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Genes & Diseases 2024年第4期11卷 141-144页

作者： Zhengyi Liu Chenxing Jian Wenzheng Yuan Guiqing jia Donghui cheng Yanzhuo Liu Yanling Zhang Bin Zhang zili zhou Gaoping Zhao Department of Breast Surgery Henan Provincial People's HospitalThe People's Hospital of Zhengzhou UniversityThe People's Hospital of Henan UniversityZhengzhouHenan 450003China Microbiome Laboratory Henan Provincia People's Hospital Zhengzhou University People's HospitalZhengzhouHenan 450000China Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Gastrointestinal Surgeryll Renmin Hospital of Wuhan UniversityWuhanHubei 430060China Department of Gastrointestinal Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China Department of Hepatobiliary Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan 610072China

Tumor-associated inflammation is an important component of the tumor microenvironment,and an important factor affecting tumor *** the tumor microenvironment,tumor-associated macrophages(TAMs)receive different stimuli and can be polarized into classically activated M1 macrophages and alternatively activated M2 *** studies have indicated that the polarization of TAMs is closely related to tumor progression.

关键词： nephrin tumor inflammation

高倍数水驱砂岩中原油黏度、岩心润湿性时变规律核磁共振实验

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石油勘探与开发 2024年第2期51卷 348-355页

作者：贾虎张瑞罗宪波周子力杨璐西南石油大学油气藏地质及开发工程全国重点实验室成都610500 中海油田服务股份有限公司天津300459 中海石油(中国)有限公司天津分公司天津300459

根据模拟原油黏度与横向弛豫时间谱几何平均值的变化关系,建立了模拟原油黏度预测模型,并结合高倍数水驱核磁共振(NMR)实验实现了孔隙介质中模拟原油黏度的时变规律定量表征;基于核磁共振弛豫理论推导出新的NMR润湿性指数计算公式,结合... 详细信息

根据模拟原油黏度与横向弛豫时间谱几何平均值的变化关系,建立了模拟原油黏度预测模型,并结合高倍数水驱核磁共振(NMR)实验实现了孔隙介质中模拟原油黏度的时变规律定量表征;基于核磁共振弛豫理论推导出新的NMR润湿性指数计算公式,结合砂岩岩心高倍数水驱实验,定量表征了水驱过程岩石润湿性的时变规律。研究表明:岩心中剩余油黏度与过水倍数正相关,过水倍数较低时剩余油黏度升高速度较快,过水倍数较高时剩余油黏度升高速度趋缓。剩余油黏度的变化与储层非均质性相关,储层均质性越强,剩余油中重质组分含量越高,黏度越高。注水后储层润湿性将发生改变,亲油储层向亲水储层转变,亲水储层则亲水性更强,且改变程度随过水倍数增加而增强。原油黏度的时变性与润湿性的时变性具有很高的关联性,原油的黏度变化不可忽略,考虑模拟原油黏度变化时计算得到NMR润湿性指数与测试Amott(自吸法)润湿性指数更具有一致性,更加符合储层润湿性时变规律。

关键词：砂岩高倍数水驱核磁共振原油黏度岩石润湿性时变规律

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基于多尺度卷积的胶囊网络知识图谱嵌入模型

曲阜师范大学学报（自然科学版） 2024年第2期50卷 93-99页

作者：周淑霄王艳娜周子力王妍董兆安曲阜师范大学网络空间安全学院曲阜市273165 曲阜师范大学计算机学院山东省日照市276826

该文基于胶囊神经网络出色的维度信息挖掘能力,加入多尺度卷积以进一步增强其特征提取和交互能力,提出了基于多尺度卷积的胶囊网络知识图谱嵌入模型.首先,通过TransE算法训练得到实体和关系的初始化嵌入向量;其次,通过多尺度卷积生成不... 详细信息

该文基于胶囊神经网络出色的维度信息挖掘能力,加入多尺度卷积以进一步增强其特征提取和交互能力,提出了基于多尺度卷积的胶囊网络知识图谱嵌入模型.首先,通过TransE算法训练得到实体和关系的初始化嵌入向量;其次,通过多尺度卷积生成不同的特征图,将得到的特征图进行特征融合,融合后得到的特征图重组为相对应的胶囊;最后,利用动态路由指定从第一层胶囊到第二层胶囊的连接,经过路由得到的第二层胶囊利用squash函数得到最终向量长度,该向量长度决定三元组的置信度.知识图谱链接预测任务的实验结果表明,较嵌入模型CapsE,本文提出的模型在WN18RR数据集上指标Hit@10提高1.8%,MRR提高1.4%,在FB15k-237数据集上Hit@10提高2.2%,MR提高4.8%.

