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Impact of atmospheric circulations on droughts and drought propagation over China

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Science China Earth Sciences 2024年第8期67卷 2633-2648页

作者： Ziye gu Lei gu Jiabo YIN Wei FANG Lihua XIONG Jun guO ziyue ZENG Jun XIA School of Civil and Hydraulic Engineering Huazhong University of Science and TechnologyWuhan 430074China State Key Laboratory of Water Resources Engineering and Management Wuhan 430072China Changjiang River Scientific Research Institute Wuhan 430010China

The GRACE satellite mission provides a new approach for monitoring,tracking,and assessing drought conditions by detecting changes in Earth's gravitational fields and inversing signals of terrestrial water storage *** studies of terrestrial water storage anomalies related droughts paid rare attention to the behind atmospheric physical mechanisms,nor quantified the risk propagation patterns between terrestrial water storage deficits and hydrological or agricultural *** this study,we first extract terrestrial water storage(TWS) droughts,hydrological droughts,and agricultural droughts by using multiple variables including TWS from the GRACE/GRACE-FO satellites,runoff and soil moisture from the ERA5-Land reanalysis *** then identify key atmospheric and oceanic oscillation indices affecting water deficits by employing machine learning *** characterize the joint distributions between drought duration and severity by using the Copula function and quantify the risk propagation of hydrological and agricultural droughts to TWS *** results show that:(1) From 2002 to 2021,there is a significant decrasing trend of TWS in China;the WPIO group atmospheric circulation indices(sea surface temperature index within the Western Pacific and Indian Ocean) contributes the most to ***,the sea surface temperature anomalies within the NINO 3.4 region as well as the Western Pacific Warm Pool area index show significantly positive correlation relationships with TWS in southern China;(2) The northwestern China,the Yangtze River basin,and the downstream of the Pearl River basin are the hotspots of TWS ***,the hotspots of hydrological droughts locate in northwestern China and the hotspots of agricultural droughts locate in South China and eastern Tibetan Plateau;(3) The elastic coefficients of hydrological droughts propagating to TWS droughts are higher than those of agricultural droughts,indicating that the TWS droughts

关键词： GRACE satellites Drought Drought propagation Atmospheric circulation Copula function

Candidate therapeutic agents in a newly established triple wild-typemucosalmelanoma cell line

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Cancer Communications 2022年第7期42卷 627-647页

作者： Chaoji Shi ziyue gu Shengming Xu Houyu Ju Yunteng Wu Yong Han Jiayi Li Chuwen Li Jing Wu Lizhen Wang Jiang Li guoyu Zhou Weimin Ye guoxin Ren Zhiyuan Zhang Rong Zhou Department of Oral and Maxillofacial-Head Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai 200011P.R.China National Clinical Research Center for Oral Diseases Shanghai 200011P.R.China Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology Shanghai 200011P.R.China Research Unit of Oral and Maxillofacial Regenerative Medicine Chinese Academy of Medical SciencesShanghai 200011P.R.China Department of Oral Pathology Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200011P.R.China

Background:Mucosalmelanoma has characteristically distinct genetic features and typically poor *** lack of representativemucosal melanoma models,especially cell lines,has hindered translational research on this melanoma *** this study,we aimed to establish and provide the biological properties,genomic features and the pharmacological profiles of a mucosal melanoma cell line that would contribute to the understanding and treatment optimization of molecularly-defined mucosal melanoma ***:The sample was collected from a 67-year-old mucosal melanoma patient and processed into pieces for the establishment of cell line and patientderived xenograft(PDX)*** proliferation and tumorigenic property of cancer cells from different passageswere evaluated,andwhole-genome sequencing(WGS)was performed on the original tumor,PDX,established cell line,and the matched blood to confirm the establishment and define the genomic features of this cell *** was conducted to depict the architecture of amplified regions detected by ***-throughput drug screening(HTDS)assay including a total of 103 therapeutic agents was implemented on the established cell line,and selected candidate agents were validated in the corresponding PDX ***:A mucosal melanoma cell line,MM9H-1,was established which exhibited robust proliferation and tumorigenicity after more than 100 serial *** analysis of MM9H-1,corresponding PDX,and the original tumor showed genetic fidelity across genomes,and MM9H-1 was defined as a triple wild-type(TWT)melanoma subtype lacking well-characterized“driver mutations”.Instead,the amplification of several oncogenes,telomerase reverse transcriptase(TERT),v-Rafmurine sarcoma viral oncogene homolog B1(BRAF),melanocyte Inducing transcription factor(MITF)and INO80 complex ATPase subunit(INO80),via large-scale genomic rearrangement potentially contributed to oncogenesis of ***,HTDS identified proteasome

