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感知求职进展对求职行为的影响:积极情绪的中介作用

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北京大学学报（自然科学版） 2012年第6期48卷 873-878页

作者：盛子桐施俊琦北京大学心理学系北京100871

针对大学毕业生这一群体,利用295个毕业生的样本点,分两个时间点进行数据收集,并采用分层回归进行中介作用分析,对求职行为的影响机制中的情绪这一路径进行研究。结果显示:求职积极情绪对下一期求职行为存在着显著预测作用,并且求职积... 详细信息

针对大学毕业生这一群体,利用295个毕业生的样本点,分两个时间点进行数据收集,并采用分层回归进行中介作用分析,对求职行为的影响机制中的情绪这一路径进行研究。结果显示:求职积极情绪对下一期求职行为存在着显著预测作用,并且求职积极情绪在感知求职进展和求职行为之间起到完全中介作用。这一结果强调了情绪在求职过程中的核心作用。最后对大学毕业生和就业指导人员提出了建议。

关键词：感知求职进展情绪求职行为

Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang Wei Pi sheng Hu Haifeng Bao Na Yao Wei Luo State Key Laboratory of New Textile Materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical M-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured with distinct M-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFeM and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

Constraints on what controls millennial-scale basin-wide denudation across mountain belts, Asia

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Science China Earth Sciences 2025年第1期68卷 74-93页

作者： Ye YANG Steven A.BINNIE sheng XU Cong-Qiang LIU Tibor J.DUNAI Institute of Surface-Earth System Science School of Earth System Science Tianjin University Institute of Geology and Mineralogy University of Cologne

The terrestrial cosmogenic nuclide dataset consisting of 123310Be measurements of fluvial sediment samples across the Asian mountain belts is used to constrain the influence of climate,tectonics and topography on Earth-surface denudation processes.10Be-derived basin-wide denudation rates were recalculated using a Monte Carlo simulation approach that relied on pixel-by-pixel production *** rates derived span four orders of magnitude,from 7.4±0.7 mm kyr-1（1σ;Central Tibetan Plateau） to 9,646744+777mm kyr-1（1σ;Southern Tibetan Plateau）,with a median of 186 mm *** our results with the traditional basin-wide production rate scaling model using a centroid coordinate and mean elevation,suggests that 96.6%of production rates will be underestimated using the latter method,especially for basins with a large *** bias between both methods reaches as large as 40%,caused by basin hypsometry and the nonlinear scaling of production rate with elevation and *** of the correlations between uniformly recalculated denudation rates and tectonics,climate,topography and rock lithology will facilitate the extrapolation of denudation rates in unknown basins using available *** the perspective of local scales,precipitation coupled with neotectonics-driven landslides is likely the most influential factor in subtropical Taiwan Island,while topography primarily constrains surface denudation rates in the eastern Tibetan Plateau within a narrow range of *** highland regions with glacier coverage,such as the Pamir,central and southern Tibetan Plateau high denudation rates are affected by glaciation,whereas lower precipitation and high erosion base level may limit river incision and evolving relief in the Central Tibetan *** contrast to local-scale findings highlighting a dominant factor constraining denudation rate,our large-scale quantitative analyses across the Asian mountain belts finds that （1） topographic metrics including

关键词： 10Be-derived denudation rate Climate change Tectonic uplift Topographic gradient Asian mountains

羟基红花黄色素A延缓高磷诱导的血管平滑肌细胞钙化及其机制研究

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中华肾脏病杂志 2019年第11期35卷 848-855页

作者：韩怡然徐天华邱小波盛子桐万鹏志李悦姚丽中国医科大学附属第一医院肾内科沈阳110000

目的探讨羟基红花黄色素A(Hydroxysafflor yellow A,HSYA)在β-甘油磷酸钠(β-GP)诱导的血管平滑肌细胞(VSMC)钙化过程中的作用及其机制.方法 VSMC用10%胎牛血清+1%双抗高糖DMEM培养液,于37℃、5%CO2培养箱中培养,根据细胞生长密度按1:... 详细信息