关键词：知识图谱多尺度卷积胶囊网络知识图谱嵌入神经网络

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House dust mite disrupts the airway epithelial barrier by affecting the expression of thymic stromal lymphopoietin through inducing Atg5

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Chinese Medical Journal 2023年第17期136卷 2128-2130页

作者： Zicong zhou Shixiu Liang zili zhou Jieyi Liu Xiaojing Meng Laiyu Liu Fei Zou Changhui Yu Shaoxi Cai Department of Respiratory and Critical Care Medicine Chronic Airways Diseases LaboratoryNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Allergy and Clinical Immunology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510120China Department of Occupational Health and Occupational Medicine School of Public Health Southern Medical UniversityGuangzhouGuangdong 510515China

To the Editor:Asthma is a complex chronic inflammatory lung disease,and its pathogenesis is not fully *** is believed that airway epithelium primarily acts as a defensive barrier to protect the lung from allergens,avoiding the *** integrity of the airway epithelial barrier is dependent on tight junctions comprised of zona occludens(ZO)1 to 3,occludin,and claudin 1 to 5,and adherens junctions mainly formed by E-cadherin,b-catenin,and junctional adhesion molecule,which maintain apicobasal polarity of bronchial epithelial cells.

关键词： airway lung epithelium

One-dimensional Incremental Constitutive Relation of SMA Wire Reinforced Smart Composites with Damages

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Journal of Materials Science & Technology 2008年第5期24卷 729-732页

作者： zili HU Wanlin zhou Institute of Unmanned Aircraft Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

A new Martensitic transformation kinetic model for shape memory alloy （SMA） is proposed based on the phenomenological description of the Martensitic transformation heat flow-temperature curve and on the linear relationship between the partial derivatives of Martensite fraction and of Gbbis free energy with respect to the temperature. A meso-mechanical model is developed to describe the longitudinal stiffness reduction and thermo-dilatation variation of the composites caused by fiber breaking or fiber peeling off the base material. One-dimensional incremental constitutive relation is then established for SMA wire reinforced smart composites with damages by introducing three parameters to respectively describe the extent of fiber breaking, fiber peeling off the base material and interface weakening. The results presented herein may provide a theoretical basis for further studying on SMA smart composites with damages.

关键词： Smart composites Constitutive relation Meso-mechanical model Damages SMA Martensitic transformation Kinetic model

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基于图注意力网络的小样本知识图谱补全

曲阜师范大学学报（自然科学版） 2024年第1期50卷 72-76页

作者：闵雪洁王艳娜周子力王妍董兆安曲阜师范大学网络空间安全学院曲阜市273165 曲阜师范大学计算机学院山东省日照市276826

提出了一种基于图注意力网络(graph attention network,GAT)的小样本知识图谱补全方法.该方法通过图注意力网络的注意力机制赋予邻居不同的权重,生成更强大的特征表示,通过匹配网络匹配查询集与参考集,选择相似性度量分数最高的候选实... 详细信息

提出了一种基于图注意力网络(graph attention network,GAT)的小样本知识图谱补全方法.该方法通过图注意力网络的注意力机制赋予邻居不同的权重,生成更强大的特征表示,通过匹配网络匹配查询集与参考集,选择相似性度量分数最高的候选实体作为补全后的尾实体.实验结果表明,图注意力网络模型对小样本知识图谱中缺失的链接能够进行有效的预测.