关键词： bortezomib cell line extrachromosomal DNA high-throughput drug screening mucosal melanoma patient derived tumor cells patient-derived xenograft whole-genome sequencing

Celastrol promotes apoptosis of breast cancer MDA-MB-231 cells by targeting HSDL2

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Acupuncture and Herbal Medicine 2024年第1期4卷 92-101页

作者： Li Liu Yanqing Liu Shujie Zhang Junzhe Zhang Yuqing Meng Dandan Liu Liwei gu Ying Zhang Liting Xu ziyue Zhang Minghong Zhao Yinkwan Wong Qixin Wang Yongping Zhu Jigang Wang College of Pharmacy Gannan Medical UniversityGanzhouChina State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijingChina Department of Pharmacological Sciences Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore

Objective:Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicinal herb,Tripterygium *** study aims to provide a scientific basis for the rational development and use of celastrol in breast ***:A quantitative chemical biology approach was used to investigate the protein targets and molecular mechanisms of celastrol in breast cancer ***:Low-concentration celastrol exerted an anti-tumor effect by directly binding to hydroxysteroid dehydrogenase-like 2(HSDL2)and inhibiting its ***,the expression of the pro-apoptotic protein,Bcl-2-associated X(BaX),increased,the level of the anti-apoptotic protein,B-cell lymphoma-2(Bcl-2),decreased,and the rate of apoptosis *** the transfection of cells with si-HSDL2,the apoptosis rate was similar to that observed after the administration of ***,apoptosis was reversed by the overexpression of ***,our mass spectrometry(MS)data indicated a relationship between HSDL2 and the mitogen-activated protein kinase(MAPK)signaling *** also found that the expression of HSDL2 was directly related to the degree of extracellular signal-regulated kinase(ERK)***:Celastrol may promote apoptosis by suppressing the HSDL2/MAPK/ERK signaling pathway.

关键词： Activity-based protein profiling Apoptosis Celastrol HSDL2

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运用疏肝合营法治疗卒中后抑郁的相关性研究

世界中医药 2017年第1期12卷 112-115页

作者：吴颖顾自悦北京市中医医院顺义医院北京101300

目的:探讨疏肝合营汤治疗卒中后抑郁的临床疗效。方法:将确诊为脑梗死的患者60例,按照区组随机化方法随机分为治疗组和对照组,所有患者给予脑梗死的神经科常规治疗方案,治疗组患者同时加用名老中医顾自悦经验方疏肝合营汤进行治疗。所... 详细信息

目的:探讨疏肝合营汤治疗卒中后抑郁的临床疗效。方法:将确诊为脑梗死的患者60例,按照区组随机化方法随机分为治疗组和对照组,所有患者给予脑梗死的神经科常规治疗方案,治疗组患者同时加用名老中医顾自悦经验方疏肝合营汤进行治疗。所有患者均于入院当天及治疗后的第2周、第6周和第8周分别应用汉密尔顿抑郁量表(HAMD)、神经功能缺损量表(NIHSS)和日常生活能力量表(ADL)来进行评分,以针对疏肝合营汤对于改善患者的神经功能缺损和抑郁症状情况给予评价。结果:与对照组相比,治疗组患者的抑郁症状及日常生活能力均较前好转(P0.05)。结论:疏肝合营汤治疗脑梗死后抑郁症状的临床疗效肯定,并兼顾改善PSD患者的卒中症状还能够促进脑梗死后患者的神经功能的缺损进一步恢复,可以明显提高患者在生活中自理的能力,值得临床推广。

