检索结果-南通市图书馆

A lysosomal polarity-specific two-photon fluorescent probe for visualization of autophagy

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2021年第5期32卷 1803-1808页

作者： zixiang yuan Jun Chen Qin Zhou Ao Liu Zeming Qiang Min Fang Man Chen Yan Feng Haizhu Yu Xiuli Yang Xiangming Meng School of Chemistry and Chemical Engineering&Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials Anhui UniversityHefei 230601China Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province Yancheng Institute of TechnologyYancheng 224051China Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China Anhui Golden Sun Biochemical Pharmaceuticals Limited Company Fuyang 236000China

Autophagy plays a vital role in maintaining the balance of normal physiological state of living *** this paper,a polarity-specific two-phot on fluorescent probe Lyso-NA based on naphthalimide was synthesized for the purpose of monitoring autophagy during biological *** results of photophysical properties and theoretical calculation con firmed that different polarities of solvents mainly effected fluorescent intensities of *** nt intensity,quantum yield and fluorescence lifetime of probe kept a good linear relationship with polarity *** addition,due to its low toxicity and selective accumulation in lysosomes,Lyso-NA is suitable for detecting changes in lysosomal polarity of living *** with the imaging results of plasmid transfection,a better performed realtime long-term fluoresce nt visualization of autophagy in living cells was *** Lyso-NA can work as an efficient and cost effective imaging tool for visualizing autophagy in living cells.

关键词： Two-photon fluorescent probe Lysosomal polarity Autophagy Visualization Plasmid transfection

Controllable transitions among phase-matching conditions in a single nonlinear crystal

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2024年第2期22卷 141-147页

作者：曾梓琦尤世欣杨子祥袁晨智由成龙金锐博 Hubei Key Laboratory of Optical Information and Pattern Recognition Wuhan Institute of TechnologyWuhan 430205China Quantum Photonics Laboratory Department of Physics and AstronomyLouisiana State UniversityBaton RougeLouisiana 70803USA

Entangled photon pairs are crucial resources for quantum information processing *** the process of spontaneous parametric downconversion(SPDC),we can generate these photon pairs using bulk nonlinear ***,the crystal is designed to satisfy a specific type of phase-matching ***,we report controllable transitions among different types of phase matching in a single periodically poled potassium titanyl phosphate *** carefully selecting pump conditions,we can satisfy different phase-matching *** allows us to observe first-order Type-II,fifth-order Type-I,third-order Type-0,and fifth-order Type-II *** temperature-dependent spectra of our source were also analyzed in ***,we discussed the possibility of observing more than nine SPDCs in this *** work not only deepens the understanding of the physics behind phase-matching conditions,but also offers the potential for a highly versatile entangled biphoton source for quantum information research.

关键词： spontaneous parametric downconversion nonlinear crystals phase-matching condition

基于CFD-DEM的胡麻风筛式清选装置仿真分析与试验

在线全文

学校读者我要写书评

暂无评论

干旱地区农业研究 2023年第6期41卷 281-290页

作者：袁子翔戴飞赵武云史瑞杰赵一鸣辛尚龙甘肃农业大学机电工程学院甘肃兰州730070

为阐明胡麻脱粒物料在振动筛上实际的筛分效果,采用CFD-DEM耦合方法,对胡麻脱粒物料在胡麻联合收获机风筛式清选装置中的清选效果进行研究,探究鱼鳞筛开口角度、气流速度、清选筛振动频率以及清选筛振幅对清选效果的影响,并通过统计胡... 详细信息

为阐明胡麻脱粒物料在振动筛上实际的筛分效果,采用CFD-DEM耦合方法,对胡麻脱粒物料在胡麻联合收获机风筛式清选装置中的清选效果进行研究,探究鱼鳞筛开口角度、气流速度、清选筛振动频率以及清选筛振幅对清选效果的影响,并通过统计胡麻籽粒含杂率和清选损失率来衡量不同工作参数下分离清选装置的工作性能。仿真试验结果表明:鱼鳞筛开口角度最优为30°,鱼鳞筛透筛率为79.77%,茎秆透筛率为65.52%,籽粒透筛率为90.01%;振动筛振动幅度最优为15 mm,胡麻籽粒损失率为3.6%,籽粒含杂率为3.4%;振动筛振动频率最优为6 Hz,清选损失率为3.5%,籽粒含杂率为3.4%;风机风速最优为5.5 m·s^(-1),籽粒含杂率为3.2%,清选损失率为3.0%。结合优化工作参数进行大田作业性能验证试验,通过对机收后的收集物料测定试验指标可知,总清选损失率为3.58%,籽粒含杂率为3.16%,大田试验结果与仿真模拟结果基本一致。机收后的胡麻籽粒外形完整,破损现象较少,含杂率与总损失率均达到相关试验标准要求,表明优化后的参数满足胡麻联合收获标准要求。

