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Alleviated mucosal and neuronal damage in a rat model of Crohn's disease

World Journal of gastroenterology 2014年第44期20卷 16690-16697页

作者： Petra Talapka Lajos István Nagy Alexandra Pál Marietta zita Poles Anikó Berkó Mária Bagyánszki László géza Puskás éva Fekete Nikolett Bódi Department of Physiology Anatomy and Neuroscience Faculty of Sciences and Informatics University of Szeged Avidin Ltd.

AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s ***:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of *** samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal *** means of the ulcerated area were measured to evaluate the macroscopic mu-cosal *** density of myenteric neurons was determined on whole mounts by Hu C/Hu D *** oxygenase-1(HO-1)expression was evaluated by molecular biological ***:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental *** widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS *** repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed ***-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints ***,the HO-1protein up-regulation after the second TNBS treatment proved to be *** the third treatment HO-1 protein expression could not be ***:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal *** persistent up-regulation of HO-1 m RNA expression may correlate with this.

关键词： Crohn's disease Experimental rat model Heme oxygenase-1 Myenteric neurons Repetitive re-lapsing inflammation

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Divergent trajectories of lean vs obese non-alcoholic steatohepatitis patients from listing to post-transplant:A retrospective cohort study

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World Journal of gastroenterology 2022年第26期28卷 3218-3231页

作者： Fakhar Ali Qazi-Arisar Raj Uchila Catherine Chen Cathy Yang Shi-Yi Chen Ravikiran Sindhuvalada Karnam Amirhossein Azhie Wei Xu zita g.lvin Nazia Selzner Leslie Lilly Mamatha Bhat Ajmera Transplant Program Toronto General HospitalUniversity Health NetworkToronto M5G 2N2OntarioCanada Division of gastroenterology and Hepatology Department of MedicineUniversity of TorontoToronto M5G 2N2OntarioCanada National Institute of Liver and gI Diseases Dow University of Health SciencesKarachi 75330Pakistan Department of Biostatistics Princess Margaret Cancer CenterUniversity Health NetworkToronto M5G 2C1OntarioCanada Division of Biostatistics Dalla Lana School of Public HealthUniversity of TorontoToronto M5G 2C1OntarioCanada

BACKgROUND Non-alcoholic steatohepatitis(NASH)cirrhosis is the second most common indication for liver transplantation(LT).The role of body mass index(BMI)on outcomes of NASH cirrhosis has been *** To compare the longitudinal trajectories of patients with lean vs obese NASH cirrhosis,from listing up to post-transplant,having adjusted their BMI for *** We retrospectively reviewed all adult NASH patients listed for LT in our program from 2012 to ***-gray Competing Risk analyses and Cox Proportional-Hazard Models were performed to examine the cumulative incidence of transplant and survival outcomes *** Out of 265 NASH cirrhosis listed patients,176 were *** age was 61.0 years;46%were females.111 patients underwent *** robust patients had better waitlist survival[hazard ratio(HR):0.12;95%CI:0.05–0.29,Pgher instantaneous rate of transplant(HR:5.71;95%CI:1.26–25.9,P=0.02).Lean NASH patients had a substantially higher risk of graft loss within 90 d post-LT(1.2%vs 13.8%,P=0.032)and death post-LT(2.4%vs 17.2%,P=0.029).1-3-and 5-year graft survival was poor for lean NASH(78.6%,77.3%and 41.7%vs 98.6%,96%and 85%respectively).Overall patient survival post-LT was significantly worse in lean NASH(HR:0.17;95%CI:0.03–0.86,P=0.0142)with 83%lower instantaneous rate of death in obese *** Although lean NASH is considered to be more benign than obese NASH,our study suggests a paradoxical correlation of lean NASH with waitlist outcomes,and graft and patient survival post-LT.

关键词： Outcomes Frailty Waitlist Liver transplant Survival

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Health Risk Assessment of Heavy Metals in the Water of the LoutétéRiver, Mfouati District, Southeast Congo

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Journal of geoscience and Environment Protection 2022年第12期10卷 77-86页

作者： Ifo grace Mazel Diamouangana Mpissi zita Flora Bibila Mafoumba Jean Claude Matini Laurent Laboratoire de Chimie Minérale et Appliquée Faculté des Sciences et Techniques Université Marien N’GOUABI Brazzaville Republic of the Congo Parcours chimie Faculté des Sciences et Techniques Université Marien N’GOUABI Brazzaville Republic of the Congo Département des Sciences Exactes Ecole Normale Supérieure Université Marien N’GOUABI Brazzaville Republic of the Congo Faculté des Sciences Appliquées Université DENIS SASSOU N’GUESSO Brazzaville Republic of the Congo

