检索结果-南通市图书馆

Regenerative Biomaterials 2021年第2期8卷 149-162页

作者： Shuo Sun zixue jiao Yu Wang Zhenxu Wu Haowei Wang Qingming Ji Yi Liu Zongliang Wang Peibiao Zhang Department of Spine Surgery The First Hospital of Jilin University1 Xinmin StreetChangchun 130021China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun 130022China

Porous microcarriers have aroused increasing attention recently by facilitating oxygen and nutrient transfer,supporting cell attachment and growth with sufficient cell seeding *** this study,porous polyetheretherketone(PEEK)microcarriers coated with mineralized extracellular matrix(mECM),known for their chemical,mechanical and biological superiority,were developed for orthopedic *** PEEK microcarriers were derived from smooth microcarriers using a simple wet-chemistry strategy involving the reduction of carbonyl *** treatment simultaneously modified surface topology and chemical ***,the microstructure,protein absorption,cytotoxicity and bioactivity of the obtained porous microcarriers were *** deposition of mECM through repeated recellularization and decellularization on the surface of porous MCs further promoted cell proliferation and osteogenic ***,the mECM coated porous microcarriers exhibited excellent bone regeneration in a rat calvarial defect repair model in vivo,suggesting huge potential applications in bone tissue engineering.

关键词： polyetheretherketone porous microcarriers mineralized extracellular matrix cell expansion bone regeneration

Gaseous sulfur trioxide induced controllable sulfonation promoting biomineralization and osseointegration of polyetheretherketone implants

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2020年第4期5卷 1004-1017页

作者： Teng Wan zixue jiao Min Guo Zongliang Wang Yizao Wan Kaili Lin Qinyi Liu Peibiao Zhang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022PR China Department of Orthopaedics The Second HospitalJilin UniversityChangchun130041PR China Institute of Advanced Materials East China Jiaotong UniversityNanchang330013PR China Department of Oral&Cranio-Maxillofacial Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai200011PR China University of Science and Technology of China Hefei230026PR China

Fabricating a desired porous structure on the surface of biomedical polyetheretherketone(PEEK)implants for enhancing biological functions is crucial and difficult due to its inherent chemical *** this study,a porous surface of PEEK implants was fabricated by controllable sulfonation using gaseous sulfur trioxide(SO3)for different time(5,15,30,60 and 90 min).Micro-topological structure was generated on the surface of sulfonated PEEK implants preserving original mechanical *** protein absorption capacity and apatite forming ability was thus improved by the morphological and elemental change with higher degree of *** combination of the appropriate micromorphology and bioactive sulfonate components,the cell adhesion,migration,proliferation and extracellular matrix secretion were obviously enhanced by the SPEEK-15 samples which were sulfonated for 15 *** from this study revealed that controllable sulfonation by gaseous SO3 would be an extraordinarily strategy for improving osseointegration of PEEK implants by adjusting the microstructure and chemical composition while maintaining excellent mechanical properties.

关键词： Polyetheretherketone Sulfonation Micro-topology Mechanical strength Osteointegration

Biomimetic polyetheretherketone microcarriers with specific surface topography and self-secreted extracellular matrix for large-scale cell expansion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2020年第1期7卷 109-118页

作者： Qingming Ji ZongliangWang zixue jiao Yu Wang Zhenxu Wu Peng Wang Yuhang Zhu Shuo Sun Yi Liu Peibiao Zhang Department of Spine Surgery The First Hospital of Jilin UniversityChangchun 130021PR China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022PR China University of Science and Technology of China Hefei 230026PR China Department of Orthopedics China-Japan Union HospitalJilin UniversityChangchun 130033PR China

Reusable microcarriers with appropriate surface topography,mechanical properties,as well as biological modification through decellularization facilitating repeated cell culture are crucial for tissue engineering ***,we report the preparation of topological polyetheretherketone(PEEK)microcarriers via gas-driven and solvent exchange method followed by hydrothermal treatment at high temperature and *** hydrothermal treated for 8 h,the resulting topological PEEK microcarriers exhibit walnut-like surface topography and good sphericity as well as uniform size distribution of 350.24619.44 *** the average width between ravine-patterned surface of PEEK microcarriers is 7806290 *** repeated steam sterilization by autoclaving for three times,topological PEEK microcarriers show nearly identical results compared with previous ones indicating strong tolerance to high temperature and *** is a unique advantage for large-scale cell expansion and clinical ***,PEEK microcarriers with special topography possess higher protein adsorption *** addition,the reutilization and biofunctionalization with repeated decellularization of topological PEEK microcarriers show highly beneficial for cell adhesion and ***,our study is of great importance for new generation microcarriers with micro-and nano-scale surface feature for a broad application prospect in tissue engineering.

