检索结果-南通市图书馆

G9a/GLP-sensitivity of H3K9me2 Demarcates Two Types of Genomic Compartments

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2020年第4期18卷 359-370页

作者： zixiang yan Luzhang Ji Xiangru Huo Qianfeng Wang Yuwen Zhang Bo Wen MOE Key Laboratory of Metabolism and Molecular Medicine Department of Biochemistry and Molecular BiologySchool of Basic Medical Sciencesand Institutes of Biomedical SciencesFudan UniversityShanghai 200032China State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and DevelopmentFudan UniversityShanghai 200438China

In the nucleus, chromatin is folded into hierarchical architecture that is tightly linked to various nuclear functions. However, the underlying molecular mechanisms that confer these architectures remain incompletely understood. Here, we investigated the functional roles of H3 lysine 9 dimethylation(H3 K9 me2), one of the abundant histone modifications, in three-dimensional(3 D)genome organization. Unlike in mouse embryonic stem cells, inhibition of methyltransferases G9 a and GLP in differentiated cells eliminated H3 K9 me2 predominantly at A-type(active) genomic compartments, and the level of residual H3 K9 me2 modifications was strongly associated with B-type(inactive) genomic compartments. Furthermore, chemical inhibition of G9 a/GLP in mouse hepatocytes led to decreased chromatin-nuclear lamina interactions mainly at G9 a/GLP-sensitive regions, increased degree of genomic compartmentalization, and up-regulation of hundreds of genes that were associated with alterations of the 3 D chromatin. Collectively, our data demonstrated essential roles of H3 K9 me2 in 3 D genome organization.

关键词： H3K9me2 G9a/GLP Chromatin organization 3D genome Genomic compartment

Multiplex intermetallic phases in a gravity die-cast Mg-6.0Zn-1.5Nd-0.5Zr(wt%) alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Magnesium and Alloys 2022年第1期10卷 225-240页

作者： Fanzhi Meng Shuhui Lv Qiang yang Xin Qiu zixiang yan Qian Duan Jian Meng State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Materials Science and Engineering Changchun University of Science and Technology130022China

Components and crystal structures of the intermetallic phases in a gravity die-cast Mg-6.0Zn-1.5Nd-0.5Zr(wt%)alloy were investigated using transmission electron *** results indicate that this alloy has multiple intermetallic phases and various inner ***,six eutectoid intermetallic phases,namely W(Mg Nd Zn_(3)),T(Mg_(39)Zn_(55)Nd_(6)),(Mg,Zr)Zn_(2),Z(Mg_(28)Zn_(65)Nd_(7)),H_(2)(Mg_(15)Zn_(70)Nd_(15)),and H1(Mg_(24)Zn_(64)Nd_(11)),were simultaneously observed at grain boundaries,and six precipitates(Z,Mg_(7)Zn_(3),T,Mg_(4)Zn_(7),β_(1)-Mg Zn_(2) and β_(2)-Mg Zn_(2))were found inα-Mg ***,faults like sub-grain boundaries,orientation domains(coherent with the same matching plane but with different orientations),stacking faults and twins were observed in the eutectoid intermetallic ***,some new orientation relationships between the known intermetallic phases were *** paper can provide new insight into alloy design for Mg-Zn-RE(RE:rare earth)based alloys.

关键词： Magnesium alloys Intermetallic phase Structure Transmission electron microscopy(TEM) Orientation relationship

Interfacial precipitation in{1012}twin boundaries of a Mg-Gd-Zn-Zr alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第34期93卷 103-109页

作者： zixiang yan Qiang yang Fanzhi Meng Rui Ma Rirong Bao Xiaojuan Liu Jian Meng Xin Qiu State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022PR China University of Science&Technology of China Hefei 230026PR China School of Materials Science and Engineering Changchun University of Science and Technology130022PR China Key Laboratory of Superlight Materials&Surface Technology Ministry of EducationHarbin Engineering UniversityHarbin 150001 PR China

Twinning and precipitation play important roles in deformation and strengthening of magnesium *** this work,interfacial precipitation in{1012}twin boundaries(TBs)of a cold-stamped Mg-12Gd-1.2Zn-0.4Zr alloy was investigated using atomic-resolution high-angle annular dark-field scanning transmission electron *** periodic segregation of Gd+Zn atoms in the~86.2°{1012}TBs with basal-prismatic facets and in the symmetric tilting TBs(obviously>86.2°)frequently occurred,resulted in the formation of new interfacial phases,namelyβ_(TB)’having a monoclinic structure in the TBs with two segregation layers andβ_(TB) having a tetragonal structure in the TBs with three or more segregation *** formation ofβ_(TB) clearly accelerates peak-aging and improves the alloy’s strength.