关键词：知识图谱补全链接预测小样本学习图注意力网络

实习护生心理压力与健康自我管理能力的关系研究

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中国高等医学教育 2024年第4期 13-15页

作者：陈阳广谢兰芳戴云云赵嘉周子力桂林医学院护理学院桂林医学院人文与管理学院广西桂林541199

目的:调查实习护生心理压力现状,并分析其与健康自我管理能力的相关性。方法:采用便利抽样方法对459名临床实习护生进行调查。结果:459名实习护生心理压力总均分为(1.26±0.69)分,健康自我管理总均分为(3.35±1.15)分,两者呈显著负相关(... 详细信息

目的:调查实习护生心理压力现状,并分析其与健康自我管理能力的相关性。方法:采用便利抽样方法对459名临床实习护生进行调查。结果:459名实习护生心理压力总均分为(1.26±0.69)分,健康自我管理总均分为(3.35±1.15)分,两者呈显著负相关(r=-0.639,P<0.01);回归分析显示,学历、实习阶段和健康自我管理能力是实习护生心理压力的主要影响因素(R^(2)=0.480,P<0.05)。结论:实习护生心理压力与健康自我管理能力均处于中等水平,健康自我管理能力越强,其心理压力越低。

关键词：实习护生心理压力健康自我管理能力相关分析

Microstructure,mechanical and fracture properties of friction stir welded 2195 Al-Li alloy joints

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Chinese Journal of Aeronautics 2024年第1期37卷 345-361页

作者： Guangda SUN Weizhao SUN Li zhou Sanfeng LUO zili ZHANG Debo LIU Huiqiang WU State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China Shandong Provincial Key Laboratory of Special Welding Technology Harbin Institute of Technology(Weihai)Weihai 264209China Beijing Institute of Astronautical Systems Engineering Beijing 100076China

The 8 mm-thick 2195 Al-Li alloy joints were achieved by Friction Stir Welding(FSW).The microstructural evolution,temperature-dependent mechanical properties,and fracture properties were *** T1,δ’/β’and θ’precipitates were observed in the Base Metal(BM)and the Heat Affected Zone(HAZ).Most of the precipitates,except for re-precipitated δ’/β’phases,were dissolved in the Nugget Zone(NZ).The tensile specimens that failed at cryogenic temperatures(-196℃)had the maximum Ultimate Tensile Strength(UTS),and the fracture surface showed the inter-granular fracture *** to those at room temperature(25℃),the decreasing tensile properties at high temperature(180℃)were related to microstructure and strain hardening *** NZ presented the optimal fracture toughness,and the Crack Tip Opening Displacement(CTOD)was mutually dominated by microhardness and grain *** on Fatigue Crack Growth(FCG)rates indicates that the Thermal-Mechanically Affected Zone(TMAZ)exhibited the most superior fatigue resistance performance at stress intensity range below17 MPa.m1/2due to compressive residual stress and the crack closure *** fatigue fracture surfaces reveal that the crack propagation zone was characterized by the striations and secondary ***,inter-granular fracture behavior was responsible for the fastest FCG rates in the NZ.

关键词： Aluminum alloys Friction stir welding Microstructural evolution Mechanical properties Fracture mechanism

Screening current in ultra-high-field non-insulated superconducting magnets

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Science China(Technological Sciences) 2024年第7期67卷 2255-2273页

作者： zhou BenZhe WANG Lei CHEN Yong WANG QiuLiang WANG KangShuai ZHANG zili LIU JianHua University of Chinese Academy of Sciences Beijing 100049China Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China

Screening current is recognized as one of the critical elements limiting the progression of superconducting magnets toward achieving higher magnetic fields. Currently, most non-insulated(NI) superconducting magnets consider the magnet as insulated when addressing the issue of screening current. However, the bypass current in the NI magnet can modify the actual history of magnetization, so the screening current in NI magnet will be different from that in the insulated magnet. This paper presents a novel method based on the homogenized T-A formulation(T is the current vector potential, and A is the magnetic vector potential), which enables real-time simulation of both the bypass current behavior and the implications of screening current in NI superconducting magnets, even when these magnets contain tens of thousands of turns. We have developed a 32 T NI hybrid superconducting magnet and validated the effectiveness of this method through experiments. Employing this efficacious method,we conducted a comprehensive calculation of screening current in NI magnets, comparing them with insulated magnets in terms of screening current-induced stress(SCIS), screening current-induced field(SCIF), and losses. The results indicate that in the NI insert coils, the sequential excitation of background coils and insert coils induces a reverse screening current, resulting in slightly lower SCIF and SCIS compared to those in the insulated magnets. The method and results can contribute to the enhancement of magnet design and provide valuable insights for the development of ultra-high fields(UHF) NI magnets.