The overall objective of this study was to assess the health risk of water in the Loutété River contaminated with heavy metals. Six surface water samples were collected during the dry season (October 2014). The physico-chemical parameters (pH, electrical conductivity, total dissolved salts) were measured using a HANNA brand device. The values of these physico-chemical parameters are below the WHO standards. The concentrations of heavy metals Cr, Cu, Fe, Pb, Zn and Mn were determined by ICP-OES. These obtained in (μg/L) are in the range: Cr (0.08 - 5.8);Cu (0.6 - 14.5);Fe (0.2 - 386.05);Pb (1.02 - 370.09);Zn (8.02 - 248.7) and Mn (37.1 - 328.08). These concentrations are below the WHO drinking water guideline value in all samples for Cr, Cu, Mn and Zn, 50, 2000, 400 and 3000 μg/L respectively. Concentrations of As, Fe and Pb exceeded the WHO guideline value for drinking water at the following stations: S1 for arsenic, S4 for iron, and for Pb at all stations except S5. The health risk assessment for adults due to ingestion exposure gave HQing. values g heavy metals: Cr, Cu, Fe, Mn, Zn, except for Arsenic and Lead. The hazard quotient calculated by dermal contact (HQ derm) in the waters of the river Loutété, showed that HQ derm 1 for lead. In the case of ingestion, HQing. g metals Arsenic, Lead and Iron.

关键词： Hazard Quotient Non-Carcinogenic Risk Heavy Metals

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Seric Calcium and Magnesium in Normal and Pre Eclamptic Pregnant Women: A Case-Control Study in Kinshasa, D R Congo

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Open Journal of Obstetrics and gynecology 2018年第4期8卷 408-415页

作者： Pascal Ngoy Wakumilua Donatien Kayembe Nzongola-Nkasu Jean Pierre Elongi Moyene Dophie Tshibuela Beya Mamy Ngole zita Jeremie Muwonga Masidi Mireille Nganga Nkanga guelord Mukiapini Luzolo Daddy Kabamba Numbi Département de Sciences de la Santé/Faculté de Sciences/Université Pédagogique Nationale Kinshasa RD Congo Département de Biologie Médicale Service de Biologie Cliniques Cliniques Universitaires de Kinshasa Kinshasa RD Congo Département de gynécologie-Obstétrique Hopital Général de Référence de Kinshasa Kinshasa RD Congo

goal: The present study aimed to determine the profile of seric calcium and magnesium in pre-eclamptic and eclamptic pregnant women of Kinshasa province in the Democratic Republic of Congo where preeclampsia is characterized not only by a high incidence, but also by a seasonal variation probably related to nutritional intake. Study Design: This is a case-control study that took place during the period from September 2014 to March 2015 in four quaternary and tertiary maternity hospitals in Kinshasa. A total of 113 healthy pregnant women (controls) and 112 pre-eclamptic and eclamptic pregnant women (cases) were included in this study. Seric calcium and magnesium were measured in all these gravidas by the principle of spectrophotometry with a HUMALYSER Primus semi-automaton. Results: The mean age of those gravidas was 26.8 ± 6.3 years (26.7 vs 26.9, p = 0.11). The majority of these gravidas were primiparous. The mean gestational age in both groups was 31.35 ± 0.9 weeks (32.1 vs 30.6, p = 0.21). The average seric calcium value was 4.47 ± 0.23 mEq /L in healthy pregnant women compared to 3.80 ± 0.71 mEq/l in pre-eclamptics (P 0.001). The mean of seric magnesium was 1.56 ± 0.15 mg/dL in healthy pregnant women compared to 1.20 ± 0.41 mg/dL in pre eclamptics (P 0.001). Seric calcium and magnesium values were low in the pre-eclamptic group and lower in the eclamptic group (P 0.001). Conclusion: This study establishes a relationship between the low concentration of seric calcium and magnesium with pre-eclampsia and eclampsia, which could be one of the determinants of the high prevalence and seasonality of the disease in Kinshasa.

关键词： Seric Calcium Magnesium Preeclampsia Kinshasa

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Characterization of the Natural and Organomodified Clay Soil of Moukosso (Republic of Congo) by Dimethylsulfoxide: Application to the Adsorption of Lead (II) in Aqueous Solution

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Materials Sciences and Applications 2023年第2期14卷 63-77页

作者： Ottard Arnaud M. R. Ossiby Mwa Ngo Ferland Ngoro-Elenga Erman E. Nzaba Madila zita F. Diamouangana Mpissi Exaucé R. Kinzonzi Ngongot Joseph Marie Moutou Laboratoire de Chimie Minérale et Appliquée Faculté des Sciences et Techniques Université Marien Ngouabi Brazzaville Congo Faculté des Sciences et Techniques Université Marien Ngouabi Brazzaville Congo Centre de Recherches géologiques et Minières Brazzaville Congo Institut de Recherche sur l’Hydrogène Université du Québec à Trois-Rivières Québec Canada Ecole Normale Supérieure Université Marien Ngouabi Brazzaville Congo

