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Journal of Rare Earths 2024年第6期42卷 1009-1019,I0001页

作者： ziyan Yang Faxin Xiao Shuchen sun Heng Zhong Ganfeng Tu School of Metallurgy Northeastern UniversityShenyang110819China Key Laboratory for Recycling of Nonferrous Metal Resources(Shenyang) Shenyang110819China

Due to the unique physical and chemical properties,rare earth elements(REEs)play a significant role in the high-tech *** the past few decades,the rare earth reserve in China has been gradually decreasing and more pressure has been exerted on the global rare earth supply for the increasing demand of REEs,which indicates that it is essential to recycle secondary resources to meet the rare earth *** for rare earth molten salt electrolytic slag(REMES),although its high rare earth content has potential huge economic value,its high fluorine content of approximately 10 wt%-20 wt%can pollute the *** methods are used to treat *** metallurgical and pyro-hydrometallurgical methods have gotten a big success for solving most of the hydrometallurgical problems,while some problems,like long route and waste water,need to be *** distillation is a new and promising method with a short process due to its harmlessness and high efficiency,but has shortcomings such as high energy consumption and material *** review presents these above three treatment methods,and the challenges and chances of using the recovery technique of REMES in an environmentally friendly way.

关键词： Rare earths Molten salt electrolytic slag Hydrometallurgy Pyro-hydrometallurgy Vacuum distillation Recovery

Comparison of two reader modes of computer-aided diagnosis in lung nodules on low-dose chest CT scan

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Journal of Innovative Optical Health Sciences 2022年第2期15卷 93-105页

作者： Qiongjie Hu Shaofang Wang Chong Chen Shichao Kang ziyan sun Yujin Wang Min Xiang Hanxiong Guan Yiwen Liu Liming Xia Department of Radiology Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology Jiefang Dadao 1095(#)Wuhan 430030Hu BeiP.R.China Department of Radiology Shenzhen Maternity&Child Healthcare Hospital Affiliated to Southern Medical UniversityHongliShenzhen 518028P.R.China

Low-dose computerized tomography(LDCT)scanning is of great significance for monitoring and management of pulmonary nodules on chest computerized tomography(CT).Nevertheless,the malignant potential of these nodules is often difficult to detect,especially for some smaller pulmonary nodules on LDCT *** advances using the state-of-art computer-aided detection(CAD)system have attempted to address this problem by identifying small nodules that can be easily missed during clinical *** is used in two reading modes:Concurrent-reader(CR)mode or second-reader(SR)*** this study,we prospectively evaluated the efficiency of a CAD system's SR and CR modes in detecting pulmonary nodules on *** found that the SR mode improves pulmonary nodule detection regardless of the dose and ex-perience level,especially for interns in the low-dose *** CR mode maintains the sensi-tivity of SR mode while significantly decreasing reading times.

关键词： Computed tomography radiation dosage pulmonary nodules computer-assisted deep learning

The Influence of Infill Walls on RC Frames under Seismic Excitation

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建筑工程（中英文版） 2014年第4期2卷 68-72页

作者： Lu Liu ziyan Wu Hongbin sun School of Mechanics and Civil Engineering & Architecture Northwestern Polytechnical University Xi'an 710129 China

Suppressing Wnt signaling of the blood-tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2716-2731页

作者： Yang Tong Pei An Puxian Tang Rui Mu Yuteng Zeng Hang sun Mei Zhao ziyan Lv Pan Wang Wanjun Han Chunshan Gui Xuechu Zhen Liang Han Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China

Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid *** inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood-tumor barrier(BTB).BTB activates its Wnt signaling to maintain barrier properties,e.g.,Mfsd2a-mediated BTB low ***,we reported VCAM-1-targeting nano-wogonin(W@V-NPs)as an adjuvant of nano-orlistat(O@V-NPs)to intensify drug delivery and inhibit lipogenesis of brain metastases.W@V-NPs were proven to be able to inactivate BTB Wnt signaling,downregulate BTB Mfsd2a,accelerate BTB vesicular transport,and enhance tumor accumulation of O@*** the ability to specifically kill cancer cells in a lipid-deprived environment with IC_(50) at 48 ng/mL,W@V-NPs plus O@V-NPs inhibited the progression of brain metastases with prolonged survival of model *** combination did not induce brain edema,cognitive impairment,and systemic toxicity in healthy *** Wnt signaling could safely modulate the BTB to improve drug delivery and metabolic therapy against brain metastases.

