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Effects of Zataria oxymel on obesity, insulin resistance and lipid profile:A randomized, controlled, triple-blind trial

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Journal of Integrative Medicine 2020年第5期18卷 401-408页

作者： Jafar Abolghasemi Mohammad Ali Farboodniay Jahromi Mohammad Hossein Sharifi zohreh mazloom Leila Hosseini Nasrindokht Zamani Majid Nimrouzi Research Center for Persian Medicine and Histony of Medicine Shiraz University of Medical SciencesShiraz ***Iran Medicinal Plants Processing Research Center Shiraz University of Medical SciencesShira 2***Iran Department of Nutrition School of Health and Nutrition.Shiraz University of Medical SciencesShiraz ***Iran Drpurment of PersianMeedicine School of MedicineShiraz University of Medical SciencesShiraz ***Iran

Background: Obesity is a major public health problem and its occurrence is markedly increasing in developed and developing countries. However, few studies have investigated the use of natural products to treat obesity. The effects of taking a combination of oxymel and Zataria multiflora Boiss.(ZM), herein referred to as Zataria oxymel(ZO), on obesity, lipid profile and insulin resistance have not yet been ***: This study evaluates the effects of oxymel and ZO on obesity, lipid profile and insulin ***, setting, participants and interventions: In this randomized, controlled, triple-blind trial, overweight patients were randomly divided into three groups and received doses of study compounds twice per day for twelve weeks. Group A received 0.75 g ZM in 10 mL oxymel in each treatment;group B received 1.5 g ZM in 10 m L of oxymel in each treatment and group C(control) only received 10 mL of oxymel in each *** outcome measures: Anthropometric parameters, including body mass index(BMI), waist circumference and hip circumference, were measured at the time of registration. Blood tests were carried out at the beginning and once again at end of the study. Blood parameters included fasting blood sugar(FBS), insulin levels, serum lipid profile(total cholesterol, triglyceride, low-density lipoprotein cholesterol and highdensity lipoprotein cholesterol) and liver enzymes(aspartate transaminase and alanine transaminase).Serum creatinine was also measured at the beginning of the project and in monthly intervals for three months. The homeostasis model assessment index was calculated as fasting insulin(μIU/mL)×FBS(mg/dL)/***: The results showed that patients receiving ZO experienced significant reduction in waist circumference in groups A, B and C, respectively(P < 0.001) but no significant change in BMI. Group A also experienced reduction in hip circumference(P = 0.01). Groups B and C had reduction in the homeostatic model assessment of

关键词： Zataria multiflora Oxymel Insulin resistance Obesity Traditional Persian medicine

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