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Human HAND1 inhibits the conversion of cholesterol to steroids in trophoblasts

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Journal of Genetics and Genomics 2022年第4期49卷 350-363页

作者： Haibin Zhu Qianlei Ren ziyi yan Shouying Xu Jiahao Luo Ximei Wu Chao Tang National Clinical Research Center for Child Health of the Children’s Hospital Zhejiang University School of MedicineHangzhouZhejiang 310052China Department of Obstetrics and Gynaecology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Pharmacology School of MedicineZhejiang UniversityHangzhouZhejiang 310058China

Steroidogenesis from cholesterol in placental trophoblasts is fundamentally involved in the establishment and maintenance of *** transcription factor gene heart and neural crest derivatives expressed1(Hand1)promotes differentiation of mouse trophoblast giant ***,the role of HAND1 in human trophoblasts remains ***,we report that HAND1 inhibits human trophoblastic progesterone(P4)and estradiol(E2)from cholesterol through downregulation of the expression of steroidogenic enzymes,including aromatase,P450 cholesterol side-chain cleavage enzyme(P450 scc),and 3β-hydroxysteroid dehydrogenase type 1(3β-HSD1).Mechanically,although HAND1 inhibits transcription of aromatase by directly binding to aromatase gene promoter,it restrains transcription of P450 scc by upregulation of the methylation status of P450 scc gene promoter through its binding to ALKBH1,a *** aromatase and P450 scc,HAND1 decreases 3β-HSD1 m RNA levels by the reduction of its RNA stability through binding to and subsequent destabilizing protein Hu ***,HAND1 suppresses circulating P4 and E2 levels derived from JEG-3 xenograft and attenuates uterine response to P4 and ***,our results uncover a hitherto uncharacterized role of HAND1 in the regulation of cholesterol metabolism in human trophoblasts,which may help pinpoint the underlying mechanisms involved in supporting the development and physiological function of the human placenta.

关键词： HAND1 Trophoblast Cholesterol Steroids

Molecular packing tuning via chlorinated end group enables efficient binary organic solar cells over 18.5%

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Carbon Energy 2024年第3期6卷 196-203页

作者： Yafeng Li Zhenyu Chen Xingzheng yan ziyi Ge Zhejiang Business Technology Institute NingboZhejiangChina Zhejiang Engineering Research Center for Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboZhejiangChina Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijingChina

Designing novel nonfullerene acceptors(NFAs)is of vital importance for the development of organic solar cells(OSC).Modification on the side chain and end group are two powerful tools to construct efficient ***,based on the high-performance L8BO,we selected 3-ethylheptyl to substitute the inner chain of 2-ethylhexyl,obtaining the backbone of *** we introduced different halogen atoms of fluorine and chlorine on 2-(3-oxo-2,3-dihydro-1Hinden-1-ylidene)malononitrile end group(EG)to construct efficient NFAs named BON3-F and BON3-Cl,*** donor D18 was chosen to combine with two novel NFAs to construct OSC ***,D18:BON3-Cl-based device shows a remarkable power conversion efficiency(PCE)of 18.57%,with a high open-circuit voltage(V_(OC))of 0.907 V and an excellent fill factor(FF)of 80.44%,which is one of the highest binary PCE of devices based on D18 as the ***,BON3-F-based device shows a relatively lower PCE of 17.79%with a decreased FF of 79.05%.The better photovoltaic performance is mainly attributed to the red-shifted absorption,higher electron and hole mobilities,reduced charge recombination,and enhanced molecular packing in the D18:BON3-Cl ***,we performed stability tests on two binary systems;the D18:BON3-Cl and D18:BON3-F devices maintain 88.1%and 85.5%of their initial efficiencies after 169 h of storage at 85°C in an N2-filled glove box,*** work demonstrates the importance of selecting halogen atoms on EG and provides an efficient binary system of D18:BON3-Cl for further improvement of PCE.

关键词： binary organic solar cell chlorinated end group molecular packing

有氧运动对降低药物成瘾患者药物渴求的影响综述

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医学研究前沿

医学研究前沿 2024年第4期2卷 31-33页

作者：闫自一代宏伟乜鲁洁胡家栋云南省第六强制隔离戒毒所云南德宏州678400 云南师范大学体育学院云南昆明650500

药物成瘾是令社会大众闻之色变的一种反复发作的慢发性脑疾病,对患者的各脏器及心理、认知等诸多方面产生深远危害。研究发现采用有氧运动能有效促进药物成瘾患者体质健康、改善认知功能、减少对药物的渴求达到降低药物渴求的目的。本... 详细信息

