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基于肠道菌群探讨乳腺癌从脾论治的作用机制

中国临床研究 2024年第5期37卷 788-792页

作者：孙心悦葛梦迪王宽宇贺紫薇黑龙江中医药大学黑龙江哈尔滨150040 哈尔滨市中医医院黑龙江哈尔滨150076 黑龙江中医药大学附属第一医院外二科黑龙江哈尔滨150040

乳腺癌发病率位居女性恶性肿瘤发病率之首。近年来越来越多的研究表明肠道微生态与乳腺癌的发生密切相关。中医理论中“从脾论治”涉及“脾主运化、脾主升清、脾藏意主思、脾为之卫”诸多方面,肠道菌群与上述生理职能具有颇高相似性。... 详细信息

乳腺癌发病率位居女性恶性肿瘤发病率之首。近年来越来越多的研究表明肠道微生态与乳腺癌的发生密切相关。中医理论中“从脾论治”涉及“脾主运化、脾主升清、脾藏意主思、脾为之卫”诸多方面,肠道菌群与上述生理职能具有颇高相似性。故本文基于肠道菌群探讨从脾论治乳腺癌的科学内涵,为中医学从脾论治乳腺癌提供分子机制层面的依据,以期拓宽乳腺癌的中西医诊疗思路。

关键词：肠道菌群乳腺癌从脾论治雌激素表观遗传微生物群

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死盒蛋白5在乳腺癌的研究进展

中国临床研究 2024年第3期37卷 339-343页

作者：葛梦迪贺紫薇杨磊刘成祥陈静王宽宇黑龙江中医药大学研究生院黑龙江哈尔滨150040 黑龙江省中医药科学院外科黑龙江哈尔滨150036 黑龙江中医药大学附属第一医院外科黑龙江哈尔滨150040

乳腺癌作为威胁我国女性生存的恶性肿瘤,其发病率逐年提升并呈年轻化趋势,控制肿瘤细胞的增殖、侵袭、转移是治疗的重点以及难点。死盒蛋白5(DDX5)作为一种调节RNA生物功能的加工因子,是参与调控RNA剪切、核糖体生物功能、转录、翻译的... 详细信息

乳腺癌作为威胁我国女性生存的恶性肿瘤,其发病率逐年提升并呈年轻化趋势,控制肿瘤细胞的增殖、侵袭、转移是治疗的重点以及难点。死盒蛋白5(DDX5)作为一种调节RNA生物功能的加工因子,是参与调控RNA剪切、核糖体生物功能、转录、翻译的多维功能蛋白,可通过基因扩增、激活致癌因子、增强上皮间质转化、重组细胞骨架来促进乳腺癌增殖、侵袭、转移,同时可作为乳腺癌预后与复发的标志物。本文综述了DDX5在促进乳腺癌增殖、侵袭、转移中的作用,其对乳腺癌分型、预后、复发的意义以及现有的中药干预DDX5影响乳腺癌的临床报道,以期为乳腺癌新的靶向治疗思路提供新角度。

关键词：死盒蛋白5 乳腺癌预后增殖侵袭转移人参皂苷

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腐蚀镀锌输电塔时变承载能力研究

四川电力技术 2024年第3期47卷 46-51页

作者：杨子烨朱超杰施伟国杨婷何紫薇何畅国网上海市电力公司上海200122 中南大学土木工程学院湖南长沙410075

为了研究材料腐蚀作用下输电塔的安全性,通过数值模拟方法结合实验数据建立了输电塔镀锌钢材腐蚀后承载力退化模型。腐蚀效应通过在模型中引入人工腐蚀试验得到的材料力学参数和本构模型实现。在精细化有限元建模基础上对结构各关键点... 详细信息

