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基于生物信息学分析及机器学习方法筛选早发型子痫前期的特征基因及相关免疫细胞浸润分析

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中华围产医学杂志 2024年第1期27卷 51-61页

作者：武紫彤郑媛媛丁新首都医科大学附属北京妇产医院(北京妇幼保健院)产科北京100026

目的通过生物信息学分析及机器学习方法探索早发型子痫前期(early-onset pre-eclampsia, EOSP)的特征基因及相关免疫细胞浸润分析。方法在基因表达综合(Gene Expression Omnibus, GEO)数据库中, 以"early-onset pre-eclampsia"为检索词,... 详细信息

目的通过生物信息学分析及机器学习方法探索早发型子痫前期(early-onset pre-eclampsia, EOSP)的特征基因及相关免疫细胞浸润分析。方法在基因表达综合(Gene Expression Omnibus, GEO)数据库中, 以"early-onset pre-eclampsia"为检索词, 检索EOSP与正常妊娠的胎盘组织mRNA序列。采用R语言对芯片数据进行背景校正、标准化、汇总和探针质量控制, 下载注释包进行ID转换, 提取表达矩阵, 使用limma软件包分析去除批次效应后的元数据中EOSP与正常妊娠之间差异表达基因(differentially expressed genes, DEGs)。通过支持向量机递归特征消除(support vector machine-recursive feature elimination, SVM-RFE)分析和LASSO回归模型识别特征基因。通过计算受试者工作特征曲线的曲线下面积(area under the curve, AUC)分析特征基因的诊断能力。然后回顾性收集2022年1月1日至2023年2月28日在首都医科大学附属北京妇产医院分娩的15例EOSP及15例正常妊娠孕产妇的胎盘组织, 应用实时荧光定量聚合酶链反应和蛋白质印迹法验证特征基因的表达情况, 并在验证集中进一步验证。最后, 使用CIBERSORT分析EOSP中免疫细胞浸润的相对比例。组间差异分析采用t检验。结果共检索获得3个基因数据集, 包括GSE44711(EOSP与正常妊娠各8例)、GSE74341(EOSP与正常妊娠分别为7例和5例)及GSE190639(EOSP与正常妊娠各13例), 合并GSE44711和GSE74341数据集后共筛选出了29个DEGs, 其中包括27个上调及2个下调的基因。GO富集分析结果显示这29个DEGs主要参与促性腺激素分泌、女性妊娠、调控内分泌过程、内分泌激素分泌及激素分泌的负调节过程。通过LASSO回归算法及SVM-RFE算法联合分析共筛选出8个特征基因, 分别为EBI3、HTRA4、TREML2、TREM1、NTRK2、ANKRD37、CST6及ARMS2;定量逆转录聚合酶链反应和蛋白质印迹法验证特征基因的表达差异均有统计学意义(P值均<0.05, CST6除外)。Logistic回归分析结果显示, TREML2、ANKRD37、NTRK2、TREM1、HTRA4、EBI3及ARMS2的AUC(95%CI)分别为0.979(0.918~1.000)、0.969(0.897~1.000)、0.969(0.892~1.000)、0.979(0.918~1.000)、0.990(0.954~1.000)、0.990(0.954~1.000)、0.903(0.764~1.000)。免疫细胞浸润结果显示EOSP胎盘组织中的M2巨噬细胞的浸润比例显著低于对照组(0.167±0.074与0.462±0.091, P=0.002), 但单核细胞和嗜酸性粒细胞的浸润比例明显高于对照组(0.201±0.004与0.085±0.006, 0.031±0.001与0.001±0.000, P值均<0.05);特征基因与浸润性免疫细胞之间的相关性分析结果显示7个特征基因与免疫细胞之间密切相关(P值均<0.05)。结论通过生物信息学分析及机器学习方法筛选出7个对于EOSP的早期诊断具有重要意义的特征基因, 为后续子痫前期的预防及治疗提供了新的研究靶点和依据。

