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基于脂肪可塑性研究大黄素对肥胖小鼠的改善作用和机制

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中草药 2024年第4期55卷 1228-1236页

作者：冯倩倩贺润铖张磊耿杨赵子阳史浩男贾占红张硕峰孙建宁董世芬北京中医药大学中药学院中药药理系北京102488

目的基于脂肪可塑性探究大黄素改善肥胖的作用和机制。方法通过高脂饲养8周建立肥胖小鼠模型,肥胖小鼠随机分为对照组、模型组、大黄素(40、80 mg/kg)组、CL316243(1 mg/kg)组和罗格列酮(10 mg/kg)组,连续给药4周。测量各组小鼠体质量,... 详细信息

目的基于脂肪可塑性探究大黄素改善肥胖的作用和机制。方法通过高脂饲养8周建立肥胖小鼠模型,肥胖小鼠随机分为对照组、模型组、大黄素(40、80 mg/kg)组、CL316243(1 mg/kg)组和罗格列酮(10 mg/kg)组,连续给药4周。测量各组小鼠体质量,检测Lee’s指数和皮下腹股沟白色脂肪组织(inguinal white adipose tissue,iWAT)、附睾白色脂肪组织(epididymal white adipose tissue,eWAT)、肾周白色脂肪组织(perirenal white adipose tissue,pWAT)、肩胛区棕色脂肪组织(brown adipose tissue,BAT)指数,测量肩胛骨体温;检测口服葡萄糖耐受量、血糖曲线下面积(area under curve,AUC)及血清中总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平;采用苏木素-伊红(HE)染色观察脂肪组织病理变化;免疫组化法检测脂肪组织中棕色化相关蛋白解偶联蛋白1(uncoupling protein 1,UCP1)表达;Western blotting检测皮下iWAT中脂肪可塑性相关蛋白葡萄糖转运蛋白4(glucose transporter 4,GLUT4)、过氧化物酶体增殖物激活受体γ共激活剂-1α(peroxisome proliferator-activated receptor-gamma coactivator-1α,PGC-1α)、PR结构域蛋白16(positive regulatory domain-containing 16,PRDM16)、线粒体转录因子A(mitochondrial transcription factor A,TFAM)、腺苷酸活化蛋白激酶(AMP-dependent/activated protein kinase,AMPK)、磷酸化AMPK(phosphorylated AMPK,p-AMPK)蛋白表达。结果与模型组比较,大黄素组小鼠体质量、Lee’s指数及皮下iWAT、eWAT、pWAT指数均显著降低(P<0.05、0.01、0.001),肩胛区体温升高(P<0.01),血糖和血清中TC、TG、LDL-C水平均显著降低(P<0.05、0.01、0.001);BAT中UCP1表达显著增加(P<0.001),皮下iWAT中PGC-1α、PRDM16、TFAM、p-AMPK/AMPK、GLUT4蛋白表达水平均显著升高(P<0.05、0.01)。结论大黄素能够有效抑制肥胖小鼠模型的体质量增加,改善糖脂代谢紊乱,其机制与激活BAT、诱导WAT棕色化有关。

关键词：大黄素脂肪可塑性肥胖糖脂代谢棕色脂肪组织白色脂肪组织

A Piezoelectrically Driven Microrobot Using a Novel Monolithic Spatial Parallel Mechanism as Its Hip Joint

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Journal of Bionic Engineering 2024年第2期21卷 803-820页

作者： Guangping Wu ziyang Wang Jiaxin zhao Feng Cui Xinghan Cai National Key Laboratory of Advanced Micro and Nano Manufacture Technology Shanghai Jiao Tong UniversityShanghai200240China Department of Micro-Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai200240China

Inspired by the fast,agile movements of insects,we present a 1.9 g,4.5 cm in length,piezoelectrically driven,quadrupedal *** microrobot uses a novel spatial parallel mechanism as its hip joint,which consists of two spatially orthogonal slider-crank *** mechanism maps two inputs of two independent actuators to the decoupled swing and lift outputs of a leg,and each leg can produce the closed trajectories in the sagittal plane necessary for robot ***,the kinematics of the transmission are analyzed,and the parameters of the flexure hinges are designed based on geometrical constraints and yield *** hip joints,legs and exoskeletons are integrated into a five-layer standard laminate for monolithic fabrication which is composed of two layers of carbon fiber,two layers of acrylic adhesive and a polyimide *** measured output force(15.97 mN)of each leg is enough to carry half of the robot’s weight,which is necessary for the robot to move *** has been proven that the robot can successfully perform forward and turning *** to the microrobot fabricated with discrete components,the monolithically fabricated microrobot is more capable of maintaining the original direction of locomotion when driven by a forward signal and has a greater speed,whose maximum speed is 25.05 cm/s.

