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Association of exposure to per- and polyfluoroalkyl substances with liver injury in American adults

Journal of Biomedical Research 2024年第6期38卷 628-639页

作者： Yuqian Yan Lu Zhang Xin Xu Jing Lu Xinyuan ge Maojie Liu Juan Yang Chan Tian zijun ge Chengxiao Yu Wen Guo Chunyan Ye Qun Zhang Health Management Center the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Epidemiology China International Cooperation Center on Environment and Human HealthCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Office of Infection Management the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Liver Diseases the Third People's Hospital of ChangzhouChangzhouJiangsu 213000China

Epidemiological data are scarce regarding the association of exposure to mixtures of per-and polyfluoroalkyl substances(PFASs)with liver injury in the general *** the current study,therefore,we examined data from the National Health and Nutrition Examination Survey(2009–2018).The PFAS exposure levels were defined by the serum concentrations of PFASs with over 70%detection in samples,namely perfluorooctanoic acid,perfluorononanoic acid,perfluorohexane sulfonic acid,perfluorodecanoic acid,and perfluorooctane sulfonic acid(PFOS).We evaluated liver injury from two aspects:first,the degree of liver inflammation was determined based on levels of the serum alanine aminotransferase,aspartate aminotransferase,glutamyltransferase,and total bilirubin;second,the degree of liver fibrosis was determined based on the fibrosis-4 *** assessed the associations of individual or total PFAS exposure with these liver injury outcomes using multivariable linear and logistic regression models,restricted cubic splines,and weighted quantile sum *** the samples of 7484 American adults,the median concentration of PFOS was the highest,followed by perfluorooctanoic acid and perfluorohexane sulfonic *** multivariable linear regression,we observed positive correlations between all PFAS exposure and liver enzyme levels,such as alanine aminotransferase,aspartate aminotransferase,and total ***,the weighted quantile sum model indicated an overall positive association between exposure to the five PFASs and liver injury *** liver function biomarkers and liver fibrosis,perfluorononanoic acid and PFOS were the most heavily weighted chemicals,*** findings provide new epidemiological evidence indicating potential associations between PFAS exposure and adverse effects on liver injury biomarkers,highlighting the potentially harmful effects of PFAS exposure on human liver health.

关键词： PFASs NHANES liver function WQS liver injury

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Coupled relationships among anammox,denitrification, and dissimilatory nitrate reduction to ammonium along salinity gradients in a Chinese estuarine wetland

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Journal of Environmental Sciences 2021年第8期33卷 39-46页

作者： zijun Zhou Lei ge Yufang Huang Yuqian Liu Siyang Wang Institute of Yellow River Water Resources Protection Zhengzhou 450003China Yellow River Institute of Hydraulic Research Zhengzhou 450003China

Salinization in estuarine wetlands significantly alters the balance between their nitrogen(N)removal and retention abilities but these processes have not yet been characterized *** the present study,the potential rates of sediment denitrification,anaerobic ammonium oxidation(anammox),and dissimilatory nitrate reduction to ammonium(DNRA)were mapped using N isotope tracing methods along salinity gradients across the Yellow River Delta wetland(YRDW)in *** contribution of anammox to total dissimilatory N transformations in YRDW was merely 6.8%,whereas denitrification and DNRA contributed 52.3%and 40.9%,*** potential rate of denitrification(5.82μmol/kg/h)decreased significantly along salinity gradients and markedly exceeded DNRA potential rate(2.7μmol/kg/h)in fresh wetlands,but was lower than that of DNRA in oligohaline wetlands(3.06 and 3.18μmol/kg/h,respectively).Moreover,a significantly positive relationship between salinity and DNRA/denitrification was obeserved,indicating that increased salinity may favor DNRA over ***,total sulfur(TS)content and ratio of total organic carbon to total nitrogen(C/N)increased with the salinity gradient and showed evident positive relationships with the DNRA/denitrification *** this study,we proved that increased salinization resulted in the dominance of DNRA over denitrification,possible through the addition of S and alteration of the C/N in estuarine wetlands,leading to increased N retention in estuarine wetlands during salinization,which would enhance the eutrophication potential within wetlands and in downstream ecosystems.

