检索结果-南通市图书馆

Molecular insights of exercise therapy in disease prevention and treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第6期9卷 2564-2597页

作者： David Walzik Tiffany Y.Wences Chirino Philipp zimmer Niklas Joisten Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund University44227 DortmundNorth Rhine-WestphaliaGermany Division of Exercise and Movement Science Institute for Sport ScienceUniversity of Göttingen37075 GöttingenLower SaxonyGermany

Despite substantial evidence emphasizing the pleiotropic benefits of exercise for the prevention and treatment of various diseases,the underlying biological mechanisms have not been fully *** exercise benefits have been attributed to signaling molecules that are released in response to exercise by different tissues such as skeletal muscle,cardiac muscle,adipose,and liver *** signaling molecules,which are collectively termed exerkines,form a heterogenous group of bioactive substances,mediating inter-organ crosstalk as well as structural and functional tissue *** scientific endeavors have focused on identifying and characterizing new biological mediators with such ***,some investigations have focused on the molecular targets of exerkines and the cellular signaling cascades that trigger adaption processes.A detailed understanding of the tissue-specific downstream effects of exerkines is crucial to harness the health-related benefits mediated by exercise and improve targeted exercise programs in health and ***,we review the current in vivo evidence on exerkine-induced signal transduction across multiple target tissues and highlight the preventive and therapeutic value of exerkine signaling in various *** emphasizing different aspects of exerkine research,we provide a comprehensive overview of(i)the molecular underpinnings of exerkine secretion,(ii)the receptor-dependent and receptor-independent signaling cascades mediating tissue adaption,and(iii)the clinical implications of these mechanisms in disease prevention and treatment.

关键词： prevention treatment collective

Impact of exercise on markers of B cell-related immunity:A systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 339-352,I0002页

作者： David Walzik Sergen Belen Karen Wilisch Marie Kupjetz Silvana Kirschke Tobias Esser Niklas Joisten Alexander Schenk Sebastian Proschinger Philipp zimmer Division of Performance and Health(Sports Medicine) Institute for Sport and Sport ScienceTU Dortmund UniversityDortmund 44227Germany

Background:B cells represent a crucial component of adaptive immunity that ensures long-term protection from infection by generating pathogen-specific *** alters B cell counts and immunoglobulin levels,but evidence-based conclusions on potential benefits for adaptive immunity are *** systematic review assessed current literatures on the impact of acute exercise and exercise training on B cells,immunoglobulins,and markers of secretory immunity in human ***:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,MEDLINE,Web of Science,and Embase were searched on March 8,***-randomized controlled trials and crossover trials investigating the impact of acute exercise or exercise training on B cell counts and proportions,immunoglobulin levels,salivary flow rate,or secretory immunoglobulin A secretion rate were *** and reporting of exercise training studies were assessed using the Tool for the Assessment of Study Quality and reporting in *** characteristics,outcome measures,and statistically significant changes were summarized ***:Of the 67 eligible studies,22 applied acute exercise and 45 applied exercise *** included outcomes revealed significant alterations over time in acute exercise and exercise training context,but only a few investigations showed significant differences compared to control *** and plasma immunoglobulin A levels were most consistently increased in response to exercise ***:B cell-related outcomes are altered by acute exercise and exercise training,but evidence-based conclusions cannot be drawn with high confidence due to the large heterogeneity in populations and exercise ***-designed trials with large sample sizes are needed to clarify how exercise shapes B cell-related immunity.

关键词： Antibody B-lymphocyte Exercise Humoral immunity Immune system

Is magnesium deficiency the major cause of needle chlorosis of Pinus taeda in Brazil?

