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健脾咳喘灵颗粒提取工艺研究

中国医药科学 2024年第9期14卷 74-77页

作者：马子君葛岩宋宇轩陈冠群马艳妮江苏省新沂市中医医院制剂室江苏新沂221400 上海药明津石医药科技有限公司上海200000 江苏省新沂市中医医院儿科江苏新沂221400

目的开展健脾咳喘灵颗粒提取工艺研究,为新沂市中医医院医疗机构制剂备案制奠定基础。方法依据处方取陈皮150 g、茯苓50 g等11味药材,平均分为10份,其中1份备用,用其余9份按照正交试验表进行正交试验,考察提取溶剂、溶剂倍数、提取次数... 详细信息

目的开展健脾咳喘灵颗粒提取工艺研究,为新沂市中医医院医疗机构制剂备案制奠定基础。方法依据处方取陈皮150 g、茯苓50 g等11味药材,平均分为10份,其中1份备用,用其余9份按照正交试验表进行正交试验,考察提取溶剂、溶剂倍数、提取次数及时间。以总黄酮、橙皮苷含量及固形物得率为评价指标,确定最佳提取工艺参数。结果综合分析正交试验结果,以固形物得率、总黄酮、橙皮苷含量为评价指标,乙醇浓度、溶剂倍数、提取时间、提取次数均没有显著性差异。综合以上分析结果,考虑到大生产降低成本等因素,最终确定最佳工艺为A3B1C1D2,即乙醇浓度为80%,溶剂倍数为8倍,提取时间为1 h,提取次数为2次。结论健脾咳喘灵颗粒的提取工艺稳定可靠,在对颗粒制备工艺研究的基础上确定了最佳提取工艺,为扩大生产规模提供参考。

关键词：正交试验参数选择工艺改进颗粒制备

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Understanding the drivers of woody plant diversity in urban parks in a snow climate city of China

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Journal of Forestry Research 2023年第4期34卷 1021-1032页

作者： zijun ma Peng Zhang Nanlin Hu Guodong Wang Yulin Dong Yujie Guo Chengcong Wang Yao Fu Zhibin Ren Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China School of Geography and Engineering of Land Resources Yuxi Normal UniversityYuxi 653100People’s Republic of China

Urban parks are an important part of urban ecosystems and play an important role in biodiversity ***,it is still unclear how park characteristics aff ect plant diversity which could hinder the conservation of urban biodiversity due to the ineff ective design of urban *** diversity of woody plants in 33 parks of Changchun,China,was measured with plot measurements and linked with urban park characteristics(e.g.,size and age of the park)to uncover the relationship between *** results show that urban woody plant species were abundant,with 98 species belonging to 51 genera and 26 families in the snow climate city of *** variation in woody plant diversity was largely explained by internal patch characteristics(e.g.,size,age,shape),and external factors surrounding the park(e.g.,land use type and socioeconomic level)accounted for only 16.0%in our *** internal patch characteristics,older urban parks with larger areas demonstrated a richer level of plant diversity and increased nonlinearly with increasing park *** threshold size signifi cantly aff ecting plant diversity variation was approximately 30 *** diversity had positive linear relationships with the ages of urban parks,supporting the legacy eff *** addition,woody plant diversity nonlinearly decreased with increasing park shape index,which suggested that the plant diversity could also be increased by optimizing the park *** the external factors surrounding parks,the spatial distribution of woody plant diversity varied greatly from the urban center to the *** prices around the park had positive linear relationships with woody plant diversity in parks,supporting the luxury eff ***,building and road proportions,and green space proportion had no relationship with plant diversity in *** study can provide a robust reference for enriching plant diversity in urban parks,thus improving the development of urban sustainable cities.

