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以实践为导向的电工电子课程教学分析

集成电路应用 2024年第2期41卷 350-352页

作者：温歆朱荣臻李竟然李子杨航天工程大学士官学校北京102200

阐述以实践为导向的电工电子类课程教学模式,以提高基本实践操作能力为核心。在电路设计、搭建及测试的技能训练中,电路设计借助Multisim仿真软件,设计完成后再按照电路图进行电路连接、测试,引导学生快速准确地完成实践。

关键词：电工电子实践导向 Multisim仿真

Epitaxial growth of hyperbranched Cu/Cu2O/CuO coreshell nanowire heterostructures for lithium-ion batteries

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Nano Research 2015年第8期8卷 2763-2776页

作者： Yuxin Zhao Ying Zhang Hu Zhao Xuejin Li Yanpeng Li Ling wen Zifeng Yan ziyang Huo State Key Laboratory for Heavy Oil Processing PetroChina Key Laboratory of Catalysis China University of Petroleum Qingdao 266580 China SINOPEC Safety Engineering Institute No 218 Yan'an 3 Road Shinan District Qingdao 266071 China China Petroleum Pipeline Bureau 87 Guangyang Road Langfang 065000 China Queensland Micro- and Nanotechnology Centre Nathan Campus Griffith University 170 Kessels Road NATHAN QLD 4111 Australia

The careful design of nano-architectures and smart hybridization of expected active materials can lead to more advanced properties. Here we have engineered a novel hierarchical branching Cu/Cu2O/CuO heteronanostructure by combining a facile hydrothermal method and subsequent controlled oxidation process. The fine structure and epitaxial relationship between the branches and backbone are investigated by high-resolution transmission electron microscopy. Moreover, the evolution of the branch growth has also been observed during the gradual oxidation of the Cu nanowire surface. The experimental results suggest that the surface oxidation needs to be performed via a two-step exposure process to varying humidity in order to achieve optimized formation of a core-shell structured branching architecture. Finally, a proof-of-concept of the function of such a hierarchical framework as the anode material in lithium-ion batteries is demonstrated. The branching core-shell heterostructure improves battery performance by several means：（i） The epitaxially grown branches provide a high surface area for enhanced electrolyte accessibility and high resistance to volume change induced by Li^＋ intercalation/extraction; （ii） the core-shell structure with its well-defined heterojunction increases the contact area which facilitates effective charge transport during lithiation; （iii） the copper core acts as a current collector as well as providing structural reinforcement.

关键词： nanowires copper oxides epitaxial growth heterostructure lithium-ion battery

基于下丘脑-垂体-性腺轴分析淫羊藿苷对男性不育症的调控

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中国性科学 2024年第8期33卷 1-4页

作者：徐磊张培海徐子龙文泓志马紫阳成都中医药大学临床医学院成都610075 成都中医药大学附属医院代谢性疾病中医药调控四川省重点实验室成都610075

近年来,不育症已成为当代男性的主要社会和健康问题之一。男性不育症病因十分复杂,目前针对男性不育症的治疗手段虽然很多,但费用相对昂贵,且疗效较差。淫羊藿作为男科常用的药物,长期以来一直在中药治疗男性不育症方面发挥着重要作用... 详细信息

近年来,不育症已成为当代男性的主要社会和健康问题之一。男性不育症病因十分复杂,目前针对男性不育症的治疗手段虽然很多,但费用相对昂贵,且疗效较差。淫羊藿作为男科常用的药物,长期以来一直在中药治疗男性不育症方面发挥着重要作用。淫羊藿苷是淫羊藿的主要化学成分,近年来,对淫羊藿苷的研究主要集中在治疗勃起功能障碍、抑制肿瘤细胞生长、控制高血压及冠心病等方面,在不育症方面的研究相对较少。因此,本文基于下丘脑-垂体-性腺轴理论,详细阐述了淫羊藿苷对睾丸前性病因、睾丸性病因及睾丸后性病因导致的不育症的调控机制,以期为临床治疗不育症提供一些思路。

关键词：淫羊藿苷男性不育症雄激素下丘脑-垂体-性腺轴

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积木式编程开发环境设计

计算机应用文摘 2024年第11期40卷 61-63页

作者：孔杞越鲁子洋张晓闻温红艳武汉轻工大学电气与电子工程学院武汉430023

当代少儿编程学习备受社会广泛关注,然而普通的编程语言学习方式并不太适合少儿,因此文章以Python语言为例,基于Scratch的积木式开发环境,探索一种将编程语言积木化的方法,旨在打造一种更适合少儿编程入门的编程环境。

关键词： Python 积木式编程 Scratch积木式开发环境

中上扬子地区震旦纪灯影组沉积期碳酸盐岩台地古地理格局及有利储集相带分布规律

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沉积学报 2024年第3期42卷 928-943页

作者：丁一刘树根文龙文华国陈代钊宋金民王瀚王林康陈明思陈荣庆李智武成都理工大学油气藏地质及开发工程国家重点实验室成都610059 成都理工大学沉积地质研究院成都610059 西华大学成都610039 中国石油西南油气田公司勘探开发研究院成都610041 中国科学院地质与地球物理研究所新生代地质与环境重点实验室北京100029