为了研究材料腐蚀作用下输电塔的安全性,通过数值模拟方法结合实验数据建立了输电塔镀锌钢材腐蚀后承载力退化模型。腐蚀效应通过在模型中引入人工腐蚀试验得到的材料力学参数和本构模型实现。在精细化有限元建模基础上对结构各关键点施加风荷载,以逐级加载方法计算不同腐蚀程度的模型关键点和塔腿的最大响应确定结构极限承载力。结果表明,由于腐蚀导致结构质量、刚度下降,输电塔基频随着腐蚀时间的增加不断降低,在镀锌钢材腐蚀周期为1200 h和4200 h时,输电塔承载力分别退化4.2%和5.3%。

关键词：风荷载腐蚀输电塔有限元模型

Tailoring the mercaptan ligands for high performance inverted perovskite solar cells with efficiency exceeding 21%

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Journal of Energy Chemistry 2021年第9期30卷 169-177页

作者： Shuangjie Wang ziwei he Jiabao Yang Tongtong Li Xingyu Pu Jian Han Qi Cao Bingyu Gao Xuanhua Li Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

Interface passivation engineering has been recognized as an effective way to simultaneously contribute to the optoelectronic characteristic and stability of perovskite solar cells(PSCs). herein, a p-conjugated dual-ligand 1,4-phenylmercaptan(PHMT) is explored to rationally tailor the surface of perovskite *** experimental and theoretical results show that the PHMT presents planar structure and obvious electron delocalization characteristics, which allow it to anchor on the surface of perovskite with a certain orientation, thereby promoting the transport of interface charge. Moreover, the two sulfhydryl groups in PHMT reduce the trap density of the perovskite film by passivating under-coordinated lead ***, the PHMT-modified inverted device based on MAPbI_(3)(MA: methylammonium) achieves enhanced efficiency from 18.11%(control) to 21.11%, along with the ambient stability up to 3500 *** being placed at 85 °C for 500 h or illuminated for 600 h, the modified device remains over 89%or 86% of initial efficiency. This discovery opens a new window for the choice of passivators to improve the performance of PSCs.

关键词： Perovskite solar cells Stability Dual-ligand Passivation Mercaptan

以泉香型白酒为酒基的秋梨杏仁露酒设计及风味研究

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中国酿造 2024年第9期43卷 196-202页

作者：王鸣浩张彦青张晨曦贺梓薇贾若鸣李菲菲贾士儒天津科技大学生物工程学院天津300457 中国食品发酵工业研究院有限公司北京100015 济南趵突泉酿酒有限责任公司山东济南250115

为了了解以泉香型白酒为酒基的植物类露酒的风味物质,该研究首先通过单因素与正交试验设计相结合的方法优化秋梨杏仁露酒勾调工艺,再采用顶空固相微萃取-气质联用(HS-SPME-GC-MS)分析方法对秋梨杏仁露酒中的挥发性风味化合物进行分析,... 详细信息

为了了解以泉香型白酒为酒基的植物类露酒的风味物质,该研究首先通过单因素与正交试验设计相结合的方法优化秋梨杏仁露酒勾调工艺,再采用顶空固相微萃取-气质联用(HS-SPME-GC-MS)分析方法对秋梨杏仁露酒中的挥发性风味化合物进行分析,利用相对香气活度值(ROAV)筛选出特征挥发性风味化合物,并与基酒比较。结果表明,秋梨杏仁露酒的最佳勾调工艺为杏仁浸提液7%、玉竹浸提液5%、枸杞浸提液6%、秋梨蒸馏液8%。在此优化条件下,秋梨杏仁露酒香气淡雅,层次突出,口感绵柔,酒体饱满,感官评分为90分。秋梨杏仁露酒样品共检出80种主要挥发性风味化合物,其中有25种特征风味化合物。与基酒相比,新增酯类、醇类、酸类、醛类、酚类和酮类的数量分别为20种、7种、5种、5种、4种和4种。秋梨杏仁露酒的重要贡献香气物质(ROAV≥10)共12种构成该露酒的香气骨架,而苯甲醛和异戊醛是该款露酒特有香气贡献化合物。

