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Chinese Chemical Letters 2022年第8期33卷 4107-4110页

作者： Jing Li Tao Zhang Jialin Sun Fengxia Ren Hongxin Jia Zixing Yu Jingchao Cheng Weiguo Shi State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing 100850China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China

Novel peptide-fentanyl analogue conjugates were synthesized by the covalent coupling of carfentanyl derivatives to the C-terminus or N-terminus of the conformationally constrained dermorphin tetrapeptide BVD03 via a chemical linker.The carfentanyl-related analogues displayed distinct binding and functional activities atμ/δopioid receptors(MOR/DOR)and antinociceptive effects when conjugated to the peptide.The most potent compound,SW-LJ-11,displayed mixed MOR/DOR agonist properties in the low nanomolar range and significant analgesic efficacy in vivo in four classic mouse models of pain.Interestingly,SW-LJ-11 did not exhibit any physical dependence or respiratory depression,in contrast to an equipotent analgesic dose of morphine or BVD03,indicating that the use of opioid peptide-fentanyl analogue conjugates as dual MOR/DOR agonists may be a promising strategy for obtaining safer opioids.

关键词： Peptide-small molecule conjugates Dual MOR/DOR agonists Lead compound Analgesics Physical dependence

Improved method for the feature extraction of laser scanner using genetic clustering

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Journal of Systems Engineering and Electronics 2008年第2期19卷 280-285页

作者： yu Jinxia Cai zixing Duan Zhuohua Coll. of Information ScienCe and Engineering Central South Univ. Changsha 410083 P. R. China Coll. of Computer Science and Technology Henan Polytechnic Univ. Jiaozuo 454003 P. R. China Dept. of Computer Science Shaoguan Univ. Shaoguan 512003 P. R. China

Feature extraction of range images provided by ranging sensor is a key issue of pattern recognition. To automatically extract the environmental feature sensed by a 2D ranging sensor laser scanner, an improved method based on genetic clustering VGA-clustering is presented. By integrating the spatial neighbouring information of range data into fuzzy clustering algorithm, a weighted fuzzy clustering algorithm （WFCA） instead of standard clustering algorithm is introduced to realize feature extraction of laser scanner. Aimed at the unknown clustering number in advance, several validation index functions are used to estimate the validity of different clustering algorithms and one validation index is selected as the fitness function of genetic algorithm so as to determine the accurate clustering number automatically. At the same time, an improved genetic algorithm IVGA on the basis of VGA is proposed to solve the local optimum of clustering algorithm, which is implemented by increasing the population diversity and improving the genetic operators of elitist rule to enhance the local search capacity and to quicken the convergence speed. By the comparison with other algorithms, the effectiveness of the algorithm introduced is demonstrated.

关键词： laser scanner feature extraction weighted fuzzy clustering validation index genetic algorithm.

An adaptive particle filter for soft fault compensation of mobile robots

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Science in China(Series F) 2008年第12期51卷 2033-2046页

作者： DUAN ZhuoHua CAI zixing yu JinXia School of Information Engineering Shaoguan University Shaoguan 512003 China School of Information Science and Engineering Central South University Changsha 410083 China College of Computer Science and Technology Henan Polytechnic University Jiaozuo 454003 China

Soft fault compensation plays an important role in mobile robot locating, mapping, and navigating. It is difficult to achieve fast and accurate compensation for mobile robots because they are usually highly non-linear, non-Gaussian systems with limited computation and memory resources. An adaptive particle filter is presented to compensate two kinds of soft faults for mobile robots, i.e., noise or factor faults of dead reckoning sensors and slippage of wheels. Firstly, the kinematics models and the fault models are discussed, and five kinds of residual features are extracted to detect soft faults. Secondly, an adaptive particle filter is designed for fault compensation, and two kinds of adaptive scheme are discussed： 1） the noise variances of linear speed and yaw rate are adjusted according to residual features; 2） the particle number is adapted according to Kullback-Leibler divergence （KLD） of two approximate distribution denoted with two particle sets with different particles, i.e., increasing particle number if the KLD is large and decreasing particle number if the KLD is small. The theoretic proof is given and experimental results show the efficiency and accuracy of the presented approach.

关键词： soft fault detection and compensation adaptive particle filter mobile robots

基于门控循环单元的移动社会网络链路预测方法

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计算机研究与发展 2023年第3期60卷 705-716页

作者：刘林峰于子兴祝贺南京邮电大学计算机学院南京210023

链路预测是指通过已知的网络拓扑和节点信息来预测未来时刻节点之间的潜在关系,链路预测能够帮助在各种存在链路的应用领域更加合理地分配资源、降低资源开销.移动社会网络属于动态网络的一种,其网络结构总是随着节点和链路的出现、消... 详细信息

