检索结果-南通市图书馆

Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang Jia Jia Shengjie yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2017年第1期44卷 63-66页

作者： BO yuan Tian-lin Cheng Kan Yang Xu Zhang zilong Qiu Institute of Neuroscience Key Laboratory of Primate Neurobiology CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Institute of Chemistry and Bioengineering Donghua University Shanghai 200051 China Shanghai Clinical Research Center Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Methyl-CpG binding protein 2 （MeCP2） has a crucial role in transcriptional regulation and neural development （Ausi6 et al., 2014）. Loss of function mutations of MECP2 in human lead to Rett syndrome （RTT）, a severe neurodevelopmental disorders （Amir et al., 1999）, whereas individuals with the chromosomal duplications containing the MECP2 locus showed severe autism-like symptoms （Ramocki et al., 2009）.

关键词： FGF Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors microRNAs

利用3D打印颅脑辐射等效体模进行个性化适形放疗的剂量验证

在线全文

学校读者我要写书评

暂无评论

中华放射医学与防护杂志 2017年第6期37卷 437-441页

作者：张琛王志鹏张昊兆何正中袁子龙杨如飞路伟钊石丽婷侯坤邱建峰泰山医学院放射学院泰安271016 湖北省肿瘤医院放疗科武汉430079 湖北省肿瘤医院放射科武汉430079

目的建立利用3D打印颅脑辐射等效体模对患者进行个性化放疗剂量验证的方法，为三维适形放射治疗安全提供一种可靠的剂量保证手段。方法采集两例患者（患者1和患者2）的CT图像数据，基于患者1的图像数据，重建其颅骨与脑组织，制作颅脑... 详细信息

目的建立利用3D打印颅脑辐射等效体模对患者进行个性化放疗剂量验证的方法，为三维适形放射治疗安全提供一种可靠的剂量保证手段。方法采集两例患者（患者1和患者2）的CT图像数据，基于患者1的图像数据，重建其颅骨与脑组织，制作颅脑体模，验证颅骨与脑组织的等效材料。基于患者2的图像数据，根据3D图像重建并选用组织等效材料重建完全的头颅结构，采用3D打印技术制作全头颅体模。通过对目标区域插入电离室剂量仪并行放射治疗方案，获得头颅体模病灶部的剂量，验证和校准实际放疗计划的安全性。结果对所获两个体模分别进行DR、CT成像，颅脑体模的等效骨骼与患者1骨骼的x射线灰度值差异为13721，颅脑体模的等效脑组织与患者1的脑组织的CT值差异为35～40HU，全头颅体模等效颞肌与患者2的颞肌组织的CT值差异为18～28HU，影像数据表明体模材质的辐射等效性与人体组织近似，并且等效剂量分布符合常规治疗范围，体模的剂量验证可以有效验证放疗计划系统的准确性。结论基于3D打印和组织等效技术所设计的个性化放疗体模，可应用于个性化放射治疗验证。体模制作方法简单快速，个性化程度高，为三维适形放射治疗安全提供一种可靠的剂量保证手段。

关键词： 3D打印体模放射治疗剂量验证

Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen yuan Zhang Jie Ma Zhiqun Lin Amor Abdelkader Maria‑Magdalena Titirici Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Research Center for Environmental Functional Materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capacitive deionization Current collector Tip effect Desalination

An Intronic Variant of CHD7 Identified in Autism Patients Interferes with Neuronal Differentiation and Development

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2021年第8期37卷 1091-1106页

作者： Ran Zhang Hui He Bo yuan Ziyan Wu Xiuzhen Wang Yasong Du Yuejun Chen zilong Qiu Institute of Neuroscience State Key Laboratory of NeuroscienceKey Laboratory of Primate NeurobiologyCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai200031China Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology Shanghai201210China University of the Chinese Academy of Sciences Beijing100049China Shanghai Mental Health Center School of MedicineShanghai Jiao Tong UniversityShanghai200030China

Genetic composition plays critical roles in the pathogenesis of autism spectrum disorder(ASD).Especially,inherited and de novo intronic variants are often seen in patients with ***,the biological significance of intronic variants is difficult to ***,among a Chinese ASD cohort,we identified a recurrent inherited intronic variant in the CHD7 gene,which is specifically enriched in East Asian ***7 has been implicated in numerous developmental disorders including CHARGE syndrome and *** investigate whether the ASD-associated CHD7 intronic variant affects neural development,we established human embryonic stem cells carrying this variant using CRISPR/Cas9 methods and found that the level of CHD7 mRNA significantly decreased compared to *** differentiation towards the forebrain neuronal lineage,we found that neural cells carrying the CHD7 intronic variant exhibited developmental delay and maturity ***,we found that TBR1,a gene also implicated in ASD,was significantly increased in neurons carrying the CHD7 intronic variant,suggesting the intrinsic relevance among ASD ***,the morphological defects found in neurons carrying CHD7 intronic mutations were rescued by knocking down TBR1,indicating that TBR1 may be responsible for the defects in CHD7-related ***,the CHD7 intronic variant generated three abnormal forms of transcripts through alternative splicing,which all exhibited loss-of-function in functional *** study provides crucial evidence supporting the notion that the intronic variant of CHD7 is potentially an autism susceptibility site,shedding new light on identifying the functions of intronic variants in genetic studies of autism.

