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1例2型糖尿病合并高血压患者的中医特色护理体会

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中西医结合护理 2024年第6期10卷 103-108页

作者：张继刘爱张敏赵丽娜明月左琳冯莹赵紫彤北京中医药大学第三附属医院急诊科北京100029

本文总结1例2型糖尿病合并高血压患者的中医特色护理经验。基于护理评估和中医辨证,在病情监测、饮食指导、药物管理等常规干预基础上,配合耳穴压丸、穴位贴敷、中药膏摩等中医护理技术进行干预,有效控制患者血压、血糖,提高患者生活质量。

关键词：糖尿病高血压血糖穴位贴敷中医特色护理

Electron modulation by atomic Ir site decoration in porous Co/N co-doped carbon for electrocatalytic hydrogen evolution

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Nano Research 2023年第2期16卷 2011-2019页

作者： Youkui zhang zitong Yan Yeli Gao Yaqin Fu Wenhao Li Yunxiang Lin Chuanqiang Wu Yujuan Pu Tao Duan Li Song State Key Laboratory of Environment-Friendly Energy Materials National Co-Innovation Center for Nuclear Waste Disposal and Environmental SafetySouthwest University of Science and TechnologyMianyang 621010China National Synchrotron Radiation Laboratory Chinese Academy of Sciences(CAS)Center for Excellence in NanoscienceUniversity of Science and Technology of ChinaHefei 230029China Institute of Physical Science and Information Technology School of Materials Science and EngineeringAnhui Key Laboratory of Information Materials and DevicesKey Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationAnhui UniversityHefei 230601China College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China

The rational design of materials at atomic scale as efficient and stable electrocatalysts for hydrogen evolution reaction(HER)is critical for energy ***,we report a novel hybrid nanostructure with iridium(Ir)and cobalt(Co)atomic pair configuration anchored in porous nitrogen-doped carbon(pNC)nanosheets(denoted as IrCo-pNC)for electrocatalytic *** investigations and theoretical calculations reveal that the interaction between Ir and Co species in pNC promotes electron accumulation and depletion around isolated Ir and Co atoms,respectively,resulting in a local asymmetry electron density *** functional theory calculations also suggest that the electrons transfer from Co to adjacent Ir atom causing the down shift of the d-band center of Ir 5d in IrCo-pNC catalyst,thus optimizing the adsorption of hydrogen on Ir *** as-prepared IrCo-pNC exhibits significant HER performance with an overpotential of 21 mV to achieve a current density of 10 mA·cm^(−2)in 0.5 M *** work provides insight into the role of asymmetry electron density distribution in nanomaterials in regulating HER electrocatalysis.

关键词： electron modulation iridium decoration porous carbon electrocatalysis hydrogen evolution reaction

Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer

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Acta Pharmaceutica Sinica B 2022年第1期12卷 353-363页

作者： Lei Fang zitong Zhao Jue Wang Ping Xiao Xiangshi Sun Yaping Ding Pengcheng zhang Dangge Wang Yaping Li Collage of Sciences Shanghai UniversityShanghai 200444China State Key Laboratory of Drug Research&Center of Pharmaceutics Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy Yantai UniversityYantai 264005China Yantai Key Laboratory of Nanomedicine&Advanced Preparations Yantai Institute of Materia MedicaYantai 264000China

Nucleic acid drugs are highly applicable for cancer immunotherapy with promising therapeutic effects, while targeting delivery of these drugs to disease lesions remains challenging. Cationic polymeric nanoparticles have paved the way for efficient delivery of nucleic acid drugs, and achieved stimuli-responsive disassembly in tumor microenvironment(TME). However, TME is highly heterogeneous between individuals, and most nanocarriers lack active-control over the release of loaded nucleic acid drugs, which will definitely reduce the therapeutic efficacy. Herein, we have developed a lightcontrollable charge-reversal nanoparticle(LCCN) with controlled release of polyinosinic-polycytidylic acid [Poly(I:C)] to treat triple negative breast cancer(TNBC) by enhanced photodynamic immunotherapy. The nanoparticles keep suitably positive charge for stable loading of Poly(I:C), while rapidly reverse to negative charge after near-infrared light irradiation to release Poly(I:C). LCCN-Poly(I:C) nanoparticles trigger effective phototoxicity and immunogenic cell death on 4 T1 tumor cells, elevate antitumor immune responses and inhibit the growth of primary and abscopal 4 T1 tumors in mice. The approach provides a promising strategy for controlled release of various nucleic acid-based immune modulators, which may enhance the efficacy of photodynamic immunotherapy against TNBC.