目的探讨羟基红花黄色素A(Hydroxysafflor yellow A,HSYA)在β-甘油磷酸钠(β-GP)诱导的血管平滑肌细胞(VSMC)钙化过程中的作用及其机制.方法 VSMC用10%胎牛血清+1%双抗高糖DMEM培养液,于37℃、5%CO2培养箱中培养,根据细胞生长密度按1:4比例传代.实验分为3组:对照组(NC)、高磷诱导钙化组(HP)、HSYA干预组(HSYA).用茜素红染色和钙测定试剂盒(邻甲酚酞络合酮比色法)检测各组细胞钙沉积量;Western印迹法检测细胞钙化指标碱性磷酸酶(ALP),Runt相关转录因子2(RUNX2),核因子κB受体活化因子配体(RANKL),α平滑肌肌动蛋白(α-SMA),及TLR4/NF-κB通路和炎性反应相关指标Toll样受体4(TLR4),白细胞介素8(IL-8),肿瘤坏死因子α(TNF-α)的变化.抽提细胞核蛋白和细胞质蛋白,Western印迹法检测细胞核NF-κB p65和细胞质p65,及细胞总蛋白中p65和磷酸化p65的改变.超氧化物歧化酶(SOD)、丙二醛(MDA)试剂盒法检测细胞抗氧化酶和氧化终产物的改变.结果 Western印迹结果显示,HSYA组细胞钙化指标ALP、RUNX2、RANKL的表达量较HP组明显减少;α-SMA表达较HP组增加(均P<0.01).HSYA组TLR4、TNF-α、IL-8和p-p65/p65的表达量较HP组减少,p65入核减少,细胞质内p65的表达增多(均P<0.05).HSYA组细胞SOD含量较HP组明显升高,MDA含量较HP组明显降低(均P<0.01).结论羟基红花黄色素A可减轻高磷诱导的血管平滑肌细胞的钙化,减少钙沉积.其机制与羟基红花黄色素A抑制了TLR4/NF-κB通路的激活和氧化应激反应有关.

关键词：红花血管钙化 NF-κB 炎症氧化应激

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia sheng Quanju Ding Yujun Wang Jiwei Zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui Chen Zuo-Tang Liang Yu-Gang Ma Xin-Li sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

Chiral phosphoramidite ligand-modulated palladium auto-tandem catalysis for asymmetric dehydrogenative dienylation of imines with α-alkenes

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Science China Chemistry 2025年

作者： Zhong-sheng Nong Hao-Fan Qian Ying-Chun Chen Pu-sheng Wang Liu-Zhu Gong Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of China Key Laboratory of Drug Targeting and Drug Delivery System (Sichuan University) Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy Sichuan University School of Materials and Chemistry Southwest University of Science and Technology

The development of efficient processes allowing rapid access to complex chiral molecules from easily available alkenes is a long-term pursuit in the synthetic chemistry community. Transition metal-catalyzed asymmetric functionalization of allylic C–H bond represents a unique alternative toward this goal. However, enantioselective dehydrogenative transformation of olefins to value-added optically enriched molecules remains yet to be discovered. Here, we report a highly enantioselective dehydrogenative dienylation of imines with unactivated α-alkenes driven by the synergistic action of palladium complex and carboxylic acid. Chiral phosphoramidite ligands turned out to be superior in modulating the performance of palladium autotandem catalysis and allowed a broad range of α-alkenes and imines to be transformed into chiral dienylamines. Mechanistic studies suggest that the dienes could be in situ generated from α-alkenes through a palladium(0)-mediated dehydrogenative process in the presence of excess benzoquinone oxidants, and then participated in the Pd-chiral phosphoramidite-catalyzed intermolecular vinylogous-type addition to the imines activated by the carboxylic acid co-catalyst. Notably, the second β-H elimination occurring in the dienylation event might be the turnover-limiting step.

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Sclerostin／Lrp4调节血管平滑肌细胞钙化的机制研究

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中华肾脏病杂志 2018年第3期34卷 208-213页

作者：王健邱小波盛子桐徐天华杜银科王力宁姚丽中国医科大学附属第一医院肾内科沈阳110001

目的探讨sclerostin／Lrp4在高磷诱导血管平滑肌细胞（vascular smooth musclecell，VSMC）钙化过程中的可能机制及银杏叶提取物的保护作用。方法提取SD大鼠主动脉血管平滑肌细胞并鉴定，分为正常对照组，高磷诱导钙化组（10mmol／L β... 详细信息

