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Artificial intelligence for assessment of Stargardt macular atrophy

Neural Regeneration Research 2022年第12期17卷 2632-2636页

作者： ziyuan wang Zhihong Jewel Hu Doheny Image Analysis Laboratory Doheny Eye InstituteLos AngelesCAUSA Department of Electrical Engineering University of CaliforniaLos AngelesCAUSA

Stargardt disease(also known as juvenile macular degeneration or Stargardt macular degeneration)is an inherited disorder of the retina,which can occur in the eyes of children and young *** is the most prevalent form of juvenile-onset macular dystrophy,causing progressive(and often severe)vision *** with Stargardt disease are characterized by the appearance of flecks in early and intermediate stages,and the appearance of atrophy,due to cells wasting away and dying,in the advanced *** primary measure of late-stage Stargardt disease is the appearance of *** autofluorescence is a widely available two-dimensional imaging technique,which can aid in the diagnosis of the ***-domain optical coherence tomography,in contrast,provides three-dimensional visualization of the retinal microstructure,thereby allowing the status of the individual retinal *** disease may cause various levels of disruption to the photoreceptor segments as well as other outer retinal *** recent years,there has been an exponential growth in the number of applications utilizing artificial intelligence for help with processing such diseases,heavily fueled by the amazing successes in image recognition using deep *** review regarding artificial intelligence deep learning approaches for the Stargardt atrophy screening and segmentation on fundus autofluorescence images is first provided,followed by a review of the automated retinal layer segmentation with atrophic-appearing lesions and fleck features using artificial intelligence deep learning *** paper concludes with a perspective about using artificial intelligence to potentially find early risk factors or biomarkers that can aid in the prediction of Stargardt disease progression.

关键词： artificial intelligence assessment deep learning fundus autofluorescence screening segmentation spectral-domain optical coherence tomography Stargardt atrophy Stargardt disease Stargardt flecks

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Reaction mechanism of dicofol removal by cellulase

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Journal of Environmental Sciences 2015年第10期27卷 22-28页

作者： ziyuan wang Ting Yang Zihan Zhai Boya Zhang Jianbo Zhang Collaborative Innovation Center for Regional Environmental Quality State Key Joint Laboratory of Environmental Simulation and Pollution ControlCollege of Environmental Science and EngineeringPeking University School of Public Health Peking University

It remains unclear whether dicofol should be defined as a persistent organic pollutant. Its environmental persistence has gained attention. This study focused on its degradation by cellulase. Cellulase was separated using a gel chromatogram, and its degradation activity towards dicofol involved its endoglucanase activity. By analyzing the kinetic parameters of cellulase reacting with mixed substrates, it was shown that cellulase reacted on dicofol and carboxyl methyl cellulose through two different active centers. Thus, the degradation of dicofol was shown to be an oxidative process by cellulase. Next, by comparing the impacts of tert-butyl alcohol（a typical OH free-radical inhibitor） on the removal efficiencies of dicofol under both cellulase and Fenton reagent systems, it was shown that the removal of dicofol was initiated by OH free radicals produced by cellulase. Finally, 4,4′-dichlorodibenzophenone and chloride were detected using gas chromatography mass spectrometry and ion chromatography analysis, which supported our hypothesis. The reaction mechanism was analyzed and involved an attack by OH free radicals at the orthocarbon of dicofol, resulting in the degradation product 4,4′-dichloro-dibenzophenone.

关键词： Dicofol Cellulase Endo-glucanases activity Oxidative degradation OH free radical

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High-Frequency Sequence Stratigraphy and Fine-Scale Reservoir Characterization of the Devonian Sandstone, Donghe Formation, North Uplift of the Tarim Basin

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Acta Geologica Sinica(English Edition) 2018年第5期92卷 1917-1933页

作者： wang ziyuan LIU Li PAN Mao SHI Yongmin XIONG Fengyang School of Earth and Space Sciences Peking University Bureau of Economic Geology Jackson School of Geosciences The University of Texas at Austin Scholl of Earth Sciences The Ohio State University

