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Genes & Diseases 2024年第4期11卷 109-112页

作者： Kaili Liao Yuhan Xu Bingying Lin Yuxuan Xie Qijun yang Wenyige Zhang Beining Zhang Jiarong Wen Jingyi Wang zimeng Li Yunqi Cheng Xiaozhong Wang Jiangxi Province Key Laboratory of Laboratory Medicine Jiangxi Provincial Clinical Research Center for Laboratory MedicineDepartment of Clinical LaboratoryThe Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Queen Mary College of Nanchang University NanchangJiangxi 330001China School of Public Health Nanchang UniversityNanchangJiangxi 330006China The Second Clinical Medical College Nanchang UniversityNanchangJiangxi 330006China The First Clinical Medical College of Nanchang University NanchangJiangxi 330006China

Pancreatic cancer is one of the most lethal malignant tumors in the world.Despite advances in diagnosis and treatment,the five-year survival rate for pancreatic cancer patients remains only 9%.1 Pancreatic adenocarcinoma(PAAD)belongs to pancreatic cancer,which occupies 85%of the whole pancreatic cancer.2 Reversible modification of Ne-methyladenosine(mA)has been shown to be involved in cancer progression,resulting in up-regulation of oncogene expression or down-regulation of tumor-suppressing genes and may affect the prognosis of patients with pancreatic cancer.

关键词： patients cancer diagnosis

The Awkward Sharing Economy:Its Status Quo and Prospect

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Proceedings of Business and Economic Studies 2024年第3期7卷 80-85页

作者： zimeng Xu Tianjin University of Commerce Tianjin 300133China

This paper comprehensively analyzes the origins,current situation,and prospects of the sharing economy.The primary purpose is to present the issues and challenges confronting the sharing economy at its current,awkward stage of development and to make reasonable speculations about its future.The research is based on academic literature on the sharing economy from both domestic and international sources.The findings indicate that despite current shortcomings in the regulatory system,industry structure,and user behavior,the scope of the sharing economy’s applications could still expand,and its technology could continue to advance.Overall,the prospects for the sharing economy are likely to be promising.

关键词： Sharing economy Current challenges Future prospects Tripartite assistance

Beyond microbial carbon use efficiency

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National Science Review 2024年第4期11卷 33-35页

作者： Ke-Qing Xiao Chao Liang zimeng Wang Jingjing Peng Yao Zhao Ming Zhang Mingyu Zhao Shuiqing Chen Yong-Guan Zhu Caroline L.Peacock State Key Lab of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Institute of Applied Ecology Chinese Academy of Sciences Department of Environmental Science and Engineering Fudan University College of Resources and Environmental Sciences China Agricultural University State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences State Key Laboratory of Agricultural Microbiology College of Resources and Environment Huazhong Agricultural University Key Laboratory of Cenozoic Geology and Environment Institute of Geology and Geophysics Chinese Academy of Sciences School of Earth and Environment University of Leeds

Microbial carbon use efficiency (CUE)is defined as the proportion of microbial biomass growth C versus substrate C uptake, and thus provides a useful measure of microbially driven accumulation and loss of soil organic carbon (SOC)[1]. In a recent study published in Nature [2],the authors used a data-driven machinelearning approach to conclude that CUE promotes global SOC storage based on a positive correlation between CUE and SOC content and that, based on sensitivity analysis, CUE is at least four times as important as six other evaluated factors,namely plant C inputs, C input allocation, non-microbial C transfer, substrate decomposability, environmental modifications and vertical transport.

关键词： SOIL-CARBON ORGANIC-MATTER

新型纳米递送系统在药物诱导肿瘤细胞焦亡中的应用

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中国肿瘤生物治疗杂志 2022年第5期29卷 391-398页

作者：杨梓萌程文静余祥三峡大学医学院肿瘤微环境与免疫治疗湖北省重点实验室湖北宜昌443000

随着纳米递送系统(NDS)研发的快速发展和对于细胞焦亡机制的深入认识,将两者巧妙结合而形成的肿瘤治疗新策略已经在部分肿瘤的实验性治疗中取得一定效果。基于NDS的药物诱导肿瘤细胞焦亡的策略,能够克服单独使用小分子焦亡诱导剂的缺陷... 详细信息

