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Mutual-structure weighted guided image filtering for depth map restoration

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Optoelectronics Letters 2025年第1期21卷 51-56页

作者： LIU zijian SONG Jian CHEN Quanmin XU Jiangtao Tianjin Key Laboratory of Imaging and Sensing Microelectronic Technology School of Microelectronics Tianjin University Spikesee Technology Co. Ltd.

Although guided image filtering(GIF) is known for preserving edges and fast computation, it may produce inaccurate outputs in depth map restoration. In this paper, a novel confidence-weighted GIF called mutual-structure weighted GIF(MSWGIF) is proposed, which replaces the mean filtering strategy in GIF during handling overlapping windows. The confidence value is composed of a depth term and a mutual-structure term, where the depth term is utilized to protect the edges of the output, and the mutual-structure term helps to select accurate windows during the structure characteristics of the guidance image are transferred to the output. Experimental results show that MSWGIF reduces the root mean square error(RMSE) by an average of 12.37%, and the average growth rate of correlation(CORR) is 0.07% on average. Additionally, the average growth rate of structure similarity index measure(SSIM) is 0.34%.

关键词： Wiener filtering

Olfactory Ensheathing Cells-Converted Neurons for CNS Repair

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Olfactory Ensheathing Cells-Converted Neurons for CNS Repair

Establishment and Characterization of Primary Astrocyte Culture from Adult Mouse Brain

中国神经科学学会第十二届全国学术会议

作者： Xiu Sun Yimin Yuan Shangyao Qin zijian tan Xiao Huang Yakun Gu Xueyan Cheng Dan Wang Zhida Su Cheng He Institute of Neuroscience Key Laboratory of Molecular Neurobiology of Ministry of Education and the Collaborative Innovation Center for Brain Science

The repair of central nervous system（CNS） injury continues to be a major challenge in the field of neurology. Damage to CNS leads to irreversible loss of neurons, which ultimately result in persistent neurological dysfunction. Currently, although cell transplantation using stem or differentiated cells has attracted the most attention as a potential therapeutic strategy for CNS injury, it faces several major hurdles such as the ethics and immunologic rejection associated with cell sources. It has been recently reported that cell reprogramming can avoid the issues of ethics or immunologic rejection by converting somatic cells into neural stem cells or neurons. Olfactory ensheathing cell（OECs）, a specific kind of glial cell in CNS, has been widely applied to experimentally treat CNS injury by transplantation. Based on the relative accessibility in the adult rodent or human and the superior compatibility with host astrocytes, OECs are identified as ideal target cells for reprogramming. Therefore, we try to reprogram OECs into functional neurons, thus providing source cells for transplantation after CNS injury. Here, OECs were prepared from adult mice. After screening a series of of transcriptional factors, we found that OECs could be reprogrammed into neurons by a single transcription factor NGN2. These OECs-converted cells expressed the pan-neuron marker Tuj1. The NGN2-induced conversion from OECs to neurons is a direct process without passing through a proliferative stem/progenitor state. Our results further demonstrated that NGN2-induced cells could differentiate into mature neurons by expression of Map2 and Neu N, as well as the specific synaptic marker Synapsin-1. Additionally, we successfully detected exact action potential in the induced neurons. Surprisingly, we found that the administration of neurotropic factors such as BDNF or co-culture with astrocytes effectively promoted maturity of the induced neurons, which were identified mainly as GABAergic and glutama

关键词： reprogramming NGN2 olfactory ensheathing cells neurons central nervous system

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Establishment and Characterization of Primary Astrocyte Cult...

Exploration of Gas‑Dependent Self‑Adaptive Reconstruction Behavior of Cu_(2)O for Electrochemical CO_(2)Conversion to Multi‑Carbon Products

中国神经科学学会第十二届全国学术会议

作者： Xiu Sun Xin Hu Dan Wang Yimin Yuan Shangyao Qin zijian tan Yakun Gu Xiao Huang Cheng He Zhida Su Institute of Neuroscience Key Laboratory of Molecular Neurobiology of Ministry of Education Second Military Medical University

As a major class of glial cells, astrocytes have been indicated to play multiroles in physiological and pathological brain. Astrocyte cultures derived from postnatal mouse brains have been extensively used to characterize their biological properties. However, the inability to culture adult mouse primary astrocytes has long stymied studies of function in adult brain. Here, we developed a protocol to successfully establish highly enriched astrocyte cultures from the brains of adult mouse. Cortical tissues were collected to prepare cell suspension by enzymatic digestion and mechanical dissociation, and then plated onto vessels pre-coated with gelatin and matrigel and cultured in DMEM medium containing 20% fetal bovine serum（FBS）. Forskolin（FSK） and glial-derived neurotrophic factor（GDNF） were used to promote astrocyte proliferation and survival respectively. These adult astrocyte cultures were identified by immunocytochemical, immunoblotingand PCR analysis. Furthermore, biological and functional analysis indicated that they possess the biochemical and physiological properties of astrocytes, suggestive of a useful cell model for astroglial studies in adult brain.