The Devonian Donghe Sandstone complex in North Uplift of the Tarim Basin comprises of a series of diachronous sandy intervals deposited from the Late Devonian to Early Mississippian. They are constrained by a Late Devonian to Early Pennsylvanian 2 nd-order supersequence and can be subdivided into five 3 rd-order sequences, namely, S1, S2, S3, S4, and S5, from the oldest to youngest. Cores from four wells, 40 wireline logs, 410 thin sections, and porosity and permeability data from 639 spots from four wells were used to study the sediment provenance, build up the sequence-stratigraphic model of S5, and characterize the reservoirs at a feet scale. Detrital modes of sandstone from point counting indicate that Donghe Sandstone is directly sourced from recycled orogeny. The low content of feldspar and volcanic rock fragments suggests that Donghe Sandstone is recycled from sediment with a cratonic ultimate source. 1 D and 2 D chronostratigraphic correlation shows that at least 12 4 th-order highfrequency sequences（HFSs）, from the oldest HFS1 to the youngest HFS12, can be recognized in S5. Each HFS is characterized by a general trend of shallowing-upward facies assemblage. Sequence boundaries were defined at where regionally correlatable deep-water facies overlaying shallow-water facies. There is a general shallowing-upward trend in the S5 3 rd-order sequence, characterized by a systematically increasing proportion of shallow-water facies（foreshore and upper shoreface）, and a decreasing proportion of deep facies（offshore transition and lower shoreface）. The shallowing-upward trend within both 3 rd-and 4 th-order sequences is resulted from a combined effect of eustatic sea-level change, tectonic activity, and sediment supply. The sequence-stratigraphic model of Donghe Sandstone S5 is similar to the rift-basin sequence-stratigraphic model. Sweet spots were defined as porosity 〉15% and permeability 〉100 md intervals, and their distribution and lateral continuity were investig

关键词： high-frequency sequences shoreline systems reservoir heterogeneity Tarim Basin

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Privacy Protection for Blockchain-Based Healthcare IoT Systems: A Survey

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1757-1776页

作者： Minfeng Qi ziyuan wang Qing-Long Han Jun Zhang Shiping Chen Yang Xiang School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyHawthorn3122VictoriaAustralia Faculty of Data Science City University of MacaoMacaoChina CSIRO Data61 SydneyNew South WalesAustralia

To enable precision medicine and remote patient monitoring,internet of healthcare things(IoHT)has gained significant interest as a promising *** the widespread use of IoHT,nonetheless,privacy infringements such as IoHT data leakage have raised serious public *** the other side,blockchain and distributed ledger technologies have demonstrated great potential for enhancing trustworthiness and privacy protection for IoHT *** this survey,a holistic review of existing blockchain-based IoHT systems is conducted to indicate the feasibility of combining blockchain and IoHT in privacy *** addition,various types of privacy challenges in IoHT are identified by examining general data protection regulation(GDPR).More importantly,an associated study of cutting-edge privacy-preserving techniques for the identified IoHT privacy challenges is ***,several challenges in four promising research areas for blockchain-based IoHT systems are pointed out,with the intent of motivating researchers working in these fields to develop possible solutions.

关键词： Blockchain internet of healthcare things(IoHT) privacy-preserving techniques(PPTs).

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Refrigeration temperature enhanced synergistic interaction of curcumin and 460 nm light-emitting diode against Staphylococcus saprophyticus at neutral pH

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Food Quality and Safety 2021年第1期5卷 15-21页

作者： ziyuan wang Lin Han Jie Liu Mingfei Yao Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology and Business UniversityBeijingChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouChina

