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IEEE/CAA Journal of Automatica Sinica 2020年第4期7卷 1134-1153页

作者： Jiahai Wang Yuyan Sun zizhen zhang Shangce Gao the Department of Computer Science and also with the Key Laboratory of Machine Intelligence and Advanced ComputingMinistry of Educationand also with the Guangdong Key Laboratory of Big Data Analysis and ProcessingSun Yat-sen UniversityGuangzhou 510275China the Department of Computer Science Sun Yat-sen UniversityGuangzhou 510275China the Faculty of Engineering University of ToyamaToyama-shi 930-8555Japan

The multitrip pickup and delivery problem with time windows and manpower planning(MTPDPTW-MP)determines a set of ambulance routes and finds staff assignment for a hospital. It involves different stakeholders with diverse interests and objectives. This study firstly introduces a multiobjective MTPDPTW-MP(MO-MTPDPTWMP) with three objectives to better describe the real-world scenario. A multiobjective iterated local search algorithm with adaptive neighborhood selection(MOILS-ANS) is proposed to solve the problem. MOILS-ANS can generate a diverse set of alternative solutions for decision makers to meet their requirements. To better explore the search space, problem-specific neighborhood structures and an adaptive neighborhood selection strategy are carefully designed in MOILS-ANS. Experimental results show that the proposed MOILS-ANS significantly outperforms the other two multiobjective algorithms. Besides, the nature of objective functions and the properties of the problem are analyzed. Finally, the proposed MOILS-ANS is compared with the previous single-objective algorithm and the benefits of multiobjective optimization are discussed.

关键词： Adaptive neighborhood selection manpower planning multiobjective optimization multitrip pickup and delivery problem with time windows

Stability enhancement of PbS quantum dots by site-selective surface passivation for near-infrared LED application

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Nano Research 2021年第3期14卷 628-634页

作者： Xinsu zhang Yujuan Chen Linyuan Lian zizhen zhang Yixuan Liu Li Song Chong Geng Jianbing zhang Shu Xu Tianjin Key Laboratory of Electronic Materials and Devices School of Electronics and Information EngineeringHebei University of TechnologyTianjin300401China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan430074China

Infrared lead chalcogenide quantum dots(QDs)suffer fast degradation due to the easy oxidation of surface chalcogen ***,we report a trioctylphosphine-mediated surface passivation method to improve the air stability of PbS *** mechanism study reveals an in situ surface reaction,which leads to site-selective passivation of surface S atoms with lead *** surface capping motif sufficiently protects PbS QDs from oxygen and improves their stability as well as quantum efficiency regardless of the QD size and original ligands on surface *** modified PbS QDs display no obvious fluorescence quenching and surface oxidization after 30 days of air *** robust surface capping also provides high compatibility of PbS QDs with polymers for optoelectronic device *** near-infrared LEDs based on the modified PbS QDs display a slight degradation of only 1.47%from the maximum intensity after continuous operation in air for 250 hours(lifetime>10,000 h)at 0.5 W/cm^(2) power density,indicating the surface passivation route is promising strategy for promoting practical optoelectronic application of PbS QDs.

关键词： PbS quantum dot surface modification stability light-emitting diode

Enhanced solution representations for vehicle routing problems with split deliveries

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Frontiers of Engineering Management 2023年第3期10卷 483-498页

作者： Wenbin ZHU Zhuoran AO Roberto BALDACCI Hu QIN zizhen zhang School of Business Administration South China University of TechnologyGuangzhou 510640China Thrust of Intelligent Transportation The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511466China College of Science and Engineering(CSE) Hamad Bin Khalifa University(HBKU)Doha 5825Qatar School of Management Huazhong University of Science and TechnologyWuhan 430074China School of Data and Computer Science Sun Yat-sen UniversityGuangzhou 510275China

In this study,we investigate a forest-based solution representation for split delivery vehicle routing problems(SDVRPs),which have several practical applications and are among the most difficult vehicle routing *** new solution representation fully reflects the nature of split delivery,and can help reduce the search space when used in heuristic *** on the forest structure,we devise three neighborhood search *** highlight the effectiveness of this solution representation,we integrate these operators into a standard tabu search *** conduct extensive experiments on three main SDVRPs addressed in the literature:The basic SDVRP,the multidepot SDVRP,and the SDVRP with time *** experimental results show that the new forest-based solution representation is particularly effective in designing and implementing neighborhood operators,and that our new approach outperforms state-of-the-art algorithms on standard datasets.

