungary

Irritable bowel syndrome (IBS) is a long-lasting, relapsing disorder characterized by abdominal pain/discomfort and altered bowel habits. Intestinal motility impairment and visceral hypersensitivity are the key factors among its multifactorial pathogenesis, both of which require effective treatment. Voltage-gated calcium channels mediate smooth muscle contraction and endocrine secretion and play important roles in neuronal transmission. Antispasmodics are a group of drugs that have been used in the treatment of IBS for decades. Alverine citrate, a spasmolytic, decreases the sensitivity of smooth muscle contractile proteins to calcium, and it is a selective 5-HT1A receptor antagonist. Alverine, in combination with simethicone, has been demonstrated to effectively reduce abdominal pain and discomfort in a large placebo-controlled trial. Mebeverine is a musculotropic agent that potently blocks intestinal peristalsis. Non-placebo-controlled trials have shown positive effects of mebeverine in IBS regarding symptom control; nevertheless, in recent placebo-controlled studies, mebeverine did not exhibit superiority over placebo. Otilonium bromide is poorly absorbed from the GI tract, where it acts locally as an L-type calcium channel blocker, an antimuscarinic and a tachykinin NK2 receptor antagonist. Otilonium has effectively reduced pain and improved defecation alterations in placebo-controlled trials in IBS patients. Pinaverium bromide is also an L-type calcium channel blocker that acts locally in the GI tract. Pinaverium improves motility disorders and consequently reduces stool problems in IBS patients. Phloroglucinol and trimethylphloroglucinol are non-specific antispasmodics that reduced pain in IBS patients in a placebo-controlled trial. Antispasmodics have excellent safety profiles. T-type calcium channel blockers can abolish visceral hypersensitivity in animal models, which makes them potential candidates for the development of novel therapeutic agents

关键词： Irritable bowel syndrome Motility Treatment Calcium channel blockers Spasmolytics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Influence of sintering time on microstructure and properties of hot oscillatory pressing sintered W–Cu refractory alloys

引用

Tungsten 2024年第2期6卷 323-332页

作者： zi-Qian Wu Wei Zhao ka Gao Shi-Hao Du Qing-Quan Kong De-Jian Sun Yang Gao School of Materials Science and Engineering Zhengzhou University of AeronauticsZhengzhou 450015China School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of General Medicine Changhai HospitalShanghai 200000China Hubei Key Laboratory of Mechanical Transmission and Manufacturing Engineering Wuhan University of Science and TechnologyWuhan 430081China Sichuan Province Engineering Technology Research Center of Powder Metallurgy Chengdu UniversityChengdu 610106China

W–Cu refractory alloys are widely used in aerospace,aviation,electronics,power,and other fi ***,because of its large melting point diff erence between alloy elements,the conventional powder metallurgy method required a long time of high temperature sintering is very likely to cause low density and abnormal grain size ***,90W-10Cu refractory alloys were successfully prepared by hot oscillatory pressing(HOP)under diff erent sintering time in this *** the infl uence of sintering time on the microstructure,grain size,density,Vickers hardness,room-tensile property,and electrical conductivity of the W–Cu refractory alloy was systematically *** results showed that during the short sintering time(30–90 min),the density,Vickers hardness,tensile strength,and electrical conductivity of the W–Cu refractory alloy increased signifi cantly to 98.7%,163.29 HV 30,507.3 MPa,and 14.2%International Annealed Copper Standard with the sintering time increasing,respectively,while its grain size showed no obvious *** the sintering time further increased to 120 min,the density was basically consistent with the sintering time of 90 ***,the prolonged high temperature sintering resulted in the grain growth of the samples,which caused the deterioration of the Vickers hardness,room-tensile strength,and conductivity properties of the W–Cu refractory *** the same sintering time,the density,Vickers hardness,and electrical conductivity of the HOP sintered W–Cu refractory alloy were signifi cantly higher than those of the HP sintered *** was indicated that high density,fi ne-grain,and excellent properties W–Cu refractory alloys could be prepared by hot oscillatory pressing under appropriate sintering time.

关键词： W–Cu refractory alloy Hot oscillatory pressing Sintering time Microstructure Property

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Learning curve of computer-assisted navigation system in spine surgery

引用

Chinese Medical Journal 2010年第21期123卷 2989-2994页

作者： BAI Yu-shu ZHANG Ye CHEN zi-qiang WANG Chuan-feng ZHAO Ying-chuan SHI Zhi-cai LI Ming LIU ka Po Gabriel Department of Orthopedic Surgery Changhai Hospital Second Military Medical University Shanghai 200433 China University Orthopaedics National University Hospital Singapore119074

