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CNS Organoid Surpasses Cell-Laden Microgel Assembly to Promote Spinal Cord Injury Repair

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Research 2022年第4期2022卷 677-692页

作者： zitian wang Haoran Zhao iaowei Tang Tianyu Meng Davit Khutsishvili Bing Xu Shaohua Ma Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Tsinghua-Berkeley Shenzhen Institute Shenzhen 518055China Shenzhen Bay Laboratory ShenzhenChina Institute for Brain and Cognitive Sciences Tsinghua UniversityBeijing 100084China

The choice of therapeutic agents remains an unsolved issue in the repair of spinal cord *** this work,various agents and configurations were investigated and compared for their performance in promoting nerve regeneration,including bead assembly and bulk gel of collagen and Matrigel,under acellular and cell-laden conditions,and cerebral organoid(CO)as the in vitro preorganized ***,in Matrigel-based agents and the CO transplantations,the recipient animal gained more axon regeneration and the higher Basso,Beattie,and Bresnahan(BBB)scoring than the grafted collagen ***,new nerves more uniformly infiltrated into the transplants in bead form assembly than the molded ***,the materials loaded the neural progenitor cells(NPCs)or the CO implantation groups received more regenerated nerve fibers than their acellular counterparts,suggesting the necessity to transplant exogenous cells for large trauma(e.g.,a 5 mm long spinal cord transect).In addition,the activated microglial cells might benefit from neural regeneration after receiving CO transplantation in the recipient *** organoid augmentation may suggest that in vitro maturation of a microtissue complex is necessary before transplantation and proposes organoids as the premium therapeutic agents for nerve regeneration.

关键词： neural gained implantation

Effects of Ce and Sb on the microstructure and properties of AZ91D magnesium alloy prepared by the EPC process

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Rare Metals 2008年第1期27卷 41-45页

作者： LI Jiqiang DONG Xuanpu FAN zitian wang Yuanqing State Key Laboratory of Material Processing and Die ＆ Mould Technology Huazhong University of Science and Technology Wuhan 430074 China

The effects of small amounts of cerium and antimony additions on the microstructure and the mechanical properties of AZ91D（Mg-9Al-Zn） based alloy were researched via the expendable pattern casting（EPC） *** results show that the microstructure is obviously refined and the tensile strength of the AZ91D based alloy at ambient temperature is significantly *** compared to AZ91D,the AZ91D-1.0%Ce-0.4%Sb alloy has higher ultimate tensile strength and *** ultimate tensile strength and elongation are enhanced by 39% and 47%,*** morphology of the tensile fracture of the AZ91D-1.0%Ce-0.4%Sb alloy has more characteristics of *** indicates that it has had a larger plastic deformation before *** tensile strength and elongation decrease with the increase of Ce and Sb contents because of the coarsening and volume increase of CeSb and Al11Ce3 phases.

关键词： AZ91D Ce Sb microstructure mechanical properties

Total flavonoids of Astragalus membranaceus protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice by inhibiting ferroptosis through SLC7A11/GPX-4 signaling pathway

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Food Science and Human Wellness 2024年第1期13卷 414-420页

作者： zitian Gao Gaorui wang Yujie Chen Wuke Yuan Jun Cai Aiping Feng Jie Fang Qi Xu Xiaojun Wu School of Public Health Shanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Key Laboratory of Compound Chinese Medicines The Ministry of Education(MOE)Key Laboratory for Standardization of Chinese MedicineInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China

Parkinson’s disease(PD)is a common neurodegenerative disorder with no *** membranaceus is used in Chinese culture as a food supplement to boost *** present study aimed to explore the neuroprotective effects of total flavonoids extracted from ***(TFA)and their protective *** offered neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)in the mouse model of Parkinsonism,by improving behavior performance in the gait analysis and pole test,and inhibiting the decline of tyrosine hydroxylase(TH)positive neurons and TH protein expression in substantia nigra of *** also prevented 1-methyl-4-phenylpyridinium(MPP+)induced neurotoxicity in SHSY5Y cells,by increasing GSH and GSH/GSSG ratio,and reducing reactive oxygen *** addition,the neuroprotective effects of TFA were associated with its ability to restore MPTP/MPP+induced downregulation of SLC7A11 and glutathione peroxidase 4(GPX-4).In conclusion,we demonstrated that TFA exerted significant neuroprotection against MPTP/MPP+induced neurodegeneration by inhibiting ferroptosis through the regulation of SLC7A11/GPX-4 axis,suggesting the use of TFA as a possible food supplement in the prevention of PD.

