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Noncoding RNAs：＇our turn＇ to join the p53 networ

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Journal of Molecular Cell Biology 2014年第3期8卷 179-180页

作者： Yong li Hua l.u Department of Biochemistry and Molecular Biology School of Medicine University of Louisville 319 Abraham Flexner Way Louisville KY40202 USA E-mail: yong.ti@louisviUe.edu Department of Biochemistry& Molecular Biology andTulane Cancer Center TulaneUniversity School ofMedicine New Orleans LA70112 USA

The p53 tumor suppressor is the guardian of the rrr- o human genome. Since ,ts discovery in pS3 has been the most studied molecule in the field of cancer. Recently, its role has also been extended to other biological and pathological processes, p53 functions primarily as a transcription factor to regulate target genes that encode proteins crucial for promot- ing apoptotic cell death, cell cycle arrest, senescence, and so on in response to diverse upstream stressors. Interestingly, some of the p53 targets are noncoding RNAs. Noncoding RNAs can be functional without being translated into proteins and are often independent RNA molecules or noncoding parts of messenger RNAs. The past decade has witnessed bur- geoning intensive investigation on the interplay of noncoding RNAs with p53, its regulators, and effectors during the development of cancer and/or other dis- eases. This issue of Journal of Molecular Cell Biology presents five essays to review the rapid progress in this area from five different angles and to offer new insight into the role of noncoding RNAs in the p53 signaling web with updated information.

关键词：非编码RNA BP网络分子细胞生物学 P53 编码蛋白质细胞周期阻滞 p53 人类基因组

Childhood malaria in the Niger delta area of Nigeria:mothers/care givers'perception,definition and treatment practices

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 52-58页

作者： Idogun E.Sylvester Airauhi l.u Department of Chemical Pathology University of Benin Teaching HospitalBenin City Department of Medical Microbiology Biology University of Benin Teaching HospitalBenin City

Objective:The objective of the study was to evaluate mothers/care givers perception of malaria,their treatment practices and the effects on the outcome of ***:Four hundred and sixty children were enrolled and their mothers/care givers *** children were screened for malaria parasitaemia and there after,blood specimens were obtained for biochemical and haematological evaluation from those children who met the criteria and tested positive to *** *** cell volume,electrolytes,urea, creatinine,plasma glucose,and serum bilirubin were ***:A total of 460 children were studied, 233(50.7%) males and 227(49.3%) *** malaria cases were 112(24.3%) and severe malaria 348(75.7%).Those who presented early 106(23.0%) and those who presented late 354(77.0%).Perception and definition of malaria as well as the treatment seeking behaviors vary significantly with the level of education of the mothers and care *** without formal education 68(51.9%) wrongly perceived that the etiology of malaria can only be diagnosed by native doctors compared to those with primary six education 61 (26.5%) and junior secondary education 10(10.1%).Only 43(9.3%) gave the correct dose of chloroquine syrup to their sick children,while 32(7.0%) gave at sub optimal ***:Wrong perception of malaria especially the complicated malaria and wrong treatment practices are major contributory factors to the high mortality and morbidity of malaria in *** is therefore a need for health education to correct the wrong ideas about the cause and treatment practices of malaria as part of malaria control programme.

关键词： Childhood malaria Mothers/Caregivers Perception and treatment practices Nigeria

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metal.urgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling lü Chunchi Zhang Dong liang lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

Plant Cell Wall-like Soft Materials:Micro-and Nanoengineering,Properties,and Applications

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Nano-Micro letters 2025年第5期17卷 37-77页

作者： Roya Koshani Mica l.Pitcher Jingyi Yu Christine l.Mahajan Seong H.Kim Amir Sheikhi Department of Chemical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Chemistry The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biology The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Huck Institutes of the life Sciences The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Neurosurgery College of MedicineThe Pennsylvania State UniversityHersheyPA 17033USA

Plant cell wall(CW)-like soft materials,referred to as artificial CWs,are composites of assembled polymers containing micro-/nanoparticles or fibers/fibrils that are designed to mimic the composition,structure,and mechanics of plant ***-like materials have recently emerged to test hypotheses pertaining to the intricate structure–property relationships of native plant CWs or to fabricate functional ***,research on plant CWs and CW-like materials is reviewed by distilling key studies on biomimetic composites primarily composed of plant polysaccharides,including cel.ulose,pectin,and hemicel.ulose,as well as organic polymers like ***-and nanofabrication of plant CW-like composites,characterization techniques,and in silico studies are reviewed,with a brief overview of current and potential ***-/nanofabrication approaches include bacterial growth and impregnation,layer-by-layer assembly,film casting,3-dimensional templating microcapsules,and particle *** characterization techniques are necessary for the comprehensive mechanical,chemical,morphological,and structural analyses of plant CWs and CW-like ***-like materials demonstrate versatility in real-life applications,including biomass conversion,pulp and paper,food science,construction,catalysis,and reaction *** review seeks to facilitate the rational design and thorough characterization of plant CW-mimetic materials,with the goal of advancing the development of innovative soft materials and elucidating the complex structure–property relationships inherent in native CWs.

