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Late polymicrobial transjugular intrahepatic portosystemic shunt infection in a liver transplant patient:A case report

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World journal of Hepatology 2022年第4期14卷 846-853页

作者： Irene De La Caridad Perez ziv j haskal john I Hogan Curtis K Argo Department of Medicine University of Virginia Medical CenterCharlottesvilleVA 22903United States Department of Radiology and Medical Imaging Division of Vascular and Interventional RadiologyUniversity of Virginia Medical CenterCharlottesvilleVA 22903United States Department of Medicine Division of Infectious Diseases and International HealthUniversity of Virginia Medical CenterCharlottesvilleVA 22903United States Department of Medicine Division of Gastroenterology and HepatologyUniversity of Virginia Medical CenterCharlottesvilleVA 22903United States

BACKGROUND Infection of a transjugular intrahepatic portosystemic shunt(TIPS)stent is a rare and serious complication that most commonly occurs during TIPS creation and *** typically present with recurrent bacteremia due to shunt occlusion or *** date there are approximately 58 cases *** present a patient diagnosed with late polymicrobial TIPS infection five years following TIPS *** SUMMARY A 63-year-old female status-post liver transplant with recurrent cirrhosis and portal hypertension presented with sepsis and recurrent extended-spectrum betalactamase Escherichia coli *** tomography of the abdomen revealed an occluded TIPS with thrombus extension into the distal right portal vein,and focal thickening of the cecum and ascending *** revealed patchy ulcers in these areas with histopathology demonstrating ulcerated colonic mucosa with fibrinopurulent *** thrombectomy and revision revealed infected-appearing *** initially cleared her infection with antibacterial therapy and TIPS revision;however,soon after,she developed Enterobacter cloacae bacteremia and Candida glabrata and *** fungemia with recurrent TIPS *** remained on antifungal therapy indefinitely and later developed vancomycin-resistant Enterococcus faecium with recurrent TIPS *** option of liver re-transplant for removal of the infected TIPS was not offered given her critical illness and complex shunt *** patient became intolerant to linezolid and elected hospice *** Clinicians should be aware that TIPS superinfection may occur as long as five years following TIPS creation in an immunocompromised patient.

关键词： Transjugular intrahepatic portosystemic shunt Endotipsitis Colitis Liver cirrhosis Liver transplantation Case report

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Precision medicine in Parkinson's disease patients with LRRK2 and GBA risk variants-Let's get even more personal

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Translational Neurodegeneration 2020年第4期9卷 499-508页

作者： Christian U.von Linstow ziv Gan-Or Patrik Brundin Center for Neurodegenerative Science Van Andel InstituteGrand RapidsMI 49503USA Montreal Neurological Institute McGill UniversityMontrealQC H3A 2B4Canada Department of Human Genetics McGill UniversityMontrealQC H3A 0C7Canada Department of Neurology and Neurosurgery McGill UniversityMontrealQC H3A 2B4Canada

Parkinson's disease(PD)is characterized by motor deficits and a wide variety of non-motor *** age of onset,rate of disease progression and the precise profile of motor and non-motor symptoms display considerable individual ***,the loss of substantia nigra dopaminergic neurons is a key feature of *** vast majority of PD patients exhibit alpha-synuclein aggregates in several brain regions,but there is also great variability in the neuropathology between *** the dopamine replacement therapies can reduce motor symptoms,current therapies do not modify the disease *** clinical trials using a wide variety of approaches have failed to achieve disease *** has been suggested that the heterogeneity of PD is a major contributing factor to the failure of disease modification trials,and that it is unlikely that a single treatment will be effective in all *** medicine,using drugs designed to target the pathophysiology in a manner that is specific to each individual with PD,has been suggested as a way *** patients can be stratified according to whether they carry one of the risk variants associated with elevated PD *** this review we assess current clinical trials targeting two enzymes,leucine-rich repeat kinase 2(LRRK2)and glucocerebrosidase(GBA),which are encoded by two most common PD risk *** the details of the pathogenic processes coupled to the different LRRK2 and GBA risk variants are not fully understood,we ask if these precision medicinebased intervention strategies will prove"precise"or"personalized"enough to modify the disease process in PD *** also consider at what phases of the disease that such strategies might be effective,in light of the genes being primarily associated with the risk of developing disease in the first place,and less clearly linked to the rate of disease ***,we critically evaluate the notion that therapies target

