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Exosomes:the next-generation therapeutic platform for ischemic stroke

Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying Sun Zhen-ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang ni-Hui Zhang Zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li Wen-Yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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Spin-glass behavior in the competing CoCrGaO_(4)cubic spinel system

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Nano Research 2025年第1期18卷 501-507页

作者： Jiyu Hu Jiangli ni Zhenfa Zi Chaocheng Liu School of Physics and Materials Engineering Hefei Normal UniversityHefei 230009China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230026China

Spin glasses(SGs),generally defined as disordered systems with randomized competing interactions,are widely investigated complex *** the ground states of spin glasses is crucial for understanding the nature of disordered magnets and many other physical manifestations,while also helping to solve some hard combinatorial optimization problems across multiple ***,the intrinsic cause of SG has always been elusive,especially in spinel oxide ***,we report the SG behavior observed in the cubic spinel oxides CoCrGaO_(4),and provide a comprehensive understanding of its intrinsic *** results indicate a frustrated state under multi-magnetic competition,and the features of SG are confirmed by susceptibility *** fitting parameters ofτ0,T0,and zv of isothermal remanent magnetization further reveal the relaxation behavior and strong spin ***,the varying exchange coupling under different temperatures and magnetic fields is unveiled,which should be responsible for the disordered *** studies unravel the underlying mechanism responsible for doping-induced magnetic frustration and introduce CoCrGaO_(4)as a potential platform for investigating spin glass behavior,thereby advancing fundamental research on frustrated magnetism within the spinel system.

关键词： spin glass(SG) magnetic frustration magnetic competition spinel ferrites

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Molecular dynamics simulation of ni_3Al melting

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Journal of University of Science and Technology Beijing 2008年第4期15卷 425-429页

作者： Rongshan Wang Huaiyu Hou Xiaodong ni Guoliang Chen State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China Department of Materials Science and Engineering Nanjing University of Science and Technology Nanjing 210094 China School of Applied Science University of Science and Technology Beijing Beijing 100083 China Power Plant Life Management Research Center Suzhou Nuclear Power Research Institute Suzhou 215004 China

With the Voter-Chen version of embedded-atom model （EAM） potential and molecular dynamics, the melting of ni3Al alloy was simulated by one-phase （conventional） and two-phase approaches. It is shown that the simulated melting point is dependent on the potential and the simulation method. The structures of the melts obtained by different simulation methods were analyzed by the pair correlation function, the coordination number, and the distribution of atom pair type （indexed by the Honeycutt-Andersen pair analysis technique）. The results show that the structures are very similar.

关键词： ni3Al melting point molecular dynamics simulation EAM potential

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Green, sustainable and massive synthesis of sodium vanadate nanowires toward industrialization

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Progress in Natural Science:Materials International 2023年第6期33卷 918-923页

作者： Wei ni ANSTEEL Research Institute of Vanadium & Titanium (Iron & Steel) State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization

One-dimensional(1D) layered materials combine the advantages of layered materials and 1D nanomaterials,which has attracted intense interest not only in the academic research but also in the industrial *** sodium vanadate nanowires have received incremental attention due to the high capacity and enhanced electrical conductivity for promising advanced energy storage and conversion. However, the mass production of these 1D layered vanadium vanadates(1D NVO) are still of great challenge and the further scalable application in energy storage and conversion systems are hampered. Herein, we developed a facile, non-hydrothermal, green synthesis strategy for scalable, mass production of layered vanadium vanadate nanowires and their assemblies such as membranes, blocks, grains, powders toward industrial scale. It will pave a way for the industrial production of 1D inorganic materials and give a new insight into the fabrication of nanostructured materials beyond commercialized 1D/2D nanomaterials including carbon nanotubes(CNT) and layered double hydroxides(LDH).