关键词： Lipogenesis Brain metastases Blood-tumor barrier Wnt signaling Drug delivery Fatty acid synthase Nanoparticles Combination therapy

Lymph node-biomimetic scaffold boosts CAR-T therapy against solid tumor

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National Science Review 2024年第4期11卷 206-215页

作者： ziyan Liao Jie Jiang Wei Wu Jiaqi Shi Yanfang Wang Yuejun Yao Tao Sheng Feng Liu Wei Liu Peng Zhao Feifei Lv Jie sun Hongjun Li Zhen Gu National Key Laboratory of Advanced Drug Delivery and Release Systems College of Pharmaceutical Sciences Zhejiang University Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang University Liangzhu Laboratory Zhejiang University Bone Marrow Transplantation Center of the First Affiliated Hospital and Department of Cell Biology Zhejiang University School of Medicine Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Department of Laboratory Medicine The First Affiliated Hospital Zhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang University Jinhua Institute of Zhejiang University MOE Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of Polymer Science and EngineeringZhejiang University Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

The limited infiltration and persistence of chimeric antigen receptor(CAR)-T cells is primarily responsible for their treatment deficits in solid tumors. Here, we present a three-dimensional scaffold, inspired by the physiological process of T-cell proliferation in lymph nodes. This scaffold gathers the function of loading,delivery, activation and expansion for CAR-T cells to enhance their therapeutic effects on solid tumors. This porous device is made from poly(lactic-co-glycolic acid) by a microfluidic technique with the modification of T-cell stimulatory signals, including anti-CD3, anti-CD28 antibodies, as well as cytokines. This scaffold fosters a 50-fold CAR-T cell expansion in vitro and a 15-fold cell expansion in vivo. Particularly, it maintains long-lasting expansion of CAR-T cells for up to 30 days in a cervical tumor model and significantly inhibits the tumor growth. This biomimetic delivery strategy provides a versatile platform of cell delivery and activation for CAR-T cells in treating solid tumors.

关键词： drug delivery cell therapy bioinspired biomaterials cancer immunotherapy

Protective effect of marine animals hydrolysis-peptides on adjuvant-induced arthritis in mice by gut microbiota and SCFAs

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Food Science and Human Wellness 2024年

作者： Zhen Zhang Shasha Tang ziyan Wang Jiaojiao Han Jun Zhou Chenyang Lu Bin Liu Xiaoling sun Rongxian Yu Rixin Wang Xiurong Su School of Marine Science， Ningbo University State Key Laboratory for Quality and Safety of Argo-products， Ningbo University Vigor Technology Group

Marine fauna provides a plentiful repository of peptides and bioactive proteins. Peptides and proteins isolated from marine animals have been studied and applied in the development of food supplements， drugs， and cosmeceutical products because of their special bioactivities， such as anti-inflammatory and antioxidant effects This study focused on exploring the alleviating effects of five major marine animal-derived peptides (Apostichopus japonicus， Acaudina leucoprocta， Melanogrammus aeglefinus， Phascolosoma esculenta and Rhopilema esculentum) on adjuvant-induced arthritis (AIA). The treatment with five marine animals-derived peptides downregulated the expression levels of pro-inflammatory cytokines of IL-1β， IL-17 and TNF-α in the bones of the mice with AIA and alleviated the rough surface of bone tissues significantly. A. japonicus-treatment ameliorates inflammation by restoring NF-κB pathway in AIA mice. High-throughput sequencing of the gut microbiota based on 16S rRNA sequencing revealed that A. japonicus peptide-treated AIA mice showed alterations and imbalance of intestinal flora and an increased abundance of Lactobacillus and Clostridium. Furthermore， metabolomic analysis showed that the level of SCFAs in the feces was enhanced to different degrees in mice treated with five major marine animal-derived peptides. Taken together， we propose that major marine animal-derived peptides can alleviate arthritis by improving the imbalance in the gut flora and increasing SCFA production to varying degrees.

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Vacancy engineering mediated hollow structured ZnO/ZnS S-scheme heterojunction for highly efficient photocatalytic H2 production

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Chinese Journal of Catalysis 2024年第9期64卷 152-165页

作者： Fangxuan Liu Bin sun ziyan Liu Yingqin Wei Tingting Gao Guowei Zhou Key Laboratory of Fine Chemicals in Universities of Shandong Jinan Engineering Laboratory for Multi‐scale Functional MaterialsSchool of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353ShandongChina Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264006ShandongChina

Designing a step-scheme(S-scheme)heterojunction photocatalyst with vacancy engineering is a reliable approach to achieve highly efficient photocatalytic H_(2)production ***,a hollow ZnO/ZnS S-scheme heterojunction with O and Zn vacancies(VO,Zn-ZnO/ZnS)is rationally constructed via ion-exchange and calcination *** such a photocatalytic system,the hollow structure combined with the introduction of dual vacancies endows the adequate light ***,the O and Zn vacancies serve as the trapping sites for photo-induced electrons and holes,respectively,which are beneficial for promoting the photo-induced carrier ***,the S-scheme charge transfer mechanism can not only improve the separation and transfer efficiencies of photo-induced carrier but also retain the strong redox *** expected,the optimized VO,Zn-ZnO/ZnS heterojunction exhibits a superior photocatalytic H_(2)production rate of 160.91 mmol g^(-1)h^(-1),approximately 643.6 times and 214.5 times with respect to that obtained on pure ZnO and ZnS,***,the experimental results and density functional theory calculations disclose that the photo-induced carrier transfer pathway follows the S-scheme heterojunction mechanism and the introduction of O and Zn vacancies reduces the surface reaction *** work provides an innovative strategy of vacancy engineering in S-scheme heterojunction for solar-to-fuel energy conversion.