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2024年第2期35卷 209-221页

作者： Antônio Carlos Vargas Motta Shizuo Maeda Valdécio dos Santos dos Santos Rodrigues Tamires Maiara Ercole Stephen Arthur Prior Ana Elisa Lyra Brumat Amanda Pacheco Cardoso Moura Julierme zimmer Barbosa João Bosco Vasconcellos Gomes Department of Soil Sciences and Agriculture Engineering Federal University of ParanáR.dos Funcionários1540.CuritibaParanáCEP 80035‑050Brazil Brazilian Agricultural Research Company Embrapa FlorestasEstr.da Ribeira–Br‑476Km 111–Parque Monte Castelo.ColomboParanáCEP 83411‑000Brazil United States Department of Agriculture‑Agricultural Research Service USDA-ARS National Soil Dynamics Laboratory411 South Donahue DriveAuburnAL 36832USA Reforestation Remasa Rodovia PR 170–Km 522.BiturunaParanáCEP 84640‑000Brazil Federal Institute of Southeast of Minas Gerais R.Luz Interior360.Juiz de ForaMinas Gerais CEP 36030‑713Brazil

Needle chlorosis(NC)in Pinus taeda *** in Brazil becomes more frequent after second and third harvest rotation *** a study to identify factors contributing to yellowing needle chorosis(YNC),trees were grown in soils originating from contrasting parent materials,and soils and needles(whole,green and chlorotic portions)from 1-and 2-year-old branches and the first and second needle flush release at four sites with YNC on *** were analyzed for various elements and *** soils had very low base levels(Ca^(2+),Mg^(2+)and K^(+))and P,suggesting a possible lack of multiple *** symptoms started at needle tips,then extended toward the needle base with *** flush needles had longer portions with YNC than second flush needles *** from the lower crown also had more symptoms along their length than those higher in the *** were similar to those reported for *** chlorotic portions,Mg and Ca concentrations were well below critical values;in particular,Mg levels were only one third of the critical value of 0.3 g kg^(-1).Collectively,results suggest that Mg deficiency is the primary reason for NC of *** in various parent soils in Brazil.

关键词： Nutritional deficiency Forest management Soil depletion Pine foliar analysis Needle chlorosis

Regulation of neuronal survival by DNA methyltransferases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第11期12卷 1768-1775页

作者： Judit Symmank Geraldine zimmer Institute of Human Genetics University Hospital JenaJenaGermany

The limited regenerative capacity of neuronal cells requires tight orchestration of cell death and survival regulation in the context of longevity, age-associated diseases as well as during the development of the nervous system. Subordinate to genetic networks epigenetic mechanisms like DNA methylation and histone modifications are involved in the regulation of neuronal development, function and aging. DNA methylation by DNA methyltransferases （DNMTs）, mostly correlated with gene silencing, is a dynamic and reversible process. In addition to their canonical actions performing cytosine methylation, DNMTs influence gene expression by interactions with histone modifying enzymes or complexes increasing the complexity of epigenetic transcriptional networks. DNMTs are expressed in neuronal progenitors, post-mi- totic as well as adult neurons. In this review, we discuss the role and mode of actions of DNMTs including downstream networks in the regulation of neuronal survival in the developing and aging nervous system and its relevance for associated disorders.

关键词： DNA methyltransferase I cortical interneurons PAK6 neuronal aging neuropsychiatric diseases neurodevelopment neuronal death

Fine-tuning of cortical progenitor proliferation by thalamic afferents

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2015年第6期10卷 887-888页

作者： Katrin Gerstmann Geraldine zimmer Institute of Human Genetics Jena University HospitalFriedrich-Schiller-University Jena CGphi MC UMR CNRS 5534 University Claude Bernard Lyon

During cerebral cortical cortex neurogenesis two major types of progenitors generate a variety of morphologically and functionally diverse projection neurons destined for the different cortical layers in non-gyrified mice. Radial glia cells （RGCs） undergo mitosis in the cortical ventricular zone and exhibit an apical-basal cell polarity, whereas non-polar intermediate progenitor cells （IPCs） divide basally in the subventricular zone （Franco and Muller, 2013; Taverna et al., 2014）.