关键词： PEEK topological microcarriers recycle decellularization cell adhesion

Improved hemostatic effects by Fe^(3+)modified biomimetic PLLA cotton-like mat via sodium alginate grafted with dopamine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第8期6卷 2346-2359页

作者： Caili Lv Linlong Li zixue jiao Huanhuan Yan Zongliang Wang Zhenxu Wu Min Guo Yu Wang Peibiao Zhang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences5625 Renmin StreetChangchun130022PR China School of Applied Chemistry and Engineering University of Science and Technology of China96 Jinzhai RoadHefeiAnhui230026PR China University of Chinese Academy of Sciences 19 Yuquan RoadBeijing100049PR China

The development of an excellent,bioabsorbable hemostatic material for deep wound remains a *** this work,a biodegradable cotton-like biomimetic fibrous mat of poly(L-lactic acid)(PLLA)was made by melt ***,SD composite was prepared by cross-linking sodium alginate(SA)with dopamine(DA).It was immobilized on the fibre surface,which inspired by mussel ***,Fe^(3+)was loaded onto the 0.5SD/PLLA composite by chelation with the carboxyl of alginate and phenolic hydroxy of *** haemostasis experiment found that the hemostatic time 47 s in ***,the bleeding volume was 0.097 g and hemostatic time was 23 s when 20Fe^(3+)-0.5SD/PLLA was applied in the haemostasis of the rat *** a result of its robust hydrophilicity and bouffant cotton-like structure,it could absorb a large water from blood,which could concentrate the component of blood and reduce the clotting ***,the addition of Fe^(3+)in the 0.5SD/PLLA had a significant effect on improve hemostatic *** also displayed excellent antibacterial property for Escherichia coli and Staphylococcus ***,it possesses superior hemocompatibility,cytocompatibility and ***,20Fe^(3+)-0.5SD/PLLA has high potential application in haemostasis for clinical settings due to its outstanding properties.

关键词： PLLA Melt spinning Sodium alginate Fe^(3+) Hemostasis Antibacterial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

污水处理系统施工中置换有害气体技术

医药工程设计 2005年第4期26卷 51-54页

作者：校自学鱼宝生西安利君制药有限责任公司 710077

介绍了污水系统中有害气体存在的原因和特点,并分析了其对施工人员的危害性。为确保施工安全,有必要对作业场所环境中的有害气体进行置换处理,同时在施工中对置换的效果要进行合理的检验,并采取必要的安全防范措施。本文结合4个实例研... 详细信息

介绍了污水系统中有害气体存在的原因和特点,并分析了其对施工人员的危害性。为确保施工安全,有必要对作业场所环境中的有害气体进行置换处理,同时在施工中对置换的效果要进行合理的检验,并采取必要的安全防范措施。本文结合4个实例研究了置换技术在施工中的应用,可为相同条件下的施工提供参考。

关键词：有害气体污水系统安全施工置换技术系统施工置换处理污水处理技术安全防范措施施工人员

Polymeric Carriers for Gene Silencing

在线全文

学校读者我要写书评

暂无评论

Polymeric Carriers for Gene Silencing

第十七届国际生物物理大会;第十二届中国生物物理大会

作者： Huayu Tian~1,Jie Chen~1,Zhaopei Guo~1,zixue jiao~1,Lin Lin~1,Xuesi Chen~1 1.Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,China

Gene silencing technology by using siRNA is the most effective way to treat a variety of gene-related diseases. The application of siRNA is largely dependent on the development of gene carriers,which must be administe... 详细信息

关键词： gene carriers siRNA gene silencing cytotoxicity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

发酵用离心式空压机组的噪声控制

医药工程设计 2005年第4期26卷 1-4页

作者：鱼宝生校自学戴晓峰西安利群制药有限责任公司 710077 湖南株洲化工集团有限责任公司 412004

介绍了发酵用离心式空压机噪声的水平和特点。调研发现,近几年噪声的控制现状,工程上没有进展,单机入口流量≥500m3/min的空压站的机器间,没有控制噪声达标的实例,主要原因是经济上的。通过引进入口流量700m3/min国外机组成套隔声罩的... 详细信息

介绍了发酵用离心式空压机噪声的水平和特点。调研发现,近几年噪声的控制现状,工程上没有进展,单机入口流量≥500m3/min的空压站的机器间,没有控制噪声达标的实例,主要原因是经济上的。通过引进入口流量700m3/min国外机组成套隔声罩的工程实践,试图把机器间的噪声控制在85dB(A),结果尚可。看来把机器间的噪声控制在90dB(A),也需要付出艰辛的努力。

关键词：发酵离心式空压机设计选型噪声控制隔声罩机器间实践发酵用空压机组入口流量

在线全文

学校读者我要写书评

暂无评论

发酵用离心式空压机组的润滑系统

医药工程设计 2005年第6期26卷 1-5页

作者：鱼宝生校自学戴晓峰西安利君制药有限责任公司 710077 湖南株洲化工集团有限责任公司 412004

从发酵用离心式空压机组设计选型的角度,探讨和介绍了①和润滑无关和油系统有关的,液压式轴向位移安全器,喘振保护机构为油动机和喷射式比例调节器,不能成套;②油系统的配管;③主机的干式联轴器;④主油泵的反转给油;⑤采用自力式温控阀... 详细信息

