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A New Kind of Subjective Trust Model

中国生理学会张锡钧基金会第十三届全国青年优秀生理学学术论文交流及评奖会议、中国生理学会第十一届全国青年生理学工作者学术会议

作者： Xiaoting Huang 冯丹丹 ziqiang luo Dept of Physiology Xiangya Medical schoolCentral South University 中南大学基础医学院生理系

It is well known that in the neuronal system,NMDA receptors(NMDARs)participate in the action of neurotransmission and modulate the excitability of neurons;the excessive activation of NMDARs produces excitotoxicity,which induces neuronal injury or cell *** contrast,littler is known about the role of NMDARs in peripheral non-neuronal tissues,including pancreatic islets and P-cells,also the studies of which were inconsistent in *** we investigated whether

关键词： The excessive activation of pancreatic NMDA receptors contributes to the cell dysfunction in type 2 diabetes in rodents

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Wuhan University Journal of Natural Sciences 2006年第6期11卷 1457-1461页

作者： ZHANG Guangwei KANG Jianchu luo ziqiang MENG Xiangyi FANG Peici LI Deyi State Key Laboratory of Software Development Environment Beijing University of Aeronautics and Astronautics Beijing 100083 China China Electronic System Engineering Company Beijing 100840 China

Based on the outstanding characteristics of Cloud Model on the process of transforming a qualitative concept to a set of quantitative numerical values, a formalized model of subjective trust is introduced by which we can transform between qualitative reputation and quantitative voting data. The present paper brings forward algorithms to compute direct trust and recommender trust. Further more, an effective similarity measuring method used to distinguish two users＇ reputation on knowledge level is also proposed. The given model properly settles the uncertainty and fuzziness properties of subjective trust which is always the weakness of traditional subjective trust model, and provides a step in the direction of proper understanding and definition of human trust.

关键词： subjective trust reputation opens network cloud model uncertainty fuzziness

LEAP2 ameliorates high fat diet-impaired glucose tolerance and enhances glucose-stimulated insulin secretion from β cells through PPARγ signal pathway

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Chinese Medical Journal 2024年第18期137卷 2266-2268页

作者： Jiaxi Li Mei Li Hao Ke Yang Han Yanhong Huang Yan Zhou ziqiang luo Chen Chen Dandan Feng Department of Physiology Xiangya School of MedicineCentral South UniversityChangshaHunan 410013China Department of Biochemistry and Molecular Biology Key Laboratory of Metabolism and Molecular MedicineSchool of Basic Medical SciencesFudan UniversityShanghai 200032China Hunan Key Laboratory of Organ Fibrosis Central South UniversityChangshaHunan 410013China School of Biomedical Sciences Faculty of MedicineUniversity of QueenslandSt LuciaBrisbaneQLD 4072Australia

To the Editor:Type 2 diabetes(T2D)is an endocrine system disease,characterized by persistent hyperglycemia,and is one of the most common and fastest growing diseases in the world.[1]Although significant progresses have been made in understanding the pathology of T2D with abnormal insulin-secretion profiles,the molecular and cellular mechanisms ofβcells remain largely ***,the liver-expressed antimicrobial peptide 2(LEAP2)may antagonize the inhibition effect of ghrelin on insulin secretion by inhibiting the ghrelin receptor(growth hormone secretagogue receptor,GHSR).The regulation of glucose homeostasis by the ghrelin-LEAP2-GHSR axis remains largely *** is hypothesized that the ghrelin-LEAP2-GHSR axis may regulate the insulin-glucose homeostasis in diabetic condition.

关键词： impaired homeostasis PPARγ

Chromosome-scale genome sequence of Suaeda glauca sheds light on salt stress tolerance in halophytes

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Horticulture Research 2023年第9期10卷 233-246页