关键词： Synthetic plants Biomimicry Acel.ular wall Composites living materials Soft matter

Reveal short range interactions between u/d quarks in the NN, D03, and D30 systems

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Science China(Physics,Mechanics & Astronomy) 2025年第3期Mechanics & Astronomy) .卷 106-115页

作者： Qi-Fang lü Yu-Bing Dong Peng-Nian Shen Zong-Ye Zhang Department of Physics Hunan Normal University Key laboratory of low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Key laboratory for Matter Microstructure and Function of Hunan Province Hunan Normal University Institute of High Energy Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences

The dynamic mechanism of short range interactions between u/d quarks remains an open and challenging problem. In order to reveal this quark dynamics, we perform a systematic analysis of N N, D03, and D30systems in the（extended） chiral Su（3） constituent quark models. By comparing results cal.ulated with different models and different parameter sets, the effects of one gluon exchange and vector meson exchange terms are carefully examined. The results indicate that the vector meson exchange interactions dominate the short range interactions between u/d quarks, whereas the small residual one gluon exchange coupling strength is also allowed.

关键词： short range interactions dibaryons constituent quark models

Kinetics of the reaction of OH radical with ethylfluoroacetate,ethyl 4,4,4-trifluorobutyrate,and butylfluoroacetate

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Journal of Environmental Sciences 2025年第5期151卷 273-283页

作者： Pedro l.lugo Vianni Straccia Mariano A.Teruel María B.Blanco laboratorio universitario de Química y Contaminación del Aire(l.u.Q.C.A) Institute for Research in Physical Chemistry of Córdoba(I.N.F.I.Q.C.)Department of Physical ChemistryFaculty of Chemical SciencesNational University of CórdobaUniversity CityCórdoba 5000Argentina Institute for Atmospheric and Environmental Research University of WuppertalWuppertal DE-42097Germany

Kinetics of the gas-phase reactions of•OH radicals with a series of fluoroesters were studied for the first time at 298±3 K and atmospheric *** rate coefficients were determined by in situ FTIR spectroscopy in nitrogen and GC-FID in air to monitor the decay of reactants and *** following coefficient values(in 10^(−12)cm^(3)/(molecule•sec))were obtained for ethyl fluoroacetate(EFA),ethyl 4,4,4-trifluorobutyrate(ETB),and butyl fluoroacetate(BFA),respectively:k_(1)(EFA+OH)=1.15±0.25 by FTIR and 1.34±0.23 by GC-FID;k_(2)(ETB+OH)=1.61±0.36 by FTIR and 2.02±0.30 by GC-FID;k_(3)(BFA+OH)=2.24±0.37 by *** trends were developed and correlated with the number of CH_(3)and F substituents in the fluoroester,and structure-activity relationships(SARs)cal.ulations were *** addition,the tropospheric lifetimes of EFA,ETB,and BFA upon degradation by OH radicals were cal.ulated to be 9,6,and 5 days,respectively,indicating that these fluorinated compounds could have a possible regional effect from the emission *** small photochemical ozone creation potentials of 9,7,and 19 were estimated for EFA,ETB,and BFA,*** GlobalWarming Potentials(GWPs)for EFA,ETB,and BFA were cal.ulated for different time *** a 20-year time horizon,the GWPs were 1.393,0.063,and 0.062,*** the case of a 100-year time horizon,the GWPs were 0.379,0.017,and 0.017,and for a 500-year time horizon,the GWPs were 0.108,0.005,and 0.005 for EFA,ETB,and BFA.

关键词： CFC replacements sinks in situ FTIR SAR Acidification potentials Greenhouse gases

The size effect and high activity of nanosized platinum supported catalysts for low temperature oxidation of volatile organic compounds

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Chinese Journal of Chemical Engineering 2021年第11期34卷 135-143页

作者： Ziqing Yuan ziyu Chen Jianxin Mao Renxian Zhou Institute of Catalysis Zhejiang UniversityHangzhou 310028China