目的探讨sclerostin／Lrp4在高磷诱导血管平滑肌细胞（vascular smooth musclecell，VSMC）钙化过程中的可能机制及银杏叶提取物的保护作用。方法提取SD大鼠主动脉血管平滑肌细胞并鉴定，分为正常对照组，高磷诱导钙化组（10mmol／L β-甘油磷酸钠＋50μg／ml抗坏血酸），高磷诱导钙化＋银杏叶提取物干预组（10mmol／L β-甘油磷酸钠＋50μg／ml抗坏血酸＋0．5mg／ml银杏叶提取物），培养基诱导干预14d。VONKOSSA染色、茜素红染色检测各组VSMC钙化情况，实时定量PCR检测β-catenin、骨钙素（bone gamma carboxyglutamic acid containing proteins，BGP）的mRNA表达，Western印迹检测sclerostin、Lrp4的蛋白表达。结果VONKOSSA染色、茜素红染色均显示，与正常对照组相比，高磷诱导VSMC钙化组有明显的钙盐沉积，银杏叶提取物干预组钙盐沉积较钙化组明显减少。实时定量PCR结果显示高磷诱导VSMC钙化组B—catenin、BGP的mRNA表达明显高于正常对照组（均P〈0．05）。银杏叶提取物干预组***、BGP的mRNA表达明显低于钙化组（均P〈0．05）。Western印迹结果显示，高磷诱导VSMC钙化组sclerostin蛋白表达明显高于正常对照组（P〈0．05），Lrp4蛋白表达明显低于正常对照组（P〈0．05）。银杏叶提取物干预组sclerostin蛋白表达明显低于钙化组（P〈0．05），Lrp4蛋白表达明显高于钙化组（P〈0．05）。结论高磷可通过激活Wnt／β-catenin信号通路诱导VSMC钙化，Sclerostin／Lrp4参与了高磷诱导的VSMC钙化过程，而银杏叶提取物可通过抑制Wnt／β．catenin信号通路减轻高磷诱导的VSMC钙化。

关键词：肾功能不全慢性钙质沉积 LDL受体相关蛋白质类骨硬化蛋白 Wnt/β-连环蛋白银杏叶提取物

虫草菌液通过增强自噬改善β-甘油磷酸诱导的血管平滑肌细胞钙化

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中华肾脏病杂志 2019年第2期35卷 119-126页

作者：邱小波盛子桐韩怡然徐天华田滨瑶赵翡于艳秋姚丽中国医科大学附属第一医院肾内科沈阳110000 中国医科大学基础医学院病理生理教研室沈阳110013

目的探讨冬虫夏草提取物虫草菌液(Cordyceps sinensis,CS)对高磷诱导的血管平滑肌细胞钙化的影响机制。方法用细胞增殖与活性检测试剂盒(cell counting kit-8,CCK-8)检测CS对细胞生存活力的影响;用β-甘油磷酸(β-GP,10mmol/L))建立大... 详细信息

目的探讨冬虫夏草提取物虫草菌液(Cordyceps sinensis,CS)对高磷诱导的血管平滑肌细胞钙化的影响机制。方法用细胞增殖与活性检测试剂盒(cell counting kit-8,CCK-8)检测CS对细胞生存活力的影响;用β-甘油磷酸(β-GP,10mmol/L))建立大鼠血管平滑肌细胞(VSMC)钙化模型,加入CS(10mg/L)、自噬抑制剂3-甲基腺嘌呤(3-methyladenine,3-MA,5mmol/L)及一磷酸腺苷(AMP)活化的蛋白激酶(AMPK)抑制剂化合物C(CC,10μmol/L)进行干预,实验分为5组:对照组(Ctrl)、β-GP组、β-GP+CS组、3-MA+β-GP+CS组、CC+β-GP+CS组。通过茜素红S染色及钙测定试剂盒检测各组细胞钙沉积量;透射电镜观察VSMC内自噬体的形成;免疫荧光检测细胞质内微管相关蛋白1轻链3(LC3)的表达;Western印迹法检测血管平滑肌标志物α-SMA蛋白、成骨指标Runx2、自噬相关蛋白LC3Ⅱ/LC3Ⅰ和Beclin1及AMPK/雷帕霉素靶蛋白(mTOR)信号通路蛋白。结果虫草菌液能使高磷环境中血管平滑肌细胞的自噬体、LC3荧光点状聚集及LC3Ⅱ/LC3Ⅰ、Beclin1、α-SMA、磷酸化(p)-AMPK蛋白表达增多,Runx2、p-mTOR蛋白表达及钙沉积减少(均P<0.01)。用3-MA抑制自噬后,β-GP+CS环境中的血管平滑肌细胞α-SMA蛋白表达减少(P<0.01),Runx2蛋白表达及钙沉积增多(均P<0.01),提示虫草菌液是通过激活自噬减轻了β-GP诱导的血管平滑肌细胞的钙化。用CC抑制AMPK/mTOR信号通路后,β-GP+CS组的血管平滑肌细胞的p-AMPK蛋白表达明显减少(P<0.01),且LC3Ⅱ/LC3Ⅰ、Beclin1、α-SMA蛋白表达量及自噬体、LC3荧光点状聚集也减少,p-mTOR、Runx2蛋白表达量及钙沉积增多(均P<0.01),提示虫草菌液是通过激活依赖AMPK/mTOR信号通路的自噬而减轻了β-GP诱导的血管平滑肌细胞的钙化。结论虫草菌液能有效减轻高磷诱导的血管平滑肌细胞钙化,其机制可能是通过激活AMPK/mTOR信号通路增强自噬。

关键词：冬虫夏草自噬肌,平滑,血管磷肾功能不全,慢性钙化