关键词： Parkinson’s disease Total fl avonoids of Astragalus membranaceus Ferroptosis SLC7A11

Extracellular scaffold design for ultra-soft microtissue engineering

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Light(Advanced Manufacturing) 2021年第2期2卷 65-77页

作者： Jiaqi wang Xiaowei Tang zitian wang Jiawei Li Shaohua Ma Institute of Biopharmaceutical and Health Engineering(iBHE) Shenzhen International Graduate School(SIGS)Tsinghua UniversityShenzhen 518055China Tsinghua-Berkeley Shenzhen Institute(TBSI) Shenzhen 518055China

Soft and ultra-soft extracellular scaffolds constitute a major fraction of most human internal organs,except for the skeletal *** these organs in vitro requires a comprehensive understanding of their native scaffolding materials and proper engineering approaches to manufacture tissue architectures with microscale *** review focuses on the properties of soft and ultra-soft scaffolds,including their interactions with cells,mechanical properties(***),and existing microtissue engineering *** also summarises challenges presented by the conflict between the properties of the materials demanded by cell behaviours and the capacities of engineering *** proposes that leveraging the engineering ability of soft and ultra-soft scaffolds will promote therapeutic advances and regenerative medicine.

关键词： aging organs engineering

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新型多向主动加载模具结构优化设计

机械工程学报 2012年第12期48卷 43-48页

作者：于建民张治民王强王子田中北大学材料科学与工程学院太原030051 中北大学镁基材料深加工教育部工程中心太原030051

开发出一种曲面分模型式的凹模,解决多向主动加载成形时产生飞边的难题。以典型枝杈类壳体零件为基础,通过对主动加载模具的结构参数(凸体的长度、宽度以及凹模下部锥度)进行优化,分析各自变化条件下飞边产生的情况和各自变形均匀程度,... 详细信息

开发出一种曲面分模型式的凹模,解决多向主动加载成形时产生飞边的难题。以典型枝杈类壳体零件为基础,通过对主动加载模具的结构参数(凸体的长度、宽度以及凹模下部锥度)进行优化,分析各自变化条件下飞边产生的情况和各自变形均匀程度,得到不同参数时的最大成形载荷曲线和飞边生成质量与模具参数的拟合方程,据此获得多向加载少、无飞边模具结构的设计准则,为多向主动加载以及开式模锻过程中减小飞边以及避免飞边的产生提供理论依据。根据模拟数据的趋势确定最佳的多向模具结构参数取值范围,模拟结果显示,基本避免壳体底部飞边的产生,变形比较均匀,水平加载载荷也很小,均符合预期结果。在模拟基础上设计模具进行试验验证,成形出合格的典型枝杈类零件,其各项性能指标都超过原来的要求。

关键词：优化设计飞边主动加载有限元法

Study on blood pressure rhythm in hypertensive patients with Yin deficiency syndrome and a random forest model for predicting hypertension with Yin deficiency syndrome

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Journal of Traditional Chinese Medicine 2024年第3期44卷 564-571页

作者： ZHOU Ying LI Ping LUAN Jianwei SHEN Rui WU Yinglan XU Qiwen wang Xinyue ZHU Yao XU Xiangru LIU zitian JIANG Yuning ZHONG Yong HE Yun JIANG Weimin Department of Cardiology the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China Department of Health Management Centre Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing 210002China Emergency Department Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Department of General Internal Medicine the Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Traditional Chinese MedicineNanjing 210029China

OBJECTIVE: To investigate blood pressure rhythm(BPR)in Yin deficiency syndrome of hypertension(YDSH)patients and develop a random forest model for predicting ***: Our study was consistent with technical processes and specification for developing guidelines of Evidence-based Chinese medicine clinical practice(T/CACM 1032-2017). We enrolled 234 patients who had been diagnosed with primary hypertension without antihypertensive medications prior to the enrollment. All participants were divided into Yin deficiency group(YX, n = 74) and non-Yin deficiency group(NYX, n = 160).Participants were professionally grouped by three experienced chief Traditional Chinese Medicine(TCM)physicians according to four examinations(i.e.,inspection, listening and smelling, inquiry and palpation).We collected data on 24 h ambulatory blood pressure monitoring(ABPM) and YDSH rating scale. We divided 24 h of a day into 12 two-hour periods [Chen-Shi(7:00-9:00), Si-Shi(9:00-11:00), Wu-Shi(11:00-13:00), Wei-Shi(13:00-15:00), Shen-Shi(15:00-17:00), You-Shi(17:00-19:00), Xu-Shi(19:00-21:00), Hai-Shi(21:00-23:00), ZiShi(23:00-1:00), Chou-Shi(1:00-3:00), Yin-Shi(3:00-5:00), Mao-Shi(5:00-7:00)] according to the theory of “midnight-midday ebb flow”. We used random forest to build the diagnostic model of YDSH, with whether it was Yin deficiency syndrome as the outcome. RESULTS: Compared with NYX group, YX group had more female participants with older age, lower waist circumference, body mass index(BMI), diastolic blood pressure(DBP), and smoking and drinking rate(all P < 0.05). The YDSH rating scores of YX group [28.5(21.0-36.0)] were significantly higher than NYX group [13.0(8.0-22.0)](P < 0.001), and the typical symptoms of YX group included vexing heat in the chest, palms and soles, dizziness, dry eyes, string-like and fine pulse, soreness and weakness of lumbus and knees, palpitations, reddened cheeks, and tinnitus(all P < 0.05). The ratio of non-dipper hypertension in YX group was higher t