关键词： Parkinson's disease Precision medicine Personalized medicine Glucocerebrosidase GCase Leucine-rich repeat kinase-2 Dopamine PD drug trials PD risk variants

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Informing management of rare species with an approach combining scenario modeling and spatially explicit risk assessment

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Ecosystem Health and Sustainability 2015年第6期1卷 9-26页

作者： jennifer M.Duggan Bradley A.Eichelberger Shan Ma joshua j.Lawler Guy ziv School of Environmental and Forest Sciences University of WashingtonSeattleWashington 98195 USA Natural Capital Project Stanford UniversityStanfordCalifornia 94305 USA School of Geography University of LeedsLeeds LS29J TUnited Kingdom Division of Science and Environmental Policy California State University Monterey BaySeasideCalifornia 93955 USA

Wildlife managers are tasked with identifying and managing stressors that threaten persistence of *** demonstrate an approach to land-use planning that combines scenario modeling and ecological risk assessment to map and quantify risk to population persistence for three rare prairie species in Washington State,*** corroboration of model output,we found that of the management scenarios considered,only a scenario with year-round restrictions on use of off-road vehicles,digging,and camping enforced in all potential habitat reduces risk to the *** risk is focused primarily in two patches of prairie habitat in our study area,indicating stringent restrictions need not be applied ***,one area is not easily accessed by two of the three species considered,suggesting reintroductions to suitable but inaccessible habitat may play an important role in management of these *** analyses suggest changes in land use and management that might improve habitat for rare species,with options for minimizing monetary and social *** the proposed approach relies on hypothetical management scenarios and uses a model flexible in data requirements to provide spatially explicit output,it can be used to inform adaptive management of rare species in diverse land-planning processes and will be especially useful when management decisions must be made under time or cost constraints.

关键词： adaptive management land-useplanning Mazamapocketgopher(Thomomysmazama) military training PugetSoundprairie rarespeciesmanagement riskassessment scenariomodeling Scotchbroom(Cytisus scoparius) spatiallyexplicitmodel StreakedHornedLark(Eremophilaalpestrisstrigata) Taylor’scheckerspot butterfly(Euphydryasedithataylori)

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双胞胎不一致性：胎儿脑MRI容量与神经发育结果的相关性研究

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国际医学放射学杂志 2021年第6期 740-741页

作者： T.Halevy M.Nezer j.Halevy T.ziv-Baran E.Barzilay E.Katorza 郭虹

目的本研究采用MRI来比较(宫内发育)不一致双胞胎的大脑容量,并通过验证性测试来检查他们出生后的神经发育情况。方法该研究为三级医院单中心前瞻性按时

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Deep Level Defect in Quasi-Vertically Oriented CuSbS2 Thin Film

Deep Level Defect in Quasi-Vertically Oriented CuSbS2 Thin F...

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第七届新型太阳能电池材料科学与技术学术研讨会

作者： Yuanfang Zhang jialiang Huang Xueyun Zhang Robert Lee Chin Michael P.Nielsen Germain Rey Yiyu Zeng Henner Kempwerth ziv Hameiri Nicholas j.Ekins-Daukes Martin A.Green Xiaojing Hao Australian Centre for Advanced Photovoltaics School of Photovoltaic and Renewable Energy EngineeringUniversity of New South Wales

The anomalous optoelectronic properties of quasi-vertical orientated Chalcostibite CuSbS2 thin film synthesized on glass substrate was studied in *** well separated absorption edges of CuSbS are identified by photothermal-deflection spectroscopy(PDS) at 1.48 eV and 0.90 *** formation mechanism of the inferred edge is found to be crystal orientation *** properties of the 0.9 eV absorption edge was detailed investigated using temperature-dependent photoluminescence(TDPL) characterizations,which ascribe the origin of this phenomenon to a deep level defect state near the mid-bandgap of CuSbS.

关键词： CuSbS2 Quasi-Vertical Orientation Deep Level Defect

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