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老年男性阻塞性睡眠呼吸暂停综合征患者骨质疏松症的发生风险

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中华老年多器官疾病杂志 2023年第3期22卷 171-175页

作者：房凤凤刘霖赵力博刘敏李开亮何子君赵哲韩继明边红艳延安大学医学院陕西延安716000 中国人民解放军总医院第二医学中心呼吸与危重症医学科北京100853 中国人民解放军总医院第二医学中心国家老年疾病临床医学研究中心北京100853 中国人民解放军总医院第二医学中心心血管内科北京100853 宁夏回族自治区盐池县中医医院宁夏盐池751500 延安大学附属医院心脑血管病医院神内心身门诊陕西延安716000

目的探讨老年男性阻塞性睡眠呼吸暂停综合征(OSAS)患者骨质疏松症的发生风险。方法选择2015年1月至2017年10月于北京和甘肃6家三甲医院的睡眠中心确诊为OSAS的623例男性患者为研究对象,根据国际骨质疏松基金会骨质疏松风险一分钟测试题... 详细信息

目的探讨老年男性阻塞性睡眠呼吸暂停综合征(OSAS)患者骨质疏松症的发生风险。方法选择2015年1月至2017年10月于北京和甘肃6家三甲医院的睡眠中心确诊为OSAS的623例男性患者为研究对象,根据国际骨质疏松基金会骨质疏松风险一分钟测试题将患者分为骨质疏松风险组(302例)和对照组(321例)。对患者进行定期随访,随访终点为发生骨质疏松风险。采用SPSS 25.0统计软件进行数据分析。根据数据类型分别采用t检验、Mann-Whitney U检验或χ^(2)检验进行组间比较。应用Cox回归分析老年男性OSAS患者骨质疏松发生的风险因素。结果48.5%(302/623)老年男性OSAS患者筛查出骨质疏松风险。与对照组相比,骨质疏松风险组年龄更高,舒张压更低,腰围更小,吸烟比例更多,睡眠参数中平均脉氧饱和度更低,甘油三酯、尿酸和C反应蛋白、红细胞计数与血红蛋白相比对照组含量更低,颈动脉粥样硬化和慢性阻塞性肺疾病患病率较对照组明显更高,差异均有统计学意义(P<0.05)。Cox比例风险回归分析结果显示,在55个月的中位随访时间中,年龄(HR=1.029,95%CI 1.013~1.045)和颈动脉粥样硬化史(HR=1.547,95%CI 1.157~2.068)是老年男性OSAS患者骨质疏松发生风险的独立危险因素;而较高的腰围(HR=0.983,95%CI 0.976~0.990)和平均脉氧饱和度(HR=0.941,95%CI 0.904~0.979)是其保护因素(P<0.05)。结论OSAS患者容易继发骨质疏松症,增龄及合并颈动脉粥样硬化的老年男性OSAS患者更容易发生骨质疏松症,较高的腰围和平均脉氧饱和度是其保护因素。

关键词：老年人,男性阻塞性睡眠呼吸暂停综合征骨质疏松症风险

heat oscillation in the upper ocean of the southern South China Sea

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Acta Oceanologica Sinica 1992年第3期11卷 375-387页

作者： he Youhai, Guan Cuihua and Gan zijun South China Sea Institute of Oceanology, Academia Sinica, Guangzhou 510301, China

Data used in this study are temperature/depth profiles taken over the upper 400 m of the ocean in the southern South China Sea (4°-14° N, 106°-120° E) for the period 1961-1973. The data are analyzed on the grid 2 (latitude) by 2 (longitude) in space and bimonthly in time. The vertically averaged temperature (TAV) over the upper 100 m of the ocean is calculated as the estimate of the heat content in the upper *** TAV is cooler in the northwest region of the study area and warmer in the southeast in the annual and seasonal mean figures. The first EOF (Empirical Orthogonal Function) of anomalous TAV accounts for 41 % of the total variance for the period 1961-1973. The time function associated with it displays a significant interannual changes in the heat content, with 2-4 a oscillation period and associated with the ENSO events. During ENSO event TAV increases with the tendency of increasing towards equator along the basin. This anomalous states also exist in the water layers below 100 m depth. The isotherm is usually deepened during ENSO period. The deepened amplitude of the isotherm decreases with depth, and varies with ENSO events, seasons and regions. The reason for that is related to weak monsoon in El Nino year and associated eddy activity. Besides this, there is a gain in heat in the upper ocean because of the strong subtropical high during ENSO period.

