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Food Science and Human Wellness 2024年第1期13卷 287-298页

作者： Hui Liu Xuenan Li ziyue Wang Lu Li Yucai Li Haiyang yan Yuan Yuan College of Food Science and Engineering Jilin UniversityChangchun 130062China

Elaidic acid(EA)stimulation can lead to endoplasmic reticulum stress(ERS),accompanied by a large release of Ca^(2+),and ultimately the activation of NLRP3 inflammasome in Kupffer cells(KCs).Mitochondrial instability or dysfunction may be the key stimulating factors to activate NLRP3 inflammasome,and sustained Ca^(2+)transfer can result in mitochondrial dysfunction.We focused on KCs to explore the damage to mitochondria by EA.After EA stimulation,cells produced an oxidative stress(OS)response with a significant increase in ROS release.Immunoprecipitation experiments and the addition of inhibitors revealed that the increase in the level of intracellular Ca^(2+)led to Ca^(2+)accumulation in the mitochondrial matrix via mitochondria-associated membranes(MAMs).This was accompanied by a significant release of m ROS,loss of MMP and ATP,and a significant increase in mitochondrial permeability transition pore opening,ultimately leading to mitochondrial instability.These findings confirmed the mechanism that EA induced mitochondrial Ca^(2+)imbalance in KCs via MAM,ultimately leading to mitochondrial dysfunction.Meanwhile,EA induced OS and the decrease of MMP and ATP in rat liver,and significant lesions were found in liver mitochondria.Swelling of the inner mitochondrial cristae and mitochondrial vacuolization occurred,with a marked increase in lipid droplets.

关键词： Elaidic acid(EA) Mitochondria-associated membranes(MAMs) Calcium Endoplasmic reticulum Mitochondria dysfunction

Bioactive materials from berberine-treated human bone marrow mesenchymal stem cells promote alveolar bone regeneration by regulating macrophage polarization

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Science China(Life Sciences) 2024年第5期67卷 1010-1026页

作者： ziyue Qin yanxing Han Yifei Du Yixuan Zhang Yifeng Bian Ruyu Wang Haoran Wang Fanyi Guo Hua Yuan Yongchu Pan Jianliang Jin Qigang Zhou Yuli Wang Feng Han yan Xu Jiandong Jiang Department of Oral and Maxillofacial Surgery The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Jiangsu Province Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing 210029China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing 210029China State Key Laboratoryof BioactiveSubstances andFunction of Natural Medicine Instituteof Materia MedicaChinese Academyof MedicalSciencesandPeking Union MedicalCollegeBeijing100050China Gusu school Nanjing medical universitySuzhou 215002China Key Laboratory of Cardiovascular&Cerebrovascular Medicine Drug Target and Drug Discovery CenterSchool of PharmacyNanjing Medical UniversityNanjing 211166 China Department of Orthodontics The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Department of Human Anatomy Research Centre for Bone and Stem CellsKey Laboratory for Aging&DiseaseThe State Key Laboratory of Reproductive MedicineNanjing Medical UniversityNanjing 211166China Department of Clinical Pharmacology School of PharmacyNanjing Medical UniversityNanjing Jiangsu211166China Department of Periodontology The Affiliated Stomatological Hospital of Nanjing Medical UniversityNanjing 210029China Department of Virology Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Alveolar bone regeneration has been strongly linked to macrophage polarization.M1 macrophages aggravate alveolar bone loss,whereas M2 macrophages reverse this process.Berberine(BBR),a natural alkaloid isolated and refined from Chinese medicinal plants,has shown therapeutic effects in treating metabolic disorders.In this study,we first discovered that culture supernatant(CS)collected from BBR-treated human bone marrow mesenchymal stem cells(HBMSCs)ameliorated periodontal alveolar bone loss.CS from the BBR-treated HBMSCs contained bioactive materials that suppressed the M1 polarization and induced the M2 polarization of macrophages in vivo and in vitro.To clarify the underlying mechanism,the bioactive materials were applied to different animal models.We discovered macrophage colony-stimulating factor(M-CSF),which regulates macrophage polarization and promotes bone formation,a key macromolecule in the CS.Injection of pure M-CSF attenuated experimental periodontal alveolar bone loss in rats.Colony-stimulating factor 1 receptor(CSF1R)inhibitor or anti-human M-CSF(M-CSF neutralizing antibody,Nab)abolished the therapeutic effects of the CS of BBR-treated HBMSCs.Moreover,AKT phosphorylation in macrophages was activated by the CS,and the AKT activator reversed the negative effect of the CSF1R inhibitor or Nab.These results suggest that the CS of BBR-treated HBMSCs modulates macrophage polarization via the M-CSF/AKT axis.Further studies also showed that CS of BBR-treated HBMSCs accelerated bone formation and M2 polarization in rat teeth extraction sockets.Overall,our findings established an essential role of BBR-treated HBMSCs CS and this might be the first report to show that the products of BBR-treated HBMSCs have active effects on alveolar bone regeneration.

