检索结果-南通市图书馆

Is there an optimal time to initiate adjuvant chemotherapy to predict benefit of survival in non-small cell lung cancer?

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2017年第3期29卷 263-271页

作者： Yutao Liu Xiaoyu Zhai Junling Li Zhiwen Li Di Ma ziping wang Department of Medical Oncology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Reproductive & Child Health Peking University Ministry of Health Key Laboratory of Reproductive Health Department of Epidemiology and Biostatistics School of Public Health Peking University Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Thoracic Medical Oncology Peking University Cancer Hospital &Institute

Objective: Adjuvant chemotherapy (AC) after curative resection is known to improve the survival of patients with non-small cell lung cancer (NSCLC); however, few studies have reported the correlation between the time to initiation of AC (TTAC) and survival in NSCLC patients. Methods: The clinical data of 925 NSCLC patients who received curative resection and post-operative AC at the Cancer Hospital of Chinese Academy of Medical Sciences between 2003 and 2013 were retrospectively analyzed. TTAC was measured from the date of surgery to the initiation of AC. Disease-free survival (DFS) was defined as the duration from surgery to the time of tumor recurrence or last follow-up evaluation. The optimal cut-off value of TTAC was determined by maximally selected log-rank statistics. The DFS curve was estimated using the Kaplan-Meier method, and the Cox proportional hazards regression model was used to identify risk factors independently associated with DFS. Propensity score matching (PSM) was performed for survival analysis using the match data. Results: The optimal discriminating cut-off value of TTAC was set at d 35 after curative resection based on which the patients were assigned into two groups: group A ( 35 d). There was no significant difference in the DFS between the two groups (P=0.246), indicating that the TTAC is not an independent prognostic factor for DFS. A further comparison continued to show no significant difference in the DFS among 258 PSM pairs (P=0.283). Conclusions: There was no significant correlation between the TTAC and DFS in NSCLC patients. Studies with larger samples are needed to further verify this conclusion.

关键词： Non-small cell lung cancer (NSCLC) adjuvant chemotherapy time to adjuvant chemotherapy(TTAC) disease-free survival

Embedding ultrasmall Ag nanoclusters in Luria-Bertani extract via light irradiation for enhanced antibacterial activity

在线全文

学校读者我要写书评

暂无评论

Nano Research 2020年第1期13卷 203-208页

作者： ziping wang Yushuang Fang Xianfeng Zhou Zhibo Li Haiguang Zhu Fanglin Du Xun Yuan Qiaofeng Yao Jianping Xie Shandong Key Laboratory of Biochemical Analysis College of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao266042China Weifang University of Science and Technology Shandong Peninsula Engineering Research Center of Comprehensive Brine UtilizationWeifang262700China Key Lab of Biobased Polymer Materials of Shandong Provincial Education Department School of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao266042China Department of Chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4117585SingaporeSingapore

Ultrasmall silver nanoclusters(Ag NCs)with rich surface chemistry and good biocompatibility are promising in antibacterial application,however,further development of Ag NCs for practical settings has been constrained by their relatively weak antibacterial *** the nutritionally-rich medium for bacteria(e.g.,Luria-Bertani(LB)medium)to coat active Ag NCs could further improve their antibacterial ***,we provide a delicate design of a highly efficient Ag NCs@ELB antibacterial agent(ELB denotes the extract of LB medium)by anchoring Ag NCs inside the ELB species via light *** as-designed Ag NCs with bacterium-favored nutrients on the surface can be easily swallowed by the bacteria,boosting the production of the intracellular reactive oxygen species(ROS,about 2-fold of that in the pristine Ag NCs).Subsequently,a higher concentration of ROS generated in Ag NCs@ELB leads to enhanced antibacterial activity,and enables to reduce the colony forming units(CFU)of both gram-positive and gram-negative bacteria with 3–4 orders of magnitude less than that treated with the pristine Ag *** addition,the Ag NCs@ELB also shows good *** study suggests that surface engineering of active species(e.g.,Ag NCs)with nutritionally-rich medium of the bacteria is an efficient way to improve their antibacterial activity.