作者： Yan Cheng Jin Sun Mengwei Jiang ziqiang luo Yu Wang Yanhui Liu Weiming Li Bing Hu Chunxing Dong Kangzhuo Ye Zixian Li Fang Deng Lulu Wang Ling Cao Shijiang Cao Chenglang Pan Ping Zheng Sheng Wang Mohammad Aslam Hong Wang Yuan Qin State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Plant ProtectionFujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyCenter for Genomics and BiotechnologyCollege of Life ScienceFujian Agriculture and Forestry UniversityFuzhou 350002China Pingtan Institute of Science and Technology Fujian Agriculture and Forestry UniversityFuzhou 350400China Department of Biochemistry Microbiology and ImmunologyUniversity of SaskatchewanSaskatoonSK S7N 5E5Canada College of Agriculture Fujian Agriculture and Forestry UniversityFuzhou 350002China College of Forestry Fujian Agriculture and Forestry UniversityFuzhou 350002China Fujian Key Laboratory on Conservation and Sustainable Utilization of Marine Biodiversity Fuzhou Institute of OceanographyMinjiang UniversityFuzhou 350108China

Soil salinity is a growing concern for global crop production and the sustainable development of ***,it is crucial to comprehend salt tolerance mechanisms and identify salt-tolerance genes to enhance crop tolerance to salt *** glauca,a halophyte species well adapted to the seawater environment,possesses a unique ability to absorb and retain high salt concentrations within its cells,particularly in its leaves,suggesting the presence of a distinct mechanism for salt *** this study,we performed de novo sequencing of the *** *** genome has a size of 1.02 Gb(consisting of two sets of haplotypes)and contains 54761 annotated genes,including alleles and *** genomic analysis revealed a strong synteny between the genomes of *** and Beta *** the *** genome,70.56%comprises repeat sequences,with retroelements being the most *** the allele-aware assembly of the *** genome,we investigated genome-wide allele-specific expression in the analyzed *** results indicated that the diversity in promoter sequences might contribute to consistent allele-specific ***,a systematic analysis of the ABCE gene families shed light on the formation of ***’s flower morphology,suggesting that dysfunction of A-class genes is responsible for the absence of petals in *** family expansion analysis demonstrated significant enrichment of Gene Ontology(GO)terms associated with DNA repair,chromosome stability,DNA demethylation,cation binding,and red/far-red light signaling pathways in the co-expanded gene families of *** and ***,in comparison with glycophytic species within the chenopodium ***-course transcriptome analysis under salt treatments revealed detailed responses of *** to salt tolerance,and the enrichment of the transition-upregulated genes in the leaves associated with DNA repair and chromosome stability,lipid biosynthetic process,an

关键词： light expanded tolerance

小鼠阴道内注入高分子聚合物HFMC的避孕实验研究

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华西医科大学学报 1989年第4期20卷 389-391页

作者：曾怀德罗自强华西医大生理学教研室

高分子聚合物HFMC是一种良好的组织相容性材料,作者用5％HFMC一次性注入小鼠阴道0.8ml,通过交配实验,观察其避孕效果。结果表明:小鼠应用HFMC后可延迟自然复孕至分娩时间112～118天,与对照组30天相比,差异十分显著(P0.05)。

关键词：阴道内避孕高分子聚合物避孕

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基于无证书加密短信验证码的移动支付方案

计算机应用研究 2020年第7期37卷 2132-2135页

作者：柳毅罗子强广东工业大学计算机学院广州510006

针对移动支付中验证码泄露问题,提出了一种基于无双线性对的无证书公钥加密短信验证码的移动支付系统方案。该方案引入了标记化思想,双因素认证,解决了移动端私钥存储泄露问题。利用无证书公钥密码签密验证码,即使密文被泄露,攻击者也... 详细信息

针对移动支付中验证码泄露问题,提出了一种基于无双线性对的无证书公钥加密短信验证码的移动支付系统方案。该方案引入了标记化思想,双因素认证,解决了移动端私钥存储泄露问题。利用无证书公钥密码签密验证码,即使密文被泄露,攻击者也无法得到真正的验证码,从而避免了验证码泄露的风险。分析结果表明,该方案可以有效抵御多种攻击,并能对用户信息进行隐私保护,是一种安全可靠的移动支付方案。

关键词：无证书公钥密码验证码移动支付签密

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APT攻击与防御

清华大学学报（自然科学版） 2017年第11期57卷 1127-1133页

作者：张瑜潘小明 LIU Qingzhong 曹均阔罗自强海南师范大学信息学院浙江省电子信息产品检验所信息安全重点实验室萨姆休斯顿州立大学计算机系

高级持续性威胁(advanced persistent threat,APT)逐渐演化为各种社会工程学攻击与零日漏洞利用的综合体,已成为最严重的网络空间安全威胁之一。APT以攻击基础设施、窃取敏感情报为目的,且具有强烈的国家战略意图,从而使网络安全威胁由... 详细信息