关键词：早发型子痫前期计算生物学机器学习基因表达细胞微环境巨噬细胞

头颈部肿瘤患者核心症状及症状群的网络分析与护理对策

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中华护理杂志 2024年第7期59卷 828-834页

作者：刘美子安然吴子童高菲陈文凤中南大学湘雅医院临床护理学教研室长沙市410008

目的调查头颈部肿瘤患者症状的发生率及严重程度,构建头颈部肿瘤患者症状网络,识别网络中的核心症状和症状群。方法便利选取于2022年3月—10月在湖南省长沙市3所三级甲等医院住院的366例头颈部肿瘤患者,采用安德森症状评估量表-头颈部... 详细信息

目的调查头颈部肿瘤患者症状的发生率及严重程度,构建头颈部肿瘤患者症状网络,识别网络中的核心症状和症状群。方法便利选取于2022年3月—10月在湖南省长沙市3所三级甲等医院住院的366例头颈部肿瘤患者,采用安德森症状评估量表-头颈部调查症状的构成。通过探索性因子分析提取症状群,采用R软件构建症状严重程度网络和症状群网络并分析网络的中心性指标,包括强度、紧密度和中介度来确定核心症状和核心症状群。结果头颈部肿瘤患者治疗期间发生率最高的4个症状是口干(93.44%)、疲乏(89.07%)、食欲不振(86.34%)、吞咽或咀嚼困难(85.79%);最严重的症状是口干、食欲不振、口腔或咽喉黏液、吞咽或咀嚼困难。提取的4个症状群分别是口腔咽喉部症状群、胃肠道症状群、情绪睡眠症状群和病感行为症状群,累计方差贡献率为67.415%。症状严重程度网络中,口腔或咽喉黏液(rs=9.60)是强度最大的症状;症状群网络中,口腔或咽喉黏液(rs=1.20)、恶心(rs=1.00)、疲乏(rs=1.10)和嗜睡(rs=0.97)是4个症状群中强度最大的症状。结论口腔或咽喉黏液、恶心、疲乏和嗜睡是头颈部肿瘤患者症状群内的核心症状,口腔咽喉部症状群是核心症状群,建议医护人员基于核心症状和症状群制订干预措施,实施精准化症状管理,提高症状管理效率。

关键词：头颈部肿瘤核心症状症状群网络分析护理

Borophene-ZnO heterostructures:Preparation and application as broadband photonic nonvolatile memory

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Nano Research 2023年第4期16卷 5826-5833页

作者： Runsheng Liu Chuang Hou Xinchao Liang zitong wu Guoan Tai The State Key Laboratory of Mechanics and Control of Mechanical Structures and Laboratory of Intelligent Nano Materials and Devices of Ministry of Education College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China

High-performance photonic nonvolatile memory which combines data storage and photosensing can achieve low power consumption and ensure computational energy *** has been theoretically and experimentally proved to have synergistic effects between two materials,which can lead to promising electronic and optical properties for advanced optoelectronic ***,we report the preparation of borophene-ZnO heterostructures and their applications of broadband photonic nonvolatile *** memory shows a good switching ratio(5×10^(3))and long-term stability(3,600 s),which are superior to those of the pristine borophene or ZnO quantum dots(QDs).It is found that the memory shows a broad light response from ultraviolet(365 nm)to near infrared(850 nm).Besides,the SET voltage will decrease when the device is exposed to light,which can be attributed to the separation of holes and electrons in accelerating the formation of vacancy conductive *** work not only provides a promising material for next-generation photoelectric information,but also paves the way for borophene-based memory towards data storage devices.

关键词： borophene ZnO heterostructure photoluminescence(PL)quenching nonvolatile memory light control

Crystalline BC_(2)N quantum dots

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Nano Research 2023年第5期16卷 7837-7843页

作者： Pengyu Zhang Chuang Hou Wei Shao Runsheng Liu zitong wu Guoan Tai The State Key Laboratory of Mechanics and Control of Mechanical Structures and Laboratory of Intelligent Nano Materials and Devices of Ministry of Education College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China