Pt/Al_(2)O_(3) catalysts with smaller size of Pt nanoparticles were prepared by ethylene glycol reduction method in two different way and their oxidation activities for three typical VOCs(volatile organic compounds)were *** catalyst prepared by first adsorption and then reduction procedure is denoted as l-Pt/Al_(2)O_(3) while the catalyst prepared by first reduction and then loading procedure is defined as R-Pt/Al_(2)O_(3).The results show that l-Pt/Al_(2)O_(3) with the stronger interaction between Pt species and Al_(2)O_(3) exhibit smaller size of Pt nanoparticles and favorable thermal stability compared with R-Pt/Al_(2)O_(3).l-Pt/Al_(2)O_(3) is favor of the formation of more adsorbed oxygen species and more Pt^(2+)species,resulting in high catalytic activity for benzene and ethyl acetate ***,R-Pt/Al_(2)O_(3) catalysts with higher proportion of Pt^(0)/Pt^(2+)and bigger size of Pt particles exhibits higher catalytic activity for n-hexane *** particles in R-Pt/Al_(2)O_(3) were aggregated much more serious than that in l-Pt/Al_(2)O_(3) at the same calcination *** Pt particles supported on Al_(2)O_(3) with~10 nm show the best catalytic activity for n-hexane oxidation.

关键词： Environment Particle size distribution Catalysis Thermal stability Size effect of Pt

Investigation of the structural, electronic and mechanical properties of CaO–SiO_(2) compound particles in steel based on density functional theory

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International Journal of Minerals,Metal.urgy and Materials 2023年第4期30卷 744-755页

作者： Chao Gu ziyu l.u Qin Hu Yanping Bao State Key laboratory of Advanced Metal.urgy University of Science and Technology BeijingBeijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China

CaO–SiO_(2)compounds compromise one of the most common series of oxide particles in liquid steels, which could significantly affect the service performance of the steels as crack initiation sites. However, the structural, electronic, and mechanical properties of the compounds in CaO–SiO_(2)system are still not fully clarified due to the difficulties in the experiments. In this study, a thorough investigation of these properties of CaO–SiO_(2)compound particles in steels was conducted based on first-principles density functional theory. Corresponding phases were determined by thermodynamic cal.ulation, including gamma dicalcium silicate(γ-C2S), alpha-prime(l) dicalcium silicate(αl′-C2S), alpha-prime(H) dicalcium silicate(αH′-C2S), alpha dicalcium silicate(α-C2S), rankinite(C3S2), hatrurite(C3S), wollastonite(CS), and pseudowollastonite(Ps-CS). The results showed that the cal.ulated crystal structures of the eight phases agree well with the experimental results. All the eight phases are stable according to the cal.ulated formation energies, and γ-C2S is the most stable. O atom contributes the most to the reactivity of these phases. The Young’s modulus of the eight phases is in the range of 100.63–132.04 GPa. Poisson’s ratio is in the range of0.249–0.281. This study provided further understanding concerning the CaO–SiO_(2)compound particles in steels and fulfilled the corresponding property database, paving the way for inclusion engineering and design in terms of fracture-resistant steels.

关键词： CaO–SiO_(2) density functional theory structural property electronic property mechanical property

Analysis of the redox environment and genesis of surface sediment in the northeast Indian Ocean at the Ninety-East Ridge

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Journal of Oceanology and limnology 2025年第1期43卷 57-72页

作者： Zhourong CAI Qianru HuANG Zhengxin YIN Xin SuI Sibo lÜ Meng TANG Juan PENG School of Marine Sciences Sun Yat-sen UniversityZhuhai 519082China Guangdong Provincial Key laboratory of Marine Resources and Coastal Engineering Zhuhai 519082China South China Sea Marine Survey Center Ministry of Natural ResourcesGuangzhou 510275China Key laboratory of Marine Environmental Survey Technology and Application Ministry of Natural ResourcesGuangzhou 510275China

The Ninety-East Ridge(NER)is located in the semioceanic to oceanic region of the southern Bengal Fan in the Northeast Indian *** sedimentary environment,ocean currents,and scientific issues related to climate change have always been the focus of *** well.understand the sedimentary environment of the sea area,we studied the modern sedimentary environment of the NER by analyzing the redox-sensitive trace elements(RSEs)and biomarkers in the surface sediments of the northern region and both sides of the NER and the mechanism of their *** ratios of Mo/u(average 2.22),(Cu+Mo)/Zn(average 1.51),and the results ofδCeles,all indicate the reduction of the sedimentary *** addition,the ratio of pristane(Pr)to phytane(Ph),C30diahopane to C30 hopane,and diasterane to sterane were low in all samples,on average of 1.03,0.9,and 0.33,*** analysis of RSE and biomarker data revealed that the sedimentary environment on seabed of the NER is generally a rare low-oxygen reduction *** the analysis of sediment characteristics,material sources,and ocean currents,we preliminarily constructed a genetic model for the low-oxygen reducing environment of surface sediments in the *** believe that the low-oxygen reduction environment of surface sediment in the NER could be influenced by multiple factors,such as terrestrial input of materials,productivity at sea surface,and sediment particle size.

关键词： Ninety-East Ridge(NER) surface sediment sedimentary environment redox-sensitive trace elements(RSEs) biomarker