随着纳米递送系统(NDS)研发的快速发展和对于细胞焦亡机制的深入认识,将两者巧妙结合而形成的肿瘤治疗新策略已经在部分肿瘤的实验性治疗中取得一定效果。基于NDS的药物诱导肿瘤细胞焦亡的策略,能够克服单独使用小分子焦亡诱导剂的缺陷,如体内清除快、全身不良反应严重及肿瘤靶向能力弱等。现已有脂质体、水凝胶、聚合物胶束、金属-有机框架(MOF)和仿生细胞膜的纳米载体等多种NDS被用于构建诱导肿瘤细胞焦亡的纳米药物复合体。在此基础上,目前已发展了多种基于NDS药物诱导肿瘤细胞焦亡的策略,包括靶向肿瘤干细胞、干扰离子稳态、促进ROS产生、诱导表观遗传学改变及递送gasdermin(GSDM)家族蛋白等。然而,这些策略要应用于临床治疗,还面临对纳米生物相互作用机制认知不够等问题。未来研究中,在全面了解纳米材料与生物系统的相互作用的基础上,如能开发新型、安全的NDS并结合有效的焦亡诱导剂,靶向诱导肿瘤细胞焦亡从而克服凋亡逃逸及多药耐药,则有望为肿瘤患者带来福音。

关键词：焦亡纳米递送系统肿瘤靶向多药耐药

Research on Practical Teaching of Ideological and Political Courses in Colleges and Universities and Collaborative Education in the Second Classroom

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Journal of Contemporary Educational Research 2024年第1期8卷 214-220页

作者： Luhua Xiao Pingping Liu zimeng Li Qilu Medical University Zibo 255000Shandong ProvinceChina

In today’s society,the need for talent training is of utmost importance due to rapid development.To achieve high-quality talent training,we need to focus on building a collaborative education mechanism.Practical teaching and the second classroom,which serve as important carriers of educational talents,must align their educational goals and complement each other.This article explores the collaborative education mechanism of the second classroom and practical teaching for the ideological and political courses in colleges and universities.It proposes reasonable construction measures to provide some guidelines for teaching work.

关键词： Colleges and universities Ideological and political courses Practical teaching Second classroom Collaborative education

Identification of LRRC46 as a novel candidate gene for high myopia

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Science China Life Sciences 2024年

作者： Lingxi Jiang Chao Dai Yao Wei Bo Zhao Qi Li Zhengzheng Wu Liang Zou zimeng Ye Zhenglin yang Lulin Huang Yi Shi Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics Department of Laboratory Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Department of Ophthalmology Sichuan Provincial People's Hospital University of Electronic Science and Technology of China School of Food and Bioengineering Chengdu University School of Medicine University of Sydney Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026) Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Jinfeng Laboratory

High myopia(HM) is the primary cause of blindness, with the microstructural organization and composition of collagenous fibers in the cornea and sclera playing a crucial role in the biomechanical behavior of these tissues. In a previously reported myopic linkage region,MYP5(17q21–22), a potential candidate gene, LRRC46(c.C235T, p.Q79X), was identified in a large Han Chinese pedigree. LRRC46 is expressed in various eye tissues in humans and mice, including the retina, cornea, and sclera. In subsequent cell experiments, the mutation(c.C235T) decreased the expression of LRRC46 protein in human corneal epithelial cells(HCE-T). Further investigation revealed that Lrrc46–/–mice(KO) exhibited a classical myopia phenotype. The thickness of the cornea and sclera in KO mice became thinner and more pronounced with age, the activity of limbal stem cells decreased, and microstructural changes were observed in the fibroblasts of the sclera and cornea. We performed RNA-seq on scleral and corneal tissues of KO and normal control wild-type(WT) mice, which indicated a significant downregulation of the collagen synthesis-related pathway(extracellular matrix, ECM) in KO mice. Subsequent in vitro studies further indicated that LRRC46, a member of the important LRR protein family, primarily affected the formation of collagens. This study suggested that LRRC46 is a novel candidate gene for HM, influencing collagen protein VIII(Col8a1) formation in the eye and gradually altering the biomechanical structure of the cornea and sclera, thereby promoting the occurrence and development of HM.

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不同多酚处理对荔枝果肉抗氧化能力的影响

中国南方果树 2022年第3期51卷 43-50页

作者：杨梓萌白新宇尹楠曾教科海南大学园艺学院海口570228

以海南“妃子笑”荔枝为试材,采用原花青素、p-香豆酸、茶多酚、苹果多酚和绿原酸等5种多酚类物质溶液浸泡荔枝果实,探究不同多酚处理对采后贮藏荔枝果肉总酚、总黄酮、维生素C等抗氧化物质含量以及抗氧化活性的影响。结果表明,与对照(... 详细信息

以海南“妃子笑”荔枝为试材,采用原花青素、p-香豆酸、茶多酚、苹果多酚和绿原酸等5种多酚类物质溶液浸泡荔枝果实,探究不同多酚处理对采后贮藏荔枝果肉总酚、总黄酮、维生素C等抗氧化物质含量以及抗氧化活性的影响。结果表明,与对照(清水)相比,不同多酚处理均可有效维持荔枝果肉较高的总酚、总黄酮和维生素C含量以及抗氧化活性。其中,原花青素处理的效果显著优于其他多酚处理。相关性、主成分分析及抗氧化活性评分发现,不同多酚处理均可有效维持荔枝果肉较高的抗氧化能力,保持效果从高到低依次为原花青素、绿原酸、苹果多酚、茶多酚和p-香豆酸处理,且均明显优于对照(清水)。

