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Research 2023年第4期2023卷 131-144页

作者： LászlóGál Tamás Bellák Annamária Marton zoltán fekécs Drew Weissman Dénes Török Rachana Biju csaba Vizler Rebeka Kristóf Mitchell B.Beattie Paulo J.C.Lin norbert Pardi Antal nógrádi Krisztián Pajer Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary national Biotechnology Laboratory Institute of GeneticsBiological Research CentreSzegedHungary Institute of Biochemistry Biological Research CentreSzegedHungary Department of Medicine University of PennsylvaniaPhiladelphiaPA19104USA Acuitas Therapeutics VancouverBCV6T 1Z3Canada

Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great ***-modified messenger RnA(mRnA)has become a promising new modality that can be utilized for the safe and efficient delivery of therapeutic ***,we used lipid nanoparticle(LnP)-encapsulated human interleukin-10(hIL-10)-encoding nucleoside-modified mRnA to induce neuroprotection and functional recovery following rat spinal cord contusion *** administration of hIL-10 mRnA-LnP to rats led to a remarkable reduction of the microglia/macrophage reaction in the injured spinal segment and induced significant functional recovery compared to ***,hIL-10 mRnA treatment induced increased expression in tissue inhibitor of matrix metalloproteinase 1 and ciliary neurotrophic factor levels in the affected spinal segment indicating a time-delayed secondary effect of IL-105 d after *** results suggest that treatment with nucleoside-modified mRnAs encoding neuroprotective factors is an effective strategy for spinal cord injury repair.

关键词： protective Restoration utilized

In-situ study of the microstructure evolution during tension of a Mg-Y-Zn-Al alloy processed by rapidly solidified ribbon consolidation technique

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Journal of Magnesium and Alloys 2024年第5期12卷 2024-2040页

作者： Jeno Gubicza Kristián Máthis Péter nagy Péter Jenei zoltán Hegedus Andrea Farkas Jozef Vesely Shin-ichi Inoue Daria Drozdenko Yoshihito Kawamura Department of Materials Physics Faculty of ScienceEotvos Loránd UniversityPázmány P.sétány 1/ABudapest H-1117Hungary Department of Physics of Materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116 Praha 2Czech Republic Deutsches Elektronen-Synchrotron DESY Notkestr.85Hamburg 22603Germany Magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

Mg-Y-Zn-Al alloys processed by rapidly solidified ribbon consolidation(RSRC)technique exhibit an exceptional mechanical performance indicating promising application *** material has a bimodal microstructure consisting of fine recrystallized and coarse non-recrystallized grains with solute-rich stacking faults forming cluster arranged layers(CALs)and nanoplates(CAnaPs),or complete long period stacking ordered(LPSO)*** order to reveal the deformation mechanisms,in-situ synchrotron X-ray diffraction line profile analysis was employed for a detailed study of the dislocation arrangement created during tension in Mg-0.9%Zn-2.05%Y-0.15%Al(at%)*** uncovering the effect of the initial microstructure on the mechanical performance,additional samples were obtained by annealing of the as-consolidated specimen at 300 and 400℃ for 2 *** heat treatment at 300℃ had no significant effect on the initial microstructure,its evolution during tension and,thus,the overall deformation behavior under tensile *** the other hand,annealing at 400℃ resulted in a significant increase of the recrystallized grains fraction and a decrease of the dislocation density,leading to only minor degradation of the mechanical *** maximum dislocation density at the failure of the samples corresponding to the plastic strain of 10-25% was estimated to be about 16-20×10^(14)m^(-2).The diffraction profile analysis indicated that most dislocations formed during tension were of non-basal and pyramidal types,what was also in agreement with the Schmid factor values revealed independently from orientation *** was also shown that the dislocation-induced Taylor hardening was much lower below the plastic strain of 3% than above this value,which was explained by a model of the interaction between prismatic dislocations and CAnaPs/LPSO plates.

关键词： Mg-Zn-Y-Al alloy Long period stacking ordered(LPSO)phase Cluster arranged nanoplates(CAnaPs) Annealing Tension Dislocation density Hardening

Methionine sources and genotype affect embryonic intestinal development,antioxidants,tight junctions,and growth-related gene expression in chickens

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Animal nutrition 2024年第1期16卷 218-230页