关键词： Magnesium alloys Twinning Scanning/transmission electron microscopy(STEM) Segregation Interfacial precipitate

The nuclear bodies formed by histone demethylase KDM7A

在线全文

学校读者我要写书评

暂无评论

Protein & Cell 2021年第4期12卷 297-304页

作者： Hui Ming Qianfeng Wang Yuwen Zhang Luzhang Ji Lu Cheng Xiangru Huo zixiang yan Zhexiao Liu Yongjun Dang Bo Wen MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology School of Basic Medical Sciencesand Institutes of Biomedical SciencesFudan UniversityShanghai 200032China State Key Laboratory of Genetic Engineering Collaborative Innovation Center of Genetics and DevelopmentFudan UniversityShanghai 200438China

Dear Editor,In the nucleus of higher eukaryotes,chromatin occupies only a small proportion of the nuclear space,while many proteins and RNAs segregate into membrane-less nuclear bodies(NBs).These NBs follow a stochast... 详细信息

关键词： stochastic ordered exchange

Dynamics of particles near the surface of amedium under ultra-strong shocks

在线全文

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2021年第2期6卷 46-53页

作者： zixiang yan Hao Liu Xinyu Zhang Guoli Ren Jie Liu Wei Kang Weiyan Zhang Xiantu He HEDPS Center for Applied Physics and Technologyand School of PhysicsPeking UniversityBeijing 100871China Department of Applied Physics School of Physics and ElectronicsHunan UniversityChangsha 410082China HEDPS Center for Applied Physics and Technologyand College of EngineeringPeking UniversityBeijing 100871China Institute of Applied Physics and Computational Mathematics Beijing 100088China Graduate School China Academy of Engineering PhysicsBeijing 100193China China Academy of Engineering Physics Mianyang 621900China

Through nonequilibrium molecular dynamics simulations,we provide an atomic-scale picture of the dynamics of particles near the surface of a medium under ultra-strong *** shows that the measured surface velocity v_(f)under ultra-strong shocks is actually the velocity of the critical surface at which the incident probe light is reflected,and v_(f)has a single-peaked *** doubling rule commonly used in the case of relatively weak shocks to determine particle velocity behind the shock front is generally not valid under ultra-strong *** a short period of acceleration,v_(f)exhibits a long slowly decaying tail,which is not sensitive to the atomic mass of the medium.A scaling law for v_(f)is also proposed,and this may be used to improve the measurement of particle velocity u in future experiments.

关键词： structure. surface doubling

在线全文

学校读者我要写书评

暂无评论

自由场听觉距离感知因素的动态虚拟实验研究

声学学报 2024年第6期49卷 1172-1185页

作者：朱俊谢菠荪赵童燕子翔华南理工大学物理与光电学院声学研究所广州510641

已有的物理分析和基于真实声源的实验研究表明,响度和近场头相关传输函数(HRTF,包括双耳声级差ILD和耳的声压谱)是自由场下听觉距离感知因素。但近年基于虚拟听觉重放(VAD)平台的相关实验结论却与此不一致,特别是在近场HRTF中的ILD是否... 详细信息

已有的物理分析和基于真实声源的实验研究表明,响度和近场头相关传输函数(HRTF,包括双耳声级差ILD和耳的声压谱)是自由场下听觉距离感知因素。但近年基于虚拟听觉重放(VAD)平台的相关实验结论却与此不一致,特别是在近场HRTF中的ILD是否为自由场距离感知的重要因素问题上存在争议。为解决这些争议并进一步研究不同因素的贡献及其协同作用,利用动态VAD平台和准确的近场HRTF合成的双耳声信号并使用耳机重放,采用心理声学实验研究了距离感知因素。结果表明,首先不同距离感知因素的贡献与声源的方向有关:(1)响度因素在所有方向都有重要贡献;(2) ILD主要在侧向有重要贡献,其贡献随着声源向前、后或高仰角偏离侧向而减少;(3)谱是较弱的因素,只有在中垂面ILD为零时才有可能检测到其贡献。其次,不同因素间存在协同交互作用和一定冗余:(1)响度与ILD的交互作用明显增强侧向距离感知;(2)响度与谱因素交互作用一定程度上增强后方的距离感知;(3)单一的ILD或响度可在一定程度上产生侧向距离感知。近年距离感知研究中的争议主要是因为这些实验是在稳态VAD平台上进行的,稳态VAD容易引起头中定位,影响距离感知;同时不准确的近场HRTF数据、不合适的实验方法与数据统计也会导致不一致的实验结论。

关键词：听觉距离感知动态虚拟听觉重放近场头相关传递函数响度

在线全文

学校读者我要写书评

暂无评论

匹配视角下知识粘性分析和对策研究

情报杂志 2016年第6期35卷 202-206,F0003,188页

作者：晏自翔卞艺杰河海大学商学院南京210098

[目的/意义]知识粘性是影响知识转移效率的重要因素,但目前对于知识粘性的研究,主要是从成本视角,依照香农-韦弗模型分析知识粘性形成的影响因素,较少基于知识特性分析粘性产生的原因。该文从知识的层次性和匹配性分析知识粘性,并提出... 详细信息