Ternary materials composed of boron,carbon,nitrogen have drawn tremendous attention because of their suitable band gap,high carrier mobility,high thermal *** properties can effectively compensate for the deficiencies of other typical carbon-based and boron-based materials,such as graphene,borophene,hexagonal boron *** the theoretical progress has advanced the development of ternary materials,it is still a great challenge to synthesize the new nanostructures with good crystallinity and high yield at low dimensional ***,we report that BC_(2)N quantum dots(QDs)can be successfully prepared by in-situ two-step thermal decomposition of sodium cyanoborohydride in a hydrogen-rich *** results show that the as-prepared BC_(2)N QDs have good crystallinity and high *** BC_(2)N QDs have an average lateral size of 3.7 nm and an average thickness of 2.83 *** experimental results show that the QDs are semiconducting with an optical band gap of 2.15 ***,a fabricated BC_(2)N QDs-based nonvolatile memory shows a low SET operating voltage(0.74 V)and a high ON/OFF ratio(more than 1.74×10^(3))as well as good stability.

关键词： BC_(2)N quantum dots graphene borophene non-volatile memory

头颈癌放疗患者中性粒细胞与淋巴细胞比值的变化轨迹与重度放射性口腔黏膜炎的风险研究

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肿瘤综合治疗电子杂志 2024年第2期10卷 131-139页

作者：刘美子安然曾巧苗吴子童高菲陈文凤中南大学湘雅医院临床护理学教研室湖南长沙410008

目的识别头颈癌(head and neck cancer,HNC)患者放疗期间中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)的变化轨迹,分析NLR的变化轨迹与重度放射性口腔黏膜炎(radiotherapy-induced oral mucositis,RIOM)之间的关系。方法采用回顾性纵向研究设计,选取2022年7月至2023年8月在中南大学湘雅医院收治的180例接受放疗的HNC患者作为研究对象。分别在放疗前(T0)、放疗开始后1周(T1)、放疗开始后2周(T2)、放疗开始后3周(T3)、放疗开始后4周(T4)、放疗开始后5周(T5)和放疗开始后6周(T6)收集HNC放疗患者的中性粒细胞计数和淋巴细胞计数,并计算7个时间点的NLR。使用潜类增长模型和增长混合模型识别最佳的NLR轨迹亚组,采用Logistic回归分析判断NLR的轨迹亚组与重度RIOM之间的关系。结果 NLR变化轨迹存在基线低水平-快速增长组(Class-1组)和基线高水平-快速增长组(Class-2组)2个潜在亚组。Logistic回归分析显示,Class-2组发生重度RIOM的危险性是Class-1组的3.67倍。在控制混杂因素的干扰后,NLR轨迹亚组仍是发生重度RIOM的危险因素,且重度RIOM发生风险从3.67倍增加到27.0倍。结论 NLR能够作为预测重度RIOM的生物标志物。NLR较高的人群发生重度RIOM的风险更高。

关键词：头颈癌中性粒细胞与淋巴细胞比值重度放射性口腔黏膜炎变化轨迹潜类增长模型增长混合模型

Borophene-based materials for energy,sensors and information storage applications

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Nano Research Energy 2023年第2期2卷 89-113页

作者： Chuang Hou Guoan Tai Yi Liu zitong wu Xinchao Liang Xiang Liu The State Key Laboratory of Mechanics and Control of Mechanical Structures and Laboratory ofIntelligent Nano Materials and Devices of Ministry of Education College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China

Borophene,as a rising-star monoelemental two-dimensional(2D)material,has motivated great interest because of its novel properties,such as anisotropic plasmonics,high carrier mobility,mechanical compliance,optical transparency,ultrahigh thermal conductance,and *** properties make it an ideal candidate for use in the field of energy,sensors,and information *** by the realization of pioneering experimental works in 2015 and the follow-up synthesis experiments,a series of high-performance borophene-based devices in the fields,including supercapacitors,batteries,hydroelectric generators,humidity sensors,gas sensors,pressure sensors,and memories,have been experimentally reported in recent years,which are beneficial to the transition of borophene-based materials from experimental synthesis to practical ***,in addition to paying attention to the experimental preparation of borophene,significant efforts are needed to promote the advancement of related applications of *** this review,after providing a brief overview of borophene evolution and synthesis,we mainly summarize the applications of borophene-based materials in energy storage,energy conversion,energy harvesting,sensors,and information ***,based on the current research status,some rational suggestions and discussions on the issues and challenges in the future research direction are proposed.