关键词：露酒感官特征顶空固相微萃取气质联用挥发性香气物质相对香气活度值

Constructing Al@C-Sn pellet anode without passivation layer for lithium-ion battery

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 552-561页

作者： Kangzhe Cao Sitian Wang Yanan he Jiahui Ma ziwei Yue Huiqiao Liu College of Chemistry and Chemical Engineering Xinyang Normal UniversityXinyang 464000China Xinyang Key Laboratory of Low-Carbon Energy Materials Xinyang 464000China henan Province Key Laboratory of Utilization of Non-Metallic Mineral in the South of henan Xinyang 464000China

Al is considered as a promising lithium-ion battery(LIBs)anode materials owing to its high theoretical capacity and appropri-ate lithation/de-lithation ***,its inevitable volume expansion causes the electrode structure instability,leading to poor cyclic ***’s worse,the natural Al2O3 layer on commercial Al pellets is always existed as a robust insulating barrier for elec-trons,which brings the voltage dip and results in low reversible ***,this work synthesized core-shell Al@C-Sn pellets for LIBs by a plus-minus *** this proposal,the natural Al2O3 passivation layer is eliminated when annealing the pre-introduced SnCl2,meanwhile,polydopamine-derived carbon is introduced as dual functional shell to liberate the fresh Al core from re-oxidization and alle-viate the volume *** from the addition of C-Sn shell and the elimination of the Al2O3 passivation layer,the as-prepared Al@C-Sn pellet electrode exhibits little voltage dip and delivers a reversible capacity of 1018.7 mAh·g^(-1) at 0.1 A·g^(-1) and 295.0 mAh·g^(-1) at 2.0 A·g^(-1)(after 1000 cycles),***,its diffusion-controlled capacity is muchly improved compared to those of its counterparts,confirming the well-designed nanostructure contributes to the rapid Li-ion diffusion and further enhances the lithium storage activity.

关键词： lithium-ion battery high-performance anode aluminum passivation layer plus-minus strategy

Surface modification with ionic liquid for efficient CsPbI2Br perovskite solar cells

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Journal of Materiomics 2021年第5期7卷 1039-1048页

作者： Xingyu Pu Jian Han Shuangjie Wang Hui Zhou Qi Cao Jiabao Yang ziwei he Xuanhua Li State Key Laboratory of Solidification Processing Center for Nano Energy MaterialsSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXián710072China Northwestern Polytechnical University-Queen Marry University of London(NPU-QMUL)Joint Research Institute of Advanced Materials and Structures(JRI-AMAS)Xián710072China

The presence of numerous trap states on the perovskite surface severely affects the performance of inorganic CsPbI_(2)Br perovskite solar *** modification has been proven to be an effective strategy to passivate the surface trap states of CsPbI_(2)Br ***,most modifiers behave high volatility and insulation,not enough to further develop the CsPbI_(2)Br solar ***,an ionic liquid of 1-viny-3-propionate ethyl imidazolium chloride([PEVIM]Cl)is applied to modify the CsPbI_(2)Br film surface,yielding a compact film with enhanced *** surface trap states of CsPbI_(2)Br film are effectively passivated via the interaction between carbonyl group of[PEVIM]Cl and uncoordinated metal cations of CsPbI_(2)Br perovskite,leading to charge recombination suppression and charge transport ***,the power conversion efficiency(PCE)of[PEVIM]Cl modified CsPbI_(2)Br device is obviously enhanced from 12.49% to 14.19% with an improved open-circuit voltage of 1.160 ***,the non-encapsulated device presents excellent thermal stability,still maintaining 91%PCE when heated at 85℃ in nitrogen atmosphere for 360 ***,the non-encapsulated device degrades only 11% PCE after stored at 50% relative humidity for 960 *** simple and efficient approach provides a promising direction to fabricate high-efficiency and stable inorganic perovskite devices.

