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Gadolinium-containing semiconducting polymer nanoparticles for magnetic resonance/fluorescence dual-modal imaging and photothermal therapy of oral squamous cell carcinoma

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Nano Research 2023年第2期16卷 2808-2820页

作者： Xiao Pan Antian Gao Yanni hu ziyang hu Chen Xie Zitong Lin Department of Dentomaxillofacial Radiology Affiliated Stomatology Hospital of Medical SchoolNanjing UniversityNanjing 210008China Key Laboratory for Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts&TelecommunicationsNanjing 210023China

Oral squamous cell carcinoma(OSCC)is the most common malignant tumor of the oral and maxillofacial *** to its unique location,earlier and more accurate diagnosis and more minimally invasive treatment of OSCC is of major ***,gadolinium-containing semiconductor polymer nanoparticles(SPN-Gd)were designed and *** nanoparticles consist of a near-infrared(NIR)absorption semiconductor polymer(PCPDTBT)served as fluorescence signal source and a photothermal conversion agent(PTA)and a gadolinium-grafted triblock amphiphilic copolymer(F127-DTPA-Gd)served as a magnetic resonance imaging(MRI)contrast agent and *** experiments in vivo showed that SPN-Gd could act as an MRI contrast agent and optical image agent with a long retention time,and it had a significant inhibiting effect on tumors of OSCC mice model through photothermal therapy(PTT).Thus our study provides a simple nanotheranostic platform composed of two components for efficient MR/fluorescence dual-modal imaging-guided PTT.

关键词： oral squamous cell carcinoma magnetic resonance imaging fluorescence imaging dual-modal imaging photothermal therapy semiconducting polymer nanoparticles

Tensile, creep behavior and microstructure evolution of an as-cast Ni-based K417G polycrystalline superalloy

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Journal of Materials Science & Technology 2018年第10期34卷 1805-1816页

作者： Beining Du ziyang hu Liyuan Sheng Chuanyong Cui Jinxia Yang Yufeng Zheng Xiaofeng Sun Shenzhen Institute Peking University 5henzhen 518057 China Institute of Metal Rearch.Chinese Academy of Sdences Shenyang 110016China Shenzhen Yezhan Electronics Co Ltd. Shenzhen 518110 China

The Ni-based K417G superalloy is extensively applied as aeroengine components for its low cost and good mid-temperature （600-900 ~C） properties. Since used in as-cast state, the comprehensive under-standing on its mechanical properties and microstructure evolution is necessary. In the present research, the tensile, creep behavior and microstructure evolution of the as-cast K417G superalloy under differ-ent conditions were investigated. The results exhibit that tensile cracks tend to initiate at MC carbide and γ＇/γ＇ eutectic structure and then propagate along grain boundary. As the temperature for tensile tests increases from 21 ℃ to 700 ℃, the yield strength and ultimate tensile strength of K417G superalloy decreases slightly, while the elongation to failure decreases greatly because of the intermediate tem- perature embrittlement. When the temperature rises to 900 ℃, the yield strength and ultimate tensile strength would decrease significantly. The creep deformation mechanism varies under different test-ing conditions. At 760 ℃/645 MPa, the creep cracks initiate at MC carbides and γ/γ＇ eutectic structures, and propagate transgranularly. While at 900℃/315 MPa and 950℃/235 MPa, the creep cracks initiate at grain boundary and propagate intergranularly. As the creep condition changes from 760 ℃/645 MPa to 900 ℃/315 MPa and 950 ℃/235 MPa, the γ＇ phase starts to raft, which reduces the creep deformation resistance and increases the steady-state deformation rate.

关键词： Ni-based superalloy Microstructure Tensile Creep

中药调节自噬相关信号通路改善激素性股骨头坏死的研究进展

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中医康复 2025年第1期2卷 60-65页

作者：马平齐鑫陈欣胡紫阳刘建军甘肃中医药大学附属医院甘肃兰州730000 甘肃中医药大学甘肃兰州730000

激素性股骨头坏死(steroid-induced avascular necrosis of the femoral head,SANFH)是一类临床骨科系统常见病与多发病,究其原因是激素的不合理使用造成股骨头缺血缺氧,而最终发展为股骨头坏死。目前来说,对SANFH的治疗尚无临床特效药... 详细信息