关键词： astrocyte primary culture adult mouse biological property

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Nano-Micro Letters 2025年第3期17卷 280-296页

作者： Chaoran Zhang Yichuan Gu Qu Jiang Ziyang Sheng Ruohan Feng Sihong Wang Haoyue Zhang Qianqing Xu zijian Yuan Fang Song State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO_(2)reduction reaction(CO_(2)RR),whereas the behavior is by far superficially ***,we report that CO_(2)accessibility results in a universal self-adaptive structural reconstruction from Cu_(2)O to Cu@CuxO composites,ending with feeding gas-dependent microstructures and catalytic *** CO_(2)-rich atmosphere favors reconstruction for CO_(2)RR,whereas the CO_(2)-deficient one prefers that for hydrogen evolution *** the assistance of spectroscopic analysis and theoretical calculations,we uncover a CO_(2)-induced passivation behavior by identifying a reductionresistant but catalytic active Cu(I)-rich amorphous layer stabilized by*CO ***,we find extra CO production is indispensable for the robust production of *** inverse correlation between durability and FECO/FEC2H4 is disclosed,suggesting that the selfstabilization process involving the absorption of*CO intermediates on Cu(I)sites is essential for durable *** by this insight,we design hollow Cu_(2)O nanospheres for durable and selective CO_(2)RR electrolysis in producing *** work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO_(2)reduction reaction Electrocatalysts Cu_(2)O Reconstruction Self-adaptive electrocatalysis

塔格糖-4-异构酶的新酶挖掘及酶学性质研究

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微生物学报 2023年第11期63卷 4197-4207页

作者：王利飞谭子瑊谢希贤朱蕾蕾天津科技大学生物工程学院天津300457 中国科学院天津工业生物技术研究所低碳合成工程生物学重点实验室天津300308 南京中医药大学药学院江苏南京210023

D-塔格糖是一种己酮糖,在自然界中天然存在但含量极少,具有降血糖、抗龋齿、改善肠道菌群、促进血液循环和抗衰等作用,可广泛应用于食品、医药和化妆品行业。目前酶催化半乳糖生成塔格糖仅需一步反应,简单易行,但半乳糖较高的成本限制... 详细信息

D-塔格糖是一种己酮糖,在自然界中天然存在但含量极少,具有降血糖、抗龋齿、改善肠道菌群、促进血液循环和抗衰等作用,可广泛应用于食品、医药和化妆品行业。目前酶催化半乳糖生成塔格糖仅需一步反应,简单易行,但半乳糖较高的成本限制了这一方法的工业应用。果糖是塔格糖的同分异构体,价格低廉,来源稳定,可通过4位差向异构化一步获得塔格糖,是产塔格糖的理想底物。【目的】因此挖掘新的塔格糖-4-差向异构酶对塔格糖的工业生产具有重要意义。【方法】本文通过基因挖掘的手段发现了热袍菌(Thermotogae bacterium)来源的未知功能蛋白(命名为HCZ0)具有塔格糖-4-差向异构酶活性,进而完成了HCZ0的异源表达、纯化及酶学性质表征。【结果】确定HCZ0表观分子量约为57.9kDa,比活力为0.9U/mg,最适反应温度和pH值分别为70°C和9.0,最适金属离子为Ni2+,最适金属离子浓度为2mmol/L,60、70和80℃半衰期分别为180、67和9 h。最适条件下,HCZ0催化200 g/L果糖在2 h内可产生28 g/L塔格糖。【结论】本研究中,HCZ0是碱性高温酶,且具有较好的热稳定性,这些特征在以后的理论研究及工业生产中具有一定的科学价值。

关键词： D-塔格糖塔格糖-4-差向异构酶果糖异构化 D-果糖

锂离子电池单层电芯内短路建模与热失控触发特性

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储能科学与技术 2024年第10期13卷 3491-3503页

作者：乔亚军任怡茂谭子健张袆柔吴伟雄广东电网公司广州供电局广东广州510620 暨南大学能源电力研究中心(国际能源学院) 广东珠海519070

锂离子电池内短路诱因复杂,为深入研究内短路引起的电池失效问题须构建合适的精细化仿真模型。本工作以NCM/石墨电池为研究对象,围绕电池内短路失效机理,基于电化学-热耦合物理场,建立了考虑热失控放热副反应的三维单层电芯内短路模型,... 详细信息