关键词： Inorganic perovskites CsPbI_(2)Br Ionic liquid Surface modification High efficiency

Nitric oxide removal from flue gas coupled with the Fe^(Ⅱ)EDTA regeneration by ultraviolet irradiation

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Chinese Journal of Chemical Engineering 2024年第4期68卷 133-143页

作者： Yuan Xu ziwei Liu Ying Dai Jinbo Ouyang Zhuyao Li Yuling Zhu Jianhua Ding Feiqiang he School of Chemistry and Materials Science East China University of TechnologyNanchang 330013China

During wet complexation denitrification of flue gas,Fe^(Ⅱ)EDTA regeneration,also known as reducing Fe^(Ⅱ)EDTA and Fe^(Ⅱ)EDTA-nitric oxide(NO)to Fe^(Ⅱ)EDTA,is *** this paper,ultraviolet(UV)light was used for the first time to reduce Fe^(Ⅱ)*** experimental result demonstrated that Fe^(Ⅱ)EDTA-NO reduction rate increased with UV power increasing,elevated temperature,and initial Fe^(Ⅱ)EDTA-NO concentration ***^(Ⅱ)EDTA-NO reduction rate increased first and then decreased as pH value increased(2.0-10.0).Fe^(Ⅱ)EDTA-NO reduction with UV irradiation presented a first order reaction with respect to Fe^(Ⅱ)*** with other Fe^(Ⅱ)EDTA regeneration methods,Fe^(Ⅱ)EDTA regeneration with UV show more superiority through comprehensive consideration of regeneration rate and ***,NO absorption experiment by Fe^(Ⅱ)EDTA solution with UV irradiation confirmed that UV can significantly promote the NO removal performance of Fe^(Ⅱ)*** oxygen concentration(3%(vol))and acidic environment(pH=4)was favorable for NO *** UV power increasing as well as temperature decreasing,NO removal efficiency *** addition,the mechanism research indicates that NO from flue gas is mostly converted to NO_(2)-,NO_(3)-,NH_(4)^(+),N_(2),and N_(2)O with Fe^(Ⅱ)EDTA absorption liquid with UV *** strengthens NO removal in Fe^(Ⅱ)EDTA absorption liquid by forming a synergistic effect of ***,compared with NO removal methods with Fe^(Ⅱ)EDTA,Fe^(Ⅱ)EDTA combined UV system shows prominent technology advantage in terms of economy and secondary pollution.

关键词： Fe^(II)EDTA Ultraviolet Flue gas Nitric oxide Regeneration Absorption

A comprehensive review on surface modifications of black phosphorus using biological macromolecules

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Frontiers of Materials Science 2024年第2期18卷 37-59页

作者： Chaiqiong Guo Xuhong he Xuanyu Liu Yuhui Wang Yan Wei ziwei Liang Di Huang Department of Biomedical Engineering Research Center for Nano-biomaterials&Regenerative MedicineCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Black phosphorus(BP),a novel two dimensional material,exhibits remarkable photoelectric characteristics,ultrahigh photothermal conversion efficiency,substantial specific surface area,high carrier mobility,and tunable band gap *** attributes have positioned it as a promising candidate in domains such as energy,medicine,and the ***,its vulnerability to light,oxygen,and water can lead to rapid degradation and loss of crystallinity,thereby limiting its synthesis,preservation,and ***,BP has demonstrated cytotoxic tendencies,substantially constraining its viability in the realm of ***,the imperative for surface modification arises to bolster its stability and biocompatibility,while concurrently expanding its utility *** macromolecules,integral components of living organisms,proffer innate advantages over chemical agents and polymers for the purpose of the BP *** review comprehensively surveys the advancements in utilizing biological macromolecules for the modifications of *** doing so,it aims to pave the way for enhanced stability,biocompatibility,and diversified applications of this material.

关键词： blackphosphorus tumor therapy biocompatibility surface modification biomacromolecule