关键词： berberine human bone marrow mesenchymal stem cells alveolar bone regeneration macrophage colony-stimulating factor AKT phosphorylation

Thermal management for the underwater frontend and readout electronics of JUNO 20‑inch PMTs

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Radiation Detection Technology and Methods 2023年第3期7卷 418-426页

作者： yangfu Wang Xiaoshan Jiang Jun Hu Peiliang Wang Lei Fan Shaojing Hou Zhe Ning Yunhua Sun Xiongbo yan Zheng Wang ziyue yan Peiran Ye Jie Zhang Alberto Garfagnini Antonio Bergnoli Riccardo Brugnera Beatrice Jelmini Filippo Marini Marco Grassi Mariia Redchuk Andrea Serafini Katharina von Sturm Institute of High Energy Physics BeijingChina University of China Academy of Sciences Beijing 100049China INFN Sezione di Padova PaduaItaly Dipartimento di Fisica e Astronomia Universita di PadovaPaduaItaly

Background The Jiangmen underground neutrino observatory(JUNO)is a new generation of long-term operation neutrino experimental platform under construction in Jiangmen,Guangdong province of southern China.The underwater frontend and readout electronics(F&R electronics)are placed nearby the 20-inch PMTs and readout current signals from three PMTs.The electronics are sealed in a stainless-steel underwater box to keep them dry,and temperature control of the electronics plays a significant role in their reliability.Methods A conductive cooling structure based on the passive cooling method is designed for the 20-inch PMT F&R electronics.Both numerical simulation and experimental tests were performed to evaluate the cooling structures'thermal performance.Results The results show that the case temperature of the respective chip for 20-inch PMT F&R electronics is less than 30℃in ambient still water.Conclusion The case temperature of the respective chip meets the strict temperature requirement for the F&R electronics.The JUNO collaboration has adopted this cooling structure for the 20-inch PMT readout electronics.

关键词： Thermal management JUNO PMT Electronics

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基于Kano模型的车厢服务配置效用评价

城市轨道交通研究 2024年第4期27卷 256-261页

作者：毛新德闫子悦刘英杰交控科技股份有限公司北京100070 山东交控科技有限公司济南250022

[目的]调查并分析车厢服务需求,优化车厢服务设施配置,提升乘客在乘车过程中的综合体验。[方法]通过研究乘客对车厢服务配置需求,构建典型的乘客服务需求空间。以Kano模型为核心建立需求评价模型,结合满意度计算方法,将感性认知进行量化... 详细信息

[目的]调查并分析车厢服务需求,优化车厢服务设施配置,提升乘客在乘车过程中的综合体验。[方法]通过研究乘客对车厢服务配置需求,构建典型的乘客服务需求空间。以Kano模型为核心建立需求评价模型,结合满意度计算方法,将感性认知进行量化,分析乘客对车厢服务配置需求的效用水平。[结果及结论]基于Kano模型并结合Better-Worse系数分析,总结出了6个魅力属性、4个期望属性、2个无差异属性和7个必备属性的乘客车厢服务配置需求清单。通过此方法清晰地展示了各种需求的重要程度,提出了在长线路列车车厢中配置充电设施、在客流量较多线路列车车厢中配置可折叠式座椅、在机场线路列车车厢中配置置物架等设计策略。