关键词： Nanoparticles Cancer immunotherapy Photodynamic therapy Polyinosinic-polycytidylic acid Triple negative breast cancer Charge-reversal Tumor microenvironment ROS-responsive

Multi-Stimuli-Responsive Field-Effect Transistor with Conjugated Polymer Entailing Spiropyran in the Side Chains

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CCS Chemistry 2020年第2期2卷 632-641页

作者： Jing Ma Jianwu Tian zitong Liu Dandan Shi Xisha zhang Guanxin zhang Deqing zhang Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsCAS Center of Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Multi-stimuli-responsive field-effect transistors(FETs)with organic/polymeric semiconductors have received increasing ***,we report a novel strategy for fabricating multi-stimuliresponsive polymeric semiconductors through the incorporation of spiropyran(SP)groups in the polymer side *** semiconducting performances of resultant FETs with a diketopyrrolopyrroles(DPP)-based conjugated donor–acceptor(D–A)polymer,that entails SP units in the side chains(pDSP-1),could be modulated reversibly through UV and visible light irradiations,or UV light irradiation and heating,or acid treatment and *** studies reveal that during the reversible transformations of closed,open,and the protonated forms of spiropyran,achieved by light irradiations,heating,and under acidic conditions,a large dipole moment changes occur,which triggers the reversible variation of semiconducting performance of the FETs.

关键词： conjugated semiconducting polymer polymeric field-effect transistor side-chain modification spiropyran multi-stimuli responsiveness

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王兰英教授治疗子宫肌瘤临证经验

中国民族民间医药 2022年第18期31卷 76-79页

作者：张子同王兰英(指导) 甘肃省中医院甘肃兰州730050

王兰英教授从事良、恶性肿瘤诊治工作多年,尤其在治疗子宫肌瘤方面具有丰富的临床经验。王兰英教授认为治疗子宫肌瘤应从八纲辩证和六淫出发,临证治疗时以散寒清热、化痰祛湿、散瘀消毒、补益气血等为基本大法。王兰英教授认为子宫肌瘤... 详细信息

王兰英教授从事良、恶性肿瘤诊治工作多年,尤其在治疗子宫肌瘤方面具有丰富的临床经验。王兰英教授认为治疗子宫肌瘤应从八纲辩证和六淫出发,临证治疗时以散寒清热、化痰祛湿、散瘀消毒、补益气血等为基本大法。王兰英教授认为子宫肌瘤的发展趋势是一个动态变化的过程,需注意观察患者行经前后的身体变化,辨证论治,治疗取得了较好疗效,并举例论证。

关键词：子宫肌瘤中药治疗王兰英

Regioselectivity of Pd-catalyzed o-carboranearylation: a theoretical view

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Organic Chemistry Frontiers 2022年第6期9卷 1686-1695页

作者： Jiying Liu Dongmin Fu zitong Chen Tiantian Li Ling-Bo Qu Shi-Jun Li Wenjing zhang Yu Lan Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhouHenan 450001China School of Chemistry and Chemical Engineering and Chongqing Key Laboratory of Theoretical and Computational ChemistryChongqing UniversityChongqing 400030China

The mechanism and the regioselectivity of Pd-catalyzed B(4)–H arylation and B(4,5)–H diarylation foro-carborane with bidentate directing groups were investigated. The complete catalytic cycle involves Pdmediated concerted metalation–deprotonation, oxidative addition, counterion exchange, and reductiveelimination, where counterion exchange is critical. The reductive elimination is the rate- and regioselectivity-determining step for the whole catalytic cycle. B(3)-Arylation is unfavorable because the stericrepulsion between the substituent group on C(2) and the metal moiety would lead to significant distortionof o-carborane and would result in a higher activation energy for reductive elimination. The distortion ofo-carborane can be clearly observed from the change of its aromaticity in the corresponding transitionstates by the calculation of nucleus-independent chemical shifts. Moreover, counterion exchange withcarboxylate before reductive elimination significantly increases the positive charge of palladium, whichleads to a lower activation free energy for the sequential step.

关键词： elimination catalyzed reductive

木糖醇通过调节PI3K/Akt/FoxO1/NF-κB通路改善2型糖尿病小鼠肾损伤

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福建医科大学学报 2024年第3期58卷 159-165页

作者：张静霞林国文黄梓彤吴雨杭潘思张趁华莆田学院基础医学院福建省肿瘤转化医学重点实验室莆田351100 莆田学院机电与信息工程学院莆田351100

目的探究木糖醇改善2型糖尿病(T2DM)肾损伤的作用机制。方法将小鼠随机分为正常对照组(NC组)、糖尿病对照组(DC组)、10%木糖醇组(DX10组)、20%木糖醇组(DX20组),每组6只。除NC组外,其余各组小鼠均用链脲佐菌素(40 mg/kg)构建T2DM模型。... 详细信息