关键词： vehicle routing multidepot time windows tabu search split delivery

Hopf Bifurcation of a Nonresident Computer Virus Model with Delay

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Analysis in Theory and Applications 2018年第3期34卷 199-208页

作者： zizhen zhang Yougang Wang Massimiliano Ferrara School of Management Science and Engineering Anhui University of Finance and Economics Department of Law Economics and Human Sciences Mediterranea University of Reggio Calabria

In this paper, a delayed nonresident computer virus model with graded infection rate is considered in which the following assumption is imposed: latent computers have lower infection ability than infectious computers. With the aid of the bifurcation theory, sufficient conditions for stability of the infected equilibrium of the model and existence of the Hopf bifurcation are established. In particular, explicit formulae which determine direction and stability of the Hopf bifurcation are derived by means of the normal form theory and the center manifold reduction for functional differential equations. Finally, a numerical example is given in order to show the feasibility of the obtained theoretical findings.

关键词： Computer virus delay Hopf bifurcation SLA model Periodic solution

SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1

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Science China(Life Sciences) 2024年第6期67卷 1199-1211页

作者： Hao Wang Wenwen Chen Yanting Wang Yuzhen Gao zizhen zhang Shuyi Mi Liangjing Wang Meng Xue Department of Gastroenterology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Institution of Gastroenterology Zhejiang UniversityHangzhou 310058China Department of Clinical Laboratory Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China

Metastasis accounts for the major cause of colorectal cancer(CRC)related mortality due to the lack of effective *** this study,we integrated the single-cell RNA-seq(sc RNA-seq)and bulk RNA-seq data and identified the transcriptional coactivator SUB1 homolog(SacSaccharomyces cerevisiae)/PC4(positive cofactor 4)associated with CRC *** SUB1 expression was correlated with advanced tumor stage and poor survival in *** vivo and vitro assays showed that SUB1 depletion could inhibit the invasive and metastatic abilities of CRC ***1 activated NF-κB signaling and its transcriptional target genes CXCL1 and CXCL3 to drive CRC ***,SUB1 integrated with the E3 ubiquitin-protein ligase UBR5 and increased its protein level in CRC ***,the increased UBR5mainly mediated Lys11-linked polyubiquitination and degradation of NF-κB negative regulator UBXN1,thus to activate the NF-κB ***,our study demonstrated that SUB1 promoted CRC progression by modulating UBR5/UBXN1 and activating NF-κB signaling,providing a new therapeutic strategy for treating metastatic CRC through targeting SUB1.

关键词： colorectal cancer Metastasis SUB1 UBR5 NF-κB signaling

Bioassay-guided isolation of α-Glucosidase inhibitory constituents from Hypericum sampsonii

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Chinese Journal of Natural Medicines 2023年第6期21卷 443-453页

作者： TAO Linlan XU Shuangyu zhang zizhen LI Yanan YANG Jue GU Wei YI Ping HAO Xiaojiang YUAN Chunmao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China Natural Products Research Center of Guizhou Province Guiyang 550014China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

This study employed the α-glucosidase inhibitory activity model as an anti-diabetic assay and implemented a bioactivity-guided isolation strategy to identify novel natural compounds with potential therapeutic *** sampsonii was investigated,leading to the isolation of two highly modified seco-polycyclic polyprenylated acylphloroglucinols(PPAPs)(1 and 2),eight phenolic derivatives(3-10),and four terpene derivatives(11-14).The structures of compounds 1 and 2,featuring an unprecedented octahydro-2H-chromen-2-one ring system,were fully characterized using extensive spectroscopic data and quantum chemistry *** compounds(1,5-7,9,and 14)exhibited potential inhibitory effects against α-glucosidase,with IC_(50) values ranging from 0.050±0.0016 to 366.70±11.08μg·mL^(-1).Notably,compound 5(0.050±0.0016μg·mL^(-1))was identified as the most potential α-glucosidase inhibitor,with an inhibitory effect about 6900 times stronger than the positive control,acarbose(IC_(50)=346.63±15.65μg·mL^(-1)).A docking study was conducted to predict molecular interactions between two compounds(1 and 5)and α-glucosidase,and the hypothetical biosynthetic pathways of the two unprecedented seco-PPAPs were proposed.

