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Cutaneous Cryptococcosis Arising in a Patient with Idiopathic Lung Disease: Related Illnesses or “Ticks and Fleas”

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Case Reports in Clinical Medicine 2023年第10期12卷 418-424页

作者： zoe Parker Cary Chisholm Lubbock Christian University Lubbock USA Dermatopathology Laboratory Epiphany Dermatology Waco USA

Cryptococcus is a yeast typically found in bird feces such as pigeon droppings. Infection may occur through inhalation of spores or via direct inoculation into the skin. Typically there is a history of immunosuppression, but cases are also reported in immunocompetent hosts. Cryptococcus may manifest as pulmonary disease or primary cutaneous infection, but dissemination to a systemic illness is the most life-threatening concern. We present the case of a 71-year-old man with a four-year history of idiopathic lung disease, treated with oral prednisone and mycophenolate, presents with a new onset skin rash on the right wrist. He has a history of cleaning and clearing barns and sheds after a recent storm devastated the area. Birds and bats were present in these structures while he was working. Initial therapy failed, and subsequent biopsy showed the presence of Cryptococcus yeast. Further investigation yielded a positive, low titer Cryptococcus antigen screen but negative blood cultures. This case illustrates three valuable facets of patient care. Ideally, one diagnosis will explain all of the clinical presentation, but when that is not the case then multiple etiologies must be explored. Sometimes first-line therapy is ineffective, and the clinician should not be afraid to recognize that and change course. Importantly with skin lesions, failure to respond to treatment or worsening of the lesion in the face of topical and/or oral steroids should lead one to consider the possibility of infection, particularly in an immunosuppressed patient, and prompt biopsy is prudent.

关键词： Cryptococcosis Cryptococcus Dermatitis Chronic Lung Disease Skin Infection

Polydactyly:Clinical and molecular manifestations

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World Journal of Orthopedics 2023年第1期14卷 13-22页

作者： Zisis Kyriazis Panagoula Kollia Ioanna Grivea Nikolaos Stefanou Sotirios Sotiriou zoe H Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500Greece Department of Genetics and Biotechnology Faculty of BiologyUniversity of AthensAthens 15701Greece Department of Paediatrics Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500Greece Laboratory of Histology and Embryology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500Greece

Polydactyly is a malformation during the development of the human limb,which is characterized by the presence of more than the normal number of fingers or *** is considered to be one of the most common inherited hand *** can be divided into two major groups:Non-syndromic polydactyly or syndromic *** to the anatomical location of the duplicated digits,polydactyly can be generally subdivided into pre-,post-axial,and mesoaxial ***-syndromic polydactyly is often inherited with an autosomal dominant trait and defects during the procedure of anterior-posterior patterning of limb development are incriminated for the final phenotype of the *** are several forms of polydactyly,including hand and foot extra digit *** deformity affects upper limbs with a higher frequency than the lower,and the left foot is more often involved than the *** treatment is always *** the clinical presentation is highly diverse,the treatment combines single or multiple surgical operations,depending on the type of *** research attention that congenital limb deformities have recently attracted has resulted in broadening the list of isolated gene mutations associated with the *** generation sequencing technologies have contributed to the correlation of phenotype and genetic profile of the multiple polydactyly manifestations and have helped in early diagnosis and screening of most nonsyndromic and syndromic disorders.

关键词： Polydactyly Gene Syndromic Non-syndromic Preaxial Postaxial

Update in combined musculoskeletal and vascular injuries of the extremities

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World Journal of Orthopedics 2022年第5期13卷 411-426页

作者： Nikolaos Stefanou Christina Arnaoutoglou Fotios Papageorgiou Miltiadis Matsagkas Sokratis E Varitimidis zoe H Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500Greece Department of Vascular Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500Greece Department of Hand Upper Extremity and MicrosurgeryIASO ThessaliasLarissa 41500Greece

Combined musculoskeletal and vascular injuries of the extremities are conditions in which a multidisciplinary approach is a sine qua non to ensure life initially and limb viability *** injuries as part of musculoskeletal trauma are usually the result of the release of a high energy load in the wound site so that the prognosis is determined by the degree of soft-tissue damage,duration of limb ischemia,patient’s medical status and presence of associated *** management of these injuries is challenging and requires a specific algorithm of action,because they are usually characterized by increased morbidity,amputation rate,infection,neurological and functional deficits,and they could be life *** vascular injuries are rare and occur either isolated or in the context of major combined musculoskeletal trauma,the high index of suspicion,imaging control,and timely referral of the patient to organized trauma centers ensure the best functional outcome of the extremity in such challenging *** after a successful initial treatment of a combined trauma pattern,long-term follow-up is crucial to prevent and detect early possible *** purpose of this manuscript is to provide an update on diagnosis and treatment of combined musculoskeletal and vascular injuries of the extremities,from an orthopedic point of view.

