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基于中医理论探索传染性非典型性肺炎、甲型H1N1流感和新型冠状病毒肺炎证治异同

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辽宁中医药大学学报 2021年第1期23卷 208-212页

作者：刘丽婷李杰彭桂英吴童黄明明于子洋赵翠云北京中医药大学北京100029 北京中医药大学东直门医院北京100700

近年来,中医在传染性非典型性肺炎(SARS)、甲型H1N1流感(甲流)等新型突发传染病的防治方面发挥了巨大的作用。新型冠状病毒肺炎(COVID-19)的流行,又给人类的健康及社会稳定带来新的威胁。结合SARS、甲流的防治经验和COVID-19现有病例资... 详细信息

近年来,中医在传染性非典型性肺炎(SARS)、甲型H1N1流感(甲流)等新型突发传染病的防治方面发挥了巨大的作用。新型冠状病毒肺炎(COVID-19)的流行,又给人类的健康及社会稳定带来新的威胁。结合SARS、甲流的防治经验和COVID-19现有病例资料及文献,该文从病因、五运六气、病证特点、辨证论治等方面,浅析3种疫病的异同。SARS病因属"热毒",病机可见"热毒、瘀血、气阴两伤",治疗以清热解毒祛邪为主;甲流属"寒疫",病机为风寒疫毒挟湿,治则以扶阳顾津、解表散寒、化饮祛湿为主;COVID-19属"湿毒",故病机为"湿、毒、虚、瘀、风",治疗以宣肺祛湿透邪为主。结合中医对既往传染性疾病的认识和防治经验,以及中国临床COVID-19治愈患者资料,为全国人民深入了解和应对COVID-19提供策略,以期完善COVID-19防治方案,发挥中医药在突发公共卫生事件中的作用。

关键词：传染性非典型性肺炎甲型H1N1流感新型冠状病毒肺炎五运六气

Erratum on “Engineering of a universal polymeric nanoparticle platform to optimize the PEG density for photodynamic therapy” [Sci. China. Chem., 2019, 62: 1379–1386]

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Science China Chemistry 2019年第10期62卷 1421-1422页

作者： Xixi Yang Jie Li yue yu Junxia Wang Dongdong Li ziyang Cao Xianzhu Yang Division of Gastroenterology Affiliated Provincial HospitalAnhui Medical UniversityHefei 230001China School of Biomedical Science and Engineering South China University of TechnologyGuangzhou 510006China Institutes for Life Sciences School of MedicineSouth China University of TechnologyGuangzhou 510006China Guangzhou Regenerative Medicine and Health Guangdong Laboratory Guangzhou 510005China

In a recent publication [1], these images in Figures 6(b, c)(^NPEG-NPCe6 group), S7, S9 and S10 were inadvertently taken the incorrect images in the production. The corrected versions are shown below. And, the quantif... 详细信息

关键词： Figure polymeric nanoparticle

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Core-shell-structured Co@Co4N nanoparticles encapsulated into MnO-modified porous N-doping carbon nanocubes as bifunctional catalysts for rechargeable Zn–air batteries

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Journal of Energy Chemistry 2020年第11期29卷 52-62页

作者： Fengmei Wang Huimin Zhao Yiru Ma yu Yang Bin Li yuanyuan Cui ziyang Guo Lei Wang Key Laboratory of Eco-Chemical Engineering Taishan Scholar Advantage and Characteristic Discipline Team of Eco Chemical Process and TechnologyCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042ShandongChina Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai University.Tianjin 300071China Shimadzu China Co. LTD.Shanghai 200233China

Designing the highly catalytic activity and durable bifunctional catalysts toward oxygen reduction/evolution reaction(ORR/OER) is paramount for metal–air batteries. Metal–organic frameworks(MOFs)-based materials have attracted a great deal of attention as the potential candidate for effectively catalyzing ORR/OER due to their adjustable composition and porous structure. Herein, we first introduce the Mn species into zeolitic-imidazole frameworks(ZIFs) and then further pyrolyze the Mn-containing bimetallic ZIFs to synthesize core-shell-structured Co@Co4N nanoparticles embedded into MnO-modified porous N-doped carbon nanocubes(Co@Co4N/MnO–NC). Co@Co4N/MnO–NC exhibits the outstanding catalytic activity toward ORR and OER which is attributed to its abundant pyridinic/graphitic N and Co4N,the optimized content of MnO species, highly dispersed catalytic sites and porous carbon matrix. As a result, the Co@Co4N/MnO–NC-based Zn–air battery exhibits enhanced performances, including the high discharge capacity(762 mA h gZn-1), large power density(200.5 mW cm-2), stable potential profile over 72 h, low overpotential(<1.0 V) and superior cycling life(2800 cycles). Moreover, the belt-shaped Co@Co4N/MnO–NC cathode-based Zn–air batteries are also designed which exhibit the superb electrochemical properties at different bending/twisting conditions.

