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Acupuncture and Herbal Medicine 2024年第1期4卷 68-78页

作者： Zihao Zhang Raorao Li yu Chen Hui Yang Martin Fitzgerald Qiaochu Wang ziwen Xu Nanxi Huang Dajun Lu Lu Luo Georgetown University Medical Center Washington DCUSA Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijingChina Institute of Acupuncture and Moxibustion China Academy of Chinese Medical SciencesBeijingChina The First Clinical Medical College Guizhou University of Traditional Chinese MedicineGuiyangChina Ashdale Clinic Half Moon LaneSouth Douglas RoadCorkIreland

Traditional medicine has garnered significant global recognition,with an estimated 80%of the global population using it.Therefore,it is essential to fully understand the integration of traditional medicines into current healthcare systems.This review aims to provide a comprehensive overview of the standard process to modernize traditional medicine scientifically in the context of modern biomedicine,further termed here as“scientization”.Specifically,we aim to summarize the advancements made in understanding the efficacy,effectiveness,and underlying mechanisms of herbal medicine.We also examined the transition from experience-to evidence-based medicine during acupuncture.Furthermore,we explore the development of universal safety and quality control standards.Finally,we discuss international trade and export markets for Chinese medical products.The development and integration of traditional medicine have allowed it to further improve human health,resulting in a more comprehensive health solution for the global population.

关键词： Acupuncture Conventional medicine Herbal medicine Modernization Scientization Traditional Chinese medicine

Particle Image Velocimetry Experimental and Computational Investigation of a Blood Pump

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Journal of Thermal Science 2012年第3期21卷 262-268页

作者： Xiaochen Yang Xingmin Gui Hui Huang Yongbin Shen ziwen yu Yan Zhang Beijing Institute of Aerospace Systems Engineering BeijingChina School of Jet Propulsion Beijing University of Aeronautics and AstronauticsBejjingChina Department of Cardiovascular Surgery Fuwai HospitalBeijingChina

Blood pumps have been adopted to treat heart failure over the past decades.A novel blood pump adopting the ro-tor with splitter blades and tandem cascade stator was developed recently.A particle image velocimetry (PIV) experiment was carried out to verify the design of the blood pump based on computational fluid dynamics (CFD) and further analyze the flow properties in the rotor and stator.The original sized pump model with an acrylic housing and an experiment loop were constructed to perform the optical measurement.The PIV testing was car-ried out at the rotational speed of 6952±50 r/min with the flow rate of 3.1 l/min and at 8186±50 r/min with 3.5 l/min,respectively.The velocity and the Reynolds shear stress distributions were investigated by PIV and CFD,and the comparisons between them will be helpful for the future blood pump design.

关键词：计算流体动力学粒子图像测速实验环血泵 PIV技术定子转子剪应力分布分流叶片

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基于固态纳米孔道的单颗粒散射光谱分析

光散射学报 2024年第2期36卷 101-108页

作者：郭紫雯于汝佳曹玥南京医科大学基础医学院江苏南京211166 南京大学化学化工学院江苏南京210023

固态纳米孔道单分子分析技术因其尺寸可控、无标记、高通量等优点,在近几年得到了快速的发展,已经被广泛应用于金属离子、DNA、RNA、蛋白质等物质的研究中。本文主要聚焦基于氮化硅固态纳米孔道的单颗粒散射光谱分析技术,简要介绍了近... 详细信息

固态纳米孔道单分子分析技术因其尺寸可控、无标记、高通量等优点,在近几年得到了快速的发展,已经被广泛应用于金属离子、DNA、RNA、蛋白质等物质的研究中。本文主要聚焦基于氮化硅固态纳米孔道的单颗粒散射光谱分析技术,简要介绍了近年来的研究进展,总结了固态纳米孔道的制备方法、单分子分析原理以及光电协同应用,并对拉曼散射光谱技术在固态纳米孔道单分子检测技术进行了展望。