Background Spine surgery using computer-assisted navigation （CAN） has been proven to result in low screw misplacement rates, low incidence of radiation exposure and excellent operative field viewing versus the conventional intraoperative image intensifier （CⅢ）. However, as we know, few previous studies have described the learning curve of CAN in spine *** We performed two consecutive case cohort studies on pedicel screw accuracy and operative time of two spine surgeons with different experience backgrounds, A and B, in one institution during the same period. Lumbar pedicel screw cortical perforation rate and operative time of the same kind of operation using CAN were analyzed and compared using CⅢ for the two surgeons at initial, 6 months and 12 months of CAN *** CAN spine surgery had an overall lower cortical perforation rate and less mean operative time compared with CⅢ for both surgeon A and B cohorts when total cases of four years were included. It missed being statistically significant,with 3.3% versus 4.7% （P=0.191） and 125.7 versus 132.3 minutes （P=0.428） for surgeon A and 3.6% versus 6.4%（P=0.058）, and 183.2 versus 213.2 minutes （P=0.070） for surgeon B. in an attempt to demonstrate the learning curve,the cases after 6 months of the CAN system in each surgeon＇s cohort were compared. The perforation rate decreased by 2.4% （P=0.039） and 4.3% （P=0.003） and the operative time was reduced by 31.8 minutes （P=0.002） and 14.4 minutes （P=0.026） for the CAN groups of surgeons A and B, respectively. When only the cases performed after 12 months using the CAN system were considered, the perforation rate decreased by 3.9% （P=0.006） and 5.6% （P 〈0.001） and the operative time was reduced by 20.9 minutes （P 〈0.001） and 40.3 minutes （P 〈0.001） for the CAN groups of surgeon A and B, *** In the long run, CAN spine surgery decreased the lumbar screw cortical perforation rate and operative time. The learning curve showed a sharp drop aft

关键词： computer-assisted navigation learning curve degenerative scoliosis spine surgery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and properties of hot-deformed magnets processed from nanocrystalline/amorphous Nd-Fe-B powders

引用

Rare Metals 2021年第8期40卷 2033-2039页

作者： Peng Zhao Yang Luo Dun-Bo Yu Hai-Jun Peng Wen-Long Yan zi-Long Wang Xin-Yuan Bai National Engineering Research Center for Rare Earth Materials General Research Institute for Nonferrous MetalsBeijing100088China Grirem Advanced Materials Co. LtdBeijing100088China

The hot-deformed magnets processed from nanocrystalline/amorphous Nd-Fe-B powders were preparedunderdifferenthot-pressingtemperatures(600-750℃,at intervals of 25℃)by the self-made hotpressing *** microstructure and magnetic properties of hot-deformed magnets prepared at different temperatures were also *** the temperature is above 650℃,the density of magnet reaches 7.5 g·cm^(-3).The optimum magnetic properties of magnetic induction intensity of B_(r)=1.3 T,optimum energy product of(BH)_(max)=282.5 kJ·m^(-3),intrinsiccoercivityof H_(cj)=1130.0 ka·m-1 of hot-deformed magnets are obtained at hot-pressing temperature of 650℃.X-ray diffractometer pattern shows that the(00 L)texture has been *** the microstructural characteristic,on the one hand,the good magnetic performance is attributed to the fine platelet-like grains with an average length of 410-440 nm at the hot-pressing temperature range from625 to 675℃.On the other hand,the unaligned coarse grains are observed in all the *** the areal fraction of those is gradually increasing with the rise of the hot-pressing temperature,which tends to deteriorate the magnetic *** composition map shows the accumulation of Nd/Pr-rich phase in the coarse grains’region.

关键词： Nanocrystalline/amorphous powders Hotpressing temperature Hot-deformed Magnets Magnetic properties Microstructure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A K-/ka-band planar shared-aperture beam-scanning array with a high-isolation for the emerging mm-Wave shared-aperture terminals

引用

Science China(Information Sciences) 2023年第5期66卷 257-270页

作者： zi-Jun GUO Zhang-Cheng HAO Zhuo-Wei MIAO Hao-Yu YIN Chen-Yu DING Hao-Jie GANG State Key Laboratory of Millimeter Waves School of Information Science and Engineering Southeast University Purple Mountain Laboratories