关键词：疏肝合营汤 @顾自悦中医药经验卒中后抑郁

p-GaN在不同掩膜和刻蚀气体中的ICP刻蚀

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半导体技术 2018年第6期43卷 449-455页

作者：钱茹程新红郑理沈玲燕张栋梁顾子悦俞跃辉中国科学院上海微系统与信息技术研究所信息功能材料国家重点实验室上海200050 上海科技大学物质科学与技术学院上海200120 中国科学院大学北京100049

p-GaN栅沟槽侧壁与AlGaN表面特性直接影响栅注入（GIT）型AlGaN/GaN HEMT器件的输出特性及击穿特性。对比研究了两种刻蚀气体（SF6/BCl3和Cl2/N2/O2）及不同的刻蚀掩膜层（SiO2,Si3N4和光刻胶）对AlGaN上p-GaN的选择性刻蚀结果,利用原... 详细信息

p-GaN栅沟槽侧壁与AlGaN表面特性直接影响栅注入（GIT）型AlGaN/GaN HEMT器件的输出特性及击穿特性。对比研究了两种刻蚀气体（SF6/BCl3和Cl2/N2/O2）及不同的刻蚀掩膜层（SiO2,Si3N4和光刻胶）对AlGaN上p-GaN的选择性刻蚀结果,利用原子力显微镜（AFM）对刻蚀沟槽的表面形貌进行表征,并通过I-V测试其电学性能。结果显示,以Cl2/N2/O2为刻蚀气体,且体积流量为18,10和2 cm^3/min时,p-GaN刻蚀速率稳定且与AlGaN的刻蚀选择比较高（约30）,并且可使p-GaN刻蚀自动停止在AlGaN界面处。此外,以Si3N4作为刻蚀掩膜,可以获得表面光滑、无微沟槽且侧壁垂直度较好的沟槽结构。采用上述刻蚀工艺制备的GIT结构器件的漏端关态电流相比肖特基栅降低约2个量级,阈值电压约为0.61 V,峰值跨导为36 m S/mm。

关键词： GaN 选择性刻蚀电感耦合等离子体(ICP)刻蚀 AlGaN/GaN HEMT 刻蚀形貌

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基于ADTDNN的低资源语音识别方法研究

软件导刊 2024年第9期23卷 76-81页

作者：顾龙昊黄连丽周奎张子越湖北汽车工业学院电气与信息工程学院湖北汽车工业学院汽车工程师学院Sharing-X重点联合实验室湖北十堰442002

为解决低资源条件下由于训练数据不足导致识别精度降低、泛化能力较差的问题,提出一种语音识别方法。该方法利用卷积池化提取特征信息,将Attention机制与DTDNN融合成为ADTDNN,以提升低资源环境下模型捕捉序列中关键信息的能力;采用链接... 详细信息

为解决低资源条件下由于训练数据不足导致识别精度降低、泛化能力较差的问题,提出一种语音识别方法。该方法利用卷积池化提取特征信息,将Attention机制与DTDNN融合成为ADTDNN,以提升低资源环境下模型捕捉序列中关键信息的能力;采用链接时序分类简化模型的识别流程;使用Transformer作为语言模型。在Aishell-1数据集上的实验结果表明,低资源环境下基于ADTDNN的语音识别模型与LAS、Transformer等主流端到端模型相比,字错误率分别降低了3.7%和1.0%。

关键词：语音识别时延神经网络 Transformer 数据增强低资源

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数字经济下新商科人才能力需求与培养研究

商业观察 2024年第18期10卷 52-56页

作者：齐英毕家寅王子玥谷丰刘阳哈尔滨商业大学黑龙江哈尔滨150028

随着数字经济的到来,商业和数智技术愈发深层次融合,商业环境的显著改变对新商科人才的培养提出了更高的要求。在此背景下,从基础能力和数智能力两个方面剖析了数字经济时代对新商科人才能力的需求,其中涵盖的人格特点、专业能力和综合... 详细信息

随着数字经济的到来,商业和数智技术愈发深层次融合,商业环境的显著改变对新商科人才的培养提出了更高的要求。在此背景下,从基础能力和数智能力两个方面剖析了数字经济时代对新商科人才能力的需求,其中涵盖的人格特点、专业能力和综合理论知识的基础能力是任何时代的商科人才所必须具备的底层能力,而数智思维和数智应用能力则是数字经济时代新商科人才应该培养并强化的。针对新商科人才能力需求分析,认为应构建面向职业需求的复合课程体系、政用产学研协同培养、数智场景教学培养数智能力、本土商业知识的挖掘与应用,进而推动新商科人才的整体培养进程。

关键词：数字经济新商科数智能力培养模式

中波紫外线对三叶青酚类物质质量分数、抗氧化能力及基因表达的影响

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浙江农林大学学报 2024年第2期41卷 223-233页