关键词：固态纳米孔道单分子检测散射光谱暗场散射

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影响松材线虫传播的生物化学物质

江苏林业科技 2024年第2期51卷 53-57页

作者：宋孜闻于杨江苏省林业科学研究院江苏南京211153 纵腾集团荷兰北荷兰省143729EP

松树萎蔫病是导致我国松林资源严重受损的主要原因之一,该病的传播主要是由于健康松树被寄生于媒介昆虫上的松材线虫侵染所引发。该文介绍了影响媒介昆虫松褐天牛携带松材线虫传播的生物化学物质。在松材线虫进入媒介昆虫体内过程中,脂... 详细信息

松树萎蔫病是导致我国松林资源严重受损的主要原因之一,该病的传播主要是由于健康松树被寄生于媒介昆虫上的松材线虫侵染所引发。该文介绍了影响媒介昆虫松褐天牛携带松材线虫传播的生物化学物质。在松材线虫进入媒介昆虫体内过程中,脂肪酸、挥发性萜烯、碳氢化合物和CO_(2)发挥重要调控作用;在媒介昆虫寻找寄主过程中,会受到寄主植物产生的挥发物质萜烯和碳氢化合物的影响;松材线虫体内的中性脂质含量高低是决定松材线虫从媒介昆虫脱落挥发物释放的化学开关。

关键词：松材线虫媒介昆虫松褐天牛生物化学物质

Design of a Web Crawler for Water Quality Monitoring Data and Data Visualization

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Journal on Big Data 2022年第2期4卷 135-143页

作者： ziwen yu Jianjun Zhang Wenwu Tan Ziyi Xiong Peilun Li Liangqing Meng Haijun Lin Guang Sun Peng Guo College of Engineering and Design Hunan Normal UniversityChangsha410081China LIHERO Technology(Hunan)Co. Ltd.Changsha410205China Big Data Institute Hunan University of Finance and EconomicsChangsha410205China University Malaysia Sabah Sabah88400Malaysia

Many countries are paying more and more attention to the protection of water resources at present,and how to protect water resources has received extensive attention from society.Water quality monitoring is the key work to water resources protection.How to efficiently collect and analyze water quality monitoring data is an important aspect of water resources protection.In this paper,python programming tools and regular expressions were used to design a web crawler for the acquisition of water quality monitoring data from Global Freshwater Quality Database(GEMStat)sites,and the multi-thread parallelism was added to improve the efficiency in the process of downloading and parsing.In order to analyze and process the crawled water quality data,Pandas and Pyecharts are used to visualize the water quality data to show the intrinsic correlation and spatiotemporal relationship of the data.

关键词： Water quality monitoring data web crawler data visualization

Gain and phase errors active calibration method based on neural network for arrays with arbitrary geometry

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The Journal of China Universities of Posts and Telecommunications 2023年第2期30卷 8-17页

作者： Han ziwen Zhang Zhi Guo yu State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing 100876China

The manifold matrix of the received signals can be destroyed when the array is with the gain and phase errors,which will affect the performance of the traditional direction of arrival(DOA)estimation approaches.In this paper,a novel active array calibration method for the gain and phase errors based on a cascaded neural network(GPECNN)was proposed.The cascaded neural network contains two parts:signal-to-noise ratio(SNR)classification network and two sets of error estimation subnetworks.Error calibration subnetworks are activated according to the output of the SNR classification network,each of which consists of a gain error estimation network(GEEN)and a phase error estimation network(PEEN),respectively.The disadvantage of neural network topology architecture is changing when the number of array elements varies is addressed by the proposed group calibration strategy.Moreover,due to the data characteristics of the input vector,the cascaded neural network can be applied to arrays with arbitrary geometry without repetitive training.Simulation results demonstrate that the GPECNN not only achieves a better balance between calibration performance and calibration complexity than other methods but also can be applied to arrays with different numbers of sensors or different shapes without repetitive training.