关键词： Denitrification Anammox DNRA Salinity C/N ratio

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2型糖尿病患者自我管理情况与控制现状的相关性分析

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南通大学学报（医学版） 2016年第4期36卷 264-266页

作者：王鑫蕾崔世维顾云娟葛子君陈炜赵小芹南通大学附属医院内分泌科南通226001 南通大学公共卫生学院

目的:评估2型糖尿病患者自我管理情况与控制现状的关系。方法 :对294例2型糖尿病患者进行体格检查、问卷调查及实验室检查。结果:2型糖尿病患者就诊频度、血糖、血压、血脂、体质量方面的监测频度差,在体质量、血糖、血压、血脂等方面... 详细信息

目的:评估2型糖尿病患者自我管理情况与控制现状的关系。方法 :对294例2型糖尿病患者进行体格检查、问卷调查及实验室检查。结果:2型糖尿病患者就诊频度、血糖、血压、血脂、体质量方面的监测频度差,在体质量、血糖、血压、血脂等方面控制情况不理想。糖尿病自我管理情况与控制现状之间具有相关性(r=0.166,P=0.000 1),此外患者文化程度及职业与糖尿病自我管理情况相关(r=0.341、0.208,均P=0.000 1)。结论:针对患者的不同文化程度及职业进行糖尿病教育,提高糖尿病患者自我管理情况,改善糖尿病的代谢指标。

关键词： 2型糖尿病糖尿病教育糖尿病自我管理控制现状

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全员培训模式提高医院感染监测效率的效果评价

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中华卫生应急电子杂志 2021年第3期7卷 146-151页

作者：金霞夏晓洁葛子君朱庆堂李琳李占结臧凤南京医科大学第一附属医院感染管理处江苏南京210029

目的探索"四步法"感控全员培训模式对医院感染监测指标的影响效果。方法选取2019年6月25日至9月30日对南京医科大学第一附属医院(江苏省人民医院)全院人员采用"四步法"感控全员培训模式进行感染预防与控制知识与技能培训。培训内容包括... 详细信息

目的探索"四步法"感控全员培训模式对医院感染监测指标的影响效果。方法选取2019年6月25日至9月30日对南京医科大学第一附属医院(江苏省人民医院)全院人员采用"四步法"感控全员培训模式进行感染预防与控制知识与技能培训。培训内容包括医院感染基本知识、手卫生、职业暴露预防与处置、消毒灭菌、医疗废物管理、规范送检、多重耐药菌防控、传染病管理等。监测指标包括医院感染率、医院感染例次率、手术切口感染率、ICU患者三管感染率、治疗性抗菌药物使用前微生物标本送检率、手卫生依从性及正确率。结果 "四步法"感控全员培训实施后全院、内科、外科、老年医学科及ICU病房的医院感染例次率有所降低(P0.05)。结论 "四步法"感控全员培训考核模式对医院感染监测指标起到正反馈作用,医院感染预防与控制水平得到显著改善。

关键词：全员培训医院感染监测感染预防和控制

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Engineering of Self-Supported Electrocatalysts on a Three-Dimensional Nickel Foam Platform for Efficient Water Electrolysis

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Transactions of Tianjin University 2024年第2期30卷 103-116页

作者： Ceneng Chen Xian Wang zijun Huang Jiahui Mo Xiaoyan Zhang Chao Peng Mohamed Khairy Junjie ge Zhi Long Multiscale Crystal Materials Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China Chemistry Department Faculty of ScienceSohag UniversitySohâg 82524Egypt Dalian National Laboratory for Clean Energy Dalian 116023China

Economical water electrolysis requires highly active non-noble electrocatalysts to overcome the sluggish kinetics of the two half-cell reactions,oxygen evolution reaction,and hydrogen evolution *** intensive efforts have been committed to achieve a hydrogen economy,the expensive noble metal-based catalysts remain under ***,the engineering of self-supported electrocatalysts prepared using a direct growth strategy on three-dimensional(3D)nickel foam(NF)as a conductive substrate has garnered significant *** is due to the large active surface area and 3D porous network offered by these electrocatalysts,which can enhance the synergistic eff ect between the catalyst and the substrate,as well as improve electrocatalytic ***-assisted growth,microwave heating,electrodeposition,and other physical methods(i.e.,chemical vapor deposition and plasma treatment)have been applied to NF to fabricate competitive electrocatalysts with low overpotential and high *** this review,recent advancements in the development of self-supported electrocatalysts on 3D NF are ***,we provide future perspectives of self-supported electrode platforms in electrochemical water splitting.