关键词： Ag nanoclusters LB broth light irradiation antibacterial agent reactive oxygen species

In-situ polymerized carbonate induced by Li-Ga alloy as novel artificial interphase on Li metal anode

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第9期34卷 294-299页

作者： ziping wang Shuyuan Xie Xuejie Gao Xinyang Chen Lina Cong Jun Liu Haiming Xie Chuang Yu Yulong Liu School of Chemistry Northeast Normal UniversityChangchun 130024China Center for Lignocellulosic Chemistry and Biomaterials College of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034China State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Li metal is considered an ideal anode material because of its high theoretical capacity and low electrode ***,the practical usage of Li metal as an anode is severely limited because of inevitable parasitic side reactions with electrolyte and dendrites *** present,single-component artificial solid electrolyte interphase cannot simultaneously meet the multiple functions of promoting ion conduction,guiding lithium ion deposition,inhibiting dendrite growth,and reducing interface side ***,multi-component design on Li metal surface is widely investigated to achieve long-term ***,we report a Li_(2)Ga-carbonate polymer interphase layer to solve volume changes,Li dendrites formation and *** a result,the Li symmetric cell can be stabilized at 3.0 m A/cm^(2)in carbonate electrolyte with limited volume of 20μ*** with 13.6 mg/cm^(2)(loading of 2 mAh/cm^(2))LiFePO_(4)cathode,discharge capacity retains at 90%for over 150 cycles under limited electrolyte *** such an alloy-polymer interphase layer,higher energy density Li metal batteries become prominent in the near future.

关键词： Lithium metal Alloy Polymer film High energy density Self-healing

Survival difference between EGFR Del19 and L858R mutant advanced non-small cell lung cancer patients receiving gefitinib:a propensity score matching analysis

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2017年第6期29卷 553-560页

作者： Minglei Zhuo Qiwen Zheng Jun Zhao Meina Wu Tongtong An Yuyan wang Jianjie Li Shuhang wang Jia Zhong Xue Yang Hanxiao Chen Bo Jia Zhi Dong Emei Gao Jingjingwang ziping wang Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Medical OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Epidermiololgy and Biostatistics School of Public HealthPeking UniversityBeijing 100191China

Objective： Although superior clinical benefits of epidermal growth factor receptor （EGFR） tyrosine kinase inhibitors （TKIs） in the treatment of advanced non-small-cell lung cancer （NSCLC） had been reported, the survival difference between exon 19 deletion （Dell9） and exon 21 Leu858Arg substitution （L858R） remains controversial. The purpose of this study is to investigate the differences in progression-free survival （PFS） and overall survival （OS） between different EGFR mutant subtypes among advanced NSCLC patients receiving gefitinib. Methods： There were 204 advanced NSCLC patients with EGFR mutations treated with gefitinib were enrolled in this retrospective cohort study. Patients were divided into the EGFR Dell9 group and the L858R mutated group according to their mutant subtype. Propensity score matching （PSM） was conducted by using a nearest-neighbor algorithm （1：1） to adjust for demographical and clinical covariates. Survival curves were constructed with the Kaplan-Meier method and compared by using the log-rank test. Results： The PFS in Dell9 group was similar to that in the L858R group [before PSM 8.6 vs. 7.2 months, P=0.072; after PSM 7.3 vs. 7.2 months, P=0.155]. No differences were detected in OS between the L858R and the Dell9 group （before PSM 17.8 vs. 13.1 months, P=0.253; after PSM 16.9 vs. 13.1 months, P=0.339）. The Dell9 group was significantly younger compared with the L858R mutation group in age （P=0.015）. Conclusions： No significant difference was found in the PFS or OS between the Dell9 and L858R mutant NSCLC patients receiving gefitinib. The age gap might contribute to the survival differences between Dell9 and L858R groups. PSM is of important value to the elimination of potential bias.

关键词： Non-small-cell lung cancer epidermal growth factor receptor tyrosine kinase inhibitors survival propensity score matching

在线全文

学校读者我要写书评

暂无评论

基于HHT的复合板非接触冲击损伤定位研究

稀有金属材料与工程 2021年第2期50卷 469-474页

作者：王自平费跃钱磊孙思江苏大学土木工程与力学学院江苏镇江212013

航空/航天器、汽车、轮船等工程设施在服役过程中受到其他物体的冲击时,造成的损伤会引起构件的失效甚至会造成灾难性事故,如何采取有效的措施监测和评定这类活性冲击损伤至关重要。为了实现实时、准确地定位工程结构中的冲击损伤,提出... 详细信息