关键词： heat heat oscillation in the upper ocean of the southern South China Sea

重组组织型纤溶酶原激活剂（rt-PA）静脉溶栓治疗急性脑大动脉闭塞患者的效果

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神经疾病与精神卫生 2018年第7期18卷 487-492页

作者：沈春森罗永春何子骏毛锦龙张振海袁春涛马尚胡野风王斌陆军总医院附属八一脑科医院北京100700 北京大学人民医院神经外科 100044

目的探讨重组组织型纤溶酶原激活剂（***）静脉溶栓治疗急性脑大动脉闭塞患者的效果及潜在的问题。方法回顾性分析2014年1月-2016年8月，在北京陆军总医院附属八一脑科医院接受rt-PA静脉溶栓治疗并有完整随访资料的165例患者，记录了MR... 详细信息

目的探讨重组组织型纤溶酶原激活剂（***）静脉溶栓治疗急性脑大动脉闭塞患者的效果及潜在的问题。方法回顾性分析2014年1月-2016年8月，在北京陆军总医院附属八一脑科医院接受rt-PA静脉溶栓治疗并有完整随访资料的165例患者，记录了MR血管成像上的闭塞位置、入院和溶栓后24h的美国国立卫生院卒中量表（NIHSS）评分，溶栓后1个月血管再通情况以及3个月后的改良Rankin评分（mRS）评分，对临床预后及可能影响因素进行比较分析。结果165例静脉溶栓患者中，89例由大动脉闭塞引起，76例为非大动脉闭塞；非大动脉闭塞组静脉溶栓后较大动脉闭塞组NIHSS评分改善明显，同时3个月mRS评分更好（P均〈0．05）。在89例大动脉闭塞组中，包括颈内动脉闭塞43例，大脑中动脉闭塞25例及椎基底动脉闭塞21例，其中颈内和大脑中动脉闭塞后3个月预后较椎基底动脉好（P均〈0．05）；考虑血栓形成导致的有69例，栓子脱落导致的有20例；栓子栓塞组3个月预后更好（P〈0．05）。其中70例接受了血管复查，总体血管再通率为21．4％；再通成功与否与闭塞部位或闭塞原因之间未发现明显差别（P=0．133、0．779）。结论***静脉溶栓治疗脑大动脉闭塞造成的急性卒中再通率和3个月预后的改善并不明显。

关键词：卒中预后溶栓脑动脉闭塞

Two ABCI family transporters,OsABCI15 and OsABCI16,are involved in grain-filling in rice

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Journal of Genetics and Genomics 2024年第5期51卷 492-506页

作者： Bin Ma Xiubiao Cao Xiaoyuan Li Zhong Bian Qi-Qi Zhang zijun Fang Jiyun Liu Qun Li Qiaoquan Liu Lin Zhang Zuhua he Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Zhongshan Biological Breeding Laboratory/Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genetics and Physiology Agricultural College of Yangzhou UniversityYangzhouJiangsu 225009China Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops Jiangsu Key Laboratory of Crop Genetics and PhysiologyYangzhou UniversityYangzhouJiangsu 225009China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology&EcologyChinese Academy of SciencesShanghai 200032China Institute of Biotechnology Hangzhou Academy of Agricultural SciencesHangzhouZhejiang 310024China Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education Yangzhou UniversityYangzhouJiangsu 225009China

Seed development is critical for plant reproduction and crop yield,with panicle seed-setting rate,grain-filling,and grain weight being key seed characteristics for yield ***,few genes are known to regulate grain ***,we identify two adenosine triphosphate(ATP)-binding cassette(ABC)I-type transporter genes,OsABCI15 and OsABCI16,involved in rice *** genes are highly expressed in developing seeds,and their proteins are localized to the plasma membrane and ***,knockout of OsABCI15 and OsABCI16 results in a significant reduction in seed-setting rate,caused predominantly by the severe empty pericarp phenotype,which differs from the previously reported low seed-setting phenotype resulting from failed *** analysis indicates that OsABCI15 and OsABCI16 participate in ion homeostasis and likely export ions between filial tissues and maternal tissues during grain ***,overexpression of OsABCI15 and OsABCI16 enhances the seed-setting rate and grain yield in transgenic plants and decreases ion accumulation in brown ***,the OsABCI15/16 orthologues in maize exhibit a similar role in kernel development,as demonstrated by their disruption in transgenic ***,ourﬁndings reveal the important roles of two ABC transporters in cereal grain filling,highlighting their value in crop yield improvement.