关键词： Nickel foam Water splitting Surface modification Hydrothermal method Microwave-assisted method Electrodeposition Chemical vapor deposition Plasma treatment

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Surface-patterned chalcogenide glasses with high-aspect-ratio microstructures for long-wave infrared metalenses

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Opto-Electronic Science 2024年第10期3卷 1-13页

作者： Zhaofeng Gu Yixiao Gao Kongsi Zhou Junyang ge Chen Xu Lei Xu Mohsen Rahmani Ran Jiang Yimin Chen zijun Liu Chenjie Gu Yaoguang Ma Jianrong Qiu Xiang Shen Laboratory of Infrared Materials and Devices Research Institute of Advanced TechnologiesNingbo UniversityNingbo 315211China Zhejiang Key Laboratory of Advanced Optical Functional Materials and Devices Ningbo 315211China Advanced Optics&Photonics Laboratory Department of EngineeringSchool of Science and TechnologyNottingham Trent UniversityNottingham NG118NSUnited Kingdom Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational ResearchCenter for Advanced PhotonicsZhejiang UniversityHangzhou 310027China Ningbo Institute of Oceanography Ningbo 315832China

Multidimensional-engineering chalcogenide glasses is widely explored to construct various infrared photonic devices,with their surface as a key dimension for wavefront ***,we demonstrate direct patterning high-aspect-ratio microstructures on the surface of chalcogenide glasses offers an efficient and robust method to manipulate longwave infrared *** chalcogenide glass being considered soft in terms of its mechanical properties,we successfully fabricate high-aspect-ratio micropillars with a height of 8μm using optimized deep etching process,and we demonstrate a 2-mm-diameter all-chalcogenide metalens with a numerical aperture of 0.45 on the surface of a 1.5-mm-thick As2Se3 *** the exceptional longwave infrared(LWIR)transparency and moderate refractive index of As2Se3 glass,the all-chalcogenide metalens produces a focal spot size of~1.39λ0 with a focusing efficiency of 47%at the wavelength of 9.78μm,while also exhibiting high-resolution imaging *** work provides a promising route to realize easy-to-fabricate,mass-producible planar infrared optics for compact,light-weight LWIR imaging systems.

关键词： chalcogenide glasses long wave infrared metalens

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Network pharmacology and metabolomics-based detection of the potential pharmacological effects of the active components in Chrysanthemum morifolium’Chuju’

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Journal of Chinese Pharmaceutical Sciences 2022年第6期31卷 412-428页

作者： Weiping Zhao Qi ge zijun Ding Leizhi Pan Ziqing Gu Yang Liu Hua Cai College of Biology and Food Engineering Chuzhou UniversityChuzhou 239000AnhuiChina School of Life Sciences Jiangsu UniversityZhenjiang 212013JiangsuChina

Chrysanthemum morifolium’Chuju’is a famous medicinal species in traditional Chinese medicine.’Chuju’contains various active ingredients that can be used to treat multiple diseases without toxic side *** the present study,we combined metabolomics and network pharmacology to further explore the active ingredients in’Chuju’,as well as the target and pharmacological mechanisms of the active ingredients.A visualized network analysis model based on chemistry,pharmacokinetics,and pharmacology was constructed to predict the potential pharmacological mechanism of’Chuju’.A total of 424 metabolites of’Chuju’were identified,of which 21 ingredients had positive pharmacological effects after ADME *** network pharmacology revealed that acacetin and beta-sitosterol in’Chuju’could act on GSK3B,MAPK14,ADRA1R,and NOS2 to regulate diabetes mellitus,Alzheimer’s disease,breast cancer,and inflammatory *** results indicated the potential pharmacological effects of the active components in’Chuju’.