关键词： Hollow structure ZnO/ZnS S-scheme heterojunction Vacancy engineering Photocatalytic H2 production

木质纤维素基生物炭对葡萄糖厌氧消化性能的影响及机理研究

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北京化工大学学报（自然科学版） 2022年第3期49卷 7-15页

作者：孙子滟李叶青潘君廷中国石油大学(北京)新能源与材料学院生物燃气高值利用北京市重点实验室北京102249 中国农业科学院农业资源与农业区划研究所北京100081

生物炭是提高厌氧消化性能的有效添加剂,由于生物炭性质的多样性和厌氧体系的复杂性,生物炭对厌氧消化的促进机理尚未得到全面认识。以生物质纯组分——纤维素、半纤维素和木质素为原料,分别采用水热法和热解法制备了生物炭,考察了生物... 详细信息

生物炭是提高厌氧消化性能的有效添加剂,由于生物炭性质的多样性和厌氧体系的复杂性,生物炭对厌氧消化的促进机理尚未得到全面认识。以生物质纯组分——纤维素、半纤维素和木质素为原料,分别采用水热法和热解法制备了生物炭,考察了生物炭对葡萄糖厌氧消化的影响,并从微生物分析、官能团组成和电导率等方面探究了其作用机理。结果表明:与对照组相比,生物炭的添加能加快葡萄糖厌氧消化速率,提高消化效率;相较于纤维素和半纤维素,以木质素为原料制备的生物炭的效果更好;以木质素为原料制备的水热炭和热解炭均能在一定程度上富集互养型发酵细菌,这可能有助于促进直接种间电子转移(DIET)机制的建立,从而提高产甲烷速率;生物炭丰富的表面含氧官能团和较大的电导率可能是其强化厌氧消化效果的关键特性;通过变异性分析发现,相较于制备方法,累积产甲烷量对生物炭原料的依赖性更大。

关键词：厌氧消化木质纤维素生物炭水热法热解法机理

民事审前准备程序的完善与证据失权制度的重构

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昆明学院学报 2023年第1期45卷 99-105页

作者：孙紫妍上海市虹口区人民法院民事审判庭上海200042

从2001年到2015年,我国的证据失权制度从严格适用走向了基本搁置。梳理证据失权制度与民事审前准备程序之间的关系,分析域外国家能够构建起相对严格的证据失权制度并加以适用的原因之后发现,目前我国缺少独立且具有实质意义的审前准备程... 详细信息

从2001年到2015年,我国的证据失权制度从严格适用走向了基本搁置。梳理证据失权制度与民事审前准备程序之间的关系,分析域外国家能够构建起相对严格的证据失权制度并加以适用的原因之后发现,目前我国缺少独立且具有实质意义的审前准备程序,以及立法上对证据失权制度的设计存在缺陷,是我国证据失权制度在司法实践中很少被适用的原因。因此,应当在完善我国民事审前准备程序的基础上,修改现行立法中关于证据失权的构成要件,重构宽严相济的证据失权制度。

关键词：证据失权审前程序证据交换争点整理

法经济学视角下的违约方申请解除合同规则探讨

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金华职业技术学院学报 2021年第4期21卷 57-62页

作者：孙紫妍华东政法大学上海200042

自"新宇公司诉冯玉梅商铺买卖合同纠纷案"登载为最高人民法院的公报案例,违约方如何处理合同僵局成为民法学界广泛争议的焦点。主流观点认为,违约方在合同出现僵局时并不享有法定解除权,仅享有申请司法解除合同的诉权。在我国合同法现... 详细信息

自"新宇公司诉冯玉梅商铺买卖合同纠纷案"登载为最高人民法院的公报案例,违约方如何处理合同僵局成为民法学界广泛争议的焦点。主流观点认为,违约方在合同出现僵局时并不享有法定解除权,仅享有申请司法解除合同的诉权。在我国合同法现有的制度无法解决合同僵局问题且引入英美法效率违约制度的条件尚不成熟的情况下,考虑到法经济学的效率原则,设立违约方申请解除合同的规则是必要的。我国《民法典》中虽已增设处理违约方申请解除合同的条款,但该条款规定得过于简单、模糊。对此,应借鉴此前《民法典合同编(二审稿)》和《九民纪要》的规定,将支持违约方解除合同申请的条件补充进《民法典》的该条款中,从而完善违约方申请解除合同规则,使之更好地指导司法实践。

关键词：违约方申请解除合同权效率原则合同僵局民法典法经济学