关键词： Eph Fine-tuning of cortical progenitor proliferation by thalamic afferents

DNMT1-dependent regulation of cortical interneuron function and survival

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第12期16卷 2405-2406页

作者： Daniel Pensold Geraldine zimmer-Bensch RWTH Aachen University Institute for Biology IIDepartment of Functional Epigenetics in the Animal ModelAachenGermany

Increased occurrence of age-associated disabilities and neurodegenerative diseases is the price we pay for the tremendous elevation in life expectancy in our modern *** comes along with structural,neurochemical and physiological alterations in the brain that cause memory decline and cognitive impairments(Rozycka and Liguz-Lecznar,2017).Numerous factors contribute to cognitive aging including hormonal,metabolic,and immune dysregulation,elevated oxidative stress and inflammation,changes in neurotransmission,and diminished neurotrophic support of neurons(Rozycka and Liguz-Lecznar,2017).

关键词： alterations elevated function

在线全文

学校读者我要写书评

暂无评论

病毒的隐秘社交

环球科学 2024年第17期 68-75页

作者：卡尔·齐默赵建元(翻译) 耶鲁大学北京协和医学院

自19世纪末期科学家发现病毒以来,他们就将病毒与其他生命体区分开来。病毒远小于细胞,它的蛋白质外壳内除了一些基因外,几乎什么都没有。它们无法生长、无法靠自身复制基因和进行其他任何活动。研究人员认为每个病毒都是独自在世界上... 详细信息

自19世纪末期科学家发现病毒以来,他们就将病毒与其他生命体区分开来。病毒远小于细胞,它的蛋白质外壳内除了一些基因外,几乎什么都没有。它们无法生长、无法靠自身复制基因和进行其他任何活动。研究人员认为每个病毒都是独自在世界上漂泊的颗粒。

关键词：复制基因病毒生命体蛋白质科学家

Imposing temporal consistency on deep monocular body shape and pose estimation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computational Visual Media 2023年第1期9卷 123-139页

作者： Alexandra zimmer Anna Hilsmann Wieland Morgenstern Peter Eisert Fraunhofer Heinrich-Hertz-Institut 10587 BerlinGermany Technische Universit¨at Berlin 10623 BerlinGermany Humboldt Universit¨at zu Berlin 10117 BerlinGermany

Accurate and temporally consistent modeling of human bodies is essential for a wide range of applications,including character animation,understanding human social behavior,and AR/VR *** human motion accurately from a monocular image sequence remains challenging;modeling quality is strongly influenced by temporal consistency of the captured body *** work presents an elegant solution to integrating temporal constraints during *** increases both temporal consistency and robustness during *** detail,we derive parameters of a sequence of body models,representing shape and motion of a *** optimize these parameters over the complete image sequence,fitting a single consistent body shape while imposing temporal consistency on the body motion,assuming body joint trajectories to be linear over short *** approach enables the derivation of realistic 3D body models from image sequences,including jaw pose,facial expression,and articulated *** experiments show that our approach accurately estimates body shape and motion,even for challenging movements and ***,we apply it to the particular application of sign language analysis,where accurate and temporally consistent motion modelling is essential,and show that the approach is well-suited to this kind of application.

关键词： motion capture surface reconstruction face modeling body model estimation

LHX1–a multifunctional regulator in preoptic area-derived interneuron development

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第7期14卷 1213-1214页

作者： Judit Symmank Geraldine zimmer-Bensch Polyclinic for Orthodontics University Hospital Jena Department of Functional Epigenetics in the Animal Model Institute for Biology ⅡRWTH Aachen University

In the cerebral cortex,local inhibition is achieved by different types of gamma-aminobutyric(GABA)-expressing interneurons,representing essential key players of cortical information processing(Marin,2012).Their development has to be highly orchestrated to ensure proper numbers and subtype composition in the adult cortex and defects in interneuron development contribute to the pathophysiology of psychiatric diseases(Marin,2012).

关键词： cerebral cortex different types gamma-aminobutyric