关键词： ABC transporters Rice Grain filling Ion homeostasis Grain yield

老年男性阻塞性睡眠呼吸暂停患者合并代谢综合征相关不良心血管事件的预后

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中国临床保健杂志 2023年第2期26卷 184-188页

作者：赵哲刘霖赵力博苏小凤王欢欢何子君房凤凤李开亮范利中国人民解放军总医院第二医学中心心血管内科北京100853 中国人民解放军总医院第二医学中心呼吸与危重症医学科国家老年疾病临床医学研究中心北京100853 延安大学医学院中共中央办公厅警卫局卫生保健处

目的明确老年男性阻塞性睡眠呼吸暂停(OSA)合并代谢综合征(MetS)患者相关主要不良心血管事件(MACE)的预后。方法选取2015年1月至2017年10月在北京及甘肃6家医院睡眠中心收集确诊为OSA的老年男性患者704例,根据有无MetS,分为MetS组(392... 详细信息

目的明确老年男性阻塞性睡眠呼吸暂停(OSA)合并代谢综合征(MetS)患者相关主要不良心血管事件(MACE)的预后。方法选取2015年1月至2017年10月在北京及甘肃6家医院睡眠中心收集确诊为OSA的老年男性患者704例,根据有无MetS,分为MetS组(392例)和非MetS组(312例)。比较2组患者的基线特征、多导睡眠监测数据及相关病史,采用Cox回归分析研究老年男性OSA患者合并MetS相关MACE的预后情况。结果在704例患者中,392例(55.68%)老年男性OSA患者合并MetS,在随访期间,68例(9.6%)患者发生了MACE,其中47例合并MetS。多因素分析显示,MetS与MACE的发生有关,调整后的风险比(aHR)为2.09,95%CI:1.19~3.68,P=0.011。亚组分析表明,年龄<70岁(aHR=2.53,95%CI:1.18~5.40,P=0.017)、重度OSA(aHR=2.39,95%CI:1.03~5.55,P=0.043)、超重(aHR=4.03,95%CI:1.63~9.94,P=0.002)的患者,其合并MetS时患MACE的风险更高。结论老年男性OSA患者合并MetS患病率较高,MetS是影响老年男性OSA患者MACE预后的相关因素。年龄<70岁、超重以及重度OSA合并MetS的男性患者发生MACE的风险显著升高。

关键词：睡眠呼吸暂停阻塞性代谢综合征心血管疾病预后老年人

Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2041-2043页

作者： Haotian Zhou Xiaozhen Zhao Ruijun Zhang Miao Miao Wenwen Pei zijun Li Yimin Li Jing he Zhanguo Li Xiaolin Sun Department of Rheumatology and Immunology Clinical Immunology CenterBeijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis(BZ0135)Peking University People’s HospitalNo.11 Xizhimen South Street100044BeijingChina Department of Rheumatology Beijing Children’s HospitalCapital Medical UniversityNational Centre for Children’s Health100045BeijingChina Peking-Tsinghua Center for Life Science BeijingChina

Dear Editor,Previous studies have proved that regulatory T cell(Treg)insufficiency contributed to the development of autoimmune conditions including systemic lupus erythematosus(SLE).Conventional immunosuppressive treatment was reported to downregulate beneficial Tregs together with pathogenic effector immune cells,which may impede a rapid achievement of optimal therapeutic effects.

关键词： glucocorticoid lupus erythematosus SLE

Short-term Wind Power Forecasting Based on BP Neural Network with Improved Ant Lion Optimizer

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Short-term Wind Power Forecasting Based on BP Neural Network...