高级持续性威胁(advanced persistent threat,APT)逐渐演化为各种社会工程学攻击与零日漏洞利用的综合体,已成为最严重的网络空间安全威胁之一。APT以攻击基础设施、窃取敏感情报为目的,且具有强烈的国家战略意图,从而使网络安全威胁由散兵游勇式的随机攻击演化为有目的、有组织、有预谋的群体式定向攻击。近年来,APT攻击与防御已受到网络空间安全社区的持续关注,获得了长足发展与广泛应用。该文首先回顾了APT起源与发展演化过程;其次讨论了APT攻击机理与生命周期;然后探讨了APT防御体系与检测方法,归纳总结目前APT检测防御的最新技术;最后讨论了APT攻击发展趋势、APT防御存在的问题和进一步研究方向。

关键词：高级持续性威胁威胁情报攻击检测网络空间安全社会工程学

基于服务系统的运行时异常处理机制研究与应用

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计算机与数字工程 2017年第2期45卷 235-241,366页

作者：文斌罗自强海南师范大学信息科学技术学院海口571158 海南师范大学云计算与大数据研究中心海口571158

软件服务成为接入和放大各类硬件基础设施能力的基本途径,服务计算成就资源共享价值,其核心是个性化定制和按需聚合实现离散服务增值。目前基于服务的软件系统缺乏运行时异常处理和服务再聚合迭代过程考虑,没有从需求出发直接对接服务... 详细信息

软件服务成为接入和放大各类硬件基础设施能力的基本途径,服务计算成就资源共享价值,其核心是个性化定制和按需聚合实现离散服务增值。目前基于服务的软件系统缺乏运行时异常处理和服务再聚合迭代过程考虑,没有从需求出发直接对接服务系统的自适应机制以克服运行时各种例外和应对客观存在的服务资源不足、上下文环境变化问题。论文主要贡献:1)构建服务资源自适应异常处理体系结构;2)设计应对需求和服务场景变化的运行时自适应调节机制;3)结合海南热带农产品电商平台获取实现能支持自适应SOA的运行时处理能力的CASE工具功能性需求和相关性能评估。理论研究与实证相结合,尝试为服务软件系统的运行时需求演化和异常处理构建自适应机制、提升SOA运行时自适应能力方面提供一种可行的解决方案。

关键词： SBS 异常处理架构演化运行时海南农产品电商平台

MK-801对新生大鼠高氧性肺损伤的保护作用

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临床儿科杂志 2005年第1期23卷 28-30页

作者：汤飞鸽岳少杰罗自强冯德云中南大学湘雅医院儿科中南大学湘雅医学院生理学系中南大学湘雅医学院病理学系

目的观察谷氨酸(Glu)的NMDA受体拮抗剂MK-801对新生大鼠高氧性肺损伤的影响,探讨Glu在高氧性肺损伤中的可能作用。方法出生12h内的SD新生大鼠随机分为:空气对照组、空气+MK-801组、高氧对照组及高氧+MK-801组。观察持续高氧暴露7d后各... 详细信息

目的观察谷氨酸(Glu)的NMDA受体拮抗剂MK-801对新生大鼠高氧性肺损伤的影响,探讨Glu在高氧性肺损伤中的可能作用。方法出生12h内的SD新生大鼠随机分为:空气对照组、空气+MK-801组、高氧对照组及高氧+MK-801组。观察持续高氧暴露7d后各组肺湿/干重比(W/D)、支气管肺泡灌洗液(BALF)中白细胞及中性粒细胞数、肺组织及BALF中一氧化氮(NO)含量的变化。结果MK-801可有效地抑制高氧所致新生大鼠肺W/D、BALF中白细胞和中性粒细胞、肺组织和BALF中NO含量的增高。结论MK-801可有效地减轻新生大鼠高氧性肺损伤,提示内源性Glu通过NMDA受体介导,促进NO的产生而加重肺损伤。

关键词：高氧肺损伤一氧化氮 NMDA受体 MK-801