关键词： Co@Co4N nanoparticles N-doped carbon nanocubes MnO species Flexibility Zn–air battery

PCSK9抑制剂联合他汀治疗对冠心病患者血脂、颈动脉斑块及炎症因子的影响

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云南医药 2024年第4期45卷 20-23页

作者：夏小花郝应禄李燕萍余子阳李玺臣李兰新玉溪市人民医院/昆明医科大学第六附属医院心血管内科云南玉溪653100

目的分析PCSK9抑制剂联合他汀治疗在冠心病患者中对血脂、炎症因子和颈动脉斑块的影响。方法应用前瞻性随机对照研究,纳入2022年9月-2022年12月期间在玉溪市人民医院心内科诊断为冠心病合并高脂血症的101例患者,随机分为2组,观察组50例... 详细信息

目的分析PCSK9抑制剂联合他汀治疗在冠心病患者中对血脂、炎症因子和颈动脉斑块的影响。方法应用前瞻性随机对照研究,纳入2022年9月-2022年12月期间在玉溪市人民医院心内科诊断为冠心病合并高脂血症的101例患者,随机分为2组,观察组50例,使用阿利西尤单抗加他汀类药物治疗,对照组51例,使用他汀类药物治疗,持续治疗6个月。对比2组患者治疗6个月后血脂、炎症指标、颈部血管斑块Crouse积分的变化情况;比较整个随访阶段2组患者不良心血管事件及不良反应的发生情况。结果治疗6个月后,观察组的TC、TG、LDL-C、ApoB、Lp(a)、hs-CRP、IL-6、PLR、NLR水平及颈动脉斑块的Crouse积分均较治疗前下降,降幅明显高于对照组,HDL-C升幅及LDL-C达标率均高于对照组,差异有统计学意义(P0.05)。结论PCSK9抑制剂联合他汀治疗可在短期内可以快速改善冠心病患者血脂水平、体内炎症反应和斑块稳定性,在短期应用中安全性良好。

关键词：冠状动脉粥样硬化性心脏病 PCSK9抑制剂血脂炎症因子

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武维屏教授肺痹-体痹合治验案举隅

天津中医药大学学报 2019年第3期38卷 259-261页

作者：李杰武维屏孙瑗赵翠云刘丽婷吴童于子洋北京中医药大学东直门医院呼吸科

基于历代医家提出的“肺痹-体痹”整体观念,文章总结武维屏教授临证经验:间质性肺病(肺痹)常与关节、皮肤病变(体痹)相合,临床患者多病情复杂,症状纷繁多变,多以祛邪通络、宣降肺气、和解表里、调畅气机、通补兼施为立法治则。阐述肺痹... 详细信息

基于历代医家提出的“肺痹-体痹”整体观念,文章总结武维屏教授临证经验:间质性肺病(肺痹)常与关节、皮肤病变(体痹)相合,临床患者多病情复杂,症状纷繁多变,多以祛邪通络、宣降肺气、和解表里、调畅气机、通补兼施为立法治则。阐述肺痹和体痹之间的关系与治疗。

关键词：肺痹-体痹名医经验武维屏

云南玉溪地区一家系Fabry病调查研究及酶替代治疗疗效观察

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云南医药 2024年第4期45卷 1-5页

作者：李兰新郝应禄李燕萍余子阳李玺臣夏小花玉溪市人民医院/昆明医科大学第六附属医院心血管内科云南玉溪653100

目的对一FD家系患者的临床特征进行分析,探讨ERT的有效性及安全性。方法收集2022年8月-2023年1月期间玉溪市人民医院心内科收治的一个主要表现为FHCM的家系,共15人。其中,10人确诊为FD,6人进行ERT治疗。分析10例FD患者的临床特征,探究6... 详细信息

目的对一FD家系患者的临床特征进行分析,探讨ERT的有效性及安全性。方法收集2022年8月-2023年1月期间玉溪市人民医院心内科收治的一个主要表现为FHCM的家系,共15人。其中,10人确诊为FD,6人进行ERT治疗。分析10例FD患者的临床特征,探究6例FD患者ERT治疗的疗效及安全性。结果10例FD患者基因检测结果显示均为:GLA错义突变c.167G>A ***56Tyr。其中,6例为经典型,4例为迟发型,经典型在男性占比和血浆Lyso-GL-3水平高于迟发型,在发病年龄和血浆α-Gal A活性低于迟发型,差异均有统计学意义(P<0.05)。临床表现多样,所有患者多脏器不同程度受累。经ERT治疗12个月后,6例患者血浆Lyso-GL-3水平显著下降(P<0.05)。治疗过程中,仅1例患者间断出现双下肢浮肿,其余未见明显不良反应。结论该家系同一基因型突变Fabry病患者的临床表现不同,不同脏器受累程度不一;短期ERT治疗过程中患者耐受性良好,无严重不良反应发生,治疗后血浆Lyso-GL-3水平均下降。

