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E2F1-mediated Up-regulation of NCAPG Promotes Hepatocellular Carcinoma Development by Inhibiting Pyroptosis

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 25-35页

作者： Cuicui Xiao Jiao Gong Yusheng Jie Weicheng Liang Yan Tai Wei Qin Tongyu Lu Yutian Chong ziqing Hei Bo hu Qi Zhang Biotherapy Center Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Anesthesiology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Key Laboratory of Liver Disease of Guangdong Province Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Laboratory Medicine Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Infectious Diseases Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Cell-Gene Therapy Translational Medicine Research Center Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Background and Aims:As a subunit of the condensin complex,NCAPG has an important role in maintaining chromosome condensation,but its biological function and regulatory mechanism in hepatocellular carcinoma(HCC)remains ***:The prognostic ability of NCAPG in HCC patients was examined by univariate and multivariate Cox regression *** curves were plotted to compare the predictive ability of NCAPG and *** luciferase reporter system,and ChIP were used to investigate transcriptional potential of E2F1 to *** was observed by scanning electron *** expression of NCAPG,E2F1,and major proteins constituting NLRP3 inflammasome was determined by western blotting and *** in vivo tumor formation assay was conducted to verify the in vitro ***:Up-regulated NCAPG was identified in HCC tissues compared with adjacent tissue and high NCAPG was positively correlated with poor *** NCAPG mRNA level was a prognostic factor in HCC patients and also a diagnostic factor with higher predictive ability compared with AFP[AUROC 0.766(95%CI:0.650–0.881)vs.0.649(95%CI 0.506–0.793)].HBx transfection resulted in concomitant up-regulation of E2F1 and NCAPG.E2F1 significantly increased the activity of luciferase reporter fused with NCAPG reporter,and the interaction of E2F1 and NCAPG gene was confirmed by *** of E2F1 resulted in significant down-regulation of *** of NCAPG promote pyroptosis mediated by NLRP3 inflammasome activation in multiple HCC cell lines and also suppressed tumorigenesis in ***:We identified a novel role of NCAPG in the regulation of NLRP3 inflammasome-mediated pyroptosis,which was regulated by its upstream transactivator,*** role of E2F1-NCAPG-NLRP3 regulation of pyroptosis network may be a potential target in HCC treatment.

关键词： NCAPG Hepatocellular carcinoma Pyroptosis NLRP3 inflammasome Serum marker circulating RNA.

Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study

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Science China(Life Sciences) 2019年第12期62卷 1617-1629页

作者： Peipei Jiang Xiaoqiu Tang huiyan Wang Chenyan Dai Jing Su hui Zhu Minmin Song Jingyu Liu ziqing Nan Tong Ru Yaling Li Jingmei Wang Jun Yang Bing Chen Jianwu Dai Yali hu Department of Obstetrics and Gynecology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Center for Reproductive Medicine Department of Obstetrics and GynecologyThe Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Nanjing Drum Tower Hospital Chinese Academy of Medical Science&Peking Union Medical CollageNanjing 210008China Department of Pathology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100190China

Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were *** study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis.

关键词： intrauterine adhesion CBD-bFGF endometrial scarring uterine infertility thin endometrium endometrial reconstruction

溶液法制备AgBi_(2)I_(7)薄膜及其光电探测性能研究

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无机材料学报 2023年第9期38卷 1055-1061,I0001,I0002页

作者：胡盈李自清方晓生复旦大学材料科学系聚合物分子工程国家重点实验室上海200433 复旦大学光电研究院上海市智能光电与感知前沿科学研究基地上海200433

AgBi_(2)I_(7)薄膜具有良好的光电特性和环境稳定性,是构筑异质结紫外光电探测器的有力候选材料之一。本研究采用溶液法制备AgBi_(2)I_(7)薄膜,通过优化前驱体溶液的浓度和溶剂类型(正丁胺和二甲基亚砜)等工艺参数,研究了其光电探测性... 详细信息