关键词： Autism CHD7 Intronic variant Inherited variant TBR1

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

基础教育高质量发展的理论内涵、逻辑架构与实践路径

在线全文

学校读者我要写书评

暂无评论

教学与管理 2025年第1期 1-5页

作者：汪源大连大学教育学院辽宁大连116622

中国式现代化作为新时代党中央针对国家发展作出的战略部署,指引着当前我国各领域的变革发展。中国式教育现代化作为其中一环,需要锚定“高质量发展”这一首要任务。而基础教育作为教育系统的基石,应在中国式教育现代化进程中充分发挥... 详细信息

中国式现代化作为新时代党中央针对国家发展作出的战略部署,指引着当前我国各领域的变革发展。中国式教育现代化作为其中一环,需要锚定“高质量发展”这一首要任务。而基础教育作为教育系统的基石,应在中国式教育现代化进程中充分发挥支柱功能。在教育现代化引领下,“教育强国”“规范管理”“公平均等”“数字赋能”等战略任务,为基础教育高质量发展指明了方向,体现出中国式现代化的独特属性。基础教育涉及面广,要想实现高质量发展需要厘清逻辑框架,从政府、学校、家庭、社会等多方面推动教育现代化发展。中国式现代化进程中,基础教育高质量发展实践路径应始终围绕教育发展核心目标,科学且有组织地探索明确教育方向、推进教育治理、持续教育改革、坚持教育创新等实践路径。

关键词：中国式现代化基础教育高质量发展教育现代化

Ru团簇对Ni/Ni_(3)Al合金纳米线形变影响的原子模拟

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

原子与分子物理学报 2025年第1期42卷 81-87页

作者：阳喜元岭南师范学院物理科学与技术学院湛江524048

镍基高温合金是制造先进航空发动机热端部件的关键材料之一,其高温力学性能直接关系到发动机运行安全和使用寿命.本文采用改进分析型嵌入原子模型(MAEAM)和分子动力学(MD)研究合金化元素钌(Ru)团簇对Ni/Ni_(3)Al纳米线形变机制的影响,... 详细信息

镍基高温合金是制造先进航空发动机热端部件的关键材料之一,其高温力学性能直接关系到发动机运行安全和使用寿命.本文采用改进分析型嵌入原子模型(MAEAM)和分子动力学(MD)研究合金化元素钌(Ru)团簇对Ni/Ni_(3)Al纳米线形变机制的影响,结果表明:在单轴拉伸应变下,纳米线的弹性模量和屈服强度随温度升高而降低.温度较低时,纳米线形变由位错产生与发射而导致晶格滑移所引起.由于晶格热振动非谐效应不明显,Ru团簇阻碍效果显著,使得晶格滑移区域仅限于Ru团簇与Ni/Ni_(3)Al相界面之间且呈非对称分布.温度较高时,纳米线的形变由位错发射而引起晶格滑移所致,但因非谐效应显著,Ru团簇无法阻碍位错运动,滑移区域在Ru团簇周围对称分布于Ni_(3)Al相中.最后从Ru团簇微观结构及其稳定性的角度进一步分析其对纳米线形变影响.

关键词： Ru团簇形变机制 Ni/Ni_(3)Al纳米线原子模拟

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

拖拉机底盘行驶性能优化模型与试验

农机化研究 2025年第1期47卷 248-252页

作者：袁新四川工业科技学院四川德阳618500

拖拉机作为一种重要的农业运输工具,可在田间与不同农业机械配合完成相关农艺操作过程。目前,农机具主要以悬挂的形式与拖拉机连接,但在进行田间试验中会发生底盘倾覆问题,故改善拖拉机底盘的动态性能对于提高拖拉机稳定性具有重要意义... 详细信息

拖拉机作为一种重要的农业运输工具,可在田间与不同农业机械配合完成相关农艺操作过程。目前,农机具主要以悬挂的形式与拖拉机连接,但在进行田间试验中会发生底盘倾覆问题,故改善拖拉机底盘的动态性能对于提高拖拉机稳定性具有重要意义。针对以上问题,提出了一种拖拉机底盘前悬机架模型用于设计拖拉机底盘防倾覆悬架,并建立了拖拉机液压前悬架平面内动力学的验证模型,对拖拉机底盘倾覆进行分析。通过数值模拟与田间试验相结合的方法进行模型验证与分析,结果表明:构建的拖拉机底盘前悬架模型能够准确地模拟高、中负荷配置下的拖拉机真实模拟系统行为。研究结果可为拖拉机底盘的优化设计提供参数借鉴与理论依据。

关键词：拖拉机悬挂系统动力学分析模型验证

维普期刊数据库博看期刊