关键词： Urban ecosystem Urban biodiversity Urban park Remote sensing Field measurement

性激素水平、精液质量与不育症患者精子DNA碎片指数的相关性

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中国民康医学 2024年第2期36卷 67-69,73页

作者：马子珺郑州市妇幼保健院生殖遗传科河南郑州450000

目的:分析性激素指标水平、精液质量与不育症患者精子DNA碎片指数(DFI)的相关性。方法:回顾性分析2022年1—12月于该院就诊的80例不育症患者的临床资料,设为观察组,另回顾性分析同期该院80名男性健康体检者的临床资料,设为对照组。统计... 详细信息

目的:分析性激素指标水平、精液质量与不育症患者精子DNA碎片指数(DFI)的相关性。方法:回顾性分析2022年1—12月于该院就诊的80例不育症患者的临床资料,设为观察组,另回顾性分析同期该院80名男性健康体检者的临床资料,设为对照组。统计两组DFI,依据DFI将观察组患者分为异常患者(DFI≥30%)和正常患者(DFI0,P<0.05)。结论:精液质量、睾酮水平均与不育症患者精子DFI呈负相关,LH、FSH水平均与不育症患者精子DFI呈正相关。

关键词：不育症精子DNA碎片指数性激素精液质量相关性

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孕期因素与婴儿牛奶蛋白过敏的关系

北京大学学报（医学版） 2024年第1期56卷 144-149页

作者：李洋洋侯林马紫君黄山雅美刘捷曾超美秦炯北京大学人民医院儿科北京100044

目的:初步探讨孕期因素与婴儿牛奶蛋白过敏的关系。方法:数据来自一项“中国儿童对牛奶蛋白过敏的遗传易感性研究”的子队列,包括2020年3月1日至12月31日在北京大学人民医院出生的婴儿,根据随访至1岁时有无牛奶蛋白过敏(cow’s milk pro... 详细信息

目的:初步探讨孕期因素与婴儿牛奶蛋白过敏的关系。方法:数据来自一项“中国儿童对牛奶蛋白过敏的遗传易感性研究”的子队列,包括2020年3月1日至12月31日在北京大学人民医院出生的婴儿,根据随访至1岁时有无牛奶蛋白过敏(cow’s milk protein allergy,CMPA),分为病例组(CMPA组)和对照组。回顾性收集婴儿及其母亲孕前和孕期的临床资料,分析孕期多因素与婴儿牛奶蛋白过敏的相关性。结果:共纳入278例婴儿,CMPA患儿52例,对照组226例;男性婴儿143例,女性婴儿135例,其中男性婴儿在CMPA组比例(69.2%)高于对照组(47.3%),差异有统计学意义(P=0.004);CMPA患儿和对照组在出生体质量、出生胎龄、低出生体重儿、早产、脐带绕颈、新生儿窒息分布上差异无统计学意义(P>0.05)。母亲孕期合并免疫性疾病、贫血者以及孕期存在抗生素暴露者在CMPA组比例均高于对照组,两组之间差异有统计学意义(P0.05)。CMPA组与对照组孕期多项血常规指标总体分布差异无统计学意义(P>0.05)。多因素Logistic回归分析发现男性婴儿、母亲妊娠合并免疫性疾病、妊娠合并贫血以及孕期抗生素暴露是CMPA发生的独立危险因素。结论:男性婴儿、母亲妊娠合并免疫性疾病、妊娠合并贫血以及孕期抗生素暴露是CMPA发生的独立危险因素。

关键词：牛奶蛋白过敏危险因素婴儿妊娠期

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Protective Effect of SGLT2 Inhibitor on D-Galactose-Induced Senescence in Mice and Its Mechanism

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Journal of Biosciences and Medicines 2023年第5期11卷 286-302页

作者： zijun ma Meilin Xu Kaiqin Jin Guangfu Zhu Xin Chen Department of Geriatric Medicine Dongfeng General Hospital Hubei University of Medicine Shiyan China Department of Cardiovascular Medicine The Second Affiliated Hospital of Anhui Medical University Hefei China