AgBi_(2)I_(7)薄膜具有良好的光电特性和环境稳定性,是构筑异质结紫外光电探测器的有力候选材料之一。本研究采用溶液法制备AgBi_(2)I_(7)薄膜,通过优化前驱体溶液的浓度和溶剂类型(正丁胺和二甲基亚砜)等工艺参数,研究了其光电探测性能。采用最优方案在宽带隙的GaN上制备AgBi_(2)I_(7)薄膜,构建AgBi_(2)I_(7)/GaN异质结。该异质结对UVA射线具有良好的选择性探测(探测半峰宽约30 nm)。在3 V偏压和350 nm紫外光照射下,器件开关比超过5个数量级,达到27.51 A/W的高响应度和1.53×10^(14)Jones的高探测率。研究表明溶液法制备的AgBi_(2)I_(7)薄膜有望应用于构建高性能的异质结紫外光电探测器。

关键词： AgBi_(2)I_(7)薄膜溶液法异质结紫外光电探测

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hung-i(Hongyi)

The Voice of Dharma 2021年第1期 126-131页

作者： LIN ziqing 不详

hung-i(Hongyi 弘一, 1880-1942) was an outstanding modern Vinaya master of China. The surname of his lay family was Li(李) and he was named Wên-t’ao(Wentao 文涛) when young. His forefathers belonged to the P’ing-hu(Pinghu 平湖) district of Chekiang(Zhejiang 浙江) Province, but he himself was born in T’ien-tsin(Tianjin 天津) in 1880.

关键词：弘一 China. district

长江经济带城市扩张的时空分异特征及影响机制

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地理学报 2024年第2期79卷 439-461页

作者：张敏杨励雅胡卓玮杨子情中国人民大学公共管理学院北京100872 首都师范大学资源环境与旅游学院北京100089

城市人口增长被普遍认为是驱动城市空间扩张的重要因素,明晰城市扩张的时空分异特征以及城市人口规模与城市用地扩张的关系是优化城市空间结构、抑制城市用地无序扩张的前提。基于卫星影像识别长江经济带包含城市生态空间的城市用地,采... 详细信息

城市人口增长被普遍认为是驱动城市空间扩张的重要因素,明晰城市扩张的时空分异特征以及城市人口规模与城市用地扩张的关系是优化城市空间结构、抑制城市用地无序扩张的前提。基于卫星影像识别长江经济带包含城市生态空间的城市用地,采用空间分析方法和计量模型,在分析长江经济带1990—2020年城市扩张时空分异特征的基础上,探索不同区域城市人口规模与城市扩张的关系。研究发现:(1) 2015年之后长江经济带的城市扩张速度大幅下降,中上游城市表现出明显不同于下游地区的城市扩张时序特征,2010年之后上游扩张速度超过中游。空间上,长江经济带城市扩张规模存在明显的空间分异,高速扩张区由东向西移动,中上游与下游间的城市用地规模差异趋于收敛;下游城市扩张存在较强的空间依赖性,中上游未表现出显著的空间自相关;(2)不同区域城市人口规模与城市扩张变化率之间的关系存在显著差异,上游呈负相关关系,中下游呈“U”型关系,表明上游城市人口规模尚未出现明显的过度扩张,而中下游部分城市已出现人口过度扩张,中游城市居民对城市舒适度的关注度和敏感度更高。最后,研究分区域提出政策建议,为城市精准施策、推动城市高质量发展提供科学参考。

关键词：城市扩张时空分异城市人口规模固定效应模型扩张差异指数长江经济带

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蛋白质在膨胀床吸附层析剂的静态和动态吸附性能

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化学工程 2001年第1期29卷 37-40页

作者：胡洪波姚善泾朱自强浙江大学化工学院生物化工研究所杭州310027

以牛血清白蛋白 (BSA)为目标蛋白 ,考察膨胀床用离子交换树脂StreamlineDEAE的静态和动态吸附性能 ,并和离子交换树脂DEAESepharoseFF进行比较 ,实验发现两者的静态吸附性能相似 ,而动态吸附性能差别较大。根据动态吸附数据计算出液膜... 详细信息

