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药桑叶多糖提取工艺优化及其降血糖活性研究

中国酿造 2017年第8期36卷 139-143页

作者：韩爱芝王丽君贾清华王子坤马玲杨玲塔里木大学分析测试中心新疆阿拉尔843300 新疆生产建设兵团塔里木盆地生物资源保护与利用重点实验室生命科学学院塔里木大学新疆阿拉尔843300

采用Box-Behnken试验设计对药桑叶多糖提取条件(液料比、提取温度、提取时间)进行优化,并用对硝基苯-α-D-吡喃葡萄糖苷(p-NPG)法对药桑叶多糖进行α-葡萄糖苷酶抑制活性测定。结果显示,药桑叶粗多糖提取最佳工艺为:在液料比25∶1(mL∶... 详细信息

采用Box-Behnken试验设计对药桑叶多糖提取条件(液料比、提取温度、提取时间)进行优化,并用对硝基苯-α-D-吡喃葡萄糖苷(p-NPG)法对药桑叶多糖进行α-葡萄糖苷酶抑制活性测定。结果显示,药桑叶粗多糖提取最佳工艺为:在液料比25∶1(mL∶g),提取温度90℃、提取时间3 h条件下,药桑叶粗多糖提取率最高为(13.39±0.53)%。降血糖初步研究结果为:药桑叶粗多糖对α-葡萄糖苷酶有较好的抑制活性,其半抑制浓度(IC_(50))为0.96 mg/mL。

关键词：药桑叶 Box-Behnken试验多糖降血糖活性

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玉米赤霉烯酮生物降解及其脱毒机制研究进展

食品科学 2025年第1期46卷 246-254页

作者：李凯龙刘昆仑辛颖杨趁仙王子坤河南工业大学粮油食品学院河南郑州450001 河南工业大学粮食和物资储备学院河南郑州450001

真菌毒素是一类严重危害谷物、食品、饲料安全的污染物,可造成大量资源浪费和严重经济损失。在霉变玉米、小麦等谷物中,玉米赤霉烯酮(zearalenone,ZEN)具有高检出率,其污染暴露可造成生殖毒性、肝毒性、肾毒性等危害。因其污染范围广泛... 详细信息

真菌毒素是一类严重危害谷物、食品、饲料安全的污染物,可造成大量资源浪费和严重经济损失。在霉变玉米、小麦等谷物中,玉米赤霉烯酮(zearalenone,ZEN)具有高检出率,其污染暴露可造成生殖毒性、肝毒性、肾毒性等危害。因其污染范围广泛、危害严重,成为食品安全的重大隐患。传统的物理化学方法在降解ZEN的同时也存在二次污染风险,因此,食品相关产业一直在寻求具有更高专一性、靶向性、安全性和适应性的生物降解技术。本文综述ZEN毒性及其危害、ZEN降解菌株与降解酶及现代生物技术在ZEN脱除中的应用,重点分析ZEN生物降解产物类型及其脱毒机制,并展望ZEN生物脱毒的潜在应用方向,为ZEN生物脱毒研究提供理论依据。

关键词：玉米赤霉烯酮生物降解脱毒机制

迷迭香酸甲酯对6-OHDA所致脑内氧化损伤的影响

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扬州大学学报（农业与生命科学版） 2017年第4期38卷 30-34页

作者：王小洪丁冬怡孙志颖杨子坤潘思华曹桂云扬州大学医学院/江苏省非编码RNA基础与临床转化重点实验室江苏扬州225001

采用脑内定位注射6-羟基多巴胺(6-OHDA)建立帕金森病小鼠模型,以阿朴吗啡诱导的转圈试验、转棒试验检测小鼠的运动功能,免疫组织化学染色法检测各组小鼠纹状体区TH阳性纤维的量,以化学比色法测定小鼠脑内超氧化物歧化酶(SOD)、过氧化氢... 详细信息

采用脑内定位注射6-羟基多巴胺(6-OHDA)建立帕金森病小鼠模型,以阿朴吗啡诱导的转圈试验、转棒试验检测小鼠的运动功能,免疫组织化学染色法检测各组小鼠纹状体区TH阳性纤维的量,以化学比色法测定小鼠脑内超氧化物歧化酶(SOD)、过氧化氢酶(CAT)及丙二醛(MDA)活性水平,以Western-blot检测小鼠纹状体区SOD1、SOD2和Nrf2水平,q-PCR检测各组脑内NQO1、Sod1、Sod2、Cat和Gpx1水平。结果表明:迷迭香酸甲酯可显著减少阿朴吗啡诱导的PD小鼠旋转圈数量,增加PD小鼠在转棒上的停留时间、纹状体区TH阳性纤维量及SOD1、SOD2和Nrf2的蛋白水平。结果提示迷迭香酸甲酯对6-OHDA诱导的PD小鼠多巴胺能神经元损伤有显著的保护作用,其可能通过抑制脑内氧化应激水平而发挥神经保护作用。