In this study, the authors characterized the raw clayey soil of Moukosso and modified by dimethylsulfoxide (DMSO) by several analytical methods, namely: X-ray diffraction (XRD), Fourier transform infrared (FTIR) and gravimetric thermal analysis (TgA). The cation exchange capacity (CEC) was also determined. Mineralogical analysis by XRD revealed the presence of muscovite (29.7%), kaolinite (8.9%), anatase (2.4%) and quartz (58.9%). The characterization of the organo-clay by infrared and by thermogravimetric analysis confirmed the intercalation of DMSO by the presence of vibration bands at 1008 cm-1 and 1070 cm-1 and a strong increase in the loss of mass. The cation exchange capacity of the raw material is 7.4 meq/100g. Rapid adsorption of Pb2+ ions was observed between 5 and 15 minutes of stirring time in both cases (raw clay and organomodified clay). The modeling of the isotherms by the models of Langmuir and Freudlich showed that these are of type S with a maximum amount of adsorption of 22.471 mg/g for the fine fraction and 41.493 mg/g for the clay intercalated with DMSO. Langmuir’s model best reproduces the experimental data of this study.

关键词： Clay Dimethylsulfoxide Organoclay Characterization Adsorption Isotherm Moukosso

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On the Exploitation of Secondary Fibre Transfer： The Use of Flock Fibres as a Tracer

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中国司法鉴定 2012年第5期 40-45页

作者： Marga H.Duinmaijer zita Y.van Zanten Paul van den Hoven Karla g.de Bruin Jaap van der Weerd Netherlands Forensic Institute HagueTheNetherlands

Objective Flock fibres are proposed as a tracer in cases where secondary transfer of the tracer is needed. Methods The research was carried out following a case in which people were suspected to commit large numbers of burglaries. Fibres were applied to the vehicle of the suspects and collected from later crime scenes. A device was developed to assist in the appli- cation of fibres and a number of experiments on secondary transfer were carried out. Results The device can be used to apply many fibres homogeneously in a short time. A single contact will not fully deplete the first surface from flock fibres. 1%~15% of the fibres are transferred to the 3rd surface representing the crime scene. The actual number of transferred fibres is dependent on variables such as the choice of surfaces. Conclusion The results indicate that, given the selected parameters, it is realistic to expect that relatively large numbers of fibres are transferred to a crime scene and can be collected.

关键词： tracer fibre secondary transfer fibre comparison burglary

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Importance of the glycated Hemoglobin Assay in Congolese Women with Polycystic Ovary Syndrome: A Case-Control Study in Kinshasa, DR Congo

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Open Journal of Obstetrics and gynecology 2019年第11期9卷 1492-1509页

作者： Daddy Kabamba Numbi Dophie Tshibuela Beya guelord Mukiapini Luzolo Passy Kimena Nyota Placide Cyanga Ngandu Mamy Ngole zita gustave Ilunga Ntita Donatien Kayembe Nzongola-Nkasu Jérémie Muwonga Masidi Mireille Nganga Nkanga Justin Mboloko Esimo Arsène Mputu Lobota Jean Bosco Kasiam Onkin Baudouin Buassa-bu-Tsumbu Cathy Ali Risasi Fons Verdonck Bernard Spitz Jean Pierre Elongi Moyene Département de Biologie Médicale Service de Biologie Clinique Cliniques Universitaires de Kinshasa Kinshasa DR Congo Département de gynécologie-Obstétrique Cliniques Universitaires de Kinshasa Kinshasa DR Congo Département de Médecine Interne Service d’Endocrinologie et Diabétologie Cliniques Universitaires de Kinshasa Kinshasa DR Congo Département de Biologie Clinique Hopital Général de Référence de Kinshasa Kinshasa DR Congo Department of Physiology KU Leuven Leuven Belgium Department of gynecology-Obstetrics KU Leuven Leuven Belgium Département de gynécologie-Obstétrique Hopital Général de Référence de Kinshasa Kinshasa DR Congo