链路预测是指通过已知的网络拓扑和节点信息来预测未来时刻节点之间的潜在关系,链路预测能够帮助在各种存在链路的应用领域更加合理地分配资源、降低资源开销.移动社会网络属于动态网络的一种,其网络结构总是随着节点和链路的出现、消失以及时间推移而不断演变.针对移动社会网络的特点,当前已有的研究使用愈加复杂的模型来分析链路之间的联系,然而复杂的模型不但空间复杂度大而且容易造成过拟合问题.为了解决以上问题,提出一种基于门控循环单元的移动社会网络链路预测方法.首先对输入数据集进行排序筛选,将目标网络划分为快照图,并按一定的规则转化为邻接矩阵形成样本集,然后基于自动编码器和门控循环单元构建预测模型,提取出移动社会网络的时间变化特征.在KONECT数据集上,与其他模型的对比实验结果表明,该方法能够保持预测性能几乎不变的情况下,使模型训练效率提升49.81%.

关键词：深度学习链路预测移动社会网络门控循环单元自动编码器

A spatial orthogonal allocation and heterogeneous cultural hybrid algorithm for multirobot exploration mission planning

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控制理论与应用（英文版） 2011年第2期9卷 171-176页

作者： yu, Lingli Cai, zixing Gao, Ping'an Liu, Xiaoying School of Information Science and Engineering Central South University Changsha Hunan 410083 China

A spatial orthogonal allocation method is devised for multirobot tasks allocation.A 3D space model is adopted to describe exploration mission;meanwhile spatial orthogonal tentative technology is utilized to update the attractor position for load balance.Heterogeneous interactive cultural hybrid architecture is proposed to solve a robot route planning problem;it utilizes good-point-set to initialize population spaces,redefine novel evolution model and particle evolution ability,and introduce near-neighbor local search strategy in order to enhance search capability.Finally,spatial orthogonal allocation and heterogeneous cultural hybrid algorithm (SOAHCHA) are verified by simulation analysis and MORCS2 planning experiments;those results show that the proposed algorithm is efficient because of its successful performance and balanced allocation.

关键词： Multirobot system Mission planning Spatial orthogonal allocation Heterogeneous cultural hybrid algorithm

Network prediction of surgical complication clusters:a prospective multicenter cohort study

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Science China(Life Sciences) 2023年第7期66卷 1636-1646页

作者： Xiaochu yu Peng Wu zixing Wang Wei Han yuguang Huang Shijie Xin Qiang Zhang Shengxiu Zhao Hong Sun Guanghua Lei Taiping Zhang Luwen Zhang yubing Shen Wentao Gu Hongwei Li Jingmei Jiang Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijing100730China Institute of Basic Medical Sciences Chinese Academy of Medical Sciences/School of Basic MedicinePeking Union Medical CollegeBeijing100005China The First Hospital of China Medical University Shenyang110001China Qinghai Provincial People’s Hospital Xining810007China Xiangya Hospital of Central South University Changsha410008China Research Department PaodingAIBeijing100083China

Complicated relationships exist in both occurrence and progression of surgical complications,which are difficult to account for using a separate quantitative method such as prediction or grading.Data of 51,030 surgical inpatients were collected from four academic/teaching hospitals in a prospective cohort study in China.The relationship between preoperative factors,22 common complications,and death was analyzed.With input from 54 senior clinicians and following a Bayesian network approach,a complication grading,cluster-visualization,and prediction(GCP)system was designed to model pathways between grades of complication and preoperative risk factor clusters.In the GCP system,there were 11 nodes representing six grades of complication and five preoperative risk factor clusters,and 32 arcs representing a direct association.Several critical targets were pinpointed on the pathway.Malnourished status was a fundamental cause widely associated(7/32 arcs)with other risk factor clusters and complications.American Society of Anesthesiologists(ASA)score≥3 was directly dependent on all other risk factor clusters and influenced all severe complications.Grade III complications(mainly pneumonia)were directly dependent on4/5 risk factor clusters and affected all other grades of complication.Irrespective of grade,complication occurrence was more likely to increase the risk of other grades of complication than risk factor clusters.

关键词： surgical complication network system complication grading complication prediction complication management

Multi-robot exploration mission planning and stochastic increment replanning for load balance

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Frontiers of Electrical and Electronic Engineering in China 2010年第2期5卷 154-162页

作者： Lingli yu zixing CAI School of Information Science&Engineering Central South UniversityChangsha 410083China

Multi-robot mission planning is composed of assignment allocation and mobile-robot route planning in this paper.Multi-robot exploration missions adopts fuzzy c-mean(FCM)algorithm to allocate,and then,heterogeneous interactive cultural hybrid algorithm(HICHA)is devised for route planning in order to optimize mobilerobot execution path.Meanwhile,we design multi-robot mission replanning mechanism based on the rules system of greedy algorithm for dynamic stochastic increment missions.Finally,extensive simulation experiments were shown that FCM for assignment allocation and HICHA for route planning were efficacious for mobile-robot exploration mission planning.Furthermore,the improved greedy algorithm based on experience rules met dynamic stochastic increment missions replanning requirement for load balance.