【目的】中上扬子地区灯影组沉积期碳酸盐岩台地古地理格局及有利储集相带发育分布规律尚存争议,阻碍了灯影组油气勘探领域由绵阳—长宁拉张槽两侧向其他广大地区拓展。【方法】通过中上扬子地区灯影组30余条剖面(钻井)开展岩石类型划... 详细信息

【目的】中上扬子地区灯影组沉积期碳酸盐岩台地古地理格局及有利储集相带发育分布规律尚存争议,阻碍了灯影组油气勘探领域由绵阳—长宁拉张槽两侧向其他广大地区拓展。【方法】通过中上扬子地区灯影组30余条剖面(钻井)开展岩石类型划分及沉积相分析,【结果】进一步明确丘滩相以块状砂屑/鲕粒白云岩及柱状、穹窿状叠层石白云岩为特征,呈环带状分布在中上扬子台地(或内缓坡)边缘,向外过渡为中—外缓坡风暴岩或斜坡—盆地相区的滑塌角砾白云岩、泥质白云岩、硅质岩等。由于丘滩的阻挡作用,其内侧以低能的潮坪及潟湖沉积环境为主:其中潮坪相主要发育微生物纹层白云岩、穹窿—缓波状叠层石白云岩、凝块石白云岩夹砂屑白云岩、泥晶白云岩,纵向上常常形成米级—厘米级旋回;潟湖相主要由泥晶白云岩、含球粒/砂屑泥晶白云岩组成。相带时空分布表明灯影组在中上扬子地区总体呈现出进积的沉积趋势,内部包含2.5个层序,即三次进积(变浅)和两次退积(变深)旋回。【结论】由于灯影组在台地边缘—斜坡区域普遍遭到剥蚀,以及灯影组沉积期上扬子台地范围远超目前的板块边界,灯影组上部灯四段很少发现高能丘滩相带。在此背景下,局部地区(如松林—岩孔地区、中扬子台地周缘)灯影组中下部灯一段—灯二段(或蛤蟆井段、石板滩段)发育的丘滩相,是重要的有利储集相带。此外,处于海退体系域的灯二段中下部和灯四段上部(或相当层位)在中上扬子台地(或内缓坡)内部广泛发育微生物白云岩,也为储层发育有利相带。在中上扬子台地微生物白云岩广泛分布的背景下,进一步分析优质储层发育机理与分布规律才是找到油气接替区的关键。

关键词：中上扬子地区灯影组碳酸盐岩台地古地理格局储集相带

鸡胰岛素耐受性及血液葡萄糖稳态调节研究进展

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动物营养学报 2022年第4期34卷 2123-2129页

作者：王子阳陈文河南农业大学动物科技学院郑州450046

鸡具有极强的胰岛素耐受性,空腹血液葡萄糖浓度是大部分哺乳动物的2倍,却无任何有害效应出现。至今关于鸡对长期高血糖和胰岛素的耐受性机制尚未知。本文针对鸡特殊的胰岛素耐受性及胰岛素信号传导通径、葡萄糖转运体(GLUT)等进行综述,... 详细信息

鸡具有极强的胰岛素耐受性,空腹血液葡萄糖浓度是大部分哺乳动物的2倍,却无任何有害效应出现。至今关于鸡对长期高血糖和胰岛素的耐受性机制尚未知。本文针对鸡特殊的胰岛素耐受性及胰岛素信号传导通径、葡萄糖转运体(GLUT)等进行综述,以期为解析鸡的糖代谢机制提供参考,也为人类糖尿病预防与治疗提供思路。

关键词：鸡胰岛素抵抗胰岛素信号通经糖代谢葡萄糖转运体

Characterization of Base-pairing of RNA in RNA Gels Formed by Nucleotide Repeat Expansion by Proton-detected Solid-state NMR

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Characterization of Base-pairing of RNA in RNA Gels Formed b...

Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1-BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy

2021年全国生物相分离和相变学术研讨会

作者： Sha Zhao ziyang wen Mengbing Zou Shenlin wang College of Chemistry and Molecular Engineering Peking University Beijing NMR Center Peking University Beijing National Laboratory for Molecular Sciences State Key Laboratory of Bioreactor Engineering East China University of Science and Technology

Hexanucleotide repeat expansions of C9 orf72,(GGGGCC)n, are related to neurological diseases,including amyotrophic lateral sclerosis(ALS) and frontotemporal dementia(FTD).Previous study showed that C9 orf72 hexanucleotide repeat undergoes a soluble to gel transition in vitro without protein *** of G-quadruplex was believed to be the main driving force of the phase transition involving the GGGGCC ***,observation of the secondary structure of(GGGGCC)n in RNA gels is still *** the key structural components would provide valuable insights into the mechanisms of RNA phase separation and clues in drug ***-state NMR is powerful in characterization of bio-macromolecules within the condensed-phase ***,we report our recent advancements of novel 2 D proton-detected SSNMR experiments to analyze the base-pairings of RNA in *** on(GGGGCC)s repeats,our results revealed that both the G-C Watson-Crick base pairs and the G-G base pairs exist in(GGGGCC)s RNA gels in the presence of *** contrast,the G-quadruplex was not observed in this *** observation is different from the early solution NMR studies,which showed major G-quadruplex topology in Kcontaining *** suggests structural rearrangements of(GGGGCC) in forming RNA gels from monomers or low number of *** data,our results provide the first direct structural evidence on RNA in insoluble gel-like state,facilitating in understanding the key driving forces of RNA *** approach is adaptable to other phase separation systems involving RNA molecules.