Objectives:As considered highly resistant to antibiotics like mecillinam,the rise of Staphylococcus saprophyticus(***)contamination of fresh foods and food processing environments necessitates the development of a new antimicrobial approach for food safety *** study aimed to investigate the synergistic effect of food-grade curcumin(CUR)and blue light-emitting diode(LED)on *** and Methods:***/ciys was subjected to the synergistic treatment at 4℃ and 25℃.The influence of parameters,including CUR concentration,light dose,and pH incubation time on the inactivation of *** vjqs characterized through plate counting ***:The combined treatment of CUR and blue light irradiation significantly(P<0.05)reduced bacterial counts and the antimicrobial effect was in a CUR concentration and light dose-dependent ***,refrigeration temperature(4℃)significantly(P<0.05)enhanced the antibacterial effect at neutral pH condition(6.2-72),resulting in approximately 6.0 log *** acidic condition(pH 2.2-5.2),there was no significant difference in bacterial population reduction between treatments at both ***:These findings proposed that synergistic interaction of CUR and 460 nm LED under refrigerated temperature could enhance the inactivation of *** at neutral pH condition.

关键词： curcumin light-emitting diode pH refrigeration temperature Staphylococcus saprophyticus

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Empirical analysis of network measures for predicting high severity software faults

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Science China(Information Sciences) 2016年第12期59卷 202-219页

作者： Lin CHEN Wanwangying MA Yuming ZHOU Lei XU ziyuan wang Zhifei CHEN Baowen XU State Key Laboratory for Novel Software Technology Nanjing University School of Computer Science and Technology Nanjing University of Posts and Telecommunications

Network measures are useful for predicting fault-prone modules. However, existing work has not distinguished faults according to their severity. In practice, high severity faults cause serious problems and require further attention. In this study, we explored the utility of network measures in high severity faultproneness prediction. We constructed software source code networks for four open-source projects by extracting the dependencies between modules. We then used univariate logistic regression to investigate the associations between each network measure and fault-proneness at a high severity level. We built multivariate prediction models to examine their explanatory ability for fault-proneness, as well as evaluated their predictive effectiveness compared to code metrics under forward-release and cross-project predictions. The results revealed the following:(1) most network measures are significantly related to high severity fault-proneness;(2) network measures generally have comparable explanatory abilities and predictive powers to those of code metrics; and(3) network measures are very unstable for cross-project predictions. These results indicate that network measures are of practical value in high severity fault-proneness prediction.

关键词： network measures high severity fault-proneness fault prediction software metrics

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Iris Segmentation Based on Matting

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Instrumentation 2022年第1期9卷 12-22页

作者： CHEN Qiru wang Qi SUN Ting wang ziyuan Northeastern University No.3-11Wenhua RoadHeping DistrictShenyangChina Tencent Tencent Binhai BuildingNo.33Haitian Second RoadNanshan DistrictShenzhenChina

In this paper,we aim to propose a novel and effective iris segmentation method that is robust to uneven light intensity and different kinds of noises such as occlusion by light spots,eyelashes,eyelids,specta-cle-frame,*** previous methods,the proposed method makes full use of gray intensities of the iris *** by the matting algorithm,a premier assumption is made that the foreground and background images of the iris image are both locally *** to the RST algorithm,trimaps are built to provide priori *** the assumption and priori,the optimal alpha matte can be obtained by least square loss function.A series of effective post processing methods are applied to the alpha image to obtain a more precise iris *** experiment on CASIA-iris-thousand database shows that the proposed method achieves a much better performance than conventional *** experimental results achieve 20.5%and 26.4%,more than the well-known integro-differential operator and edge detection combined with Hough transform on iris seg-mentation rate *** stability and validity of the proposed method is further demonstrated through the complementary experiments on the challenging iris images.

关键词： Iris Segmentation Trimap Image Processing

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A Review on Metal-Organic Framework-Derived Porous Carbon-Based Novel Microwave Absorption Materials

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Nano-Micro Letters 2021年第4期13卷 1-29页

作者： Zhiwei Zhang Zhihao Cai ziyuan wang Yaling Peng Lun Xia Suping Ma Zhanzhao Yin Yi Huang National Institute for Advanced Materials Tianjin Key Laboratory of Metal and Molecule Based Material Chemistry Key Laboratory of Functional Polymer MaterialsCollaborative Innovation Center of Chemical Science and Engineering(Tianjin)School of Materials Science and EngineeringNankai UniversityTianjin 300350People’s Republic of China