关键词： multi-robot mission planning heterogeneous interactive cultural hybrid algorithm(HICHA) replanning

A precision medicine approach to managing 2019 novel coronavirus pneumonia

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Precision Clinical Medicine 2020年第1期3卷 14-21页

作者： Minjin Wang Yanbing Zhou Zhiyong Zong Zongan Liang yu Cao Hong Tang Bin Song zixing Huang Yan Kang Ping Feng Binwu Ying Weimin Li Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China Center of Infectious Diseases West China HospitalSichuan UniversityChengdu 610041China Department of Respiratory and Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Emergency Medicine West China HospitalSichuan UniversityChengdu 610041China Department of Radiology West China HospitalSichuan UniversityChengdu 610041China Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041China

In December 2019,several patients with pneumonia of an unknown cause were detected in Wuhan,China.On 7 January 2020,the causal organism was identified as a new coronavirus,later named as the 2019 novel coronavirus(2019-nCoV).Genome sequencing found the genetic sequence of 2019-nCoV homologous to that of severe acute respiratory syndrome-associated coronavirus.As of 29 January 2020,the virus had been diagnosed in more than 7000 patients in China and 77 patients in other countries.It is reported that both symptomatic and asymptomatic patients with 2019-nCoV can play a role in disease transmission via airborne and contact.This finding has caused a great concern about the prevention of illness spread.The clinical features of the infection are not specific and are often indistinguishable from those of other respiratory infections,making it difficult to diagnose.Given that the virus has a strong ability to spread between individuals,it is of top priority to identify potential or suspected patients as soon as possible—or the virus may cause a serious pandemic.Therefore,a precision medicine approach to managing this disease is urgently needed for detecting and controlling the spread of the virus.In this article,we present such an approach to managing 2019-nCoV-related pneumonia based on the unique traits of the virus recently revealed and on our experience with coronaviruses at West China Hospital in Chengdu,China.

关键词： 2019-nCoV COVID-19∗ coronavirus pneumonia SARS MERS epidemic pandemic precision medicine

日常生活视角下的山洞传统风貌区公共空间微更新——以老菜市场片区为例

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住区 2023年第4期 139-147页

作者：温泉刘梓星余俏重庆交通大学建筑与城市规划学院重庆市住房与城乡建设局重庆交通大学

以重庆市山洞传统风貌区老菜市场片区为研究对象,通过对其中居民自发性建造与日常生活的观察,总结并解析了其中人与空间关系和潜在的空间秩序,探讨了在当下传统风貌区更新活动中,特别是居民住区中,“人”的语境的寻回及市井气息存续的... 详细信息

以重庆市山洞传统风貌区老菜市场片区为研究对象,通过对其中居民自发性建造与日常生活的观察,总结并解析了其中人与空间关系和潜在的空间秩序,探讨了在当下传统风貌区更新活动中,特别是居民住区中,“人”的语境的寻回及市井气息存续的公共空间更新设计路径,总结提出了日常生活视角下的传统风貌区公共空间更新设计策略,并以场地中三个不同类型公共空间的更新作为实践,以期对类似的传统风貌区的更新活动提供参考。

关键词：传统风貌区日常生活非正规空间城市微更新

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高低维特征引导的实时语义分割网络

计算机应用 2023年第10期43卷 3077-3085页

作者：虞资兴瞿绍军何鑫王卓湖南师范大学信息科学与工程学院长沙410081 湖南华诺星空电子技术有限公司长沙410221

多数语义分割网络利用双线性插值将高级特征图的分辨率恢复至与低级特征图一样的分辨率再进行融合操作,导致部分高级语义信息在空间上无法与低级特征图对齐,进而造成语义信息的丢失。针对以上问题,改进双边分割网络(BiSeNet),并基于此... 详细信息

多数语义分割网络利用双线性插值将高级特征图的分辨率恢复至与低级特征图一样的分辨率再进行融合操作,导致部分高级语义信息在空间上无法与低级特征图对齐,进而造成语义信息的丢失。针对以上问题,改进双边分割网络(BiSeNet),并基于此提出一种高低维特征引导的实时语义分割网络(HLFGNet)。首先,提出高低维特征引导模块(HLFGM)来通过低级特征图的空间位置信息引导高级语义信息在上采样过程中的位移;同时,利用高级特征图来获取强特征表达,并结合注意力机制来消除低级特征图中冗余的边缘细节信息以及减少像素误分类的情况。其次,引入改进后的金字塔池化引导模块(PPGM)来获取全局上下文信息并加强不同尺度局部上下文信息的有效融合。在Cityscapes验证集和CamVid测试集上的实验结果表明,HLFGNet的平均交并比(mIoU)分别为76.67%与70.90%,每秒传输帧数分别为75.0、96.2;而相较于BiSeNet,HLFGNet的mIoU分别提高了1.76和3.40个百分点。可见,HLFGNet能够较为准确地识别场景信息,并能满足实时性要求。

关键词：实时语义分割上采样注意力机制金字塔池化上下文信息