Thyroid Hormone Biomonitoring:A Review on Their Metabolism and Machine-Learning Based Analysis on Effects of Endocrine Disrupting Chemicals

第37届中国控制会议

作者： Feng Jiang Jiaqi he zijun Peng School of Statistics and Mathematics Zhongnan University of Economics and Law

In order to improve the prediction accuracy of short-term wind power, this paper proposes a short-term wind power prediction model based on an improved ant lion optimizer algorithm to optimize BP neural network（IALO-BP）. The model uses the improved ant lion optimizer algorithm（IALO） to optimize the weights and thresholds of BP neural network, so as to improve the convergence rate and generalization ability of BP neural network. The algorithm is tested by the data of an Irish wind farm in November 2017. The experimental results show that the IALO algorithm can overcome the defect that the original algorithm is easy to fall into the local optimum and the convergence speed is slow. Moreover, the IALO-BP algorithm is superior to BP neural network, GRNN and SVR in the prediction accuracy and stability.

关键词： Wind Power Ant Lion Optimizer Levy Flight BP Neural Network

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Environment & health 2024年第6期2卷 350-372页

作者： Shijie Chen Mengjie Yu Yiming Yao Yongcheng Li Ana he zijun Zhou Liyang Pan Nan Xiao Haining Luo Hongwen Sun MOE Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300071China Tianjin Tianshi College Tianjin 301700China Dalian Center for Disease Control and Prevention DalianLiaoning Province 116000China Department of Center for Reproductive Medicine Tianjin Central Hospital Of Gynecology Obstetrics/Tianjin Key Laboratory Of Human Development And Reproductive RegulationTianjin 300052China

The thyroid is an essential endocrine organ in human body,and thyroid hormones(THs)are pivotal signaling molecules and mediators in various physiological ***,particularly in their free form,play a critical role in regulating body temperature and in the metabolism of lipid and glucose,making the maintenance of TH levels crucial for human *** undergo a series of metabolic processes,producing TH metabolites(THMs).THMs are significant in endocrine regulation,such as 3,5-diiothyronine(3,5-T2)and 3-iodothyronamine(3-T1AM),which exhibit activities akin to *** production and distribution of THMs are intricately linked to the function of specific organs and tissues,highlighting the need for advanced research into the determination and mechanisms of THMs in *** to endocrine disrupting chemicals(EDCs)can significantly affect the levels of thyroid stimulating hormone(TSH)and *** review utilizes machine learning to analyze epidemiological data,identifying potential EDCs that pose risks of hyperthyroidism and ***,it delves into the toxicological mechanisms of these EDCs,examining their effects on TH production,binding processes,related proteins,and metabolic *** approach effectively bridges the gap between epidemiological studies and toxicological researches,laying the groundwork for future research *** integrating epidemiological studies with machine learning,this review offers insightful perspectives on the potential risks associated with chemical exposure and underscores the necessity for further research in understanding the impact of EDCs on TH metabolism and TH-related health effects.

关键词： Thyroid stimulating hormone Emerging contaminants Data mining Thyroxine 3,3′,5-Triiodothyronine Homeostasis

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

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Frontiers of Medicine 2016年第1期10卷 52-60页

作者： Zhi Xu Chunxiang Cao Haiyan Xia Shujing Shi Lingzhi Hong Xiaowei Wei Dongying Gu Jianmin Bian zijun Liu Wenbin Huang Yixin Zhang Song he Nikki Pui-Yue Lee Jinfei Chen Department of Oncology Nanjing First Hospital Nanjing Medical University Nanjing 210006 China Department of General Surgery Nanjing First Hospital Nanjing Medical University Nanjing 210006 China Department of Pathology Nanjing First Hospital Nanjing Medical University Nanjing 210006 China Department of General Surgery Nantong Tumor Hospital Nantong 226361 China Department of Pathology Nantong Tumor Hospital Nantong 226361 China Department of Surgery Faculty of Medicine The University of Hong Kong Hong Kong China

hepatocellular carcinoma （HCC） is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 16 （PPM1D） was highly expressed in the majority of HCC cases （approximately 59%） and significantly associated with high serum a-fetoprotein （AFP） level （P = 0.044）. Kaplan- Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCC- specific overall survival （HR, 2.799; 95% CI, 1.346-5.818, P = 0.006）. Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.

关键词： PPM1D hepatocellular carcinoma prognosis target therapy