关键词： active array calibration cascaded neural network direction of arrival(DOA)estimation

Asian,regional,and national burdens of respiratory tract cancers and associated risk factors from 1990 to 2019:A systematic analysis for the global burden of disease study 2019

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2023年第4期1卷 249-258页

作者： Ran Zhong Xiuyu Cai Jianfu Li Peiling Chen Runchen Wang Xinting Li Feng Li Shan Xiong Caichen Li Huiting Wang Yang Xiang Shuting Zhan ziwen yu Haixuan Wang Chunyan Li Lixuan Lin Wenhai Fu Xin Zheng Shen Zhao Kang Zhang Jianxing He Department of Thoracic Surgery and Oncology The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhouGuangdong 510000China Guangzhou Medical University GuangzhouGuangdong 510000China Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510050China The First People Hospital of Zhaoqing ZhaoqingGuangdong 526000China Center for Biomedicine and Innovations Faculty of MedicineMacao University of Science and TechnologyMacao 999078China

Background:Respiratory cancer is the leading cause of cancer-related deaths worldwide,but its statistics vary between the East and West.This study aimed to estimate the burdens of tracheal,bronchus,and lung(TBL)cancer and larynx cancer and their attributable risks from 1990 to 2019 in Asia,and at regional and national levels.Methods:This research evaluated the incidence,mortality,years lived with disability,years of life lost,and disability-adjusted life years(DALYs)for respiratory tract cancers using the Global Burden of Diseases,Injuries,and Risk Factors Study(GBD)2019 database.Age-standardized rates were calculated for TBL cancer from 1990 to 2019,adjusted for smoking and socio-demographic index(SDI).Deaths from TBL cancer and larynx cancer attributable to each risk factor were estimated for 33 Asian countries.Results:The age-standardized incidence and death rates for TBL cancer in Asia declined from 2010 to 2019,while the incidence rate of larynx cancer increased.Smoking was the leading specific risk factor for deaths from both TBL and larynx cancers.The burden of TBL cancer in Asian countries was influenced by SDI and smoking,particularly among males in Central Asia.Deaths,DALYs,and incidences of larynx cancer in East Asia had not changed significantly over the past 30 years,but showed slight downward trends in males and both sexes combined,and an upward trend in females in recent years.Conclusions:The past decade saw increases in numbers of incident cases and deaths from TBL cancer and larynx cancer in Asia.SDI and smoking were the main factors influencing the disease burden of TBL cancer in Asian countries.This study highlights the need for tailored cancer control programs to address the burden of respiratory tract cancers in different Asian countries.

关键词： Tracheal,bronchus,and lung(TBL)cancer Larynx cancer Smoking Socio-demographic index Global burden of diseases,injuries,and risk factors study(GBD) Asia

Siglec-15与肿瘤免疫关系的研究进展

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中华肿瘤防治杂志 2024年第10期31卷 632-636页

作者：刘子文李涛于源滋付国斌胡锦华山东第一医科大学附属省立医院消化内科山东第一医科大学附属省立医院肿瘤科

目的总结唾液酸结合免疫球蛋白样凝集素-15(Siglec-15)在肿瘤免疫领域的研究进展，以期为肿瘤免疫治疗提供新的理论依据。方法以“Siglec-15、肿瘤、免疫调节、信号通路、免疫治疗”为中文关键词，以“Siglec-15、tumor、immunoregula... 详细信息