激素性股骨头坏死(steroid-induced avascular necrosis of the femoral head,SANFH)是一类临床骨科系统常见病与多发病,究其原因是激素的不合理使用造成股骨头缺血缺氧,而最终发展为股骨头坏死。目前来说,对SANFH的治疗尚无临床特效药物,但随着研究手段的进步,已发现自噬在该病的致病过程中扮演重要角色,且已明确部分信号通路能够对自噬产生影响。现阶段,中药防治SANFH的研究备受关注,但其作用机制尚不清楚。本文通过查阅相关国内外文献,就自噬(成骨细胞、破骨细胞、线粒体等)与SANFH的发病关系及中药(如黄芪多糖、葛根素、柚皮苷、川芎嗪、淫羊藿苷等中药单体及化合物,以及桂枝芍药知母汤、右归饮、健骨散、骨痹通消方、活血通络汤等中药复方)调节自噬相关信号通路从而改善SANFH进行概述,以期为拓展SANFH的治疗措施及明确中药应用价值提供参考。

关键词：激素性股骨头坏死自噬中药单体复方信号通路凋亡成骨细胞破骨细胞

Effect of extrusion process on the mechanical and in vitro degradation performance of a biomedical Mg-Zn-Y-Nd alloy

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Bioactive Materials 2020年第2期5卷 219-227页

作者： Beining Du ziyang hu Jiali Wang Liyuan Sheng hui Zhao Yufeng Zheng Tingfei Xi Shenzhen Institute Peking UniversityShenzhen518057China Shenzhen Yezhan Electronics Co. LtdShenzhen518110China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou510006China School of Materials Science and Engineering Xi'an Shiyou UniversityXi'an710065China

A new type of biomedical Mg-Zn-Y-Nd alloy was developed and thermal extruded by different processes to investigate the effect of extrusion ratio and extrusion pass on its microstructure,mechanical property and degradation *** results show that the increase of extrusion ratio could promote the dynamic recrystallization(DRX)process and led to the coarsening of DRXed *** the increase of extrusion pass also contributes to the DRX process but refines the DRXed *** simultaneous increasing of extrusion ratio and extrusion pass refines the secondary phases *** increase of extrusion ratio has reduced the tensile strength but improved the elongation of the alloy ***,the increase of extrusion pass could enhance the tensile strength and elongation simultaneously,especially the *** degradation performance has been optimized effectively through increasing the extrusion ratio and extrusion pass.

关键词： Mg-Zn-Y-Nd alloy Microstructure Tensile property Degradation performance

Self-assembled interlayer aiming at the stability of NiOx based perovskite solar cells

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Journal of Energy Chemistry 2022年第6期31卷 211-220,I0006页

作者： Tonghui Guo Zhi Fang Zequn Zhang Zhiqiang Deng Rui Zhao Jing Zhang Minghui Shang Xiaohui Liu ziyang hu Yuejin Zhu Liyuan Han Department of Microelectronic Science and Engineering Ningbo UniversityNingbo 315211ZhejiangChina School of Materials Science and Engineering Ningbo University of TechnologyNingbo 315016ZhejiangChina State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240China

Inorganic NiO_(x) based inverted structure perovskite solar cells (PSCs) is reported to be more stable than that with the organic hole transport *** this work,NiO_(x)/MAPbI_(3) interface chemical reaction induced instability of perovskite is unveiled:Ni^(3+) and I^(-) exhibit redox reactions and deprotonation of MA^(+) happens,which result in interface defects and perovskite lattice *** the defective interface accelerates the degradation of perovskite by defect pathways from the bottom interface to the perovskite surface contacting H_(2)O/O_(2).Self-assembled interlayer of NH_(2)^(-)end silane on NiO_(x)separates the reactive NiO_(x)and MAPbI_(3),tunes the interface energy states by–NH_(2) end *** a result,the PSC based on the silane treated NiO_(x)achieves enhanced PCE of 20.1%with decent stability under environmental and extreme conditions (high temperature,high humidity,light infiltration).Our work highlights the interface chemical problem induced PSC instability and a simple interface modification to achieve the stable PSCs.

关键词： Perovskite solar cells Interface chemical problem NiOx hole transport material Self assemble Stability

Storyline Extraction of Document-Level Events Using Large Language Models

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Journal of Computer and Communications 2024年第11期12卷 162-172页

作者： ziyang hu Yaxiong Li School of Foreign Studies Zhongnan University of Economics and Law Wuhan China Information Center Hubei University of Science and Technology Wuhan China

This article proposes a document-level prompt learning approach using LLMs to extract the timeline-based storyline. Through verification tests on datasets such as ESCv1.2 and Timeline17, the results show that the prompt + one-shot learning proposed in this article works well. Meanwhile, our research findings indicate that although timeline-based storyline extraction has shown promising prospects in the practical applications of LLMs, it is still a complex natural language processing task that requires further research.