关键词：清选装置胡麻联合收获机仿真试验参数优化 CFD-DEM

搜索引擎优化技术对网站友好性影响的实证研究

在线全文

学校读者我要写书评

暂无评论

情报杂志 2014年第9期33卷 173-180页

作者：李忆袁志会袁梓翔重庆邮电大学经济管理学院重庆400065 东北大学秦皇岛分校控制工程学院秦皇岛066000

以248家企业网站为样本,基于第三方统计工具提供的数据,对搜索引擎优化技术与网站友好性(对搜索引擎的友好性、对用户的友好性)的关系进行实证研究,发现:特别设计的404错误页面、更大的链接广度和更大的网页大小能提高网站对搜索引擎的... 详细信息

以248家企业网站为样本,基于第三方统计工具提供的数据,对搜索引擎优化技术与网站友好性(对搜索引擎的友好性、对用户的友好性)的关系进行实证研究,发现:特别设计的404错误页面、更大的链接广度和更大的网页大小能提高网站对搜索引擎的友好性;特别设计的404错误页面、更大的链接广度能提高网站对用户的友好性;更长的标题长度既降低网站对搜索引擎的友好性,也降低日均页面访问量,标题长度与百度权重呈U型关系。

关键词：搜索引擎搜索引擎优化网站友好性用户行为百度

在线全文

学校读者我要写书评

暂无评论

基于深度教学的地理情境梯度标准与创设策略

地理教学 2024年第1期 19-22页

作者：李琳刘守江袁章棋张蕊杰樊丽翁子翔西华师范大学地理科学学院四川南充637009

地理情境梯度是学生认知进阶发展的“脚踏点”,为探寻学生的认知过程、评估学生的认知水平提供了载体。本文从深度教学的视角,说明设置梯度式地理情境的必要性;从地理情境的参量构成和地理核心素养,构建地理情境梯度的层级标准。本文以... 详细信息

地理情境梯度是学生认知进阶发展的“脚踏点”,为探寻学生的认知过程、评估学生的认知水平提供了载体。本文从深度教学的视角,说明设置梯度式地理情境的必要性;从地理情境的参量构成和地理核心素养,构建地理情境梯度的层级标准。本文以“区域发展对交通运输布局的影响”为例,设定“区域情境促认知”“问题情境促探究”“综合情境促反思”三个相互关联的梯度情境,促使教师深度教学和学生深度学习的落地。

关键词：深度教学认知进阶高中地理情境梯度

Predictors and dynamic online nomogram for postoperative delayed hyponatremia after endoscopic transsphenoidal surgery for pituitary adenomas:a single-center,retrospective,observational cohort study with external validation

在线全文

学校读者我要写书评

暂无评论

Chinese Neurosurgical Journal 2023年第4期9卷 241-250页

作者： Xiangming Cai An Zhang Peng Zhao Zhiyuan Liu Yiliyaer Aili Xinrui Zeng yuanming Geng Chaonan Du Feng yuan Junhao Zhu Jin Yang Chao Tang zixiang Cong Yuxiu Liu Chiyuan Ma Department of Neurosurgery Jinling HospitalNanjingChina School of Medicine Southeast UniversityNanjingChina Department of Molecular Cell Biology and Immunology Amsterdam UMCVrije Universiteit AmsterdamAmsterdamNetherlands Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina Department of Neurosurgery The Affiliated Jinling Hospital of Nanjing Medical UniversityNanjingChina Department of Neurosurgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingChina Department of Critical Care Medicine Jinling HospitalNanjing Medical UniversityNanjingChina Department of Biostatistics School of Public HealthSouthern Medical UniversityGuangzhouChina Department of Neurosurgery Jinling Hospitalthe First School of Clinical MedicineSouthern Medical UniversityNanjingChina

Background Postoperative delayed hyponatremia(PDH)is a major cause of readmission after endoscopic transsphenoidal surgery(eTSS)for pituitary adenomas(PAs).However,the risk factors associated with PDH have not been well established,and the development of a dynamic online nomogram for predicting PDH is yet to be *** aimed to investigate the predictive factors for PDH and construct a dynamic online nomogram to aid in its *** We analyzed the data of 226 consecutive patients who underwent eTSS for PAs at the Department of Neurosurgery in Jinling Hospital between January 2018 and October *** additional 97 external patients were included for external *** was defined as a serum sodium level below 137 mmol/L,occurring on the third postoperative day(POD)or *** Hyponatremia on POD 1-2(OR=2.64,P=0.033),prothrombin time(PT)(OR=1.78,P=0.008),and percentage of monocytes(OR=1.22,P=0.047)were identified as predictive factors for PDH via multivariable logistic regression *** on these predictors,a nomogram was constructed with great discrimination in internal validation(adjusted AUC:0.613-0.688)and external validation(AUC:0.594-0.617).Furthermore,the nomogram demonstrated good performance in calibration plot,Brier Score,and decision curve *** analysis revealed robust predictive performance in patients with various clinical subtypes and mild to moderate *** Preoperative PT and the percentage of monocytes were,for the first time,identified as predictive factors for *** dynamic nomogram proved to be a valuable tool for predicting PDH after eTSS for PAs and demonstrated good *** could benefit from early identification of PDH and optimized treatment decisions.