目的探究木糖醇改善2型糖尿病(T2DM)肾损伤的作用机制。方法将小鼠随机分为正常对照组(NC组)、糖尿病对照组(DC组)、10%木糖醇组(DX10组)、20%木糖醇组(DX20组),每组6只。除NC组外,其余各组小鼠均用链脲佐菌素(40 mg/kg)构建T2DM模型。造模成功后,在正常饲料中加入不同比例的木糖醇连续喂养8周。通过试剂盒检测小鼠空腹血糖(FBG);采用ELISA法测定血清中白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)含量;比色法检测肾组织过氧化氢酶(CAT)、丙二醛(MDA)和总抗氧化能力(T-AOC);苏木精-伊红(H-E)染色观察肾组织的形态学变化;Western-blot法检测小鼠肾组织p-PI3K、PI3K、p-Akt、Akt、p-FoxO1、FoxO1、NF-κB、ICAM-1、Bcl-2和Bax蛋白的表达情况。结果(1)与NC组比较,DC组FBG升高(P<0.01),木糖醇干预后下降,且DX20组下降更显著(P<0.05);(2)与NC组比较,DC组IL-6和TNF-α分泌增加(P<0.0001),木糖醇干预后均下降,且DX20组下降更显著(P<0.0001);(3)与NC组比较,DC组CAT和T-AOC活性下降、MDA含量升高(P<0.01),木糖醇干预后,CAT和T-AOC活性升高而MDA含量降低(P<0.05),且DX20组变化更显著(P<0.05);(4)H-E染色显示,木糖醇干预可改善小鼠糖尿病肾损伤,且DX20组效果更佳(P<0.05);(5)Western-blot检测显示,与NC组比较,DC组小鼠肾组织中p-PI3K、p-Akt、p-FoxO1和Bcl-2/Bax均降低(P<0.0001,P<0.001,P<0.01,P<0.001)、NF-κB入核增多(P<0.0001)、ICAM-1升高(P<0.01);与DC组比较,木糖醇干预可逆转相关蛋白的变化,且DX20组变化更显著(P<0.05)。结论木糖醇可通过活化PI3K/Akt/FoxO1及抑制NF-κB通路改善T2DM小鼠肾损伤。

关键词：木糖醇 2型糖尿病肾损伤 PI3K/Akt/FoxO1/NF-κB通路炎症

烟草高亲和硝酸盐转运蛋白基因NtNRT2.5的克隆及表达模式分析

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中国烟草学报 2024年第2期30卷 71-79页

作者：李晨依朱紫童湛佳伟温海洋罗勇杨永霞张松涛贾宏昉河南农业大学烟草学院河南郑州450002

【背景和目的】高亲和硝酸盐转运蛋白NRT2家族基因在植物硝酸盐吸收转运和再利用过程中发挥重要作用,为探索烟草NRT2家族基因NtNRT2.5对烟草氮素调控的作用。【方法】从烟草烤烟品种K326中克隆得到高亲和硝酸盐转运蛋白基因NtNRT2.5,进... 详细信息

【背景和目的】高亲和硝酸盐转运蛋白NRT2家族基因在植物硝酸盐吸收转运和再利用过程中发挥重要作用,为探索烟草NRT2家族基因NtNRT2.5对烟草氮素调控的作用。【方法】从烟草烤烟品种K326中克隆得到高亲和硝酸盐转运蛋白基因NtNRT2.5,进行生物信息和表达模式分析,创制NtNRT2.5启动子融合GUS报告基因的K326转基因烟草材料,进行GUS组织化学染色。【结果】NtNRT2.5基因的全长ORF为1509 bp,编码502个氨基酸,属于稳定性疏水蛋白,其蛋白跨膜结构域具有NRT2家族结构特征;烟草NtNRT2.5蛋白与拟南芥AtNRT2.5蛋白亲缘关系最近,功能相似;该基因启动子包含多种激素和胁迫响应元件;NtNRT2.5蛋白定位于细胞质膜;NtNRT2.5基因在烟草各组织都有表达,在下部叶中表达最强,且受低氮诱导表达增强,GUS组织染色结果表明,正常供氮和低氮条件下,在转基因烟草的根(中轴)和下部叶片(叶脉)中都检测到了GUS报告基因,均能显蓝色,且低氮条件下表达更加强烈,蓝色更深。【结论】烟草NtNRT2.5是高亲和硝酸盐转运蛋白的编码基因,该基因受低氮诱导表达增强,可能参与烟草硝酸盐的转运及再利用过程。

关键词：烟草 NtNRT2.5 基因克隆表达分析

Using deep learning to solve computer security challenges:a survey

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Cybersecurity 2018年第1期1卷 815-846页

作者： Yoon-Ho Choi Peng Liu zitong Shang Haizhou Wang Zhilong Wang Lan zhang Junwei Zhou Qingtian Zou The Pennsylvania State University PennsylvaniaUSA Pusan National University BusanRepublic of Korea Wuhan University of Technology WuhanChina

Although using machine learning techniques to solve computer security challenges is not a new idea,the rapidly emerging Deep Learning technology has recently triggered a substantial amount of interests in the computer security *** paper seeks to provide a dedicated review of the very recent research works on using Deep Learning techniques to solve computer security *** particular,the review covers eight computer security problems being solved by applications of Deep Learning:security-oriented program analysis,defending return-oriented programming(ROP)attacks,achieving control-flow integrity(CFI),defending network attacks,malware classification,system-event-based anomaly detection,memory forensics,and fuzzing for software security.

关键词： Deep learning Security-oriented program analysis Return-oriented programming attacks Control-flow integrity Network attacks Malware classification System-event-based anomaly detection Memory forensics Fuzzing for software security