[目的/意义]知识粘性是影响知识转移效率的重要因素,但目前对于知识粘性的研究,主要是从成本视角,依照香农-韦弗模型分析知识粘性形成的影响因素,较少基于知识特性分析粘性产生的原因。该文从知识的层次性和匹配性分析知识粘性,并提出相应的管理对策。[方法/过程]首先界定了知识粘性的相关概念,分析了知识粘性和知识类别的关系,然后从知识与它事物的匹配程度分析了知识粘性的分类和成因,通过对所转移知识的有效性分析得出知识粘性的减弱思路,最后提出了基于知识守门人的知识转移网络作为减弱知识粘性的具体方法。[结果/结论]分析提出了知识粘性的4种类别,构建了基于知识守门人的知识转移网络,可以有效识别、分析和减弱所转移知识的粘性,提高组织间的知识转移效率。

关键词：知识匹配知识粘性知识转移知识转移网络知识守门人

Progress and future prospects of decadal prediction and data assimilation:A review

在线全文

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2024年第1期17卷 53-62页

作者： Wen Zhou Jinxiao Li zixiang yan Zili Shen Bo Wu Bin Wang Ronghua Zhang Zhijin Li Key Laboratory of Polar Atmosphere-ocean-ice System for Weather and Climate of the MOE Department of Atmospheric and Oceanic Science&Institute of Atmospheric ScienceFudan UniversityShanghaiChina Key Laboratory for Polar Science of the MNR Polar Research Institute of ChinaShanghaiChina Shanghai Investigation Design and Research Institute Co.Ltd.ShanghaiChina LASG Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina School of Marine Science Nanjing University of Information Science&TechnologyNanjingChina

年代际预测,也称为“近期气候预测”,旨在预测未来1-10年内的气候变化,是气候预测和气候变化研究领域的一个新关注点.它位于季节至年际预测和长期气候变化预测之间,结合了初值问题和外部强迫问题的两个方面.年代际预测的核心技术在于用... 详细信息

年代际预测,也称为“近期气候预测”,旨在预测未来1-10年内的气候变化,是气候预测和气候变化研究领域的一个新关注点.它位于季节至年际预测和长期气候变化预测之间,结合了初值问题和外部强迫问题的两个方面.年代际预测的核心技术在于用于模式初始化的同化方法的准确性和效率,其目标是为模式提供准确的初始条件,其中包含观测到的气候系统内部变率,年代际预测的初始化通常涉及在耦合框架内同化海洋观测,其中观测到的信号通过耦合过程传递到其他分量,如大气和海冰.然而,最近的研究越来越关注在海洋-大气耦合模式中探索耦合数据同化(CDA),有人认为CDA有潜力显著提高年代际预测技巧.本文综合评述了该领域的三个方面的研究现状:初始化方法,年代际气候预测的可预测性和预测技巧,以及年代际预测的未来发展和挑战.

关键词：年代际预测四维数据同化海气相互作用

An experimental investigation on cues of auditory distance perception in the free field based on dynamic virtual experiment

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Acoustics 2024年第4期 397-421页

作者： ZHU Jun XIE Bosun ZHAO Tong yan zixiang Acoustic Lab. School of Physics and OptoelectronicsSouth China University of Technology

Previous physical analysis and experiments with real sound source indicated that loudness and near-field head-related transfer functions (HRTFs,including interaural level difference ILD and pressure spectra at ears) are cues for auditory distance perception in the free ***,recent experiments conducted on the platform of virtual auditory display (VAD) have yielded inconsistent results,especially regarding the controversy over whether ILD in near-field HRTF is a crucial cue on distance perception in the free *** work aims to settle the controversy and further investigate the contribution and interaction of various distance perception cues in the free *** on a platform of dynamic VAD and accurate near-field HRTFs,binaural signals under different conditions are synthesized and presented by headphone,and the contributions of distance perception cues are then identified by psychoacoustic ***,results indicate that the contributions of various distance perception cues depend on source direction:(1) Loudness contributes significantly to distance perception in all directions.(2) ILD contributes importantly at lateral *** of ILD reduces as source departs from lateral to the frontal,back or high-elevation directions.(3) Spectral cue contributes weakly to distance *** in the median plane where the ILD vanishes may the contribution of spectral cue be ***,different cues interact with one another but are somewhat redundant:(1) The coordination of ILD and loudness obviously enhances distance perception at lateral directions.(2) The coordination of loudness and spectral cue enhances distance perception at rear direction to some extent.(3) ILD or loudness alone enables to moderately distance perception at lateral *** controversy on the results of some recent experiments is due to the fact that these experiments were conducted on the platform of static VAD,which were inclined to cause in-he

关键词：