Objective: To observe the cerebral protective effect of dagliflozin, a sodium-glucose co-transport protein 2 (SGLT2) inhibitor, in aging mice and to explore its molecular mechanism. Methods: 1. 66 male C57BL/6 mice were divided into control group (13) and model group (53), and the model group was moulded by subcutaneous injection of D-galactose into the back of the neck, while the control group was treated with equal amount of saline for 8 weeks. The weight of each group of mice was observed and recorded every 7 days, and two groups of mice were randomly selected for frozen sections of brain tissue at the end of the modelling period to verify the aging model. 2. After the aging model was successfully established, the aging groups were divided into 5 groups: model group, dagliflozin-treated group (high and low dose), and dagliflozin + ex527-inhibited group (high and low dose). Fasting blood glucose was measured in each group every 2 weeks for 8 weeks. At the end of treatment, Morris water maze was performed at the end of the treatment. After execution of the mice, the organ indices of heart, brain, liver, kidney and spleen were measured;the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in serum were determined. Results: After the successful establishment of the aging model, it was found that during the treatment phase of dagliflozin. 1) The organ indices of mice in the aging group were significantly lower than those of other groups, and no significant hypoglycemia was observed throughout the treatment process. 2) In the water maze test, mice in the aging group had a significantly longer latency in the plateau phase compared to the control and treatment groups, while the number of times the mice crossed the original plateau and the percentage of time spent exploring the original plateau quadrant were reduced after the plateau was removed. 3) The nerve cells in the aging mice were disorganized and the nuclei of the mice were deeply stained;the dagliflo

关键词： Aging Neurodegenerative Diseases SGLT2 Inhibitors Oxidative Stress SIRT1 Signalling Pathway

Two ABCI family transporters,OsABCI15 and OsABCI16,are involved in grain-filling in rice

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Journal of Genetics and Genomics 2024年第5期51卷 492-506页

作者： Bin ma Xiubiao Cao Xiaoyuan Li Zhong Bian Qi-Qi Zhang zijun Fang Jiyun Liu Qun Li Qiaoquan Liu Lin Zhang Zuhua He Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genetics and Physiology Agricultural College of Yangzhou UniversityYangzhouJiangsu 225009China Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Jiangsu Key Laboratory of Crop Genetics and PhysiologyYangzhou UniversityYangzhouJiangsu 225009China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology&EcologyChinese Academy of SciencesShanghai 200032China Institute of Biotechnology Hangzhou Academy of Agricultural SciencesHangzhouZhejiang 310024China Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education Yangzhou UniversityYangzhouJiangsu 225009China

Seed development is critical for plant reproduction and crop yield,with panicle seed-setting rate,grain-filling,and grain weight being key seed characteristics for yield ***,few genes are known to regulate grain ***,we identify two adenosine triphosphate(ATP)-binding cassette(ABC)I-type transporter genes,OsABCI15 and OsABCI16,involved in rice *** genes are highly expressed in developing seeds,and their proteins are localized to the plasma membrane and ***,knockout of OsABCI15 and OsABCI16 results in a significant reduction in seed-setting rate,caused predominantly by the severe empty pericarp phenotype,which differs from the previously reported low seed-setting phenotype resulting from failed *** analysis indicates that OsABCI15 and OsABCI16 participate in ion homeostasis and likely export ions between filial tissues and maternal tissues during grain ***,overexpression of OsABCI15 and OsABCI16 enhances the seed-setting rate and grain yield in transgenic plants and decreases ion accumulation in brown ***,the OsABCI15/16 orthologues in maize exhibit a similar role in kernel development,as demonstrated by their disruption in transgenic ***,ourﬁndings reveal the important roles of two ABC transporters in cereal grain filling,highlighting their value in crop yield improvement.

关键词： ABC transporters Rice Grain filling Ion homeostasis Grain yield

Coxsackievirus B3 HFMD animal models in Syrian hamster and rhesus monkey

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Virologica Sinica 2024年第2期39卷 290-300页

作者： Suqin Duan Wei Zhang Yongjie Li Yanyan Li Yuan Zhao Weihua Jin Quan Liu Mingxue Li Wenting Sun Lixiong Chen Hongjie Xu Jie Tang Jinghan Hou zijun Deng Fengmei Yang Shaohui ma Zhanlong He Institute of Medical Biology Chinese Academy of Medical Sciences Medical Primate Research Center Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research Development on Severe Infectious DiseaseKunming650118China