药物成瘾是令社会大众闻之色变的一种反复发作的慢发性脑疾病,对患者的各脏器及心理、认知等诸多方面产生深远危害。研究发现采用有氧运动能有效促进药物成瘾患者体质健康、改善认知功能、减少对药物的渴求达到降低药物渴求的目的。本文对药物成瘾的形成机制进行梳理,研究有氧运动对降低药物渴求三个阶段的影响并进行总结和综述,以期为药物成瘾的非药物干预提供科学依据,为临床实践提供指导建议。

关键词：有氧运动降低药物渴求体质健康水平

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连续刚构桥0#块首件工程施工分析

工程质量 2024年第8期42卷 32-37页

作者：刘威颜子一秦璐遥史志阳霍正中国建筑第七工程局有限公司河南郑州451100

以武汉北四环线泾河互通立交桥左幅6#墩0#块为研究对象,采取首件工程的方式来对0#块施工组织和施工工艺进行检验,保证悬臂浇筑0#块的施工质量,避免盲目施工造成损失。结果显示:0#块钢筋绑扎过程中,箍筋在自重和外力作用下产生不同程度... 详细信息

以武汉北四环线泾河互通立交桥左幅6#墩0#块为研究对象,采取首件工程的方式来对0#块施工组织和施工工艺进行检验,保证悬臂浇筑0#块的施工质量,避免盲目施工造成损失。结果显示:0#块钢筋绑扎过程中,箍筋在自重和外力作用下产生不同程度的下沉;竖向预应力钢棒定位安装后,在后续安装过程中,邻近钢筋对钢棒产生挤压,造成钢棒弯曲、扭转、间距不均;波纹管穿入内衬管后,波纹管端头处线形沿内衬管弧度产生弯曲;内箱倒角混凝土表面存在错台和涨模;腹板与倒角连接处局部存在漏振现象;底板与倒角接缝处混凝土超厚。对上述问题,论文提出了专业性建议,采取了相应的解决措施,以便更好地指导后续施工。

关键词：桥梁工程悬臂施工施工工艺

基于无人机高光谱的稻田杂草识别和空间分布研究

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激光生物学报 2024年第4期33卷 335-346页

作者：颜子一沈奕扬唐伟张艳超周豪哲浙江理工大学信息科学与工程学院浙江310000 中国水稻研究所水稻生物学国家重点实验室浙江311400

稗草是稻田中一种典型的杂草,会严重影响水稻的生长发育,并最终导致减产。由于其外观与水稻极其相似,难以区分,给治理带来了极大的挑战。基于室内环境下的稗草识别条件理想,难以推广,因此,在复杂稻田环境下对稗草进行识别和制图具有重... 详细信息

稗草是稻田中一种典型的杂草,会严重影响水稻的生长发育,并最终导致减产。由于其外观与水稻极其相似,难以区分,给治理带来了极大的挑战。基于室内环境下的稗草识别条件理想,难以推广,因此,在复杂稻田环境下对稗草进行识别和制图具有重要的研究价值和意义。首先,利用无人机载高光谱获取低空稻田影像,经拼接校正和SG(Savitzky-Golay)卷积平滑滤波后,采用连续投影算法(SPA)对区分水稻和稗草的敏感波段进行提取,基于全波段和特征波段,使用支持向量机(SVM)、随机森林(RF)、一维卷积神经网络(1DCNN)和三维卷积神经网络(3DCNN)进行建模。结果表明,SPA-3DCNN对水稻(0.9420)和稗草(0.8936)的识别效果最好。SPA选择的7个特征波段(482.5234、546.5415、675.0806、709.1382、762.0431、922.0157和944.6371 nm)对区分稗草和水稻具有重要的参考价值。随后,将模型应用于整个高光谱数据集,生成稗草的空间分布图与密度图。本文成功探索了无人机载高光谱在复杂稻田环境下稗草识别的可行性,并绘制了稗草空间分布图与密度图,为稗草的治理防范提供了有力的数据支撑。

关键词：稻田杂草识别无人机高光谱空间分布精准除草

Facile access to C-N bonds via unexpected side reactions of Knoevenagel condensation and their application in high-efficiency organic solar cells

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Science China Chemistry 2024年第1期67卷 323-329页

作者： Daobin yang Shuncheng yang Hongqian Wang Lin Xie Pengyu yan ziyi Ge Zhejiang Engineering Research Center for Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The construction of C-N bonds is of great importance in the fields of biology,medicine,chemistry and materials ***,the replacement of organic base from pyridine to piperidine in the Knoevenagel condensation process unexpectedly yields a series of novel organic molecules containing C-N ***,the synthesis method does not require any external transition-metals catalysis,and photo-/***,when the new compound 1b is added as a third component to a well-known binary system of PM6:Y6,the efficiency of the organic solar cell is significantly improved,resulting in an outstanding efficiency of 18.0%,which is one of the highest values reported to date for PM6:Y6-based ternary organic solar cells.