Context: Polycystic ovary syndrome (PCOS) is considered a syndrome related to the metabolic syndrome with a high risk for developing diabetes mellitus. The evaluation of the glycated hemoglobin (HbA1c) seems to be an interesting tool to detect states of hyperglycemia that may be associated with this syndrome and to understand her pathophysiology. Aims: The purposes of this study are to determine the profile of HbA1c in Congolese women with PCOS, to determine the frequency of states of hyperglycemia and to assess the impact of this marker on clinical signs on this syndrome. Material and methods: This is a case-control study of 130 Congolese subfertile women;65 with a diagnosis of PCOS and 65 others without PCOS. This is conducted from June 2016 to June 2019 among Congolese women of childbearing age. All these women were recruited at the subfertility outpatient clinic of the University Hospital of UNIKIN as well of the YANgA medical centers in Kinshasa, Democratic Republic of Congo. Sickle cell disease was excluded as also the cases of anemia. HbA1c was assayed via the immunoturbidimetric method and the results interpreted according to the ADA recommendations with a pathological cut-off point ≥ 6.5%. Results: Mean hemoglobin was 11.6 ± 1.2 g/dl (11.5 ± 1.1 g/dl vs. 11.8 ± 1.4 g/dl, P = 0.568). The proportion of diabetics was 1.6% (1.6% vs. 1.5%, P = 0.74). Higher HbA1c values were noted in the PCOS group compared to the control group (7.3% ± 2.1% vs. 5.6% ± 0.6%, P 0.001). The multivariate analysis showed a strong correlation between elevated HbA1c levels and PCOS (OR 14.79 (CI 5.43 - 40.32), P 0.001). In the PCOS group, higher HbA1c values were significantly correlated with a higher socio-economic status (OR 3.38 (1.67 - 8.47), P = 0.018) and with obesity (OR 3.48 IC (1.31 - 7.13) P = 0.029). A perfect, positive and significant linear correlation was found between HbA1c and fasting blood glucose (r = 0.807). 60% of women in the PCOS group had pathological values of H

关键词： PCOS HbA1c Subfertility Congolese Women

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The Profile of glycated Hemoglobin in Non-Diabetic Pregnant Women with Preeclampsia: A Case-Control Study in Kinshasa, the Democratic Republic of Congo

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Open Journal of Obstetrics and gynecology 2020年第3期10卷 365-389页

作者： guelord Mukiapini Luzolo Dophie Tshibuela Beya Daddy Kabamba Numbi Passy Kimena Nyota Placide Cyanga Ngandu Blaise Sumbu Matondo Manzambi Aliocha Nkodila Natuhoyila Mamy Ngole zita gustave Ilunga Ntita Mireille Nganga Nkanga Jérémie Muwonga Masidi Donatien Kayembe Nzongola-Nkasu Dieudonné Sengeyi Mushengezi Arsene Mputu Lobota Baudouin Buassa-Bu-Tsumbu Cathy Ali Risasi Fons Verdonck Bernard Spitz Jean Pierre Elongi Moyene Département de Biologie Médicale Service de Biologie Clinique Cliniques Universitaires de Kinshasa Kinshasa Congo Département de Médecine interne Cliniques Universitaires de Kinshasa Kinshasa Congo Département de gynécologie-Obstétrique Cliniques Universitaires de Kinshasa Kinshasa Congo Département de Biologie Clinique Hopital Général de Référence de Kinshasa Kinshasa Congo Department of Physiology KU Leuven Belgium Department of gynecology-Obstetrics KU Leuven Belgium Département de gynécologie-Obstétrique Hopital Général de Référence de Kinshasa Kinshasa Congo

Background: A disturbed glucose metabolism is quite common during pregnancy. It is due to the diabetogenic potential of pregnancy and responsible for many obstetric complications. The glycated hemoglobin is one of the markers used to depict these disorders. Higher concentrations of this marker would be associated with unfavorable results of pregnancy. Objective: To describe the profile of HbA1c in non-diabetic preeclamptic pregnant women and to establish the association between the values of this marker and the maternal and fetal complications. Materials and Method: This is a case-control study of 142 pregnant women in their second and third trimester. They were followed in the maternity hospitals of University Clinics and the general Reference Hospital in Kinshasa, Democratic Republic of Congo between May and October 2019. The sampling of preeclamptic pregnant women was exhaustive. Controls were healthy pregnant women carrying pregnancies of the same type and of the same gestational age as the cases. Ultimately, 71 were preeclamptic and 71 healthy (controls). HbA1c was determined by immunoturbidimetry. Results: A total of 142 pregnant women took part in this study consisting of 71 preeclamptic women (cases) and 71 healthy pregnant women (controls). The average age of these pregnant women was 28.8 ± 6.8 (28.2 ± 6.8 years vs 29.5 ± 6.8 years p = 0.559), with an average parity of 2.3 ± 1.5 (2.2 ± 1.7 vs 2.4 ± 1.2, p = 0.005). The majority were carriers of monofoetal pregnancy. Higher HbA1c values were observed in the preeclamptic pregnant women compared to the controls (5.7 ± 1.3% vs 4.8 ± 0.7%, p 0.001). The proportion of pregnant women with pathological HbA1c values (>5.6%) was also higher in the group of preeclamptic pregnant women (46.5% vs 9.9%, p Conclusion: This study established that 46.5% of non-diabetic pregnant women with preeclampsia have high HbA1c values, which moreover are associated with preeclampsia and its complications. Systematic screening is essen

关键词： HbA1c Preeclampsia Prognosis Congo

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