Coxsackievirus B3(CVB3)is the pathogen causing hand,foot and mouth disease(HFMD),which manifests across a spectrum of clinical severity from mild to ***,CVB3-infected mouse models mainly demonstrate viral myocarditis and pancreatitis,failing to replicate human HFMD *** several enteroviruses have been evaluated in Syrian hamsters and rhesus monkeys,there is no comprehensive data on *** this study,we have first tested the susceptibility of Syrian hamsters to CVB3 infection via different *** results showed that Syrian hamsters were successfully infected with CVB3 by intraperitoneal injection or nasal drip,leading to nasopharyngeal colonization,acute severe pathological injury,and typical HFMD ***,the nasal drip group exhibited a longer viral excretion cycle and more severe pathological *** the subsequent study,rhesus monkeys infected with CVB3 through nasal drips also presented signs of HFMD symptoms,viral excretion,serum antibody conversion,viral nucleic acids and antigens,and the specific organ damages,particularly in the ***,there were no significant differences in myocardial enzyme levels,and the clinical symptoms resembled those often associated with common,mild *** summary,the study successfully developed severe Syrian hamsters and mild rhesus monkey models for CVB3-induced *** models could serve as a basis for understanding the disease pathogenesis,conducting pre-trial prevention and evaluation,and implementing post-exposure intervention.

关键词： Coxsackievirus B3(CVB3) Hand foot and mouth disease(HFMD) Animal models Syrian hamster Rhesus monkey

基于最小剩余时间算法与SR-IOV技术的GPU资源优化调度方案

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计算机应用文摘 2024年第9期40卷 140-145页

作者：梁桂才何现海马梓钧陆富业广西机电职业技术学院信息管理中心南宁530007 广西长基电子科技有限公司南宁530022 广西机电工程学校信息中心南宁530007

为了优化GPU资源利用率,文章提出了一种新型的GPU资源调度方案。该方案结合了最小剩余时间算法与SR-IOV(SingleRootI/OVirtualization)技术,可优化多用户、多任务环境下的GPU资源利用率和系统性能。传统的GPU调度方法往往面临资源利用... 详细信息

为了优化GPU资源利用率,文章提出了一种新型的GPU资源调度方案。该方案结合了最小剩余时间算法与SR-IOV(SingleRootI/OVirtualization)技术,可优化多用户、多任务环境下的GPU资源利用率和系统性能。传统的GPU调度方法往往面临资源利用不足、任务等待时间长和系统吞吐量受限等问题。为了应对这些挑战,该方案通过动态分析任务的剩余执行时间,利用SR-IOV技术实现了GPU资源的细粒度隔离与共享,可为更高效的资源分配和任务调度提供支持。实验结果表明,相较于传统的无调度、容器调度和常见机器学习调度方案,该方案在均值准确率、GPU利用率、系统吞吐量和任务执行时间等方面均具有一定的优势,可为多用户多任务场景下的GPU资源管理提供有益的参考。

关键词：最小剩余时间算法 SR-IOV技术 GPU资源调度资源利用率

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改性市政污泥对水中苯酚的吸附性能研究

化学工业与工程 2023年第2期40卷 85-93页

作者：马紫珺马宏瑞朱超崔家烨陕西科技大学环境科学与工程学院西安710021

采用高效、低成本的吸附材料去除废水中酚类有机物一直是工业废水深度处理的迫切需求,利用市政污泥分别经碳化、碱活化及磁化后制备获得改性污泥基吸附剂为碳化污泥(Carbonized sludge,CS)、碱活化污泥(Activated carbonized sludge,ACS... 详细信息

采用高效、低成本的吸附材料去除废水中酚类有机物一直是工业废水深度处理的迫切需求,利用市政污泥分别经碳化、碱活化及磁化后制备获得改性污泥基吸附剂为碳化污泥(Carbonized sludge,CS)、碱活化污泥(Activated carbonized sludge,ACS)、磁改性污泥(magnetic activated carbonized sludge,maCS),对水溶液中苯酚进行了吸附实验,并对3种吸附材料特性进行了表征。研究表明,KOH活化可提升CS的孔隙率,磁改性可显著提高材料的比表面积,使孔径范围向介孔集中,改性后羟基和羰基等含氧官能团大幅增加,ACS和maCS均表现出较高的吸附量,但其吸附量显著受污染物浓度和反应时间影响,CS对苯酚的吸附主要受化学过程控制,而ACS和maCS的吸附除有化学吸附外,介孔效应也是其吸附的重要机制,综合吸附效能从高到低依次为maCS>ACS>CS。

关键词：剩余污泥碳化改性吸附苯酚