关键词： Document-Level Storyline Extraction Timeline Large Language Models Topological Structure of Storyline Prompt Learning

Functioned fullerene between the perovskite grains visualized by scanning probe microscopy

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Functioned fullerene between the perovskite grains visualize...

Stability analysis of a hybrid flexible-rigid pipe conveying fluid

第六届新型太阳能电池材料科学与技术学术研讨会

作者： ziyang hu Jing Zhang Yuejin Zhu Department of Microelectronic Science and Engineering Ningbo University

In perovskite solar cells(PSCs), hybrid perovskite:fullerene phases have been proposed to suppress macroscopic current hysteresis behavior by alleviating ion migration. However, the understanding of how fullerenes exactly alleviate the current hysteresis and what is the influence of fullerenes in such hybrid phases are still unclear from a microscopic viewpoint. Here, the intentional incorporation of fullerene into perovskite has been employed to examine how fullerene exactly reduces the macroscopic current hysteresis. The location and distribution of fullerenes in the hybrid phase were confirmedly visualized by conductive atomic force microscopy and Kelvin probe force microscopy measurements. Fullerenes located at grain boundaries function as the beneficial effect on choking the channels of ion migration and also as the electron traps that compromise the photocarrier extraction. Macroscopic current hysteresis originating from the influxes of all nanoscopic grain boundary current signals is avoided in PSCs based on the hybrid perovskite:fullerene phases. Our results not only provide the strong correlation between nanoscopic and macroscopic current hysteresis behaviors, but also clearly clarify the role of fullerene how to reduce the current hysteresis in hybrid phases and thus prototype devices.

关键词： Current hysteresis perovskite solar cells fullerene grain boundary nanoscopic current

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Acta Mechanica Sinica 2022年第2期38卷 141-153,I0005页

作者： Yikun Wang ziyang hu Lin Wang Tao Qin Mo Yang Qiao Ni School of Mechanical Engineering Hubei University of Arts and ScienceXiangyang 441053China Department of Engineering Mechanics Huazhong University of Science and TechnologyWuhan 430074China

The stability and dynamical behavior of flexible and articulated rigid pipes conveying fluid have attracted the attention of many researchers in the field of fluid-structure *** system of an articulated pipe composed of a flexible pipe and a rigid pipe is a class of hybrid flexible-rigid dynamical problems involving flow-induced *** paper establishes the governing equations of motion of a hybrid flexible-rigid pipe system based on Hamilton's principle,with the rigid pipe being hinged to the lower end of a flexible cantilevered pipe via a rotational *** coupling equations of motion are discretized via a Galerkin's *** mathematical model is validated by comparing the eigenvalue branches of a degenerated system by choosing extreme values of the parameters of the hybrid pipe with previous *** the theoretical analysis,the critical flow velocities are calculated as a function of the stiffness of the rotational spring,mass ratio and length ratio of the rigid and flexible *** unstable modes are detected from the eigenvalue branches and compared with those of a flexible cantilevered *** results show that the critical flow velocity is greatly influenced by several structural *** is found that a small stiffness of the rotational spring tends to predict higher-mode instability,whereas a large rotational spring stiffness would generate a second-mode instability in most *** several system parameter spaces,the hybrid pipe may experience a transference of unstable modes with the increase of flow *** is also shown that the hybrid pipe system may lose stability first in the fourth mode in some *** of the fresh results obtained for the hybrid pipe system are expected to be helpful in understanding and controlling the dynamical responses of hybrid flexible-rigid fluid-conveying pipes.

关键词： Hybrid flexible-rigid pipe Flow-induced vibration Eigenvalue Critical flow velocity Flutter

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精密装配的基准信息链模型和3D偏差计算

中国机械工程 2005年第21期16卷 1931-1935页

作者：杨文玉胡紫阳华中科技大学武汉430074

研究了精密零件装配的基准信息链模型与基于该模型的3D偏差累积计算方法。以微硬盘装配为实例,分析了装配过程中的多约束关系,采用基准信息链模型建立了装配空间结构和尺寸偏差关系的数字化表达,给出了齐次变换矩阵和误差矩阵关系式,实... 详细信息

研究了精密零件装配的基准信息链模型与基于该模型的3D偏差累积计算方法。以微硬盘装配为实例,分析了装配过程中的多约束关系,采用基准信息链模型建立了装配空间结构和尺寸偏差关系的数字化表达,给出了齐次变换矩阵和误差矩阵关系式,实现了关键特征的3D偏差累积计算。实例表明,该计算方法可有效应用于数字产品开发的设计决策过程。

关键词：基准信息链关键特征精密装配 3D偏差