关键词： Hypericum sampsonii Chemical constituents Structure elucidation α-Glucosidase Molecular docking

Enhanced Removal Ciprofloxacin by Self-assembled Hydrogel with Anatase Titanium Oxide Nanotubes and Grapheme

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Journal of Donghua University(English Edition) 2019年第4期36卷 377-384页

作者： ZHENG Kai zhang zizhen LI Yuran XU Qiuyi GUO Tailin SUN Xinpeng School of Environmental Engineering Nanjing Institute of Technology

A novel hydrogel,consisting of titanium dioxide nanotubes and graphene oxide(H-TN-GO),was fabricated to remove ciprofloxacin(CIP)from aqueous *** adsorbent was characterized by scanning electron microscope(SEM),transmission electron microscope(TEM),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR)and Raman *** adsorption experiments systematically investigated the effect of contact time,temperature and pH on the capacity of H-TN-GO for *** property of H-TN-GO and its regeneration performance was evaluated.H-TN-GO exhibited high adsorption capacity of 530 mg/g and Langmuir model was more suitable for fitting adsorption *** removal ratio of CIP was more than 99%when initial concentrations were less than 100 mg/***,the initial pH of CIP solution had a distinct influence on the removal ratio,and adsorption capacity of adsorbance could be recovered by regeneration with mild alkaline *** pore size and abundant oxygen-containing groups on the surface further improved its adsorption *** enhancing effect of H-TN-GO mainly attributed to the immobilization of TiO 2 onto graphene oxide andπ-πinteractions stacking between H-TN-GO and graphene *** potential adsorbents,H-TN-GO exhibited remarkable regeneration capacity for water treatment.

关键词： hydrogel TiO 2 nanotubes graphene oxide adsorption ciprofloxacin

一类时滞计算机网络病毒模型的动力学行为（英文）

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浙江大学学报（理学版） 2015年第6期42卷 677-686页

作者：张子振安徽财经大学管理科学与工程学院安徽蚌埠233030

研究了一类具有2个时滞的SLBRS计算机病毒模型的局部稳定性和局部Hopf分支.以2个时滞的不同组合为分支参数,得到了模型的局部稳定性和局部Hopf分支存在的充分条件.利用中心流形定理和规范型理论研究了Hopf分支的方向和稳定性等性质.最后... 详细信息

研究了一类具有2个时滞的SLBRS计算机病毒模型的局部稳定性和局部Hopf分支.以2个时滞的不同组合为分支参数,得到了模型的局部稳定性和局部Hopf分支存在的充分条件.利用中心流形定理和规范型理论研究了Hopf分支的方向和稳定性等性质.最后,利用仿真示例对理论分析结果的正确性进行了验证.

关键词：时滞 Hopf分支 SLBRS模型稳定性周期解

Isotope Hydrogeological Study of Karst Water in the Lu' an Mining District and the Xin'ancun Spring Basin, Shanxi

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Acta Geologica Sinica(English Edition) 1994年第3期68卷 311-328页

作者： Gong zizhen, Li Zhaolin, zhang Zhigan, Institute of Karst Geology, Ministry of Geology and Mineral Resources, Guilin, GuangxiFu Liqun and Zuo Baolin The First Hydrogeological Party, Ministry of Coal Industry, Handan, Hebei Chinese Academy of Geological Sciences Beijing China

Isotope hydrogeological study has shown that the water supply exploration area in the Lu' an coal mine may be divided into four zones of hydrodynamic conditions and the Xin'ancun Spring Basin where the mine is located may be divided into three Middle Ordovician karst water systems. This paper discusses the features of recharge, runoff and discharge of karst water in various zones, and hydrogeological parameters such as the age, flow rate and natural recharge of karst water have been estimated.

关键词： isotope karst water main runoff zone natural recharge age

食饵具有庇护的时滞捕食系统稳定性和Hopf分支(英文)

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浙江大学学报（理学版） 2014年第6期41卷 642-649页

作者：张子振汪凯安徽财经大学管理科学与工程学院安徽蚌埠233030 安徽财经大学统计与应用数学学院安徽蚌埠233030

研究了一类具有2个食饵、1个捕食者,且食饵具有庇护所的Holling-II类时滞竞争捕食系统.结果表明,当时滞的值足够小时,系统的正平衡点是局部渐近稳定的.一旦时滞的值超过临界值,系统将失去稳定性并产生周期解.并利用规范型方法和中心流... 详细信息

研究了一类具有2个食饵、1个捕食者,且食饵具有庇护所的Holling-II类时滞竞争捕食系统.结果表明,当时滞的值足够小时,系统的正平衡点是局部渐近稳定的.一旦时滞的值超过临界值,系统将失去稳定性并产生周期解.并利用规范型方法和中心流形定理确定了Hopf分支的方向和周期解的稳定性.最后,给出数值仿真验证了理论结果的正确性.

关键词： Hopf分支捕食系统食饵庇护周期解时滞