从发酵用离心式空压机组设计选型的角度,探讨和介绍了①和润滑无关和油系统有关的,液压式轴向位移安全器,喘振保护机构为油动机和喷射式比例调节器,不能成套;②油系统的配管;③主机的干式联轴器;④主油泵的反转给油;⑤采用自力式温控阀控制油温;⑥突然断电时,机组惯性停车过程中的润滑保障;⑦除油雾器;⑧主电机的轴承选择。要重视润滑系统的技术进步,对庞大而复杂的3m3容积的润滑油系统,在选型中切不可掉以轻心。

关键词：发酵离心式空压机润滑干式联轴器主油泵反转给油自力式温控阀技术进步选型

Rare variants in FANCJ induce premature ovarian insufficiency in humans and mice

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第2期51卷 252-255页

作者： Xi Yang Shuting Ren Jialin Yang Yuncheng Pan zixue Zhou Qing Chen Yunzheng Fang Lingyue Shang Feng Zhang Xiaojin Zhang Yanhua Wu State Key Laboratory of Genetic Engineering at School of Life Sciences Human Phenome InstituteObstetrics and Gynecology HospitalFudan UniversityShanghai 200438China Obstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentState Key Laboratory of Genetic Engineering at School of Life SciencesFudan UniversityShanghai 200011China Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 201203China Obstetrics and Gynecology Hospital Institute of Reproduction and DevelopmentFudan UniversityShanghai 200011China State Key Laboratory of Genetic Engineering at School of Life Sciences Obstetrics and Gynecology HospitalFudan UniversityShanghai 200438China National Demonstration Center for Experimental Biology Education School of Life SciencesFudan UniversityShanghai 200433China

Premature ovarian insufficiency(POI)is a severe female reproductive disorder that affects 1%of women in general populations(European Society for Human Reproduction and Embryology[ESHRE]Guideline Group on POI et al.,2016).An increasing prevalence up to 3.7%has been reported in a recent meta-analysis(Golezar et al.,2019).POl can lead to infertility or subfertility,as well as a range of complex complications suffering multi-organ systems,seriously threatening women's health and reducing the life *** contrast,POl is a representative heterogeneous disease with multiple *** more than 70 causative POI genes have been identified,the etiology of more than half of the POI patients is still ambiguous(jiao et al.,2018).Unreported POI causative genes,therefore,remain to be identified.

关键词： insufficiency fertility

云南省儿童青少年近视危险因素列线图判别分析

在线全文

学校读者我要写书评

暂无评论

中国学校卫生 2023年第9期44卷 1387-1391页

作者：张金娇常利涛肖洁李佩谦谢雪妮马子雪李茜茜罗筱陈茂森黄莹昆明医科大学公共卫生学院云南650500 云南省疾病预防控制中心学校卫生所

目的探讨云南省儿童青少年近视的相关因素,并对影响因素进行预测评估,为近视防控提供科学依据。方法2023年3月9—14日,采用多阶段分层整群随机抽样方法,抽取云南省大理和丽江两个地区6所中小学校的848名学生进行视力检测和近视相关影响... 详细信息

目的探讨云南省儿童青少年近视的相关因素,并对影响因素进行预测评估,为近视防控提供科学依据。方法2023年3月9—14日,采用多阶段分层整群随机抽样方法,抽取云南省大理和丽江两个地区6所中小学校的848名学生进行视力检测和近视相关影响因素的问卷调查,使用多因素Logistic回归分析将筛选出的影响因素建立列线图(Nomogram)预测模型。结果调查对象总体近视率为68.3%,男生近视率(63.4%)低于女生(72.9%),小学生近视率(46.7%)低于初中生(81.1%),差异有统计学意义(χ^(2)=值分别为8.71,108.07,P值均9 h、父母双方均不近视与云南省儿童青少年近视发生呈负相关(OR值分别为0.64,0.63,0.56,0.28,0.48,P值均<0.05);每天放学后读写时间≥3 h、家长不限制玩电子游戏时间与近视发生呈正相关(OR值分别为1.94,1.78,P值均<0.05)。在影响因素基础上建立Nomogram预测模型定量评价近视风险,结果显示,对于云南省儿童青少年来说发生近视风险较大的3个因素分别是每天睡眠时间、父母近视情况、每天放学后读写时间。结论遗传因素和环境因素与儿童青少年近视发生均相关,列线图预测模型有利于筛查近视高风险因素及采取相应防治措施。

关键词：近视危险因素列线图回归分析儿童青少年

同方期刊数据库