目的总结唾液酸结合免疫球蛋白样凝集素-15(Siglec-15)在肿瘤免疫领域的研究进展，以期为肿瘤免疫治疗提供新的理论依据。方法以“Siglec-15、肿瘤、免疫调节、信号通路、免疫治疗”为中文关键词，以“Siglec-15、tumor、immunoregulation、signal pathway、immunotherapy”为英文关键词，系统检索中国知网和PubMed数据库2013-01-01-2023-12-31发表的相关文献。纳入标准：(1)Siglec-15的发现及分子特征；(2)Siglec-15在肿瘤免疫调节中的作用机制及相关信号通路；(3)Siglec-15的免疫治疗前景。排除标准：低质量以及数据陈旧的文献。最终纳入51篇文献进行分析。结果现有研究表明，Siglec-15在多种肿瘤细胞以及肿瘤相关巨噬细胞(TAM)中均高表达。其通过抑制T细胞的活化和增殖来诱导肿瘤的免疫逃逸。此外，Siglec-15还可通过介导特定的分子信号通路调节肿瘤微环境。目前，多种具有抗肿瘤活性的Siglec-15相关药物正在积极开发中，这为肿瘤免疫治疗提供了新的思路。结论近年来，随着程序性死亡受体1(PD-1)及其配体(PD-L1)抗体耐药性问题的出现，Siglec-15可被认为是替代或协同抗PD-1/PD-L1治疗的新兴靶点，有望发挥重要作用。

关键词： Siglec-15 肿瘤免疫调节信号通路免疫治疗

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紫楠种子休眠原因和快速解除方法研究

热带亚热带植物学报 2024年第3期32卷 387-396页

作者：林秀灵史锋厚余中华龙字文蒋学莉沈永宝南京林业大学林学院南京210037 广东生态工程职业学院园艺与食品学院广州510000 常州市林业工作站江苏常州213161 镇江市林业工作站江苏镇江212423

通过了解紫楠(Phoebe sheareri)种子休眠原因,采取机械、酸碱腐蚀、层积处理(5℃~25℃)等措施研究解除种子休眠的最佳方法。结果表明,种皮透水性差是抑制紫楠种子萌发的主要原因,种子休眠类型为物理休眠。酸碱腐蚀处理未能有效促进种子... 详细信息

通过了解紫楠(Phoebe sheareri)种子休眠原因,采取机械、酸碱腐蚀、层积处理(5℃~25℃)等措施研究解除种子休眠的最佳方法。结果表明,种皮透水性差是抑制紫楠种子萌发的主要原因,种子休眠类型为物理休眠。酸碱腐蚀处理未能有效促进种子的萌发,浓硫酸和氢氧化钠处理种子不同时间(1~25 min)后,种子发芽率提高了33%~55%,但种子出现严重的伤害现象,其腐烂率高达30%~97%。机械处理和层积处理均能有效打破种子的休眠,其中机械处理以去种皮处理效果最好,种子发芽率和发芽势分别提高了99.33%和76.00%,但操作耗时、费力。层积处理以25℃暖温层积45 d、25℃/15℃和5℃/25℃/5℃变温层积60 d效果较好,其发芽率达89%~93%,发芽势达79%~83%,且各层积处理间发芽率、发芽势没有差异;但与暖温层积相比,变温层积所需层积时间更长,种子腐烂率更高。25℃暖温层积45 d是破除紫楠种子休眠的最佳方法。

关键词：紫楠种子休眠解除休眠种子发芽层积

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基于仪器法的肼类推进剂快速分析技术研究进展

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化学推进剂与高分子材料 2024年第3期22卷 8-13页

作者：李明徐泽龙黄希云于舒婷侯子文酒泉卫星发射中心甘肃酒泉732750

总结了当前应用于肼类推进剂分析的仪器分析技术,包括用于主要组分含量测定的自动电位滴定法、气相色谱分析法和近红外光谱法,以及用于微量组分含量测定的分光光度法和比色法等,讨论了目前在分析仪器、方法、流程以及误差分析等方面的... 详细信息

总结了当前应用于肼类推进剂分析的仪器分析技术,包括用于主要组分含量测定的自动电位滴定法、气相色谱分析法和近红外光谱法,以及用于微量组分含量测定的分光光度法和比色法等,讨论了目前在分析仪器、方法、流程以及误差分析等方面的不足和改良,并展望了未来有望提高快速分析能力的技术方法。

关键词：肼液体推进剂质量检验仪器分析快速化验