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HPLC法同时测定盐酸阿霉素与氯尼达明的含量

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药学实践与服务 2024年第3期42卷 127-130页

作者：孙雨菡许子艺廖峻张翮樊莉鲁莹海军军医大学药学系药剂学教研室上海200433 上海大学医学院上海200444

目的建立同时测定盐酸阿霉素(DOX·HCl)与氯尼达明(LND)含量的测定方法。方法采用HPLC法,色谱柱为Agilent 5 HC-C_(18)(2)(4.6 mm×250 mm,5μm),流动相为甲醇-0.1%TFA水溶液,梯度洗脱,甲醇比例随时间变化为:0~3 min,65%甲醇;3~7 min,65... 详细信息

目的建立同时测定盐酸阿霉素(DOX·HCl)与氯尼达明(LND)含量的测定方法。方法采用HPLC法,色谱柱为Agilent 5 HC-C_(18)(2)(4.6 mm×250 mm,5μm),流动相为甲醇-0.1%TFA水溶液,梯度洗脱,甲醇比例随时间变化为:0~3 min,65%甲醇;3~7 min,65%→90%甲醇;7~13 min,90%甲醇;13~15 min,90%→65%甲醇;15~20 min、65%甲醇。采集时间20 min,平衡时间3 min,紫外检测波长205 nm及253 nm,流速1.0 ml/min,柱温35℃,进样量:10μl。结果该方法专属性好,盐酸阿霉素在1~40μg/ml的浓度范围内线性良好,氯尼达明在6~240μg/ml的浓度范围内线性良好。该方法之下,两种化合物的精密度、稳定性、回收率均符合要求。结论建立了同时检测盐酸阿霉素与氯尼达明含量的液相分析方法,该方法专属性强,准确可靠。

关键词：氯尼达明盐酸阿霉素高效液相色谱法联合用药梯度洗脱

Adjuvant and neo‐adjuvant immunotherapy in resectable non‐small cell lung cancer (NSCLC): Current status and perspectives

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Cancer Innovation 2023年第1期2卷 65-78页

作者： ziyi xu Zihua Zou xuezhi Hao Puyuan Xing Junling Li Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Medical Oncology Fujian Provincial Cancer HospitalFuzhouChina

Surgery followed by adjuvant chemotherapy is the standard of care for selectedpatients with early‐stage or locally advanced non‐small cell lung cancer(NSCLC). However, many of these patients still experience postoperativerecurrence at 5 years. At present, peri‐operative treatment methods areemerging to prevent early relapse, such as targeted therapy and *** on predictive biomarkers of responses to adjuvant andneoadjuvant therapies is also continuously ongoing. Immunotherapy representedby immune checkpoint inhibitors (ICIs), either by monotherapy or incombination with chemotherapy, has shown benefit in promoting pathologicalresponses and prolonging survival for patients with NSCLC without oncogenicmutations. Exploratory studies have also provided evidence regarding theselection of patients who benefit from ICI‐based perioperative treatment. Thisreview focuses on the existing data of current clinical trials of adjuvant andneoadjuvant strategies with ICIs in resectable NSCLC, the exploration ofpredictive biomarkers, and the perspectives and urgent challenges in thefuture.

关键词： biomarker peri‐operative immunotherapy resectable NSCLC

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载阿霉素金纳米粒的制备和细胞毒性研究

药学实践与服务 2024年第2期42卷 73-77,81页

作者：许子艺孙雨菡樊莉卢光照张鹰楠张翮海军军医大学药学系药剂学教研室上海200433

目的构建载阿霉素(DOX)的甲氧基聚乙二醇(mPEG)修饰的金纳米粒AuNPs-mPEG@DOX,以降低DOX的毒副作用。方法制备AuNPs-mPEG@DOX,通过粒径、电位和紫外可见光吸收光谱(UV-Vis)进行表征。考察连接巯基的DOX(HS-DOX)投药浓度对AuNPs-mPEG@DO... 详细信息

目的构建载阿霉素(DOX)的甲氧基聚乙二醇(mPEG)修饰的金纳米粒AuNPs-mPEG@DOX,以降低DOX的毒副作用。方法制备AuNPs-mPEG@DOX,通过粒径、电位和紫外可见光吸收光谱(UV-Vis)进行表征。考察连接巯基的DOX(HS-DOX)投药浓度对AuNPs-mPEG@DOX吸附率和载药量的影响。建立未吸附HS-DOX含量测定的高效液相色谱法(HPLC),对专属性、线性、精密度、稳定性和加样回收率进行考察。采用CCK-8法检测AuNPs-mPEG@DOX对MCF-10A和MCF-7细胞的毒性作用。结果成功制备了AuNPs-mPEG@DOX,粒径为(46.12±0.49)nm,电位为(18.60±1.51)mV,最大吸收波长为530 nm。建立了可用于检测AuNPs-mPEG@DOX未吸附HS-DOX含量的HPLC方法,测定最佳投药浓度11.18μg/ml,HS-DOX条件下的吸附率为(9.21±2.88)%,载药量为(2.01±0.62)%。细胞毒性实验表明AuNPs-mPEG@DOX可明显降低DOX对正常乳腺细胞的毒副作用;DOX在≥4.75μmol/L时,AuNPs-mPEG@DOX与游离DOX对乳腺肿瘤细胞的细胞毒性作用一致。结论AuNPs-mPEG@DOX可有效降低DOX的毒副作用,为后续AuNPs连接药物降低其毒副作用的研究提供参考。