关键词：荔枝多酚抗氧化能力贮藏原花青素

基于CiteSpace的中国历史地段研究的知识图谱分析

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城市建筑 2022年第12期19卷 72-77页

作者：郭明昊杨子萌苏州科技大学建筑与城市规划学院河南农业大学风景园林与艺术学院

为探究我国历史地段的研究趋势与热点,本文以1985—2021年的CNKI中文期刊数据库相关论文为数据基础,采用信息可视化软件CiteSpace对我国历史地段发展的情况进行可视化的知识图谱绘制。从发文量时间、作者群体、发文机构、研究热点演变... 详细信息

为探究我国历史地段的研究趋势与热点,本文以1985—2021年的CNKI中文期刊数据库相关论文为数据基础,采用信息可视化软件CiteSpace对我国历史地段发展的情况进行可视化的知识图谱绘制。从发文量时间、作者群体、发文机构、研究热点演变四个方面对我国历史地段的研究进程进行分析与总结。结果表明,我国历史地段发文量整体呈上升趋势,研究作者以夏青、王建国等人为主。东南大学、西安建筑科技大学、天津大学、同济大学和北京清华同衡规划设计院是该领域内发文量较多的研究机构。当前历史地段的研究主题主要集中在历史地段中的案例库应用研究、历史地段中个体行为偏好研究和历史地段评价研究三个方面,量化研究成为现在研究的热点,并且呈现多学科交叉的趋势。

关键词：历史地段 CiteSpace 知识图谱

基于改进CEEMD和RF的低压串联故障电弧识别方法

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电力系统保护与控制 2024年第1期52卷 97-108页

作者：江永鑫陈丽安郭梦倩徐子萌厦门理工学院电气工程与自动化学院福建厦门361024 厦门市高端电力装备及智能控制重点实验室福建厦门361024

为了解决完整集合经验模态分解(complete ensemble empirical mode decomposition,CEEMD)得到的固有模态函数分量数目及其频段不固定,以及故障电弧特征难以准确提取导致故障识别准确率低的不足,引入T检验和方差贡献率形成了一种改进CEEM... 详细信息

为了解决完整集合经验模态分解(complete ensemble empirical mode decomposition,CEEMD)得到的固有模态函数分量数目及其频段不固定,以及故障电弧特征难以准确提取导致故障识别准确率低的不足,引入T检验和方差贡献率形成了一种改进CEEMD方法,进一步提出一种基于改进CEEMD和随机森林(random forest,RF)的串联故障电弧识别方法。首先,依托串联电弧故障试验平台,采集不同负载的电流信号。然后,采用改进CEEMD对信号进行分析并提取故障特征量,以TreeBagger函数进行特征降维,形成特征向量样本集。最后,结合RF构建故障电弧诊断模型,对样本集进行分类识别。结果表明:改进CEEMD能有效地提取不同负载电流的故障特征,所提故障电弧识别方法的识别准确率达到97.50%。通过进行不同特征提取方法和不同分类模型对诊断结果影响的消融实验,进一步证明了所提方法的可行性。

关键词：故障识别串联故障电弧改进CEEMD T检验方差贡献率随机森林

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基于APT特征的铁路网络安全性能研究

信息网络安全 2024年第5期24卷 802-811页

作者：郭梓萌朱广劼杨轶杰司群中国铁道科学研究院集团有限公司研究生部北京100081 中国铁道科学研究院集团有限公司电子计算技术研究所北京100081

为了探究新网络安全形势下APT攻击对铁路网络安全造成的影响,文章首先分析APT攻击特点,提出融合APT过程的杀伤链模型,并据此总结APT攻击特点及对铁路网络安全可能产生的影响;然后分析铁路网络架构,对铁路外部服务网架构进行研究;最后根... 详细信息

为了探究新网络安全形势下APT攻击对铁路网络安全造成的影响,文章首先分析APT攻击特点,提出融合APT过程的杀伤链模型,并据此总结APT攻击特点及对铁路网络安全可能产生的影响;然后分析铁路网络架构,对铁路外部服务网架构进行研究;最后根据提出的铁路网络模型图进行APT攻击建模,详细分析连接过程和连接指数,通过连接指数反映网络性能,进而展示网络攻击对网络安全性能的影响。仿真实验结果表明,APT攻击的发起对网络性能造成了显著不利影响,APT攻击产生后,非法用户的网络连接指数平均提升5倍以上。对比实验表明,APT攻击产生后,非法用户的连接指数比普通网络攻击平均提升2倍以上,这表明APT攻击的影响更加严重。

关键词： APT攻击铁路网络系统网络性能连接指数