锂离子电池内短路诱因复杂,为深入研究内短路引起的电池失效问题须构建合适的精细化仿真模型。本工作以NCM/石墨电池为研究对象,围绕电池内短路失效机理,基于电化学-热耦合物理场,建立了考虑热失控放热副反应的三维单层电芯内短路模型,探究了热失控触发边界,并从内外部特征讨论了单层电芯内短路-热失控的演变过程。首先利用Arrhenius公式得到内短路触发的四种放热副反应产热量与反应速率,探究对电池温升影响最大的副反应类别,结果表明内短路过程放热副反应中负极与电解液反应总热量最大。进一步分析单层电芯内四种典型内短路形式的热失控触发特性,综合考虑组分材料导电性和导热性,得到铝-阳极内短路危险程度最高,其短路电阻值与热失控触发时间呈现正相关趋势,且临界短路电阻的高温热点区域面积值约为30 mm^(2)。模拟结果获得了四种形式内短路临界短路电阻值,并揭示了单层电芯内短路-热失控触发时内部锂离子浓度和温度分布的空间演变规律,相关结果可为研究内短路失效机制和设计安全锂离子电池提供理论指导。

关键词：锂离子电池单层电芯内短路模型热失控触发

Workshop Discussions:On"The Grieved Dance,""Wooden Radio"&"The Vanilla Camp"

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2020年第3期14卷 434-479页

作者： Xudong ZHANG Su Tong Cong Zhou Jing Wang Shiqi Liao zijian tan Yue PU Honey Watson Todd Foley Chenglin YU Chao DENG Hanchi LÜ Tairan LI Jinyi CHU Han Zhuyuan(Translated) Departments of Comparative Literature and East Asian Studies New York University The Chinese University of Hong Kong New York University NYU China House Department of East Asian Studies New York University Department of Comparative Literature New York University Department of English Shanghai International Studies University School of the Arts New York University Department of Slavic Languages and Literatures Yale University 不详

Xudong Zhang:We all encounter this problem when we read early avant・garde works:Although the reading itself is enjoyable,we still want to figure out the exact meanings of the text.I discussed this question with Su Tong蘇童on our way here,and he agreed that this is true when reading short stories・I will invite him to say a few more words on the subject later.

关键词： Dance exact agreed

All-day solar power generation enabled by photo/thermoelectric conversion and thermal energy storage

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Science China Chemistry 2025年

作者： zijian Liu Chengzhi Chen Junda Liu Qi Sun Bingchen Huo Chunyu Du Guangming Chen College of Materials Science and Engineering Shenzhen University

Thermoelectric materials hold promises for direct conversion of heat into electricity, making them viable power sources for electronic devices. However, their practical applications in diverse outdoor environment are hindered by limited and discontinuous electricity output. In this study, we propose an all-day solar power generator to achieve highly efficient and continuous electricity generation by harnessing the synergistic effects of photoelectric-thermoelectric conversion and latent thermal energy storage. The all-day solar power generator exhibits an average open-circuit voltage of 6.8 m V during daylight and a remaining 0.9 mV during nighttime. Importantly, the all-day solar power generator achieves dependable outdoor power supply for communication transmission in diverse environmental scenarios. Our research opens a new way for highly efficient and sustainable power generation.

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Modifying metabolic and immune hallmarks of cancer by a copper complex

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Science China Chemistry 2025年

作者： Chengyan Chu Yunhua Zhang Chengyuan Qian Xiuzhi Yang Yicun Shang zijian Guo Xiaoyong Wang State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University

Metabolic adaptation of cancer cells is a key tactic for maintaining their tumorigenicity and viability in the tumor immune microenvironment （TIME）.Concurrent modulation on the metabolic pathway and immune system could change the living condition of cancer cells and potentiate the efficacy of anticancer drugs.A copper complex （DDCu） was designed to influence the energy metabolism of cancer cells and reshape the *** restrained the production and transportation of lactate by inhibiting the expression of lactate dehydrogenase and monocarboxylate transporter 4,thereby altering the metabolic pathway of cancer cells and improving the acidic tumor ***,DDCu was reduced to Cu+by cellular glutathione to react with lipoylated proteins of the tricarboxylic acid cycle and destabilize the Fe–S cluster proteins,leading to the aggregation of dihydrolipoamide S-acetyltransferase and cuproptosis in cancer ***,DDCu promoted the polarization of macrophages from the M2 to M1 phenotype,activated CD4+and CD8+T cells,and reversed the *** a result,DDCu inhibited the tumor growth through a synergy between metabolic regulation and immunomodulation.

关键词：