作者： James K.Lugata Sawadi F.ndunguru Gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal Levente Czeglédi Gabriella Gulyás Renáta Knop János Oláh zoltán Mészár Rita Varga Brigitta csernus csaba Szabó Department of Animal nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Department of Animal Husbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture and Food Sciences and Environmental Management Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research and Educational Farm University of DebrecenDebrecenHungary Department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Evolutionary Zoology and Human Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Methionine(Met)is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and *** present study examined the effect of in ovo injection of DL-Met and L-Met sources and genotypes on chicken embryonic-intestinal development and *** eggs of the two genotypes,TETRA-SL layer hybrid(TSL)—commercial layer hybrid and Hungarian Partridge colored hen breed(HPC)—a native genotype,were randomly distributed into four treatments for each *** treatment groups include the following:1)control non-injected eggs(noIn);2)saline-injected(SaIn);3)DL-Met injected(DLM);and 4)L-Met injected(LM).The in ovo injection was carried out on 17.5 d of embryonic development;after hatching,eight chicks per group were sacrificed,and the jejunum was extracted for *** results showed that both DLM and LM groups had enhanced intestinal development as evidenced by increased villus width,villus height,and villus area(Pnificantly reduced crypt depth,glutathione(GSH)content,glutathione S-transferase 3 alpha(GST3),occludin(OCLn)gene expression and increased villus height to crypt depth ratio in the TSL genotype than the LM group(Pnotype has overexpressed insulin-like growth factor 1(IGF1)gene,tricellulin(MD2),occludin(OCLn),superoxide dismutase 1(SOD1),and GST3 genes than the TSL genotype(Pn conclusion,these findings showed that in ovo injection of Met enhanced intestinal development,and function,with genotypes responding differently under normal *** also influenced the expression of intestinal antioxidants,tight junction,and growth-related genes.

关键词： DL-Methionine L-Methionine In ovo injection Intestinal development Poultry

Long-term outcomes after endoscopic removal of malignant colorectal polyps:Results from a 10-year cohort

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World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 193-205页

作者： Anna Fábián Renáta Bor Béla Vasas Mónika Szűcs Tibor Tóth Zsófia Bősze Kata Judit Szántó Péter Bacsur Anita Bálint Bernadett Farkas Klaudia Farkas Ágnes Milassin Mariann Rutka Tamás Resál Tamás Molnár zoltán Szepes Department of Internal Medicine University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Pathology University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6725Hungary Department of Medical Physics and Medical Informatics University of SzegedSzent-Györgyi Albert Medical SchoolSzeged 6720Hungary USZ Translational Colorectal Research Group Hungarian Centre of Excellence for Molecular MedicineSzeged 6725Hungary

BACKGROUnD Choosing an optimal post-polypectomy management strategy of malignant colorectal polyps is challenging,and evidence regarding a surveillance-only strategy is *** To evaluate long-term outcomes after endoscopic removal of malignant colorectal *** A single-center retrospective cohort study was conducted to evaluate outcomes after endoscopic removal of malignant colorectal polyps between 2010 and *** disease rate and nodal metastases after secondary surgery and local and distant recurrence rate for those with at least 1 year of follow-up were *** rates for categorical variables and means for continuous variables with 95%confidence intervals were calculated,and Fisher’s exact test and Mann-Whitney test were *** risk factors of adverse outcomes were RESULTS In total,135 lesions(mean size:22.1 mm;location:42%rectal)from 129 patients(mean age:67.7 years;56%male)were *** proportion of pedunculated and non-pedunculated lesions was similar,with en bloc resection in 82%and 47%of lesions,*** differentiation,distance from resection margins,depth of submucosal invasion,lymphovascular invasion,and budding were reported at 89.6%,45.2%,58.5%,31.9%,and 25.2%,*** tumor was found in 10 patients,and nodal metastasis was found in 4 of 41 patients who underwent secondary surgical *** analysis identified piecemeal resection as a risk factor for residual malignancy(odds ratio:1.74;P=0.042).At least 1 year of follow-up was available for 117 lesions from 111 patients(mean follow-up period:5.59 years).Overall,54%,30%,30%,11%,and 16%of patients presented at the 1-year,3-year,5-year,7-year,and 9-10-year surveillance *** outcomes occurred in 9.0%(local recurrence and dissemination in 4 patients and 9 patients,respectively),with no difference between patients undergoing secondary surgery and surveillance *** Reporting of histological featur

关键词： Malignant colorectal polyps T1 tumor Endoscopic removal Outcomes Long-term Surveillance

Anthropogenic Pseudokarstic Depressions on Mount Bocskor(Bakony Region, Hungary)

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Journal of Earth Science 2023年第1期34卷 214-231页

作者： Márton Veress zoltán Unger Szilárd Vetési-Foith Department of Geography Savaria University centreEötvös Lóránd UniversitySzombathely9700Hungary Institute of Geography University of PécsPécs7600Hungary