关键词： Endoscopic transsphenoidal surgery Nomogram Pituitary adenomas Postoperative delayed hyponatremia Predictors

超临界二氧化碳印刷电路板式换热器设计及应用研究

在线全文

学校读者我要写书评

暂无评论

工程热物理学报 2022年第5期43卷 1351-1356页

作者：丁源童自翔王文奇曹锋西安交通大学能源与动力工程学院热流科学与工程教育部重点实验室西安710049

作为超临界二氧化碳(S-CO_(2))动力循环中的关键换热设备,印刷电路板式换热器(PCHE)对S-CO_(2)循环效率有着重要影响。为了提升S-CO_(2)循环效率,本文首先建立了PCHE的设计计算模型,并与文献数据进行对比验证了其可靠性;基于此,分析了... 详细信息

作为超临界二氧化碳(S-CO_(2))动力循环中的关键换热设备,印刷电路板式换热器(PCHE)对S-CO_(2)循环效率有着重要影响。为了提升S-CO_(2)循环效率,本文首先建立了PCHE的设计计算模型,并与文献数据进行对比验证了其可靠性;基于此,分析了水力直径与通道数量等关键几何参数对平直翅片和翼型翅片2种典型PCHE流动与换热性能的影响规律;进一步,详细考察了翼型翅片PCHE内部流场分布特性;最后,对装机功率为兆瓦级的S-CO_(2)熔盐光热电站中的4种主要换热器分别进行了设计计算。结果表明,本文建立的PCHE设计计算模型具有较高的可靠性,可用于S-CO_(2)等工质的PCHE的设计与优化。

关键词：印刷电路板式换热器设计计算超临界二氧化碳太阳能光热电站

在线全文

学校读者我要写书评

暂无评论

复杂刃形陶瓷刀具微波烧结技术研究

中国机械工程 2022年第8期33卷 899-907页

作者：殷增斌朱智勇王子祥袁军堂南京理工大学机械工程学院南京210094

利用微波烧结技术实现了复杂刃形陶瓷刀具的高效制备。仿真研究了微波电场和温度场随试样加载方式的变化规律,实验验证了不同试样加载方式对陶瓷刀具致密度、力学性能和微观结构的影响以及复杂槽型陶瓷刀具的切削性能。研究结果表明,多... 详细信息

利用微波烧结技术实现了复杂刃形陶瓷刀具的高效制备。仿真研究了微波电场和温度场随试样加载方式的变化规律,实验验证了不同试样加载方式对陶瓷刀具致密度、力学性能和微观结构的影响以及复杂槽型陶瓷刀具的切削性能。研究结果表明,多个试样平行横放且处于微波烧结腔中心位置时,试样之间的电场强度均匀、温差小,更有利于多个试样同时达到致密。利用微波烧结技术制备的复杂槽型Al_(2)O_(3)/SiC陶瓷刀具刃形结构完整,具有较好的切削性能。相较于传统平刀面陶瓷刀具,复杂槽型陶瓷刀具的金属去除量提高了近2倍,加工表面粗糙度降低了约33%。基于微波烧结的复杂陶瓷刀具“结构-性能”一体化高效制造技术具有广阔的应用前景。

关键词：陶瓷刀具复杂刃形刀具微波烧结微波电场刀具制造

Quantitative analysis of the dynamic change and spatial differences of the ecological security: a case study of Loess Plateau in northern Shaanxi Province

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Geographical Sciences 2006年第2期16卷 251-256页

作者： LI Jing REN Zhiyuan ZHOU zixiang College of Tourism and Environmental Sciences Shaanxi Normal University Xi＇an 710062 China

Using the theory and method of the ecological footprint, and combining the changes of regional land use, resource environment, population, society and economy, this paper calculated the ecological footprint, ecological carrying capacity and ecological surplus/loss in 1986-2002 on the Loess Plateau in northern Shaanxi Province. What is more, this paper has put forward the concept of ecological pressure index, set up ecological pressure index models, and ecological security grading systems, and the prediction models of different ecological footprints, ecological carrying capacity, ecological surplus and ecological safety change, and also has assessed the ecological footprint demands of 10,000 yuan GDE The results of this study are as follows：（1） the ecological carrying capacity in northern Shaanxi shows a decreasing trend, the difference of reducing range is the fastest; （2） the ecological footprint appears an increasing trend; （3） ecological pressure index rose to 0.91 from 0.44 during 1986-2002 on the Loess Plateau of northern Shaanxi with an increase of 47%; and （4） the ecological security in the study area is in a critical state, and the ecological oressure index has been increasing rapidlv.

关键词： regional ecological security dynamic change spatial difference quantitative analysis the Loess Plateau in northern Shaanxi Province