关键词：帕金森病迷迭香酸甲酯 6-羟基多巴胺氧化应激

GO改性的铈基纳米复合光催化剂性能对比研究

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石油化工高等学校学报 2022年第1期35卷 63-67页

作者：陈佳慧黎泓麟杨紫坤罗鸿仙张金生李丽华辽宁石油化工大学石油化工学院辽宁抚顺113001

纳米材料的紫外屏蔽性能及光催化性能会由于材料自身的表面结合能不同而不同。制备纳米氧化锌(NPs-ZnO)、纳米二氧化铈(NPs-CeO_(2))、NPs-ZnO/CeO_(2)及氧化石墨烯改性氧化锌/氧化铈纳米复合材料(NPsZnO/CeO_(2)@GO),并对制备样品进行... 详细信息

纳米材料的紫外屏蔽性能及光催化性能会由于材料自身的表面结合能不同而不同。制备纳米氧化锌(NPs-ZnO)、纳米二氧化铈(NPs-CeO_(2))、NPs-ZnO/CeO_(2)及氧化石墨烯改性氧化锌/氧化铈纳米复合材料(NPsZnO/CeO_(2)@GO),并对制备样品进行了XRD、FT-IR、SEM等表征和紫外屏蔽性能及光催化性能测试研究。结果表明,紫外屏蔽能力:NPs-ZnONPs-ZnO(0.89)>ZnO/CeO_(2)(0.75)>NPs-CeO_(2)(0.66);并且NPs-ZnO/CeO_(2)@GO的光催化性强于参与实验的其他光催化剂。

关键词：氧化锌氧化铈 GO改性纳米复合材料光催化

Evaluation method for helicopter maritime search and rescue response plan with uncertainty

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Chinese Journal of Aeronautics 2021年第4期34卷 493-507页

作者： Hu LIU zikun CHEN Yongliang TIAN Bin WANG Hao yang Guanghui WU School of Aeronautic Science and Engineering Beihang UniversityBeijing 100083China Donghai No.2 Flying Service of Ministry of Transport Xiamen 361006China Commercial Aircraft Corporation of China Ltd Shanghai 200210China

Helicopter plays an increasingly significant role in Maritime Search and Rescue(MSAR),and it will perform MSAR mission based on response plans when an accident *** the rationality of response plan determines the success of MSAR mission to a large ***,with the impact of many uncertainty factors,it is difficult to evaluate response plans comprehensively before performing *** at these problems,an evaluation framework of helicopter MSAR response plan named UMAD is proposed in this paper,which reveals the influence mechanism of uncertainty factors based on Multi-Agent method and analyzes the mission flow based on Discrete Event System(DEVS)***,the evaluation criterion and indicators of response plan are extracted from the aspects of safety and ***,the Monte Carlo method is adapted to calculate the probability distribution and robustness of response plan comprehensive ***,in order to illustrate the validity of this method,it is discussed and verified by an application example of evaluating multiple response plans to the same MSAR *** results show that this method can analyze the influence of uncertainty more systematically and optimize response plans more comprehensively.

关键词： Evaluation method Maritime search and rescue Probability distribution Response plan Robustness Uncertainty factors

Helicopter maritime search area planning based on a minimum bounding rectangle and K-means clustering

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Chinese Journal of Aeronautics 2021年第2期34卷 554-562页

作者： Peisen XIONG Hu LIUa Yongliang TIAN zikun CHEN Bin WANG Hao yang School of Aeronautic Science and Engineering Beihang UniversityBeijing 100083China Dong Hai No.2 Rescue Flying Service of The Ministry of Transport Xiamen 361006China

Helicopters are widely used in maritime Search and Rescue(SAR) missions. To ensure the success of SAR missions, search areas need to be carefully planned. With the development of computer technology and weather forecast technology, the survivors’ drift trajectories can be predicted more precisely, which strongly supports the planning of search areas for the rescue helicopter. However, the methods used to determine the search area based on the predicted drift trajectories are mainly derived from the continuous expansion of the area with the highest Probability of Containment(POC), which may lead to local optimal solutions and a decrease in the Probability of Success(POS), especially when there are several subareas with a high POC. To address this problem, this paper proposes a method based on a Minimum Bounding Rectangle and Kmeans clustering(MBRK). A silhouette coefficient is adopted to analyze the distribution of the survivors’ probable locations, which are divided into multiple clusters with K-means clustering. Then,probability maps are generated based on the minimum bounding rectangle of each cluster. By adding or subtracting one row or column of cells or shifting the planned search area, 12 search methods are used to generate the optimal search area starting from the cell with the highest POC in each probability map. Taking a real case as an example, the simulation experiment results show that the POS values obtained by the MBRK method are higher than those obtained by other methods,which proves that the MBRK method can effectively support the planning of search areas and that K-means clustering improves the POS of search plans.