关键词：城市轨道交通车厢服务设施 Kano模型效用评价

Effect of Ga content on corrosion behavior of Mg–Zn-Ga alloys in Hank's solution

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Progress in Natural Science:Materials International 2023年第6期33卷 954-964页

作者： ziyue Zhang Xueying Wang Xiaolong Ma yang Zheng yan Li School of Materials Science and Engineering Beihang University Zhongfa Aviation Institute Beihang University School of Aeronautics and Astronautics Tiangong University Beijing Advanced Innovation Centre for Biomedical Engineering Beihang University

Mg–Zn-Ga alloys have been studied as potential biodegradable materials with excellent mechanical properties.However, its corrosion behavior under physiological conditions remains a subject of investigation for future applications. In this study, the corrosion behavior of extruded Mg–2Zn-x Ga(x = 1, 3, 5 and 7 wt%) in Hank’s solution was investigated. The corrosion products formed on the alloy surfaces were characterized by X-ray diffraction spectroscopy(XRD), scanning electron microscope(SEM) and Fourier-transform infrared spectroscopy(FT-IR). The corrosion products layer was found to consist of two distinct layers based on composition. The inner layer contained Mg(OH)2and carbonate, while the outer layer was composed of amorphous phosphate with Ca and Mg. The corrosion products layer exhibited a porous structure and was prone to detachment, particularly in regions undergoing non-uniform corrosion. Non-uniform corrosion behavior, attributed to micro-galvanic corrosion, was observed during the immersion of Mg–2Zn-x Ga alloys. With an increase in Ga content, the increased amount of Mg5Ga2phase intensify the non-uniform corrosion, resulting in an increased corrosion rate.

关键词： Amorphous phosphate Corrosion Magnesium alloys Mg–Zn-Ga

基于转录组数据挖掘外源褪黑激素影响水貂卵巢发育的分子机制

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畜牧兽医学报 2024年第2期55卷 607-618页

作者：高娅薇彭弟孙朝阳晏子越崔凯马泽芳青岛农业大学动物科技学院青岛266109

旨在探究外源褪黑激素(melatonin,MLT)影响水貂卵巢发育的分子机制。本研究随机选取相同饲养条件下、体重相似的200只3月龄健康白色雌性水貂,均分为试验组和对照组。试验组埋植1粒含MLT 18 mg·粒-1的埋植剂,对照组埋植1粒不含MLT的空粒... 详细信息

旨在探究外源褪黑激素(melatonin,MLT)影响水貂卵巢发育的分子机制。本研究随机选取相同饲养条件下、体重相似的200只3月龄健康白色雌性水貂,均分为试验组和对照组。试验组埋植1粒含MLT 18 mg·粒-1的埋植剂,对照组埋植1粒不含MLT的空粒,当水貂处于准备配种期时随机采集试验组和对照组各4只水貂的卵巢,然后采用Trizol法进行总RNA提取,构建cDNA文库,并利用Illumina平台测序后进行生物信息学分析,对差异表达基因进行GO功能分类和KEGG通路注释,寻找MLT调控卵巢发育的相关候选基因和代谢通路。为进一步验证测序数据的可靠性,随机选取6个差异表达基因进行qPCR验证。转录组结果显示,试验组和对照组的SNPs位点均在120000个以上,且均主要出现在基因区,两组的SNP突变类型均为转换型多于颠换型和杂合型;试验组与对照组相比,差异表达基因发生SE事件的数量最多;本试验共获得9631个新基因,其中有1323个、1317个新基因分别注释到TrEMBL和NR数据库,注释比例明显高于其他数据。试验组与对照组相比共发现206个差异表达基因(其中有36个未被注释的基因),69个为上调基因,137个为下调基因;GO功能富集显示,共计7个差异表达基因富集于生殖过程;KEGG通路富集结果显示,共计7个差异表达基因富集于5条与繁殖相关的通路。综合GO功能分类和KEGG通路注释结果分析,共筛选得到4个与MLT影响卵巢发育相关的候选基因,均为上调基因,分别是KRT19、GSTT1、ALAS 1和NR 4A1。本研究通过对MLT埋植和未埋植MLT的准备配种期水貂卵巢进行转录组学分析,挖掘出MLT可能通过调节KRT19、GSTT1、ALAS1、NR 4A1等基因促进卵巢发育,研究结果对水貂的育种工作提供了理论基础。