关键词： borophene energy energy storage energy conversion sensors information storage

Gesture Recognition Based on Time-of-Flight Sensor and Residual Neural Network

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Journal of Computer and Communications 2024年第6期12卷 103-114页

作者： Yuqian Ma zitong Fang Wen Jiang Chang Su Yuankun Zhang Junyu wu Zhengjie Wang College of Electronic and Information Engineering Shandong University of Science and Technology Qingdao China

With the advancement of technology and the increase in user demands, gesture recognition played a pivotal role in the field of human-computer interaction. Among various sensing devices, Time-of-Flight (ToF) sensors were widely applied due to their low cost. This paper explored the implementation of a human hand posture recognition system using ToF sensors and residual neural networks. Firstly, this paper reviewed the typical applications of human hand recognition. Secondly, this paper designed a hand gesture recognition system using a ToF sensor VL53L5. Subsequently, data preprocessing was conducted, followed by training the constructed residual neural network. Then, the recognition results were analyzed, indicating that gesture recognition based on the residual neural network achieved an accuracy of 98.5% in a 5-class classification scenario. Finally, the paper discussed existing issues and future research directions.

关键词： Hand Posture Recognition Human-Computer Interaction Deep Learning Gesture Datasets Real-Time Processing

Ballistic performances of the hourglass lattice sandwich structures under high-velocity fragments

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Defence Technology（防务技术） 2024年第1期31卷 312-325页

作者： He-xiang wu Jia Qu Lin-zhi wu Key Laboratory of Advanced Ship Materials and Mechanics College of Aerospace and Civil EngineeringHarbin Engineering UniversityHarbin150001China School of Civil Engineering Northeast Forestry UniversityHarbin150040China

In this paper,the numerical simulation method is used to study the ballistic performances of hourglass lattice sandwich structures with the same mass under the vertical incidence of *** is paid to elucidating the influences of rod cross-section dimensions,structure height,structure layer,and rod inclination angle on the deformation mode,ballistic performances,and ability to change the ballistic direction of *** results show that the ballistic performances of hourglass lattice sandwich structures are mainly affected by their structural *** this respect,structural parameters optimization of the hourglass lattice sandwich structures enable one to effectively improve their ballistic limit velocity and,consequently,ballistic performances.

关键词： Hourglass lattice sandwich structures Ballistic performances high-velocity Finite element analysis

Resilience-incorporated seismic risk assessment of precast concrete frames with“dry”connections

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 403-425页

作者： wu Chenhao Tang Yuchuan Cao Xuyang wu Gang Key Laboratory of Concrete and Prestressed Concrete Structures of the Ministry of Education Nanjing 211102China Department of Civil and Environmental Engineering University of CaliforniaLos AngelesCA 90095USA School of Civil Engineering Southeast UniversityNanjing 211102China College of Civil and Transportation Engineering Hohai UniversityNanjing 210024China

A resilience-incorporated risk assessment framework is proposed and demonstrated in this study to manifest the advantageous seismic resilience of precast concrete frame(PCF)structures with“dry”connections in terms of their low damage and rapid *** framework integrates various uncertainties in the seismic hazard,fragility,capacity,demand,loss functions,and post-earthquake *** this study,the PCF structures are distinguished from ordinary reinforced concrete frame(RCF)structures by characterizing multiple limit states for the PCF based on its unique damage ***,probabilistic story-wise pushover analyses are performed to yield story-wise capacities for the predefined limit *** the seismic resilience analysis,a step-wise recovery model is proposed to idealize the functionality recovery process,with separate considerations of the repair and non-repair *** recovery model leverages the economic loss and downtime to delineate the stochastic post-earthquake recovery curves for the resilience loss *** such,contingencies in the probabilistic post-earthquake repairs are incorporated and the empirical judgments on the recovery parameters are largely *** proposed framework is demonstrated through a comparative study between two“dry”connected PCFs and one RCF designed as alternative structural systems for a prototype *** results from the risk quantification indicate that the PCFs show reduced loss hazards and lower expected losses relative to the ***,the PCF equipped with energy dissipation devices at the“dry”connections largely reduces the expected economic loss,downtime,and resilience loss by 29%,56%,and 60%,respectively,compared to the RCF.

关键词： precast concrete frame non-emulative precast system seismic resilience seismic risk functional recovery