关键词： K-means clustering Minimum bounding rectangle Mission planning Probability map Search and rescue

Structural disruption of melanin-like polymers with boosted UV protection

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Science China Chemistry 2024年第5期67卷 1653-1663页

作者： Zhen yang Xianheng Wang Wanjie Bai zikun Zou Haoxing Wu Yiwen Li Department of Radiology Huaxi MR Research CenterFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

Manipulating the energy structure of materials represents an efficient way to regulate their light absorption behaviors. For example, constructing donor-acceptor(D-A) structures to increase the polarizability and reduce the energy bandgap of local molecules has been widely used in the field of organic photovoltaics with ordered structures. Remarkably, even in disordered and chaotic systems such as melanin-like polydopamine(PDA), visible and near-infrared light absorption can be significantly improved using this strategy. However, there has been a noticeable dearth of research on the ultraviolet(UV) light absorption regulation of bioinspired polymers with disordered and chaotic architectures by tailoring the D-A microstructures. In this study, a series of benzoheterocyclic molecules with strong electron-donating features screened by molecular simulation calculations were involved in disrupting the D-A structures within PDA. The destruction of D-A structures promoted the increase of the energy band gap and finally boosted the UV absorption of PDA. The resulting PDA nanoparticles with enhanced UV absorption were further employed to fabricate UV shielding composite films to protect the growth of plants from harmful UV radiation. This research may open up new avenues for structural disruption of bioinspired polymers for enhanced photoprotection applications.

关键词： melanin-like polymers polydopamine D-A structure UV absorption photoprotection

The signal pathways and treatment of cytokine storm in COVID-19

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2371-2390页

作者： Lan yang Xueru Xie zikun Tu Jinrong Fu Damo Xu Yufeng Zhou Institute of Pediatrics Children's Hospital of Fudan UniversityNational Children's Medical Centerand the Shanghai Key Laboratory of Medical EpigeneticsInternational Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyInstitutes of Biomedical SciencesFudan UniversityShanghaiChina National Health Commission(NHC)Key Laboratory of Neonatal Diseases Fudan UniversityShanghaiChina General Department Children's Hospital of Fudan UniversityShanghaiChina State Key Laboratory of Respiratory Disease for Allergy at Shenzhen University Shenzhen Key Laboratory of Allergy and ImmunologyShenzhen University School of MedicineShenzhenChina Institute of Infection Immunity and InflammationUniversity of GlasgowGlasgowUK

The Coronavirus Disease 2019(COVID-19)pandemic has become a global crisis and is more devastating than any other previous infectious *** has affected a significant proportion of the global population both physically and mentally,and destroyed businesses and *** evidence suggested that immunopathology may be responsible for COVID-19 pathogenesis,including lymphopenia,neutrophilia,dysregulation of monocytes and macrophages,reduced or delayed type I interferon(IFN-I)response,antibody-dependent enhancement,and especially,cytokine storm(CS).The CS is characterized by hyperproduction of an array of pro-inflammatory cytokines and is closely associated with poor *** excessively secreted pro-inflammatory cytokines initiate different inflammatory signaling pathways via their receptors on immune and tissue cells,resulting in complicated medical symptoms including fever,capillary leak syndrome,disseminated intravascular coagulation,acute respiratory distress syndrome,and multiorgan failure,ultimately leading to death in the most severe ***,it is clinically important to understand the initiation and signaling pathways of CS to develop more effective treatment strategies for ***,we discuss the latest developments in the immunopathological characteristics of COVID-19 and focus on CS including the current research status of the different cytokines *** also discuss the induction,function,downstream signaling,and existing and potential interventions for targeting these cytokines or related signal *** believe that a comprehensive understanding of CS in COVID-19 will help to develop better strategies to effectively control immunopathology in this disease and other infectious and inflammatory diseases.

关键词： cytokine distress storm

An intelligent impulsive noise mitigation with deep learning method

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International Journal of Mechanical System Dynamics 2024年第3期4卷 346-360页

作者： Guo yang Yuwen Qian zikun Wang Xiangwei Zhou Wen Wu The School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjingChina The Division of Electrical and Computer Engineering Louisiana State UniversityBaton RougeLouisianaUSA

To enable message transmission among sensors and equipment,power line communication(PLC)is a widely adopted smart ***,due to the occurrence of impulsive noise(IN),reliable transmissions over PLC channels in the smart grid are ***,in this paper,we propose an adaptive noise mitigation scheme to clip the IN with the sliding window-based method,where the altitude of the received signal in the current time slots is obtained by computing the average altitude of signals in the previous and next time *** detect the states of IN and dynamically estimate the power threshold of signals for the IN mitigation scheme,we develop an intelligent algorithm based on the long short-term memory *** prevent the useful signals from being eliminated as IN signals,we propose the accelerated proximal gradient method(APGM)based on tone reservation to reduce the peak-to-average power ratio(PAPR)for the transmitting signals with low computational *** addition,the closed-form expression of the bit error rate(BER)is derived for the proposed sliding window-based IN mitigation scheme according to the probability density function of the *** results demonstrate that the proposed IN mitigation scheme achieves a better BER performance than the conventional IN mitigation *** addition,the APGM aided by IN mitigation can further improve BER performance due to the PAPR reduction.

关键词： impulsive noise deep learning smart grid