关键词：水貂褪黑激素转录组卵巢发育差异表达基因

Improving the tensile properties of extruded Mg–Ga alloy by ageing treatment

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Progress in Natural Science:Materials International 2022年第6期32卷 724-731页

作者： Donglei He Hao Gong ziyue Zhang yang Zheng Hu Zhang yan Li School of Materials Science and Engineering Beihang University Key Laboratory of Aerospace Advanced Materials and Performance (Beihang University) Ministry of Education School of Aeronautics and Astronautics Tiangong University Beihang Hangzhou Innovation Institute Yuhang Beihang University Beijing Advanced Innovation Centre for Biomedical Engineering Beihang University

A hot-extruded Mg-5Ga alloy was subjected to ageing treatment at 150℃,190℃ and 230℃.The microstructures and mechanical properties of the extruded and aged alloy were examined in this study.Microstructure examinations suggested that particle-shaped and rod-shaped Mg5Ga2were precipitated in the alloy after peak ageing treatment.The extruded alloy showed the yield strength,ultimate tensile strength and elongation to fracture of 157.6 MPa,248.6 MPa and 17.5%,respectively.After peak ageing,the yield strength and ultimate tensile strength can be enhanced by as much as 15.7% and 8.6% reaching 182.3 MPa and 270 MPa,respectively.The improvement of the tensile strengths is mainly attributed to the enhanced precipitation strengthening by newly formed fine Mg5Ga2precipitates.The ductility of the alloy was slightly increased by peak ageing at low temperatures(150℃ and 190 ℃),but remarkably decreased by peak ageing at high temperature(230℃) due to the formation of coarsened Mg5Ga2particles which easily initiated the cracks during tensile deformation.

关键词： Mg-Ga alloy Microstructure Mechanical property Ageing treatment

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改性煤气化渣催化降解双酚A的性能研究

化工学报 2024年第3期75卷 877-889页

作者：卫月星贺子岳燕可洲李林玉秦育红贺冲焦路畅太原理工大学环境科学与工程学院山西太原030024 山西大学国家环境保护煤炭废弃物资源化高效利用重点实验室山西太原030006

以航天炉煤气化细渣为研究对象,以双酚A(BPA)为模型污染物,以过硫酸盐(PMS)为氧化剂,对煤气化渣进行酸、碱、盐改性处理,探究了改性煤气化渣活化PMS降解BPA的性能。研究表明,三种改性方式均可提升煤气化渣活化PMS降解BPA的性能,其中NaO... 详细信息

以航天炉煤气化细渣为研究对象,以双酚A(BPA)为模型污染物,以过硫酸盐(PMS)为氧化剂,对煤气化渣进行酸、碱、盐改性处理,探究了改性煤气化渣活化PMS降解BPA的性能。研究表明,三种改性方式均可提升煤气化渣活化PMS降解BPA的性能,其中NaOH改性效果最佳。对NaOH改性浓度研究发现,5.5NaOH-FS/PMS/BPA体系中,在30℃,催化剂投加量2g/L,PMS投加量10mmol/L的条件下,15mg/LBPA在60min内可以实现完全去除。XRF、XRD、SEM-EDS、FTIR分析表明,NaOH改性煤气化渣中保留了活性Fe_(2)O_(3)组分,并且碳含量最高,达到52.7%,其存在加速了BPA的降解。自由基淬灭实验证明,5.5NaOH-FS/PMS降解BPA过程中,·O_(2)^(-)与^(1)O_(2)为主要活性氧物种。研究成果为煤气化渣作为催化剂在污染物去除领域中的应用提供了一定的基础数据。

关键词：煤气化渣改性催化剂活化 BPA降解

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考虑电动汽车充电负荷及储能寿命的充电站储能容量配置优化

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电网与清洁能源 2024年第4期40卷 92-101页

作者：马永翔韩子悦闫群民万佳鹏淡文国陕西理工大学电气工程学院陕西汉中723001 陕西省电力有限公司咸阳供电公司陕西咸阳712000 乌兰察布电业局内蒙古乌兰察布012000