航空/航天器、汽车、轮船等工程设施在服役过程中受到其他物体的冲击时,造成的损伤会引起构件的失效甚至会造成灾难性事故,如何采取有效的措施监测和评定这类活性冲击损伤至关重要。为了实现实时、准确地定位工程结构中的冲击损伤,提出了一种基于扫描式激光多普勒测振仪(SLDV)的非接触式冲击损伤定位方法。将希尔伯特黄变换(Hilbert-Huang transform, HHT)应用于信号处理中,得出最佳响应频率谱,将分离出的本征模函数(IMF1)用于幅值全加和幅值全乘的圆轨迹定位成像中。实验结果表明,HHT方法可用于实现复合材料的非接触式冲击损伤定位中。

关键词：冲击损伤希尔伯特黄变换非接触激光多普勒测振圆轨迹

Study on Sustainable Development Capability of Shandong Province

在线全文

学校读者我要写书评

暂无评论

Science Foundation in China 2005年第2期13卷 66-71页

作者： Ren ziping Luo Qishan wang Yanchun Deng Hongbing Zhao Jingzhu Research Center for Eco-Environmental Sciences CAS Beijing 100085

Based on the indicator system of Sustainable Development (SD), Shandong Province was select- ed as an example for assessment with AHP method and the standard year was 1978. The conclusion was that Shandong Province’ s ability of SD was be- ing strengthened step by step, and there were also some restrictive factors, and according to the basic conditions of Shandong Province, countermeasures and strategy of SD were put forward.

关键词： sustainable development assessment Shandong Province

单层声表面波叉指换能器(SAW-IDT)结构优化设计

在线全文

学校读者我要写书评

暂无评论

稀有金属材料与工程 2021年第11期50卷 3917-3923页

作者：王自平费跃钱磊薛显 Karthik Reddy 江苏大学土木工程与力学学院高端装备关键结构健康管理国际联合研究中心江苏镇江212013 北卡罗莱纳州立大学机械与航空航天工程系美国罗利27606

为优化单层声表面波换能器的驱动性能,改善现有δ函数分析方法在计算过程中的不足之处,采用有限元仿真优化方法对叉指式换能器的静力学性能进行了分析,研究了支路电极宽度w、电极间距s和基片厚度t对驱动性能的影响。仿真结果表明,当w/t=... 详细信息

为优化单层声表面波换能器的驱动性能,改善现有δ函数分析方法在计算过程中的不足之处,采用有限元仿真优化方法对叉指式换能器的静力学性能进行了分析,研究了支路电极宽度w、电极间距s和基片厚度t对驱动性能的影响。仿真结果表明,当w/t=0.7时,可以得到最佳应变响应;当s/t>3.2时,可以得到最大应变。同时还得出了电极间距越小,驱动电压越低的结论。根据仿真优化结果制备了声表面波叉指换能器(SAW-IDT),并进行了频率响应测试。研究结果为声表面波叉指换能器的制备、性能测试和应用提供了指导。

关键词：叉指换能器结构优化设计驱动性能

在线全文

学校读者我要写书评

暂无评论

宽频带TIDT结构优化设计与应用研究

稀有金属材料与工程 2020年第11期49卷 3790-3795页

作者：王自平钱磊费跃陈良彬郝东晖江苏大学土木工程与力学学院高端装备关键结构健康管理国际联合研究中心江苏镇江212013

针对现有矩形IDT带宽窄的不足,研究宽频带梯形叉指换能器(trapezoidal interdigital transducer,TIDT)。采用有限元分析方法对TIDT的尺寸进行结构优化设计,并对设计的TIDT进行性能测试,通过实验研究了TIDT用于结构损伤检测的初步应用。... 详细信息

针对现有矩形IDT带宽窄的不足,研究宽频带梯形叉指换能器(trapezoidal interdigital transducer,TIDT)。采用有限元分析方法对TIDT的尺寸进行结构优化设计,并对设计的TIDT进行性能测试,通过实验研究了TIDT用于结构损伤检测的初步应用。结果表明,TIDT在实际应用中进一步提高了损伤识别精度,具有广泛的应用前景。

关键词：梯形叉指换能器结构优化设计结构健康监测

在线全文

学校读者我要写书评

暂无评论

“居住下垫面”在高层住宅中的应用

建筑学报 2005年第10期 34-36页

作者：王子平王竹浙江大学建筑系杭州310058

本文针对高层住居存在的一系列问题,引入”居住下垫面”来组织其“空间层次”与“居住结构”,以找回高层住居中日渐失落的自然与人文环境,重塑家园感与邻里感。

关键词：高层住居 “居住下垫面” 空间层次社会结构高层住宅下垫面居住应用人文环境邻里