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Primary Extra-Gastrointestinal Stromal Tumors (E-GIST) of the Liver, about Two Cases and Review of the Literature Oncology Hospital Experience at Chu Hassan II in FES

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Journal of Cancer Therapy 2023年第3期14卷 117-126页

作者： Oumaima Siyouri Mohammed Ismaili Khaoula Alaoui Ismaili Imane Stitou Hajar Medyouni Jihane Chouef Lamiae Amaadour Karima Oualla zineb Benbrahim Samia Arifi Nawfel Mellas Hospital Center University Hassan II Fez Morocco

Introduction: Primary extra-gastrointestinal stromal tumors (E-GIST) of the liver are rare. The clinical presentation can range from asymptomatic to bleeding or manifestations of mass effect. Cancer surgery followed by adjuvant treatment with imatinib is the standard of care. However, in special circumstances, a cytoreductive approach may represent a therapeutic option. We describe here the case of two patients who presented with a painful and protruding epigastric mass, the first case was a localized E-GIST candidate for neoadjuvant treatment with imatinib with complete resection surgery thereafter with very good evolution, and the second is that of an E-GIST of the liver at an advanced stage with an evolution very quick to death. Conclusion: Primary liver E-GIST is a rare condition. Treatment is based on systemic therapy and total resection surgery. However, cytoreductive surgery will be required when complete resection is not possible.

关键词： Extra GIST Foie Imatinib

Primary Testicular Lymphoma: A Case Report and Review of the Literature

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Journal of Cancer Therapy 2022年第3期13卷 145-154页

作者： Nioka Pierre Xavier Sia Tarik Chekrine Mouna Bourhafour Karima Ouadii zineb Bouchbika Nadia Benchakroun Hassan Jouhadi Nezha Tawfiq Abdellatif Benider Farida Marnissi Abdellah Madani Mehdi Karkouri Souha Sahraoui Department of Radiation Oncology University Hospital Center Ibn Rochd Faculty of Medicine and Pharmacy Hassan II University Casablanca Morocco Department of Medical Oncology University Hospital Center Ibn Rochd Faculty of Medicine and Pharmacy Hassan II Univer-sity Casablanca Morocco Department of Pathology University Hospital Center Ibn Rochd Faculty of Medicine and Pharmacy Hassan II University Casablanca Morocco Department of Pathology University Hospital Center Ibn Rochd Faculty of Medicine and Pharmacy Hassan II University Cas-ablanca Morocco Department of Clinical Hematology and Pediatric Oncology University Hospital Center Ibn Rochd Faculty of Medicine and Pharmacy Hassan II University Casablanca Morocco

Background and Aim: Primary testicular lymphoma (PTL) is a rare form of extranodal non-Hodgkin’s lymphoma. It represents for 1% - 2% of non-Hodgkin’s lymphoma, and mostly affects the elderly. We describe an interesting case of PTL managed by a combined multimodal approach with a review of the literature. Case Presentation: Patient aged 56 years, consulted for an increase in the volume of the right testicle without associated pain, all evolving in the context of a slight decline in general condition. Clinical examination revealed a large painless mass in the right scrotal bursa. A scrotal ultrasound showed a right intra-testicular mass. The patient had undergone inguinal orchiectomy. Pathological analysis showed diffuse large B-cell lymphoma of the testis. Whole-body 18-fluorodeoxyglucose positron emission tomography (18-FDG-PET-CT) showed no suspicious hypermetabolism. Lumbar puncture did not reveal malignant cells in the cerebrospinal fluid (CSF). The patient then received 6 cycles of chemotherapy according to the R-CHOP protocol (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) and 2 cycles of intrathecal methotrexate. After chemotherapy, scrotal radiotherapy at a dose of 30 Gy was delivered. The evolution was marked by the death of the patient six months after the end of the scrotal radiotherapy following a diffuse lymph node relapse with a profound alteration of the general state. Conclusion: The treatment depends imperatively on the stage of the disease. The therapeutic approach is multimodal and combined based on orchiectomy, systemic and intrathecal treatment and scrotal radiotherapy. PTL is an aggressive malignant with a poor prognosis. Randomized trials are needed to define a better therapeutic strategy.

关键词： Primary Testicular Lymphoma Diffuse Large-B Cell Lymphoma Orchiectomy Chemotherapy Radiotherapy Testis

Biological Characterisation and Pathogenicity of a Pasteurella multocida Isolate from Sheep in Morocco

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Journal of Agricultural Science and Technology(A) 2021年第1期11卷 53-64页

作者： zineb Boumart Zahra Bamouh Noha Semmate Khalid Omari Tadlaoui Mehdi El Harrak Research and Development Bacteriology Multi-Chemical IndustryLot.157ZISud-Ouest(ERAC)B.P.:278Mohammedia 28810Morocco

In this study,55 suspected pasteurellosis clinical cases from different provinces of Morocco were *** analysis revealed that 47%of samples were positive for Pasteurella multocida,all typed as serogroup A,and 11%positive for Mannheimia *** isolates were recovered from 26 *** positive samples,and characterized by biochemical and molecular typing *** these isolates,two strains(S13 and S14)were selected for genes(RNA16S and rpoB)sequence analysis and virulence study in mice,guinea pigs and *** study showed similarities of both S14 and S13 isolates with strains from other *** laboratory animals,the strain S14 was more virulent than S13 and induced severe illness in *** high mortality of infected mice suggests that this model may represent an alternative for testing pathogenicity and vaccine efficacy.

关键词： Pasteurella multocida phylogeny mice sheep pathogenicity

Place of Total Self-Skin Transplant in the Management of Burns in Children:Results and Predictive Factors

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Innovative surgical approaches for hepatocellular carcinoma

Open Journal of Pediatrics（儿科学期刊） 2021年第4期

作者： Fatoumata Binta Balde zineb Benmassaoud Thierry Mukenge Majdouline Zemmari

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World Journal of Hepatology 2016年第13期8卷 591-596页

作者： Riccardo Memeo Nicola de’Angelis Vito de Blasi zineb Cherkaoui Oronzo Brunetti Vito Longo Tullio Piardi Daniele Sommacale Jacques Marescaux Didier Mutter Patrick Pessaux Department of Digestive Surgery University Hospital of Strasbourg IRCAD Research Institute Against Cancer of the Digestive Tract IHU-Strasbourg Institute for Image-Guided Surgery Inserm U1110 Institutde Recherche sur les Maladies Virales et Hépatiques Unit of Digestive Hepato-Pancreato-Biliary Surgery and Liver Transplantation Henri Mondor Hospital AP-HP Université Paris-Est Val de Marne UPEC Medical Oncology Unit Cancer institute"Giovanni Paolo II" Medical Oncology Unit Hospital "Di Miccoli" Service de Chirurgie Générale Digestive et Endocrinienne Hopital Robert Debré Centre Hospitalier Universitaire de Reims Université de Reims Champagne-Ardenne

Hepatocellular carcinoma(HCC)is the sixth most common cancer worldwide,with an increasing diffusion in Europe and the United *** management of such a cancer is continuously progressing and the objective of this paper is to evaluate innovation in the surgical treatment of *** this review,we will analyze the modern concept of preoperative management,the role of laparoscopic and robotic surgery,the intraoperative use of three dimensional models and augmented reality,as well as the potential application of fluorescence.

关键词： Hepatocellular carcinoma Liver resection Hepatectomy New prespectives Innovative surgical approaches