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Walking th. th.n line…ten years later:th. dilemma of aboveversus below-ground features to support ph.logenies in th. Russulaceae(Basidiomycota)

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Fungal Diversity 2018年第2期89卷 267-292页

作者： Bart Buyck Stefan zoller Valerie h.fstetter Museum national d’h.stoire naturelle Departement Systematique et OriginesCP 39Institut pour la SystematiqueEvolutionBiodiversiteSorbonne UniversiteUMR 7205 CNRS MNHN UPMC EPHE12 Rue Buffon75005 ParisFrance Department of Environmental Systems Science Genetic Diversity CentreETH ZurichCHN E 55Universitatstrasse 168092 ZurichSwitzerland Department of Plant Protection Agroscope ChanginsWadenswil Research StationACWRte de Duiller1260 NyonSwitzerland

For th. very first time,morph.-anatomical features of both.fruiting bodies as well as below-ground structures h.ve been confronted with.a newly produced multigene ph.logeny of root symbiotic basidiomycetes using one of th. most speciose genera of ectomycorrh.zal fungi(Russula,Russulales)as an *** th.s first of two papers,th. auth.rs focus more specifically on below-ground *** five-gene ph.logeny divides th. genus in five main clades,h.re interpreted as representing seven subgenera,all significantly *** more conserved th.n features of fruiting bodies,th. anatomy of ectomycorrh.za does not allow for an unambiguous ch.racterization of th. main clades resolved by ph.logenetic analysis,but th. anatomy of ectomycorrh.za performs better to naturally classify th. species of th.s *** of fruiting bodies remain much.more adequate for th. delimitation of terminal clades and are irreplaceable for morph.logical species *** taxa mostly nest in ancient lineages,but are also present in some terminal clades of oth.rwise temperate species *** sh.ft from plectench.matic to pseudoparench.matic ECM outer mantle structures h.ppened most likely already in th. paleotropics,and is h.re h.poth.sized to h.ve facilitated a major diversification of th. genus with.new h.sts in th. north.rn *** data as well as our own observations on below ground structures of several Lactifluus species suggests th.t th.s genus sh.res with.Russula th. absence of lactifers in ECM mantles and rh.zomorph.,contrary to species of Lactarius wh.re lactifers are always *** observations on rh.zomorph. of species in Multifurca confirm th. presence of vessel-like and ladder-like h.ph.e,also found in th. oth.r agarioid genera of th.s family,wh.le distinct lactifers are only present in th. lactarioid,but not in russuloid members of th.s genus.

关键词： Ectomycorrh.zal anatomy Lactifluus Multifurca Multigene ph.logeny Rh.zomorph.

Pancreatic cancer stem cell markers and exosomes-th. incentive push

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World Journal of Gastroenterology 2016年第26期22卷 5971-6007页

作者： Sarah.h.iler Zh. Wang Margot zoller Tumor Cell Biology University Hospital of SurgeryD 69120 HeidelbergGermany

Pancreatic cancer(Pa Ca) h.s th. h.gh.st death.rate and incidence is increasing. Poor prognosis is due to late diagnosis and early metastatic spread, wh.ch.is ascribed to a minor population of so called cancer stem cells(CSC) with.n th. mass of th. primary tumor. CSC are defined by biological features, wh.ch.th.y sh.re with.adult stem cells like longevity, rare cell division, th. capacity for self renewal, differentiation, drug resistance and th. requirement for a nich.. CSC can also be identified by sets of markers, wh.ch.for pancreatic CSC(Pa-CSC) include CD44v6, c-Met, Tspan8, alph.6beta4, CXCR4, CD133, Ep CAM and claudin7. Th. functional relevance of CSC markers is still disputed. We h.poth.size th.t Pa-CSC markers play a decisive role in tumor progression. Th.s is fostered by th. location in glycolipid-enrich.d membrane domains, wh.ch.function as signaling platform and support connectivity of th. individual Pa-CSC markers. Outsidein signaling supports apoptosis resistance, stem cell gene expression and tumor suppressor gene repression as well as mi RNA transcription and silencing. Pa-CSC markers also contribute to motility and invasiveness. By ligand binding h.st cells are triggered towards creating a milieu supporting Pa-CSC maintenance. Furth.rmore, CSC markers contribute to th. generation, loading and delivery of exosomes, wh.reby CSC gain th. capacity for a cell-cell contact independent crosstalk with.th. h.st and neigh.oring non-CSC. Th.s allows PaCSC exosomes(TEX) to reprogram neigh.oring nonCSC towards epith.lial mesench.mal transition and to stimulate h.st cells towards preparing a nich. for metastasizing tumor cells. Finally, TEX communicate with.th. matrix to support tumor cell motility, invasion and h.ming. We will discuss th. possibility th.t CSC markers are th. initial trigger for th.se processes and wh.t is th. special contribution of CSC-TEX.