关键词： RNA Phase separation Solid-state NMR

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Acta Pharmaceutica Sinica B 2023年第8期13卷 3382-3399页

作者： Xin Yue Tingyu Liu Xuecen wang Weijian Wu Gesi wen Yang Yi Jiaxin Wu ziyang wang Weixiang Zhan Ruirui Wu Yuan Meng Zhirui Cao Liyuan Le wenyan Qiu Xiaoyue Zhang Zhenyu Li Yong Chen Guohui Wan Xianzhang Bu Zhenwei Peng Ran-yi Liu State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Radiation Oncology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Department of Clinical Research Guangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Gastrointestinal Surgery the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Oncology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Traditional Chinese Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080China Laboratory of Chemical Oncogenomics Guangdong Provincial Key Laboratory of Chemical GenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China

Radiotherapy is widely used in the management of advanced colorectal cancer(CRC).However,the clinical efficacy is limited by the safe irradiated *** tumor cells to radiotherapy via interrupting DNA repair is a promising approach to conquering the *** BRCA1-BARD1 complex has been demonstrated to play a critical role in homologous recombination(HR)DSB repair,and its functions may be affected by HERC2 or *** evidence illustrates that the ubiquitination-deubiquitination balance is involved in these processes;however,the precise mechanism for the cross-talk among these proteins in HR repair following radiation hasn’t been *** activity-based profiling,we identified PT33 as an active entity for HR repair ***,we revealed that BAP1 serves as a novel molecular target of PT33 via a CRISPR-based deubiquitinase ***,pharmacological covalent inhibition of BAP1 with PT33 recruits HERC2 to compete with BARD1 for BRCA1 interaction,interrupting HR ***,PT33 treatment can substantially enhance the sensitivity of CRC cells to radiotherapy in vitro and in ***,these findings provide a mechanistic basis for PT33-induced HR suppression and may guide an effective strategy to improve therapeutic gain.

关键词： Pharmacological inhibition BAP1 HERC2recruitment BRCA1 BARD1 Competitively dissociation HR-Mediated DNArepair,CRCradiosensitization

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外源Cd对川芎苓种萌发及幼苗生长的影响

天然产物研究与开发 2024年第5期36卷 838-846页

作者：张德林陈云子陈蓉喻文袁文洪苟琰刘薇李敏成都中医药大学西南特色中药资源国家重点实验室成都611137 眉山药科职业学院眉山620000 资阳市食品药品检验检测中心资阳641300 四川省药品检验研究院成都611731

本研究旨在探究不同浓度镉(Cd)对川芎苓种萌发和幼苗生长的影响。采用以石英砂为基质的水培试验,施加不同浓度CdCl 2·2.5 H 2O(0、0.1、0.25、0.5、1、2 mmol/L)溶液处理川芎苓种,研究Cd胁迫对川芎苓种萌发、幼苗生长、生理代谢及Cd含... 详细信息

本研究旨在探究不同浓度镉(Cd)对川芎苓种萌发和幼苗生长的影响。采用以石英砂为基质的水培试验,施加不同浓度CdCl 2·2.5 H 2O(0、0.1、0.25、0.5、1、2 mmol/L)溶液处理川芎苓种,研究Cd胁迫对川芎苓种萌发、幼苗生长、生理代谢及Cd含量的影响。结果显示,随着Cd浓度的增加,株高抑制率、根长抑制率上升;根、叶及节盘Cd含量显著升高;株高、根长、叶鲜重、根鲜重下降;抗氧化酶(过氧化氢酶、过氧化物酶、超氧化物歧化酶)活性、非酶系统物质(可溶性蛋白、谷胱甘肽、脯氨酸)含量以及丙二醛含量先升高后降低。研究表明,0.1~2.0 mmol/L Cd对川芎苓种萌发和早期幼苗生长均有明显的毒害作用,随着Cd胁迫浓度的升高毒害作用增强,其中川芎幼苗根对Cd胁迫最敏感。Cd胁迫下川芎幼苗生理生化指标整体上呈现低促高抑的Hormesis效应。川芎幼苗通过提高抗氧化酶活性和非酶系统物质积累,减少膜系统损伤、活性氧蓄积,缓解Cd毒害作用,提高耐受性。

关键词：川芎苓种 Cd 胁迫种子萌发生长发育