关键词： Insect-like Crawling microrobot Piezoelectric drive Parallel mechanism Monolithic fabrication

Deployment of Edge Computing Nodes in IoT:Effective Implementation of Simulated Annealing Method Based on User Location

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China Communications 2024年第1期21卷 279-296页

作者： Junhui zhao ziyang Zhang Zhenghao Yi Xiaoting Ma Qingmiao Zhang School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing 100044China School of Information Engineering East China Jiaotong UniversityNanchang 330013China

Edge computing paradigm for 5G architecture has been considered as one of the most effective ways to realize low latency and highly reliable communication,which brings computing tasks and network resources to the edge of *** deployment of edge computing nodes is a key factor affecting the service performance of edge computing *** this paper,we propose a method for deploying edge computing nodes based on user *** the combination of Simulation of Urban Mobility(SUMO)and Network Simulator-3(NS-3),a simulation platform is built to generate data of hotspot areas in Io T *** effectively using the data generated by the communication between users in Io T scenario,the location area of the user terminal can be *** this basis,the deployment problem is expressed as a mixed integer linear problem,which can be solved by Simulated Annealing(SA)*** analysis of the results shows that,compared with the traditional method,the proposed method has faster convergence speed and better performance.

关键词： deployment problem edge computing internet of things machine learning

Low-power soft transistors triggering revolutionary electronics

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The Innovation 2024年第3期5卷 21-22页

作者： ziyang Liu Yaoshen zhao Zhigang Yin State Key Laboratory of Power Transmission Equipment Technology School of Electrical EngineeringChongqing UniversityChongqing 400044China

Transistors have been reshaping our lives since their initial appearance in the *** the central element of logic gates and integrated circuits(chips),they undoubtedly play an incomparable role in promoting the development of computers,smartphones,flat panel displays,Internet of Things,and even all electronic or electrical *** past decades have witnessed dominant transistors usually made from inorganic semiconductors such as silicon materials and metal oxides,which are advantageous to achieve high mobility,fast switching speed,and excellent ***,silicon transistors and metal oxide semiconductor field-effect transistors have been broadly used for electronic ***,these transistors are rigid and nearly approaching the fundamental limits on speed and power consumption,despite being manufactured at a much smaller scale to meet the projection of Moore’s *** future transistors with mechanical flexibility/robustness and low-power consumption are demanded,innovation in functional materials,device configurations,and integrated processing techniques to facilitate the evolution from rigid devices to soft,durable,and biocompatible devices is imperative.

关键词： approaching evolutionary doubt

A Wind Power Prediction Framework for Distributed Power Grids

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Energy Engineering 2024年第5期121卷 1291-1307页

作者： Bin Chen ziyang Li Shipeng Li Qingzhou zhao Xingdou Liu Power Grid Design Institute Shandong Electric Power Engineering Consulting Institute Co.Ltd.Jinan250013China School of Electrical Engineering Shandong UniversityJinan250012China

To reduce carbon emissions,clean energy is being integrated into the power *** power is connected to the grid in a distributed form,but its high variability poses a challenge to grid *** article combines wind turbine monitoring data with numerical weather prediction(NWP)data to create a suitable wind power prediction framework for distributed ***,high-precision NWP of the turbine range is achieved using weather research and forecasting models(WRF),and Kriging interpolation locates predicted meteorological data at the turbine ***,a preliminary predicted power series is obtained based on the fan’s wind speed-power conversion curve,and historical power is reconstructed using variational mode decomposition(VMD)filtering to form input variables in chronological ***,input variables of a single turbine enter the temporal convolutional network(TCN)to complete initial feature extraction,and then integrate the outputs of all TCN layers using Long Short Term Memory Networks(LSTM)to obtain power prediction sequences for all turbine *** proposed method was tested on a wind farm connected to a distributed power grid,and the results showed it to be superior to existing typical methods.