以牛血清白蛋白 (BSA)为目标蛋白 ,考察膨胀床用离子交换树脂StreamlineDEAE的静态和动态吸附性能 ,并和离子交换树脂DEAESepharoseFF进行比较 ,实验发现两者的静态吸附性能相似 ,而动态吸附性能差别较大。根据动态吸附数据计算出液膜扩散系数和孔内扩散系数。

关键词：蛋白质膨胀床吸附层析剂离子交换扩散系数牛血清白蛋白静态动态吸附性能

c-di-GMP directly binds to human siderocalin and inhibits its antibacterial activity

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c-di-GMP directly binds to human siderocalin and inhibits it...

(Z)-3,3-二甲基-1-(1H-1,2,4-三唑-1-基)-2-丁酮肟(5-芳基-1,3,4-噁二唑-2-基)甲基醚的合成和抑菌活性

第五届全国人畜共患病学术研讨会

作者： Weihui Li Tao Cui Lihua hu ziqing Wang Zongqiang Li Lei Liu 何正国 College of Life Science and Technology Huazhong Agricultural University 华中农业大学

Cyclic diguanylate monophosphate(c-di-GMP)is a well-conserved second messenger found in multiple bacterial *** participates in the regulation of a wide range of cellular processes,such as bacterial metabolism,motility,drug resistance,and *** infection,the innate immune system can also sense c-di-GMP and subsequently triggers type I interferon innate immune response that is essential for successful pathogen ***,whether bacterial

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高等学校化学学报 2017年第8期38卷 1375-1382页

作者：谭英肖梦武叶姣胡艾希曾子清欧晓明湖南大学化学化工学院长沙410082 湖南化工研究院国家农药创制工程技术研究中心长沙410007

以3,3-二甲基-1-(1H-1,2,4-三唑基)-2-丁酮肟为原料,经醚化、肼解及腙化3步反应得到(E)-N'-(取代苯亚甲基)-2-[(Z)-3,3-二甲基-1-(1H-1,2,4-三唑-1-基)丁基-2-亚甲氨氧基]乙酰肼(3a^3u),化合物3与二乙酸碘苯(IBD)反应,合成了21个(Z)-3,3-二甲基-1-(1H-1,2,4-三唑-1-基)-2-丁酮肟-(5-芳基-1,3,4-噁二唑-2-基)甲基醚(4a^4u),化合物4的化学结构经核磁共振谱、高分辨质谱和元素分析确证.采用单晶X射线衍射仪测定了化合物4c的晶体结构.抑菌活性测试结果表明,在500 mg/L浓度下,化合物4k,4f,4j和4n对纹枯病菌的防效率分别为70.9%,60.2%,60.0%和60.6%;在25 mg/L浓度下,化合物4b,4c,4d和4e对菌核病菌的抑制率为71.8%~76.9%.

关键词： 1,3,4-噁二唑二乙酸碘苯单晶结构抑菌活性

外推瀑布多网格法(EXCMG)——大规模求解椭圆问题的新算法

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计算数学 2009年第3期31卷 261-274页

作者：胡宏伶陈传淼谢资清湖南师范大学数学与计算机学院长沙410081

基于有限元的渐近展开式,导出了新的外推公式,它们更精确地逼近密网上的有限元解(而不是微分方程的解),提出了新的外推瀑布型多网格法(EXCMG),采用新外推公式及其二次插值提供密网上的好初值,数值实验表明,新方法有很高的精度和效率.最... 详细信息

基于有限元的渐近展开式,导出了新的外推公式,它们更精确地逼近密网上的有限元解(而不是微分方程的解),提出了新的外推瀑布型多网格法(EXCMG),采用新外推公式及其二次插值提供密网上的好初值,数值实验表明,新方法有很高的精度和效率.最后在PC机上求解了大规模二维椭圆问题。

关键词：瀑布多网格法有限元新外推公式二次插值大规模椭圆问题