关键词：法布里病酶替代治疗阿加糖酶α

基于数据挖掘现代中药复方治疗非小细胞肺癌用药规律探讨

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世界中医药 2021年第1期16卷 104-116页

作者：刘丽婷李杰彭桂英赵翠云吴童于子洋黄明明孙瑗北京中医药大学东直门医院呼吸科北京100700 北京中医药大学生命科学学院北京100029

目的:基于数据挖掘技术探讨现代复方治疗非小细胞肺癌的用药规律,为临床用药提供参考。方法:选取2010年至2017年北京301医院治疗非小细胞肺癌(NSCLC)的中药复方,建立现代中药复方治疗NSCLC方剂数据库,并采用SPSS 22.0及SPSS Modeler14.... 详细信息

目的:基于数据挖掘技术探讨现代复方治疗非小细胞肺癌的用药规律,为临床用药提供参考。方法:选取2010年至2017年北京301医院治疗非小细胞肺癌(NSCLC)的中药复方,建立现代中药复方治疗NSCLC方剂数据库,并采用SPSS 22.0及SPSS Modeler14.2软件进行频数及频率分析、因子分析、关联分析等,进而对中药复方用药规律进行定量、定性分析并探讨其可能相关机制。结果:中药复方治疗肺癌复方231首,中药389种,高频中药135味,其中用药频次排名前5位的中药依次是川贝母、炒黄芩、生龙骨、茯神、半枝莲;在涉及的39类药物中清热解毒药、补气药居于前列;归经以肺经、脾经、胃经为主;四气以寒、温、平、微寒为主;五味以甘、苦、辛为主。因子分析最后提取了12个公因子,累积贡献率达65.595%,其中以补益气血、养阴清热散结、健脾理气化痰为主;通过聚类分析,提取了40常用得药对或药组;关联分析共得到63条关联规则,药对以茯苓→陈皮、炒白术→陈皮为常用,3味药组以生黄芪→炒白术、茯苓,生神曲→炒白术、茯苓,陈皮→炒白术、茯苓为常用。结论:肺癌主因癌毒阻滞,痰热互结,临床诊疗以扶正祛邪为基本原则,以祛邪宜清热解毒、为主,并兼顾正气,补益气血以培元扶正。

关键词：数据挖掘现代中药复方非小细胞肺癌用药规律

A comprehensive analysis of DAC-SDC FPGA low power object detection challenge

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Science China(Information Sciences) 2024年第8期67卷 300-320页

作者： Jingwei ZHANG Guoqing LI Meng ZHANG Xinye CAO yu ZHANG Xiang LI ziyang CHEN Jun YANG School of Electronics Science and Engineering Southeast University

The lower power object detection challenge(LPODC) at the IEEE/ACM Design Automation Conference is a premier contest in low-power object detection and algorithm(software)-hardware co-design for edge artificial intelligence, which has been a success in the past five years. LPODC focused on designing and implementing novel algorithms on the edge platform for object detection in images taken from unmanned aerial vehicles(UAVs), which attracted hundreds of teams from dozens of countries to participate. Our team SEUer has been participating in this competition for three consecutive years from 2020 to 2022 and obtained sixth place respectively in 2020 and 2021. Recently, we achieved the championship in 2022. In this paper, we presented the LPODC for UAV object detection from 2018 to 2022, including the dataset, hardware platform,and evaluation method. In addition, we also introduced and discussed the details of methods proposed by each year's top three teams from 2018 to 2022 in terms of network, accuracy, quantization method, hardware performance, and total score. Additionally, we conducted an in-depth analysis of the selected entries and results, along with summarizing representative methodologies. This analysis serves as a valuable practical resource for researchers and engineers in deploying the UAV application on edge platforms and enhancing its feasibility and reliability. According to the analysis and discussion, it becomes evident that the adoption of a hardware-algorithm co-design approach is paramount in the context of tiny machine learning(TinyML).This approach surpasses the mere optimization of software and hardware as separate entities, proving to be essential for achieving optimal performance and efficiency in TinyML applications.

关键词： tiny machine learning object detection convolutional neural networks algorithm-hardware co-design low power field programmable gate array

Four-function model analysis of nonsuicidal self-injury-related posts on Sina Weibo

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General Psychiatry 2024年第1期37卷 168-172页

作者： Kexin Zhang ziyang Wang Xin yu Peking University Sixth Hospital BeijingChina Department of Industrial EngineeringandManagement Peking University College of EngineeringBeijingChina institute of Mental Health Peking University Sixth HospitalBeijingChina

To the editor:Non-suicidal self-injury(NSSI)is defined as direct,repetitive self-injury to bodily tissues without suicidal intent. The estimated prevalence of NsSI among adolescents is 17.2%worldwide with a comparable rate observed in China. As a behavioural addiction, NSSI poses a significant suicide risk,and is emerging as a major mental health problem among *** unravel this puzzle,the four-function model(FFM)distinguishes between interpersonal and intrapersonal functions,as well as positive and negative reinforcement functions,proving relatively comprehensive among various theoretical models.

关键词： function behaviour analysis