关键词： Wind power prediction distributed power grid WRF mode deep learning variational mode decomposition

Multi-process production occurs in the iron and steel industry,supporting‘dual carbon'target:An in-depth study of CO_(2)emissions from different processes

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Journal of Environmental Sciences 2024年第6期140卷 46-58页

作者： Hongming Na Yuxing Yuan Tao Du Tianbao Zhang Xi zhao Jingchao Sun ziyang Qiu Lei Zhang SEP Key Laboratory of Eco-Industry Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

Reducing CO_(2)emissions of the iron and steel industry,a typical heavy CO_(2)-emitting sector is the only way that must be passed to achieve the‘dual-carbon’goal,especially in *** previous studies,however,it is still unknown what is the difference between blast furnace basic oxygen furnace(BF-BOF),scrap-electric furnace(scrap-EF)and hydrogen metallurgy *** quantitative research on the key factors affecting CO_(2)emissions is insufficient There is also a lack of research on the prediction of CO_(2)emissions by adjusting industria *** on material flow analysis,this study establishes carbon flow diagrams o three processes,and then analyze the key factors affecting CO_(2)***_(2)emissions of the iron and steel industry in the future is predicted by adjusting industrial structure The results show that:(1)The CO_(2)emissions of BF-BOF,scrap-EF and hydrogen metallurgy process in a site are 1417.26,542.93 and 1166.52 kg,respectively.(2)By increasing pellet ratio in blast furnace,scrap ratio in electric furnace,etc.,can effectively reduce CO_(2)emissions(3)Reducing the crude steel output is the most effective CO_(2)reduction *** is still 5.15×10^(8)-6.17×10^(8) tons of CO_(2)that needs to be reduced by additional measures.

关键词： Blast furnace-basic oxygen furnace process Scrap-electric furnace process Hydrogen metallurgy process Carbon flow diagram Influencing factors CO_(2)emission prediction

Heterosis Analysis in Endogenous Substances in Root Bleeding Sap of Sorghum

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 1963-1980页

作者： Renjie zhao Yueqiao Li Chen Xu Zhian Zhang ziyang Zhou Yihan Zhou Zexin Qi College of Agriculture Jilin Agricultural UniversityChangchun130118China Jilin Academy of Agricultural Sciences Changchun130033China Jilin Engineering Vocational College Siping136001China

Despite hybrid dominance contributing to the genetic improvement of crops,little is known about heterosis and inheritance patterns of endogenous substances in sorghum(Sorghum bicolor(L.)Moench)root bleeding *** this study,six sterile and six restorer lines of sorghum and 36 hybrid sorghum combinations formulated as incomplete double-row crosses were selected as test materials,and heterosis,combining ability,heritability,and their interrelationships of root bleeding sap endogenous substances in different hybrid sorghum combinations and their parents were *** results showed that the root bleeding sap of the F1 generation of hybrid sorghum had a high heterosis in both soluble sugar content and amino acid content at the flowering stage,and the average high-parent heterosis was 129.34%and 74.57%,***-3-acetic acid(IAA),cytokinins(CTK),gibberellic acid(GA_(3)),abscisic acid(ABA),soluble sugar,amino acid,and root bleeding intensity were mainly affected by non-additive genetic effects of the *** protein was affected by additive genetic effects of the genes and had a high narrow heritability(75.50%),which could be selected at low generations in *** combining ability analyses showed that the sterile lines 521A and 170A,and the restorer lines Ji318R and 0–30 were promising parents with high general combining *** analysis showed that all endogenous substances of root bleeding sap were positively correlated with the sum of parental general combining ability(GCA)at highly significant levels,and IAA,CTK,GA_(3),ABA,soluble sugar,amino acid,and root bleeding intensity were positively correlated with male GCA at significant or highly significant ***,the GCA of the restorer lines root bleeding sap endogenous material or the sum of both parents’GCA can be used to predict the performance of wounding endogenous material in the F1 generation of hybrid ***,this study results can help elucidate hetero