关键词： Pancreatic cancer Cancer stem cells Stem cell markers Exosomes Crosstalk

Extremely severe h.poch.oremic metabolic alkalosis after ileorectal anastomosis in a patient with.ch.onic intestinal pseudo-obstruction

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Gastroenterology Report 2023年第1期11卷 563-565页

作者： Peter h.inz-Erian Andreas RJanecke Th.mas Muller Peter Reh.er Elisabeth.Bruder Th.mas Menter h.inz zoller Markus Pirklbauer Mich.el Rieger Department of Pediatric and Adolescent Medicine Medical University of InnsbruckInnsbruckTyrolAustria Department of Urology Medical University of InnsbruckInnsbruckTyrolAustria Institute of Path.logy University Hospital BaselBaselBaselSwitzerland Department of Internal Medicine I Medical University of InnsbruckInnsbruckTyrolAustria Department of Internal Medicine IV Medical University of InnsbruckInnsbruckTyrolAustria Department of Radiology District Hospital HallHallTyrolAustria

Introduction Ch.onic intestinal pseudo-obstruction(CIPO),defined as ch.onic constipation with.ut mech.nical obstruction of th. gastrointestinal tract[1,2],often presents with.a truly ch.meleon-like symptomatology including irregular defecation,abdominal pain and distension,nausea,vomiting,and sometimes fluid/electrolyte *** diarrh.a was found in17%of CIPO cases,its nature,h.wever,h.s not been precisely *** deviations of electrolyte and acid–base status,to th. best of our knowledge,h.ve not been reported.

关键词： obstruction diarrh.a ch.onic

patients with.inflammatory bowel disease:Mech.nisms and possible clinical impact

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World Journal of Gastroenterology 2021年第17期27卷 2039-2053页

作者： Trond Espen Detlie Jonas Ch.istoffer Lindstrøm Marte Eide Jah.sen Elisabeth.Finnes h.inz zoller Bjørn Moum Jørgen Jah.sen Department of Gastroenterology Akershus University HospitalLørenskog 1478Norway Institute of Clinical Medicine University of OsloOslo 0316Norway h.alth.Services Research.Unit Akershus University HospitalLørenskog 1478Norway Division of Medicine Department of GastroenterologyOslo University Hospital UllevålOslo 0424Norway Department of Medicine II Gastroenterology and HepatologyMedical University of InnsbruckInnsbruck A-6020Austria

BACKGROUND h.gh.dose intravenous iron is an effective treatment option for iron deficiency(ID)or ID anaemia(IDA)in inflammatory bowel disease(IBD).h.wever,treatment with.ferric carboxymaltose(FCM)h.s been associated with.th. development of *** To investigate mech.nisms beh.nd th. development of h.poph.sph.temia after intravenous iron treatment,and disclose symptoms and clinical manifestations related to h.poph.sph.temia *** A prospective observational study of adult IBD patients with.ID or IDA was conducted between February 1,2017 and July 1,2018 at two separate university h.spitals in th. south.ast region of *** received one dose of 1000 mg of eith.r FCM or ferric derisomaltose(FDI)and were followed for an observation period of at least 7 *** and urine samples were collected for relevant analyses at baseline,week 2 and at week *** symptoms were assessed at th. same timepoints using a respiratory function test,a visual analogue scale,and a h.alth.related quality of life *** A total of 106 patients was available for analysis in th.s *** FCM treatment group consisted of 52 patients and h.poph.sph.temia was present in 72.5%of th. patients at week 2,and in 21.6%at week *** comparison,th. FDI treatment group consisted of 54 patients and 11.3%of th. patients h.d h.poph.sph.temia at week 2,and 3.7%at week *** difference in incidence was h.gh.y significant at both.week 2 and 6(Ph.gh.r mean concentration of intact fibroblast growth.factor 23(Ph.sph.te(P=0.004),a significant decrease of 1,25-dih.droxyvitamin D(Ph. FCM-treated patients compared with.patients wh. received *** clinical symptoms could with.certainty be related to h.poph.sph.temia,since neith.r th. respiratory function test,SF-36(36-item sh.rt form h.alth.s

关键词： Iron deficiency h.poph.sph.temia Inflammatory bowel disease Ferric carboxymaltose Ferric derisomaltose

卓乐刀具预调和检测技术让刀具制造商阔步迈向未来

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航空制造技术 2005年第7期48卷 41-43页

作者： Ch.istoph.zoller 卓乐(上海)精密检测仪器有限公司

卓乐公司凭借世界领先的刀具预调设备、刀具检测设备、热收缩系统和刀具管理软件系统。

关键词：刀具检测技术调和制造商管理软件系统检测设备服务水平产品质量热收缩

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成功的测量

世界制造技术与装备市场 2012年第5期 118-120页

作者： zoller公司 zoller公司

质量、精度、可靠性辅之以给人强烈震感的效率和经济性。基地位于德国Pleidelsh.im的***公司将技术创新与易操作性有机结合在一起，开发出了新型测量软件，可预先设定测量机，用于各种切削刀具的测量、检验和管理。

关键词：测量软件易操作性技术创新切削刀具经济性可靠性测量机

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先进固体火箭发动机

固体火箭技术 1990年第3期13卷 73-77页

作者： K.Joh.s L.zoller 陈向明

本文介绍的先进固体火箭发动机(ASRM)是一个直径为3810mm的分段式发动机,为提高航天飞机的可靠性和设计安全裕度,对该发动机做了大量的设计改进,它的推力特性使得不必要在最大动压期间调节航天飞机主发动机(SSME),这可减少或消除大约17... 详细信息

本文介绍的先进固体火箭发动机(ASRM)是一个直径为3810mm的分段式发动机,为提高航天飞机的可靠性和设计安全裕度,对该发动机做了大量的设计改进,它的推力特性使得不必要在最大动压期间调节航天飞机主发动机(SSME),这可减少或消除大约175个航天飞机系统的临界状态1/1R失效模式,它将能提供5443kg的有效截荷增量,为保证该发动机的高质量、高重现性和可靠性,需要建立新型的全自动化的加工设施,ASRM的设计和计划安排是在A和B两阶段研究的基础上提出的,ASRM航天飞机的研制飞行,暂定于1994年下半年进行。

关键词：火箭发动机固体火箭航天飞机