关键词： Vascular injury Musculoskeletal trauma Combined injury Arterial injury Mangled extremity Limb salvage

Real-Time H.265/HEVC Intra Encoding with a Configurable Architecture on FPGA Platform

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Chinese Journal of Electronics 2019年第5期28卷 1008-1017页

作者： DING Dandan WANG Silong LIU zoe YUAN Qingshu School of Information Science and Engineering Hangzhou Normal University College of Information Science and Electronic Engineering Zhejiang University

This paper proposes a flexible design scheme for H.265/HEVC encoding based on FPGA, which allows an easy incorporation of a variety of algorithms applied to different scenarios. In particular, we present an H.265/HEVC intra encoder as an instantiation of our proposed scheme. The key idea is to develop an encoder system by configuring basic Processing elements(PEs) of fundamental algorithms. Our intra encoder using the flexible framework is structured with fourstage CTU based pipeline. Pixel-level PEs are designed to unify the intra prediction of 35 modes and a multiscale compatible transform array is proposed to process variable size transform. 32 PEs are paralleled for intra mode decision to support 35 combinations of modes and partitions. In the reconstruction stage, 16 PEs are paralleled for intra prediction and a 16 × 16 multiplier array is configured for transforms of variable sizes with a constant 16 pixels/cycle throughput. Implementation results show that our proposed architecture costs about63 K Lookup tables and 62 KB on-chip memories on Xilinx Kintex-7 platform with the maximum working frequency at 175 MHz, which is sufficient for real-time encoding of 1920 × 1080 @60 fps video at 160 MHz. The flexibility and extension capability of our framework provides a great potential for future FPGA solutions serving for different purposes.

关键词： H.265/HEVC Configuration Flexibility Intra prediction FPGA

Stamen specification and anther development in rice

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Chinese Science Bulletin 2009年第14期54卷 2342-2353页

作者： ZHANG DaBing WILSON zoe A Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders of Ministry of Education School of Life Science and Biotechnology Shanghai Jiaotong University Shanghai 200240 China Plant Sciences Division School of Biosciences University of Nottingham Loughborough Leics LE125RD United Kingdom

Male reproductive development is a complex biological process which includes the formation of the stamen with differentiated anther tissues, in which microspores/pollens are generated, then anther dehiscence and subsequently pollination. Stamen specification and anther development involve a number of extraordinary events such as meristem transition, cell division and differentiation, cell to cell communication, etc., which need the cooperative interaction of sporophytic and gametophytic genes. The advent of various tools for rice functional gene identification, such as complete genome sequence, genome-wide microarrays, collections of mutants, has greatly facilitated our understanding of mechanisms of rice stamen specification and anther development. Male sterile lines are critical for hybrid rice breeding, therefore understanding these processes will not only contribute greatly to the basic knowledge of crop developmental biology, but also to the development of new varieties for hybrid rice breeding in the future.

关键词：水稻育种花药雄蕊组织分化细胞分裂基因鉴定细胞间通讯基因组序列

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文化智商对创新的影响——以中国侨民为案例

文化智商对创新的影响——以中国侨民为案例

作者： REICHMAN zoe 华东师范大学

学位级别：硕士

1978年,中国拥抱全球化,向世界敞开大门。随之而来的是,中国经济取得了显著的总体增长,促使更多的中国工人融入国际企业的发展。本文以中国侨民(在国外生活和工作的中国人)为研究对象,探究文化智商与创新之间的关系。本研究利用创新工... 详细信息