作者：夏敬青刘海荣顾依雯王子玥邢巧月张宇翔李姗白岩浙江农林大学浙江省中药资源保护与创新重点实验室浙江杭州311300 浙江农林大学食品与健康学院浙江杭州311300 中国储备粮管理集团有限公司浙江分公司浙江杭州311500

【目的】探究短时间中波紫外线(UV-B)辐射对三叶青Tetrastigma hemsleyanum酚类成分、抗氧化能力及相关基因表达的影响。【方法】将3年生三叶青苗经UV-B持续辐射12.0 h,在0、0.5、1.0、3.0、6.0和12.0 h观察表型;另取三叶青辐射1.0和3.0... 详细信息

【目的】探究短时间中波紫外线(UV-B)辐射对三叶青Tetrastigma hemsleyanum酚类成分、抗氧化能力及相关基因表达的影响。【方法】将3年生三叶青苗经UV-B持续辐射12.0 h,在0、0.5、1.0、3.0、6.0和12.0 h观察表型;另取三叶青辐射1.0和3.0 h(记为T1和T3)并补充暗处理至24.0 h(记为T1+23和T3+21),以未经处理为对照(ck),进行酚类物质(总酚和总黄酮)质量分数、抗氧化能力和叶片中抗逆酶活性、丙二醛(MDA)质量摩尔浓度测定以及转录组分析。【结果】持续UV-B辐射对三叶青表型有影响,3.0 h组叶片局部发黄,6.0和12.0 h组叶片明显发黄和略微卷曲。叶片和块根的总酚(2.65和2.63 mg·g^(−1))和总黄酮(7.16和7.30 mg·g^(−1))、块根中的抗氧化能力(86.56%)均在T1+23组达到最大值。同时,UV-B辐射后施以黑暗处理可促进过氧化氢酶(CAT)、过氧化物酶(POD)、超氧化物歧化酶(SOD)活性的大幅提升,且在T1+23组达到最大,MDA质量摩尔浓度在T3+21组达到最高(7.21 mmol·g^(−1))。UV-B辐射和黑暗处理下调了黄酮合成通路基因(ThF3H、ThANS、ThCHS、ThANR等)和上调了氧化相关调节因子(CAT和SOD)的表达。【结论】UV-B辐射后增加黑暗处理可提高三叶青酚类物质质量分数、抗氧化能力及抗逆酶活性,且在T1+23组达最大值,同时下调黄酮合成酶基因表达,上调氧化应激相关基因的表达。

关键词：三叶青中波紫外线胁迫多酚类物质抗氧化能力差异表达

2023年3月河南省一次极端暴雪和雷电天气成因分析

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气象与环境学报 2024年第4期40卷 10-18页

作者：崔丽曼谷秀杰席乐张亚春薛紫月中国气象局·河南省农业气象保障与应用技术重点开放实验室河南郑州450003 河南省气象台河南郑州450003

选用自动气象站、双偏振雷达、风廓线雷达和ERA5再分析等资料,分析2023年3月16日河南省一次极端暴雪和雷电天气成因。结果表明:此次极端暴雪过程主要天气系统为低槽、切变线、急流以及东北冷涡。冷涡配合-39℃冷中心稳定维持,其后部冷... 详细信息

选用自动气象站、双偏振雷达、风廓线雷达和ERA5再分析等资料,分析2023年3月16日河南省一次极端暴雪和雷电天气成因。结果表明:此次极端暴雪过程主要天气系统为低槽、切变线、急流以及东北冷涡。冷涡配合-39℃冷中心稳定维持,其后部冷空气持续南下,850 hPa以下形成深厚冷垫,中高层西南暖湿气流沿冷垫爬升,形成河南省典型的降雪天气类型“天南地北型”。此次强降雪区位于整层大气可降水量大于20 mm区域的北部与700 hPa强辐合中心重叠的区域,河南中西部地形的抬升作用利于此极端降雪天气发生。冷平流与其次级环流共同作用,使局地气温骤降,导致降水相态转换较预期提前,以致多站降雪量或积雪深度超历史极值。双偏振雷达零滞后相关系数产品(CC)为相态转换监测提供了重要参考。850 hPa以下大气温度均低于0℃,且2 m气温降至1℃左右,可作为降雪预报指标。辐合切变及锋面次级环流有利于高架雷暴天气出现,20 dBz回波高度超过-20℃层高度可作为产生雷暴的关键指标。

关键词：降雪预报雷暴天气东北冷涡相态转换