Surface forms above the mine(ármin mine) of Mount Bocskor(Southern Bakony, Hungary) were examined. We made contour maps, plan maps, morphological maps and atectonic grike(cave) maps of some of the forms and their surroundings. We examined the distribution of the depth, length, elongation ratio in case of some depressions, the relation between the depth and the diameter of some depressions, the relationship between depression group directions and mine cut directions, the standard deviation of the direction differences of depression groups and of their depressions. The forms of the mountain related to surface mining can be separated to open and closed. The former are trenches and stairs, the latter are circular, elongated, and complex depressions. The formation of these forms can be related to the balancing movements of the vault over the mountain’s mine. At thin vault, stairs develop by collapses, while at the atectonic fissures of thicker vault, trenches and depressions are formed at the surface. In areas bordered by sinking(subsidence through) and downwardly cohesive faults, depression groups of diverse features are arranged in the marginal bands. Elongated depressions are formed at atectonic blocks bounded by dispersing faults in non-banded distribution. Where there is a superficial deposit, atectonic fissures can also be inherited directly by collapse to the surface and form depressions. They can also form indirectly over atectonic fissures by compaction, subsequent collapse and/or suffosion of the superficial deposit. The results of the study make it possible to analyse the material loss due to mining on the vault if the atectonic structures of the vault are partly or completely covered by superficial deposit.

关键词： mining pseudokarstic depression atectonic fissure atectonic block collapse suffosion

Endangered lowland oak forest steppe remnants keep unique bird species richness in Central Hungary

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Journal of Forestry Research 2022年第1期33卷 343-355页

作者： GáborÓnodi zoltán Botta‑Dukát Dániel Winkler Tamás Rédei Institute of Ecology and Botany Centre for Ecological ResearchVácrátótHungary Department of Botany and Biodiversity Research University of ViennaViennaAustria Institute of Wildlife Management and Wildlife Biology University of SopronSopronHungary

The biodiversity of natural or semi-natural native,old oak woodlands have high conservation importance,especially in landscapes of monocultural forest plantations and arable *** a wider variety of microhabitats and foraging sources,such old oak forests can provide essential habitat for native forest bird *** conducted a study using bird point counts to compare the forest bird communities of old pedunculate oak(Quercus robur)remnants with native and non-native plantations in central Hungary in a landscape of mostly arable fields,settlements,and monocultural *** surveys were carried out in old oak forest remnants,middle-aged oak,white poplar(Populus alba),hybrid poplar(Populus×euramericana),black locust(Robinia pseudoacacia),and pine(Pinus spp.)*** has been carried out in nine study sites,where all six habitat types were represented(with a few exceptions),to determine total abundance,species richness,Shannon–Wiener diversity,species evenness,dominant and indicator species,and guild *** found that old oak forest remnants were the most diverse habitats among the studied forest types,while hybrid poplar and pine plantations exhibited the lowest avian *** avian guilds most sensitive to the loss of old oak forest remnants were ground foragers,bark foragers,cavity-nesters,residents,and Mediterranean migratory *** habitats were more diverse than non-native *** results suggest that it is important to conserve all remaining high biodiversity old oak stands and to avoid clear-cutting of monocultural plantations in favour of practices such as mixed-species plantations,longer rotation lengths,or retention forestry.

关键词： Forest bird community Bird conservation Old oak forest-steppe remnant Plantation forestry Forest conservation non-native plantation

Prevalence of refractive errors in Hungary reveals three-fold increase in myopia

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1174-1179页

作者： János németh TennóDaiki Gergely Dankovics István Barna Hans Limburg zoltán Zsolt nagy Department of Ophthalmology Semmelweis UniversityBudapest 1085Hungary Comprehensive Health Test Program of Hungary Szentendre 2000Hungary Department of Media and Education Informatics Eötvös Loránd UniversityBudapest 1053Hungary 1st Department of Internal Medicine Semmelweis UniversityBudapest 1083Hungary Health Information Services Grootebroek 1613LCThe Netherlands

AIM:To examine the prevalence and composition of refractive errors in ***:nationwide cross-sectional data collected between 2014 and 2019 were analysed from the Comprehensive Health Screening Program of Hungary,which provided spectacle dioptric power and autorefractometry data for 68227 people(35850 women and 32377 men).Their age distribution,18-99y,was similar to the national demographic ***:Of the total population,16.50%of the refractive errors exhibited hyperopia,40.05%emmetropia,and 43.45%*** was 3 times more frequent(58.7%)in younger ages(18-35y of age)compared to older age groups(19.4%of those 56-70y of age;Pnce(0.21%),and an increase parallel with ageing(r=0.716;P=0.009).COnCLUSIOn:Myopia is the most frequent refractive error in *** prevalence of myopia is especially increased,up to 2-3 times,in the younger age *** actions need to be taken to reduce the onset of myopia and its associated consequences.