关键词： Sorghum heterosis root bleeding sap combining ability heritability

3D printedβ-sheet-reinforced natural polymer hydrogel bilayer tissue engineering scaffold

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Science China(Technological Sciences) 2024年第4期67卷 1170-1184页

作者： zhao XinRui NIE XiongFeng ZHANG XiaoPing SUN YaGe YANG Rong BIAN XinYu ZHANG Qian WANG HongYing XU ziyang LIU WenGuang School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin 300350China

It remains a significant challenge to fabricate natural polymer(NP)hydrogels with anti-swelling ability and high strengths in the physiological ***,theβ-sheet-reinforced NP hydrogel is developed by copolymerizing methacrylated gelatin(GelMA)and methacrylated silk fibroin(SFMA)in aqueous solution,followed by ethanol treatment(named GelMA-SFMAAL).Theβ-sheets formed by SFMA can act as a stable physical crosslink to enhance the mechanical properties and prolong the degradation of the GelMA ***,the chemical crosslinking in the GelMA-SFMA hydrogel prevents excessive aggregation of hydrophobicβ-sheets,thereby avoiding the formation of brittle *** obtained GelMA-SFMA-AL hydrogels exhibit considerably enhanced mechanical properties(Young's modulus:0.89–3.68 MPa;tensile strength:0.31–0.96 MPa;toughness:0.09–0.63 MJ/m^(3);compressive modulus:0.78–2.20 MPa;compressive strength:2.65–5.93 MPa)compared with GelMA-SFMA hydrogels(Young's modulus:0.04–0.13 MPa;tensile strength:0.04–0.07 MPa;toughness:0.01–0.02 MJ/m^(3);compressive modulus:0.03–0.09 MPa;compressive strength:0.30–0.64 MPa).A bilayer osteochondral scaffold is constructed via digital light processing(DLP)three-dimensiaonl(3D)printing technology,comprising GelMA-SFMA@diclofenac sodium(DS)-AL as the top layer and GelMA-SFMA@bioactive glass(BG)-AL as the bottom *** bilayer hydrogel scaffold is demonstrated to support cell attachment and spreading,and facilitate osteogenic differentiation of rat bone marrow stem cells in *** vivo implantation experiment suggests this bilayer scaffold is promising to be used for osteochondral tissue regeneration.

关键词： silk fibroin β-sheet high-strength hydrogel natural polymer osteochondral regeneration

Two‑Dimensional Cr_(5)Te_(8)@Graphite Heterostructure for Efficient Electromagnetic Microwave Absorption

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Nano-Micro Letters 2024年第3期16卷 407-422页

作者： Liyuan Qin ziyang Guo Shuai zhao Denan Kong Wei Jiang Ruibin Liu Xijuan Lv Jiadong Zhou Qinghai Shu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081People’s Republic of China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081People’s Republic of China Tangshan Research Institute Beijing Institute of TechnologyTangshan 063099People’s Republic of China

Two-dimensional(2D)transition metal chalcogenides(TMCs)hold great promise as novel microwave absorption materials owing to their interlayer interactions and unique magnetoelectric ***,overcoming the impedance mismatch at the low loading is still a challenge for TMCs due to the restricted loss pathways caused by their high-density ***,an interface engineering based on the heterostructure of 2D Cr_(5)Te_(8) and graphite is in situ constructed via a one-step chemical vapor deposit to modulate impedance matching and introduce multiple attenuation ***,the Cr_(5)Te_(8)@EG(ECT)heterostructure exhibits a minimum reflection loss of up to−57.6 dB at 15.4 GHz with a thin thickness of only 1.4 mm under a low filling rate of 10%.The density functional theory calculations confirm that the splendid performance of ECT heterostructure primarily derives from charge redistribution at the abundant intimate interfaces,thereby reinforcing interfacial polarization ***,the ECT coating displays a remarkable radar cross section reduction of 31.9 dB m^(2),demonstrating a great radar microwave scattering *** work sheds light on the interfacial coupled stimulus response mechanism of TMC-based heterogeneous structures and provides a feasible strategy to manipulate high-quality TMCs for excellent microwave absorbers.

关键词： Chemical vapor deposition Interface polarization engineering Cr_(5)Te_(8)-graphite heterojunctions Microwave absorption