关键词：金纳米粒阿霉素乳腺肿瘤毒副作用

NiO@Ni nanoparticles embedded in N-doped carbon for efficient photothermal CO_(2) methanation coupled with H_(2)O splitting

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Nano Research 2024年第4期17卷 2283-2290页

作者： Yun Zhou Peng Zheng Fang Wang Fangna Gu Wenqing xu Qinyang Lu Tingyu Zhu ziyi Zhong Guangwen xu Fabing Su Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China Key Laboratory on Resources Chemicals and Materials of Ministry of Education Shenyang University of Chemical TechnologyShenyang 110142China Institute of Industrial Chemistry and Energy Technology Shenyang University of Chemical TechnologyShenyang 110142China School of Ecology and Environment Beijing Technology and Business UniversityBeijing 100048China Beijing Key Laboratory of Enze Biomass Fine Chemicals College of New Materials and Chemical EngineeringBeijing Institute of Petrochemical TechnologyBeijing 102617China International School of Beijing 10 An Hua Street Shunyi DistrictBeijing 100048China Department of Chemical Engineering Guangdong Technion Israel Institute of Technology(GTIIT)Shantou 515063China Technion Israel Institute of Technology(IIT) Haifa32000Israel

Photothermal carbon dioxide(CO_(2))methanation has attracted increasing interest in solar fuel synthesis,which employs the advantages of photocatalytic H_(2)O splitting as a hydrogen source and photothermal catalytic CO_(2) *** work prepared three-dimensional(3D)honeycomb N-doped carbon(NC)loaded with core–shell NiO@Ni nanoparticles generated in situ at 500℃(NiO@Ni/NC-500).Under the photothermal catalysis(200℃,1.5 W/cm^(2)),the CH_(4) evolution rate of NiO@Ni/NC-500 reached 5.5 mmol/(g·h),which is much higher than that of the photocatalysis(0.8 mmol/(g·h))and the thermal catalysis(3.7 mmol/(g·h)).It is found that the generated localized surface plasmon resonance enhances the injection of hot electrons from Ni to NiO,while thermal heating accelerates the thermal motion of radicals,thus generating a strong photo-thermal synergistic effect on the *** CO_(2) reduction to CH_(4) follows the*OCH *** work demonstrates the synergistic effect of NiO@Ni and NC can enhance the catalytic performance of photothermal CO_(2) reduction reaction coupled with water splitting reaction.

关键词： Ni localized surface plasmon resonance photothermal methanation

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对MIS结构热弛豫时间的分析计算

电气电子教学学报 2024年第1期46卷 137-140页

作者：程骏骥朱麒瑾徐子逸王俊凯杨洪强电子科技大学集成电路科学与工程学院(示范性微电子学院) 成都610054 电子科技大学广东电子信息工程研究院东莞523808

对MIS(金属-绝缘层-半导体)结构从深耗尽过渡至强反型状态所需的热弛豫时间进行了研究。通过建立较教科书更精确的模型,对热弛豫时间τth与深耗尽时耗尽区宽度x d0、强反型时耗尽区最大宽度x dm、耗尽区内少子净产生率G和掺杂浓度N D等... 详细信息

对MIS(金属-绝缘层-半导体)结构从深耗尽过渡至强反型状态所需的热弛豫时间进行了研究。通过建立较教科书更精确的模型,对热弛豫时间τth与深耗尽时耗尽区宽度x d0、强反型时耗尽区最大宽度x dm、耗尽区内少子净产生率G和掺杂浓度N D等关键物理量之间的关联进行了推导,并基于MEDICI平台对推导结果完成了仿真验证,从而加强了学生对半导体表面效应的理解,也利于他们未来从事半导体方面的创新研究。

关键词：半导体物理 MIS结构热弛豫时间

Controlling Three-Step and Five-Step Spin Transitions by Polymorphism in an Fe^(Ⅲ) Spin Crossover Complex

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Chinese Journal of Chemistry 2024年第8期42卷 879-886页

作者： Yingying Wu Shuang Peng ziyi Zhang Yue Gao Guangyan xu Jingwei Dai Zhao-Yang Li Masahiro Yamashita School of Materials Science and Engineering Nankai University38 Tongyan RoadHaihe Educational ParkTianjin300350 China State Key Laboratory of Medicinal Chemical Biology Nankai UniversityTianjin300071 China Department of Chemistry Graduate School of ScienceTohoku UniversitySendai980-8578 Japan