关键词： ultra-high-field superconducting magnet screening current REBCO coil NI coil stress loss

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桔梗素D通过下调成纤维细胞TRPC6表达改善小鼠肺纤维化

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南方医科大学学报 2024年第1期44卷 60-69页

作者：梁梓琛余常辉梁世秀周梓聪周子丽孟晓静邹飞蔡绍曦南方医科大学南方医院呼吸与危重症医学科广东广州510515 南方医科大学公共卫生与热带医学学院广东广州510515

目的探究桔梗素D(PD)对肺纤维化的影响及其机制。方法博来霉素(BLM)气道内滴入构建C57BL/6J小鼠肺纤维化模型,再予PD(10 mg/kg)灌胃,28 d后处死小鼠。分组如下:对照组(control)、BLM(10 mg/kg)模型组、BLM(10 mg/kg)+PD(10 mg/kg)组。... 详细信息

目的探究桔梗素D(PD)对肺纤维化的影响及其机制。方法博来霉素(BLM)气道内滴入构建C57BL/6J小鼠肺纤维化模型,再予PD(10 mg/kg)灌胃,28 d后处死小鼠。分组如下:对照组(control)、BLM(10 mg/kg)模型组、BLM(10 mg/kg)+PD(10 mg/kg)组。肺组织石蜡切片HE染色、免疫组化和天狼星红染色评估小鼠肺组织纤维化程度和瞬时受体电位离子通道亚族C成员6(TRPC6)的表达与分布。Westernblot检测肺组织α-平滑肌肌动蛋白(α-SMA)的表达水平。小鼠原代肺成纤维细胞体外培养,分别用PD、TRPC6抑制剂醋酸落叶松酯(LA)预处理后加入转化生长因子-β1(TGF-β1)刺激细胞,根据加入的TGF-β1和PD浓度不同分组如下:control组、TGF-β1(10 ng/mL)组、PD(2.5μmol/L)+TGF-β1组、PD(5μmol/L)+TGF-β1组和PD(10μmol/L)+TGF-β1组,LA处理分组如下:control组、TGF-β1(10 ng/mL)组和LA(10μmol/L)+TGF-β1组,测定细胞存活率、collagenⅠ、α-SMA和TRPC6的表达水平、活性氧(ROS)生成水平、线粒体膜电位、细胞增殖能力等指标。利用网络药理学方法结合文献分析PD作用于肺纤维化可能通过的机制。结果PD可明显减轻BLM诱导小鼠模型的肺部纤维化程度、减少α-SMA表达(P<0.05)。CCK-8结果显示PD、TGF-β1和LA的最适宜刺激浓度分别是10μmol/L、10 ng/mL和10μmol/L;5-乙炔基-2'-脱氧尿苷(EdU)染色结果显示PD能够有效抑制肺成纤维细胞增殖;2,7-二氯荧光素二乙酸酯(DCFH-DA)染色显示PD能有效减少TGF-β1诱导的细胞ROS生成(P<0.0001);线粒体膜电位检测(Jc-1染色)结果显示PD能有效缓解TGF-β1诱导的细胞线粒体膜电位下降(P<0.001);蛋白电泳结果显示PD能显著抑制TGF-β1诱导的α-SMA和collagenⅠ的表达(P<0.05)。网络药理学结合文献分析发现PD可能通过TRPC6作用于肺纤维化。免疫组织化学结果显示PD明显减轻了BLM诱导的肺组织TRPC6表达。蛋白电泳结果显示PD可明显抑制TGF-β1诱导的TRPC6表达(P<0.05);使用LA可明显抑制细胞TRPC6、α-SMA、collagenⅠ的表达(P<0.05)。结论PD可降低小鼠肺纤维化,其机制可能与下调TRPC6并减少ROS产生有关。

关键词：肺纤维化桔梗素D 瞬时受体电位离子通道亚族C成员6 活性氧

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