关键词： refractive errors myopia hyperopia emmetropia Hungary

Efficiency of local minima and GLM techniques in sinkhole extraction from a LiDAR-based terrain model

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International Journal of Digital Earth 2019年第9期12卷 1067-1082页

作者： Péter Enyedi Melinda Pap zoltán Kovács László Takács-Szilágyi Szilárd Szabó a Department of Physical Geography and Geoinformatics University of DebrecenDebrecenHungary Internet of Things Research Institute Eszterházy Károly University of Applied SciencesEgerHungary

The aim of this paper was to study reliable automated delineationpossibilities of karst sinkholes using a LiDAR-based digital terrain model(DTM) with pixel-based classifications. We applied two approaches toextract sinkholes: (1) general linear modeling (GLM) with morphometricindices derived from DTM;(2) and a local minima-based delineationusing only LiDAR DTM as the input layer. The outcome of the localminima was significantly different from the reference ones but found allthe sinkholes without previous knowledge of the area. The GLM-basedoutcome did not differ statistically from the reference. Results showedthat these approaches were efficient in detecting sinkholes based onLIDAR derivatives, and can be used for risk assessment and hazardpreparedness in karst areas: GLM had an overall accuracy of 89.5% andlocal minima had an accuracy of 92.3%;both methods identifiedsinkholes but also had commission errors, identifying depressions assinkholes.

关键词： Karst mapping sinkhole identification general linear model statistical evaluation sink fill

ZnO/PAnI nanoflake arrays sensor for ultra-low concentration and rapid detection of nO_(2)at room temperature

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Rare Metals 2023年第2期42卷 536-544页

作者： Qiu-Yue Zheng Meng Yang Xin Dong Xian-Fa Zhang Xiao-Li Cheng Li-Hua Huo zoltán Major Ying-Ming Xu Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin150080China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education School of Chemistryand State Key Laboratory of Optoelectronic Materials and TechnologiesSun Yat-Senen UniversityGuangzhou510275China Institute of Polymer Product Engineering Johannes Kepler University Linz124040LinzAustria

With the development of environmental monitoring,it is urgent to establish nO_(2)sensor with good sensing *** with the traditional nO_(2)sensors made of metal oxides,nO_(2)sensors made of n-p heterostructure nanocomposites have good sensing performance in detection limit and operating *** nanoflake arrays with polyaniline film grown on the surface were prepared on ceramic tubes by hydrothermal and vapor diffusion *** gas-phase diffusion method can control the heterostructure by adjusting the diffusion *** room temperature(25℃),the construction of rich n-p heterogeneous interface enables the sensor prepared by the nanocomposite to respond to nO_(2),showing the sensing performance with the response value of 28.00 to10.00×10^(-6)nO_(2);the detection limit improved to0.01×10^(-6)and the recovery time of 18 *** this work,the sensing mechanism of nO_(2)at heterogeneous interface is analyzed,which provides a promising material for the detection of low concentration nO_(2)at room temperature.

关键词： ZnO/polyaniline(PAnI)nanoflake arrays n-p heterostructure Ultra-low concentration nO_(2)gas sensor Rapid detection

Shear banding-inducedslip enables unprecedented strength-ductility combination of laminated metallic composites

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Journal of Materials Science & Technology 2022年第15期110卷 260-268页

作者： Shuang Jiang Ru Lin Peng Kristián Máthis Hai-Le Yan Gergely Farkas zoltán Hegedues Ulrich Lienert Johan Moverare Xiang Zhao Liang Zuo nan Jia Yan-Dong Wang Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) School of Material Science and EngineeringNortheastern UniversityShenyang 110819China Division of Engineering Materials Department of Management and EngineeringLinköping UniversityLinköping 58183Sweden Department of Physics of Materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 5Prague 12116Czech Republic nuclear Physics Institute of the Czech Academy of Sciences Rež130Husinec-ˇRež25068Czech Republic Deutsches Elektronen-Synchrotron(DESY) Notkestr.85Hamburg 22607Germany Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China

Shear bands in metallic materials have been reported to be catastrophic because they normally lead to non-uniform plastic deformation. Ductility of laminated metallic composites deteriorates with increasing processing strain, particularly for those having hexagonal-close-packed(hcp) constituents due to inadequate slip systems and consequently prominent shear banding. Here, we propose a design strategy that counterintuitively tolerates the bands with localized strains, i.e. the shear banded laminar(SBL) structure, which promotes dislocation activation in hcp metals and renders unprecedented strengthductility combination in hcp-metal-based composites fabricated by accumulative roll bonding(ARB). The SBL structure is characterized with one soft hcp metal constrained by adjacent hard metal in which dislocations have been accumulated near the bimetal interfaces. High-energy X-ray diffraction astonishingly reveals that more than 90% of dislocations are non-basal in Ti layers of the SBL Ti/nb composite processed by eight ARB cycles. Moreover, dislocations occupy a high fraction of ~30%, promoting further cross slip. The unique stress field tailored by both shear banding and heterophase interface-mediated deformation accommodation triggers important slip. This SBL design is of significance for developing hcp-based laminates and other heterostructured materials with high performances.

关键词： Shear band Laminated metallic composites Ductility High-energy X-ray diffraction Dislocation slip