A planar K-/ka-band shared-aperture array with the steerable beam is proposed in this paper. The substrate-integrated coaxial line(SICL)-excited short-circuited-stub-loaded longitudinal slot and substrate-integrated double line(SIDL)-excited slot-loaded patches are employed to radiate K-/ka-band waves, respectively. Then, to constitute the 1-D K-/ka-band arrays, the center-fed SICL feed network and SIDL-based full diferential feed network are introduced to widen the bandwidth. Finally, the GCPW-toSICL and GCPW-to-SIW transitions are adopted to excite the proposed array, respectively. Both SICL and SIDL feed networks are located below the radiating aperture. Those arrays are interleaved and shared the same radiation aperture, as well as the shielding metallic-via-array for achieving a compact footprint. To excite the above radiating elements, the SICL center feed network and fully diferential feed network are introduced to widen the bandwidth. The channel isolation is improved by utilizing the fully diferential feed network and the filtering response of the SIW. Equivalent circuits are proposed for designing the proposed antenna. Thanks to the miniaturized geometries of K-/ka-band arrays, the proposed antenna is able to scan up to 60? and 35? at K-/ka-band, respectively. As an example, a shared-aperture array with a steerable beam is developed and fabricated by using a multilayer printed circuited board with the designed frequencies of 19 GHz(17.7–20.2 GHz) and 29 GHz(27.5–30 GHz). The aperture dimension of the array antenna is49.6 mm×40.75 mm. A good consistency between the simulation and measurement is acquired. The measured peak gains in K-/ka-band are 16.6 and 17.6 d Bi. When the radiation beam points to 0?, the 3-d B gain bandwidth at K-band is 14.9%(17.4–20.2 GHz), while the 3 d B gain bandwidth at ka-band covers from 27.6to 30.4 GHz, i.e., a bandwidth of 9.7%. When the radiation beams are deflected to 60? and 35?, the measured gains of the proposed antenna flu

关键词： shared-aperture high isolation beam-scanning substrate-integrated coaxial line substrate-integrated double line

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

不列颠最北端的维京传奇

引用

旅行者 2019年第11期 112-119页

作者：卡兹不详

这里是大不列颠王国北方的尽头,传承着维京人的血脉,北欧海盗曾在这里横行一时。冬天结束前会举行盛大的维京火祭,古老的歌谣被人们反复吟唱。时间的钟摆仿佛停止,北大西洋凛冽的风中恍若浮现出世界尽头。

关键词：北欧海盗维京人大不列颠世界尽头歌谣北大西洋

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Permanent magnetic properties of Nd-Fe-B melt-spun ribbons with Y substitution

引用

Rare Metals 2020年第1期39卷 55-61页

作者： Cao-Huan Zhang Yang Luo Dun-Bo Yu Ning-Tao Quan Gui-Yong Wu Ya-Kun Dou Zhou Hu zi-Long Wang National Engineering Research Center for Rare Earth Materials General Research Institute for Nonferrous MetalsBeijing100088China Grirem Advanced Materials Co.Ltd Beijing100088China

Phase constituents,microstructures and magnetic properties of melt-spun Nd12-xYxFe81B6 Nb ribbons were investigated *** influence of Y substitution for Nd on the phase stability,grain size and magnetic exchange coupling was *** is found that all the ribbons crystallize in the tetragonal 2:14:1 structure,i.e.,with single hard magnetic phase at the roll speed of25 m *** the increase in Y doping,Curie temperature(Tc)increases,while the coercivity decreases monoclinic ***,remanence magnetization(Br)and maximum energy product((BH)max)fluctuate and the maximum value is obtained at certain amount of *** optimum magnetic properties of intrinsic coercivity of intrinsic coercivity(Hcj)=908.2 ka·m-1 and(BH)max=118.52 kJ·m-3 are achieved when x=*** can be attributed to the strengthened exchange coupling between the neighboring nanograins in Nd-Y-Fe-B meltspun powder based on the Henkel ***,Y substitution also significantly improves the temperature stability of magnetic *** coercivity temperature coefficient ofβ=-0.157%·℃-1 and remanence temperature coefficient ofα=-0.32%·℃-1 are gained,which are greatly reduced compared with those of the undoped Nd-Fe-B compounds.

关键词： Rapid quenching (Nd,Y)-Fe-B alloy Exchange coupling Thermal stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

地球背面的好空气

引用

旅行者 2019年第5期 10110-10117页

作者：卡兹(图/文) 不详

记忆是一种负担,这些失落的老旧物品,代我们减轻负担。周日市集寻宝与南美其他城市周日全城关门一片死寂不同,布城的周日是全民赶集的日子,城中心变身为跳蚤市场,沿着Defensa大街的摊档,从北到南贯穿N个街区,来来往往的人把道路挤得水... 详细信息

记忆是一种负担,这些失落的老旧物品,代我们减轻负担。周日市集寻宝与南美其他城市周日全城关门一片死寂不同,布城的周日是全民赶集的日子,城中心变身为跳蚤市场,沿着Defensa大街的摊档,从北到南贯穿N个街区,来来往往的人把道路挤得水泄不通。

关键词：空气背面地球减轻负担跳蚤市场城市南美赶集

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

古巴·来根雪茄

引用

旅行者 2019年第7期 10034-10040页

作者：卡兹(文/图) 不详

如果说古巴朗姆酒离一统江湖还差点火候的话,那么古巴雪茄绝对早已登上武林盟主的宝座,可以底气十足地吼一声“古巴之外无雪茄”!记住,世界上最好的烟叶产在古巴,而古巴最好的烟叶就生长在比尼亚莱斯山谷的这片红土中。

关键词：古巴雪茄烟叶盟主红土

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：