Comprehensive Summary,Regulating spin crossover(SCO)behavior,especially controlling the spin transition steps,is an important scientific issue,mainly because people aim to control spin bistability and ***,SCO bistability can be regulated by changing the ligand-modifying species,non-coordinated anions,guest molecules,and metal-ion ***,the control of multistability is extremely challenging,especially in Fe(III)SCO ***,we report that[FeIII(H-5-Br-thsa)(5-Br-thsa)]·H2O(5-Br-thsa=(5-bromo-2-hydroxybenzylidene)hydrazinecarbothioamide),a compound we have reported before,exists in two polymorphic forms:polymorph 1 exhibits three-step SCO,and polymorph 2 shows five-step SCO,with multi-step SCO behavior effectively regulated by *** to single-crystal and powder X-ray diffractometry,polymorphs 1 and 2 crystallize in different space groups during their spin transitions,with two-step symmetry breaking observed(Pbcn→Pnc2→Pbcn for polymorph 1;P21/n→Pn→P21/n for polymorph 2).We realized that the behavior of these two polymorphs depends significantly on the structure,including(i)the average Fe—N bond distance,(ii)deformation of octahedral FeIII atoms,and(iii)distinct crystal packing,which account for the large differences observed in magnetic properties.

关键词： Spin crossover Multi-step spin transition Symmetry breaking Polymorphism Magnetic property

Sources appointment and health risks of PM_(2.5)-bound trace elements in a coastal city of southeastern China

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Journal of Environmental Sciences 2024年第4期138卷 561-571页

作者： ziyi Lin Xiaolong Fan Gaojie Chen Youwei Hong Mengren Li Lingling xu Baoye Hu Chen Yang Yanting Chen Zhiqian Shao Jinsheng Chen Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy ofSciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China Minnan Normal University Zhangzhou 363000China

To gain a comprehensive understanding of sources and health risks of trace elements in an area of China with high population densities and low PM_(2.5)concentrations,15 trace elements(Al,K,Ca,Ti,V,Cr,Mn,Fe,Ni,Cu,Zn,As,Sn,Ba,Pb)in PM_(2.5)were monitored from December 2020 to November 2021 in a representative city,*** concentrations of trace elements in Xiamen displayed an obvious seasonal variation and were dominated by K,Fe,Al,Ca and *** on Positive Matrix Factorization analysis,source appointment revealed that the major sources of trace elements in Xiamen were traffic,dust,biomass and firework combustion,industrial manufacture and shipping *** to health risk assessment combined with the source appointment results,it indicated that the average noncarcinogenic risk was below the threshold and cancer risk of four hazardous metals(Cr,Ni,As,Pb)exceeded the threshold(10^(-6)).Traffic-related source had almost half amount of contribution to the health risk induced by PM_(2.5)-bound trace *** the dust transport period or Spring Festival period,the health risks exceeded an acceptable threshold even an order of magnitude higher,suggesting that the serious health risks still existed in low PM_(2.5)environment at certain *** risk assessment reminded that the health risk reduction in PM_(2.5)at southeastern China should prioritize traffic-related hazardous trace elements and highlighted the importance of controlling vehicles emissions in the future.

关键词： PM_(2.5)-bound trace elements Seasonal variations Source appointment Health risks Traffic-related source

NIR-triggered on-site NO/ROS/RNS nanoreactor:Cascade-amplified photodynamic/photothermal therapy with local and systemic immune responses activation

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Opto-Electronic Advances 2024年第6期7卷 58-73页

作者： Ziqing xu Yakun Kang Jie Zhang Jiajia Tang Hanyao Sun Yang Li Doudou He xuan Sha Yuxia Tang ziyi Fu Feiyun Wu Shouju Wang Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Women&Children Research Center The First Affiliated HospitalNanjing Medical UniversityNanjing 210029China

Photothermal and photodynamic therapies(PTT/PDT)hold promise for localized tumor treatment,yet their full potential is hampered by limitations such as the hypoxic tumor microenvironment and inadequate systemic immune *** these challenges,we present a novel near-infrared(NIR)-triggered RNS nanoreactor(PBNO-Ce6)to amplify the photodynamic and photothermal therapy efficacy against triple-negative breast cancer(TNBC).The designed PBNOCe6 combines sodium nitroprusside-doped Prussian Blue nanoparticles with Chlorin e6 to enable on-site RNS production through NIR-induced concurrent NO release and ROS *** not only enhances tumor cell eradication but also potentiates local and systemic antitumor immune responses,protecting mice from tumor *** in vivo evaluations revealed that treatment with PBNO-Ce6 leads to a remarkable 2.7-fold increase in cytotoxic T lymphocytes and a 62%decrease in regulatory T cells in comparison to the control PB-Ce6(Prussian Blue nanoparticles loaded with Chlorin e6),marking a substantial improvement over traditional PTT/*** such,the PBNO-Ce6 nanoreactor represents a transformative approach for improving outcomes in TNBC and potentially other malignancies affected by similar barriers.

关键词： photothermal therapy photodynamic therapy nitric oxide reactive nitrogen species triple-negative breast cancer immune response nanoreactor

Ultrashorts Instant Gratification

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China Weekly 2024年第7期 36-38页

作者： Yi ziyi xu Pengyuan 不详

In China,a newkind ofonline show is enhancing mealtimes:“digital pickles”-short,engaging dramas that make eating more enjoyable by“adding flavor”to a boring meal *** the trend are micro-dramas。

关键词： adding break trend