1978年,中国拥抱全球化,向世界敞开大门。随之而来的是,中国经济取得了显著的总体增长,促使更多的中国工人融入国际企业的发展。本文以中国侨民(在国外生活和工作的中国人)为研究对象,探究文化智商与创新之间的关系。本研究利用创新工作行为来进一步解释文化智商与创新之间的联系;同时,创造力被用作文化智商和创新工作行为之间的中介变量。在研究方法上,本研究采用了一份面向海外华人的调查问卷,测量文化智商、创造力、创新工作行为和组织创新等指标。我们还对来自以色列和塞尔维亚的与中国侨民打交道的个人进行了三次采访。我们假设文化智商与创新工作行为呈正相关,创造力介导了文化智商对创新工作行为的影响;同时,创新工作行为与组织创新呈正相关。研究发现,具有特定品质的中国侨民拥有更强的创新能力。这使得他们能够为组织带来革新,并帮助他们在竞争激烈的全球经济环境中更能取得可持续发展。

关键词：中国侨民文化智商创造力创新工作行为创新

Deriving striatal projection neurons from human pluripotent stem cells with Activin A

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Neural Regeneration Research 2015年第12期10卷 1914-1916页

作者： zoe Noakes Marija Fjodorova Meng Li Stem Cell Neurogenesis Group Neuroscience and Mental Health Research InstituteSchool of Medicine and School of BioscienceCardiff University

The striatum is the main input structure of the basal ganglia and is involved in voluntary motor control,habit learning and reward *** spiny neurons（MSNs）comprise80%and 95%of striatal neurons in primates and rodents... 详细信息

关键词： cell MSNs PSCs Deriving striatal projection neurons from human pluripotent stem cells with Activin A stem

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报告主诉:削弱患者权力的语言

英国医学杂志中文版 2022年第10期25卷 564-567页

作者： Caitriona Cox zoe Fritz 李俊(译) 李昕璇(译) The Healthcare Improvement Studies(THIS)Institute University of CambridgeCambridgeUK 北京大学医学部医学人文学院

Caitriona Cox和zoe Fritz认为,表达怀疑、贬低或指责患者过时的医学用语会损害治疗关系,现在是时候做出改变了。语言很重要。它是分享知识和见解的工具,是我们向他人表达和交流价值观的手段。在医学场景下,语言的功能不仅仅是在患者和... 详细信息

Caitriona Cox和zoe Fritz认为,表达怀疑、贬低或指责患者过时的医学用语会损害治疗关系,现在是时候做出改变了。语言很重要。它是分享知识和见解的工具,是我们向他人表达和交流价值观的手段。在医学场景下,语言的功能不仅仅是在患者和医疗机构之间传递信息,它还有塑造治疗关系(therapeutic relationship)的潜力1-2。

关键词：医疗机构传递信息患者权力

Bugs beneath the surface： the functional significance of soil macroinvertebrates to landscape health in Australia＇s tropical savannas

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Insect Science 2005年第4期12卷 307-312页

作者： TRACY zoe DAWES-GROMADZKI CSIRO Sustainable Ecosystems and Tropical Savannas Cooperative Research Centre Australia

土壤宏无脊椎动物在在澳大利亚的热带无树平原支撑生产和生物多样性起一个重要作用。例如，通过他们的 foraging 和嵌套的活动，白蚁再循环营养素和碳并且生产便于水渗入的土壤毛孔。挑战向前到份量上理解驾驶这的关系和进程。不同种类... 详细信息

土壤宏无脊椎动物在在澳大利亚的热带无树平原支撑生产和生物多样性起一个重要作用。例如，通过他们的 foraging 和嵌套的活动，白蚁再循环营养素和碳并且生产便于水渗入的土壤毛孔。挑战向前到份量上理解驾驶这的关系和进程。不同种类和宏无脊椎动物的功能的组在各种各样的风景过程起什么作用？是不同陆地管理的效果的，练习(例如，国内牛放牧，火)在为风景健康的这些关系，和后果上?这篇论文在北澳大利亚从研究论述初步的结果，检验在土壤宏无脊椎动物上放牧的陆地状况和国内牛的效果，并且为要用作一个工具恢复的白蚁的潜力在降级的区域玷污功能。在北澳大利亚，增加了降级似乎在差异和活动 ofmacroinvertebrates 与衰落被联系。白蚁看起来是最有弹性的组之一，与能够维持在降级的风景的活动的某种类。

关键词：大型无脊椎动物陆地动物健康状态澳大利亚热带地区生态环境生活习性