关键词： Chrysanthemum morifolium’Chuju’ Metabonomics Network pharmacology Anti-cancer Anti-diabetes

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黄河调水调沙对下游鱼类影响研究

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人民黄河 2024年第12期46卷 105-109,116页

作者：潘轶敏葛雷周子俊黄河水资源保护科学研究院河南郑州450004

为掌握黄河调水调沙对鱼类影响过程,在2023年黄河调水调沙期小浪底坝址至花园口河段开展水生态系统监测,初步探讨了黄河调水调沙对鱼类影响的主要途径、范围、时限以及程度,结果表明:调水调沙对鱼类的影响局限在排沙期;水体短期内含沙... 详细信息

为掌握黄河调水调沙对鱼类影响过程,在2023年黄河调水调沙期小浪底坝址至花园口河段开展水生态系统监测,初步探讨了黄河调水调沙对鱼类影响的主要途径、范围、时限以及程度,结果表明:调水调沙对鱼类的影响局限在排沙期;水体短期内含沙量剧增和溶解氧迅速降低,是对鱼类及其栖息生境产生不利影响的主要因素;小浪底水库高含沙水体排泄是引发坝下“流鱼”的主要原因,“流鱼”分为水库鱼类机械性损伤死亡、坝下鱼类窒息死亡以及“浮头”等,随着含沙量沿程迅速降低,“流鱼”现象逐渐减弱,至伊洛河口基本消失;在调水调沙结束两个月后,鱼类总质量基本可恢复至调水调沙前水平。

关键词：调水调沙水生生物鱼类含沙量溶解氧黄河

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构网型储能支撑新型电力系统建设的思考与实践

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电力系统保护与控制 2023年第5期51卷 172-179页

作者：王新宝葛景韩连山俞秋阳高玉喜刘子俊南京南瑞继保电气有限公司江苏南京211102

构网型储能因具备类似常规发电机控制响应特性而受到广泛关注,被视为支撑新型电力系统建设的关键装备。目前针对该技术的研究大多针对微电网应用场景,尚无大电网应用层面的系统级研究。基于该情况,首先在构网型控制技术原理的基础上提... 详细信息

构网型储能因具备类似常规发电机控制响应特性而受到广泛关注,被视为支撑新型电力系统建设的关键装备。目前针对该技术的研究大多针对微电网应用场景,尚无大电网应用层面的系统级研究。基于该情况,首先在构网型控制技术原理的基础上提出构网型储能建模方法。并结合构网型储能电压源的本质属性,推导其接入系统后参与系统功率分配机制,探讨其在电网装机占比问题。最后,以国内某工程为案例,开展构网型储能模型搭建及在大电网应用场景下的仿真分析。结果表明,所提的建模和分析方法能够指导构网型储能的系统级工程应用。

关键词：新型电力系统构网型储能电压源储能规划

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基于非热法结晶的高水回收率技术及其应用

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水处理技术 2018年第10期44卷 103-105,118页

作者：夏子君通用电气(中国)研究开发中心有限公司上海201203

针对水资源短缺和逐渐增加的工业废水处理成本以及日益严格的环保规范,提出了将新型的AquaSel非热法结晶的高水回收率技术应用于煤化工、食品饮料行业等具有高结垢风险的工业废水处理。介绍了AquaSel系统用于某煤化工公司处理排放的工... 详细信息

针对水资源短缺和逐渐增加的工业废水处理成本以及日益严格的环保规范,提出了将新型的AquaSel非热法结晶的高水回收率技术应用于煤化工、食品饮料行业等具有高结垢风险的工业废水处理。介绍了AquaSel系统用于某煤化工公司处理排放的工业废水和生活污水中试情况,和用于某可口可乐厂处理进水产生的高盐度废水中试情况,表明单元水回收率可以达到95%以上,进而将整套系统的水回收率提高到99.5%以上,达到近零排放。

关键词：废水回收零排放 AquaSel 非热法结晶煤化工食品饮料

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