The development of microwave absorption materials(MAMs) is a considerable important topic because our living space is crowed with electromagnetic wave which threatens human’s *** MAMs are also used in radar stealth for protecting the weapons from being *** nanomaterials were studied as MAMs,but not all of them have the satisfactory ***,metal-organic frameworks(MOFs) have attracted tremendous attention owing to their tunable chemical structures,diverse properties,large specific surface area and uniform pore *** can transform to porous carbon(PC) which is decorated with metal species at appropriate pyrolysis ***,the loss mechanism of pure MOF-derived PC is often relatively *** order to further improve the MA performance,the MOFs coupled with other loss materials are a widely studied *** this review,we summarize the theories of MA,the progress of different MOF-derived PC-based MAMs,tunable chemical structures incorporated with dielectric loss or magnetic loss *** different MA performance and mechanisms are discussed in ***,the shortcomings,challenges and perspectives of MOF-derived PC-based MAMs are also *** hope this review could provide a new insight to design and fabricate MOF-derived PC-based MAMs with better fundamental understanding and practical application.

关键词： Metal-organic frameworks Porous carbon Microwave absorption material Reflection loss Effective absorption bandwidth

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Methods for Shale Gas Play Assessment: A Comparison between Silurian Longmaxi Shale and Mississippian Barnett Shale

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Journal of Earth Science 2015年第2期26卷 285-294页

作者： Songqi Pan Caineng Zou Zhi Yang Dazhong Dong Yuman wang Shufang wang Songtao Wu Jinliang Huang Qun Liu Dule wang ziyuan wang School of Earth and Space Sciences Peking University Research Institute of Petroleum Exploration & Development Petro China Southwest Petroleum University

Based on field work, organic geochemical analyses and experimental testing, a six-property assessment method for shale gas is proposed. These six properties include organic matter properies, lithofacies, petrophysical properties, gas content, brittleness and local stress field. Due to the features of continuous distribution over a large area and low resource abundance in shale plays, a sweet spot should have these following properties：（a） TOC〉2%; （b） brittle minerals content （〉40%） and clay minerals （〈30%）; （c） Ro （〉1.1%）; （d） porosity （〉2%） and permeability （〉0.000 1 mD）, and （e） effective thickness （30-50 m）. Applying these criteria in the Sichuan Basin, the Silurian Longmaxi shale consists of four prospecting sweet spots, including blocks of Changning, Weiyuan, Zhaotong and Fushnn-Yongchuan. Although these four blocks have some similarities, different features were usually observed. After comprehensive analyses using the six-property assessment method, the Fushun-Yongan Block ranks the most favorable sweet spot, followed by the Weiyuan Block. For the other two blocks, the Changning Block is better than the Zbaotong Block. By comparing with the Mississippian Barnett shale, characteristics that are crucial for a high-yielding in the Sichuan Basin include a high content of organic matter （TOC〉2.5%）, a moderate thermal maturity （Ro=0.4%-2%）, a high content of brittle minerals （quartz： 30%-45%）, a high gas content （〉2.5 m^3·t^-1）, and types I and II1 kerogen.

关键词： shale gas play Silurian Longmaxi shale Barnett shale sweet spot six-property assessment.

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Landscape Greening of Subway Stations Close to Commercial Districts in Beijing

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Journal of Landscape Research 2019年第1期11卷 38-45页

作者： wang ziyuan YANG Xin School of Architecture and Art North China University of Technology

Due to the rapid urban construction, commercial districts in Beijing are constructed near subway stations. Good landscape greening plays a crucial role in improving the environmental quality of the area around subway stations. At present, there are few studies on the landscape greening around subway stations adjacent to commercial districts. In this paper, field research on landscapes in the commercial district around seven typical subway stations was conducted to monitor real-time noise and crowd activities and analyze the utilization status of street parks, in order to provide a reference for the construction and renovation of the landscape greening around subway stations near commercial districts.

关键词： Commercial district Area around the subway station Noise Landscape greening

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