关键词： C-N bonds Knoevenagel condensation cross-coupling reaction third component organic solar cells

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通州文旅区的民宿特色建设探索

语言与文化研究

语言与文化研究 2024年第3期32卷 209-211页

作者：陈雨萱杜欣然严子怡李邢鱼姚鑫鑫沈健北京物资学院北京101149

本文以北京通州大运河附近的一家中式四合院民宿为切入点,对通州文旅区的民俗特色建设进行了探索研究。探索的各个方面分别为内部装修格式、饮食特色、外观设计特色、庭院特色以及娱乐特色,针对这几方面,本文进行了详细描述,旨在全方面... 详细信息

本文以北京通州大运河附近的一家中式四合院民宿为切入点,对通州文旅区的民俗特色建设进行了探索研究。探索的各个方面分别为内部装修格式、饮食特色、外观设计特色、庭院特色以及娱乐特色,针对这几方面,本文进行了详细描述,旨在全方面了解特色民宿的各个方面的同时,探索出能够对运河文化传播起到良好作用的民俗特点,为宣传和弘扬运河文化做出贡献。

关键词：大运河通州文旅民宿特色运河文化

19.3% Efficiency ternary organic solar cells enabled by the alkyl side-chain effect of guest non-fullerene acceptors

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Science China Chemistry 2024年第8期67卷 2686-2693页

作者： Hongqian Wang Sijian Wu Daobin yang Xueliang Yu Shuncheng yang Pengfei Ding Pengyu yan Zaifei Ma Jianfeng Zhang ziyi Ge School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China Zhejiang Engineering Research Center for Energy Optoelectronic Materials and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

The effect of side-chain engineering of conjugated molecules on the morphology and device performance in binary organic solar cells has been widely investigated. However, this relationship has hardly been studied in the guest components of ternary organic solar cells. In this study, a family of non-fullerene guest acceptors, namely XY-3, XY-5 and XY-7, with hydrogen substituent,straight and branched alkyl chains on the bithiophene units, respectively, were designed and synthesized to understand their effects on aggregation properties and device performance. The straight and branched alkyl chains on the bithiophene units result in sightly blue-shifted absorption compared to the hydrogen substituent and the XY-7 demonstrates the most appropriate phase separation scale and the most balanced charge transport. Consequently, the OSCs based on D18:e C9:XY-7 achieve a high shortcircuit current density(JSC) and fill factor(FF), while maintaining the enhancement of the open-circuit voltage(VOC) achieving an efficiency of 19.32%, exceeding those of D18:e C9, D18:e C9:XY-3, D18:e C9:XY-5(PCE:18.28%, 19.04%, 18.75%, respectively). These results highlight that the side-chain engineering of Y series non-fullerene acceptors as the guest acceptors has great potential in optimizing morphology properties and promoting photovoltaic performance.

关键词： organic solar cells side chain engineering ternary strategy non-fullerene energy losses

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The clinical application and advancement of robot-assisted McKeown minimally invasive esophagectomy for esophageal cancer

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第1期7卷 6-10页

作者： Raojun Luo Yiming Li Xiumin Han Yunzheng Wang Zhengfu He Peijian yan ziyi Zhu Department of Thoracic Surgery Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Operating Room Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Robotic surgery systems,as emerging minimally invasive approaches,have been increasingly applied for the treatment of esophageal cancer because they provide a high-definition three-dimensional surgical view and mechanical rotating arms that surpass the limitations of human hands,greatly enhancing the accuracy and flexibility of surgical ***-assisted McKeown esophagectomy(RAME),a common type of robotic esophagectomy,has been gradually implemented with the aim of reducing postoperative complications,improving postoperative recovery and achieving better long-term *** centers worldwide have reported and summarized their experiences with the RAME,and some have also discussed and analyzed its perioperative effects and survival prognosis compared with those of video-assisted minimally invasive *** to traditional surgery,the RAME has significant advantages in terms of lymph node dissection although there seems to be no difference in overall survival or disease-free *** the continuous advancement of technology and the development of robotic technology,further development and innovation are expected in the RAME *** review elaborates on the prospects of the application and advancement of the RAME to provide a useful reference for clinical practice.

关键词： Esophageal cancer Minimally invasive esophagectomy Robot-assisted McKeown esophagectomy Lymph node dissection