提出了一种优化电动汽车充电站储能容量配置的方法。该方法考虑了季节性电动汽车充电负荷波动与光伏出力之间的关系,并且考虑了储能寿命。论文利用蒙特卡罗法考虑了不同类型电动汽车的多种影响因素,对整体负荷进行预测。以每日运行成本... 详细信息

提出了一种优化电动汽车充电站储能容量配置的方法。该方法考虑了季节性电动汽车充电负荷波动与光伏出力之间的关系,并且考虑了储能寿命。论文利用蒙特卡罗法考虑了不同类型电动汽车的多种影响因素,对整体负荷进行预测。以每日运行成本最低为优化目标,在考虑四季光伏出力和储能寿命的影响下,采用了3种算法对目标函数进行优化,以得到最佳的光储充电站储能配置方案。研究以西北某地区为例。结果表明:冬季下综合成本为3.0432×10^(6)元,相比于其余3个季节综合成本最低;采用遗传算法时,在综合成本相差不多时,获得的储能配置最优,储能容量为22.82 MWh,储能功率为7.31MW,从而得到光储充电站最优的储能容量配置。

关键词：光储充电站电动汽车储能寿命储能容量优化遗传算法粒子群算法蚁群算法

1990-2019年中国痛风疾病负担趋势及未来十年预测研究

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中国全科医学 2024年第2期27卷 245-252页

作者：方珈文冯天元周志衡李子悦颜丹虹林凯程南方医科大学卫生管理学院广东省广州市510515 广东省深圳市坪山区人民医院 518118 南方医科大学南方医院广东省广州市510515

背景痛风是常见的炎症性关节炎之一,对人们的健康造成很大的危害,但目前针对我国痛风疾病负担趋势分析与预测的相关研究有限。目的分析1990—2019年中国痛风疾病负担的变化趋势,并预测未来10年痛风的标化伤残调整寿命年(DALYs)率、标化... 详细信息

背景痛风是常见的炎症性关节炎之一,对人们的健康造成很大的危害,但目前针对我国痛风疾病负担趋势分析与预测的相关研究有限。目的分析1990—2019年中国痛风疾病负担的变化趋势,并预测未来10年痛风的标化伤残调整寿命年(DALYs)率、标化发病率和标化患病率。方法提取全球疾病负担研究(GBD)2019有关中国痛风DALYs、发病情况和患病情况等疾病负担指标,采用Joinpoint回归模型计算标化DALYs率、标化发病率和标化患病率的年度变化百分比(APC)和平均年度变化百分比(AAPC),采用自回归移动平均模型(ARIMA模型)对2020—2029年的标化DALYs率、标化发病率和标化患病率进行预测。结果1990—2019年,中国痛风DALYs从187436人年增至510485人年,增长了172.35%,发病人数从1181969例增至3041329例,增长了157.31%,患病人数从5864143例增至16161325例,增长了175.60%(对应的标化率分别增长了28.45%、25.92%和28.63%)。Joinpoint回归结果显示,1990—2019年,标化DALYs率、标化发病率、标化患病率整体呈上升趋势(AAPC分别为0.9%、0.8%、0.9%,P<0.05)。痛风疾病负担具有明显的性别和年龄差异,男性疾病负担高于女性,标化DALYs率、标化发病率和标化患病率男女性别比范围分别为3.23~3.51、3.14~3.40和3.17~3.42。女性各指标年龄高峰总体比男性延后,女性在45岁之后疾病负担开始加重,男女性疾病负担均在90岁之后再次增加。ARIMA模型结果显示,预计到2029年,因痛风造成的标化DALYs率和标化发病率分别下降0.33%和0.45%,标化患病率上升0.71%。结论1990—2019年中国痛风疾病负担增长趋势明显,存在明显的性别和年龄差异,且出现年轻化趋势。预计到2029年,因痛风造成的标化患病率略有上升。

关键词：痛风发病率患病率疾病负担趋势分析 ARIMA模型伤残调整寿命年