关键词： hypertension Yin deficiency syndrome random forest blood pressure rhythm blood pressure variability

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 81-92页

作者： zitian Huo Yaqi Duan Dongdong Zhan Xizhen Xu Nairen Zheng Jing Cai Ruifang Sun Jianping wang Fang Cheng Zhan Gao Caixia Xu Wanlin Liu Yuting Dong Sailong Ma Qian Zhang Yiyun Zheng Liping Lou Dong Kuang Qian Chu Jun Qin Guoping wang Yi wang Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China National Health Commission Key Laboratory of Respiratory Diseases Tongji HosptialTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Beijing Pineal Diagnostics Co. Ltd.Beijing 102206China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China Institution of Pathology The First Affiliated Hospital of Henan UniversityKaifeng 475001China Department of Tumor Biobank Shanxi Cancer HospitalTaiyuan 030013China Chongqing Key Laboratory of Big Data for Bio Intelligence School of BioinformationChongqing University of Posts and TelecommunicationsChongqing 400065China

Small cell lung cancer(SCLC)is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction ***,we analyzed formalin-fixed,paraffin-embedded(FFPE)samples of surgical resections by proteomic profiling,and stratified SCLC into three proteomic subtypes(S-I,S-II,and S-III)with distinct clinical outcomes and chemotherapy *** proteomic subtyping was an independent prognostic factor and performed better than current tumor–node–metastasis or Veterans Administration Lung Study Group staging *** subtyping results could be further validated using FFPE biopsy samples from an independent cohort,extending the analysis to both surgical and biopsy *** signatures of the S-II subtype in particular suggested potential benefits from *** overexpressed proteins in S-III,the worst prognostic subtype,allowed us to nominate potential therapeutic targets,indicating that patient selection may bring new hope for previously failed clinical ***,analysis of an independent cohort of SCLC patients who had received immunotherapy validated the prediction that the S-II patients had better progression-free survival and overall survival after first-line ***,our study provides the rationale for future clinical investigations to validate the current findings for more accurate prognosis prediction and precise treatments.

关键词： Small cell lung cancer Proteomics Prognosis Chemotherapy response Immunotherapy

Lipozyme TL IM催化油酸酯化反应制备1,3-甘油二酯

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高等学校化学学报 2015年第8期36卷 1535-1541页

作者：王子田苏剑晓杜伟戴玲妹刘德华清华大学化学工程系北京100084

探究了固定化脂肪酶Lipozyme TL IM催化单甘酯与油酸进行酯化反应制备1,3-甘油二酯的可能性,考察了溶剂、水活度、反应温度、底物摩尔比以及溶剂用量对甘油二酯产率及脂肪酶1,3-位置选择性的影响.在优化的实验条件(45℃,1.5 g Lipozyme ... 详细信息

探究了固定化脂肪酶Lipozyme TL IM催化单甘酯与油酸进行酯化反应制备1,3-甘油二酯的可能性,考察了溶剂、水活度、反应温度、底物摩尔比以及溶剂用量对甘油二酯产率及脂肪酶1,3-位置选择性的影响.在优化的实验条件(45℃,1.5 g Lipozyme TL IM,油酸与单甘酯摩尔比1.5∶1,6.0 g三氯甲烷,水活度为0.33)下,反应6 h时,甘油二酯产率可达80%,其中1,3-甘油二酯产率高达92%以上.Lipozyme TL IM循环使用5次后,甘油二酯产率及脂肪酶选择性无明显下降.

关键词： Lipozyme TL IM 油酸单甘酯 1,3-甘油二酯位置选择性

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三头挤出成形氧化铝基陶瓷的精度研究

中国机械工程 2024年第3期35卷 481-486页

作者：彭子伟王寅成杨力樊自田华中科技大学材料科学与工程学院武汉430074

在自主构建的三头分层挤出成形装备的基础上,研究了单头挤出时挤出头直径d、挤出头移动速度v_(s)、挤出层高h对成形的氧化铝基陶瓷表面粗糙度及尺寸精度的影响;然后研究了双头和三头协同挤出时陶瓷坯体试样的配合精度。实验结果表明:单... 详细信息

在自主构建的三头分层挤出成形装备的基础上,研究了单头挤出时挤出头直径d、挤出头移动速度v_(s)、挤出层高h对成形的氧化铝基陶瓷表面粗糙度及尺寸精度的影响;然后研究了双头和三头协同挤出时陶瓷坯体试样的配合精度。实验结果表明:单头挤出时,d为0.41 mm,v_(s)为10 mm/s,h/d为0.85条件下,陶瓷侧表面粗糙度较低(为24.423μm),尺寸偏差最小为0.67%;双头协同挤出成形时,双头定位配合误差为1.03%,侧表面尺寸粗糙度为30.671μm;三头协同挤出成形时,三头定位配合误差为1.15%,侧表面尺寸粗糙度为30.671μm。最后,采用双头与三头挤出成形工艺方法制备出氧化铝基陶瓷试样,验证了多头多材料协同挤出的可行性。

关键词：三头挤出成形氧化铝基陶瓷多头协同多材料精度