关键词： Sodium vanadate nanowires Mass production Vanadium-based Barnesite 1D nanomaterials Self-assembly Nanowire membrane Green synthesis

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基于AHP的传统村落“活态”评价研究——以中国贵州省铜仁市传统村落为例

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城市建筑 2025年第01期22卷 13-18+65页

作者：倪默璘刘泽倪琪九州大学人间环境学府北京工业大学城市建设学部大连民族大学建筑学院

可以预见未来中国农村的发展趋势是传统农业农村被现代农业农村取代，演绎传统村落的生态舞台发生了变化。面向未来，传统村落在多大程度上还保持着“活态”，或者说传统村落的“活态”由哪些要素构成是本文的关注点。文章以贵州省铜仁... 详细信息

可以预见未来中国农村的发展趋势是传统农业农村被现代农业农村取代，演绎传统村落的生态舞台发生了变化。面向未来，传统村落在多大程度上还保持着“活态”，或者说传统村落的“活态”由哪些要素构成是本文的关注点。文章以贵州省铜仁市的传统村落为案例，通过实地调查、文献检索等方法收集第一手数据信息构建评价体系，运用AHP对案例村落进行“活态”评价，寻求和把握使传统村落处于“活态”的要素，为传统村落面向未来发展如何保持活力提供参考依据。

关键词：传统村落 “活态”化层次分析法(AHP) 铜仁地区

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Recent progress in MnBi2nTe3n+1 intrinsic magnetic topological insulators: crystal growth, magnetism and chemical disorder

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National Science Review 2024年第2期11卷 65-80页

作者： Chaowei Hu Tiema Qian ni ni Department of Physics and Astronomy and California Nano Systems Institute University of California-Los Angeles

The search for magnetic topological materials has been at the forefront of condensed matter research for their potential to host exotic states such as axion insulators, magnetic Weyl semimetals, Chern insulators,etc. To date, the MnBi2nTe3n+1family is the only group of materials showcasing van der Waals-layered structures, intrinsic magnetism and non-trivial band topology without trivial bands at the Fermi level. The interplay between magnetism and band topology in this family has led to the proposal of various topological phenomena, including the quantum anomalous Hall effect, quantum spin Hall effect and quantum magnetoelectric effect. Among these, the quantum anomalous Hall effect has been experimentally observed at record-high temperatures, highlighting the unprecedented potential of this family of materials in fundamental science and technological innovation. In this paper, we provide a comprehensive review of the research progress in this intrinsic magnetic topological insulator family, with a focus on single-crystal growth, characterization of chemical disorder, manipulation of magnetism through chemical substitution and external pressure, and important questions that remain to be conclusively answered.

关键词： MnBi2Te4 magnetic topological insulator magnetism tuning antiferromagnetism ferromagnetism pressure chemical doping

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Ordered proposition fusion based on consistency and uncertainty measurements

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Science China(Information Sciences) 2017年第8期60卷 117-135页

作者： Dayou LIU Yungang ZHU ni ni Jie LIU College of Computer Science and Technology Jilin University Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin University Beijing Entry-Exit Inspection and Quarantine Bureau

The fusion of ordered propositions is an important and widespread problem in artificial intelligence,but existing fusion methods have difficulty handling the fusion of ordered propositions. In this paper, we propose a solution based on consistency and uncertainty measurements. The main contributions of this paper are as follows. First, we propose the concept of convexity degree, mean, and center of basic support function to comprehensively describe the basic support function of ordered propositions. Second, we introduce entropy as a measure of uncertainty in the basic support function of ordered propositions. Third, we generalize the indeterminacy of the basic support function and propose a novel method to measure the consistency between two basic support functions. Finally, based on the above researches, we propose a novel algorithm for fusing ordered propositions. Theoretical analysis and experimental results demonstrate that the proposed method outperforms state-of-the-art methods.

关键词： uncertainty processing ordered proposition evidence theory dempster rule of combination information fusion

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Hepatitis C:a successful story of cure

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Science Bulletin 2016年第24期61卷 1884-1887页

作者： Yi ni Department of Infectious Diseases Molecular VirologyUniversity Hospital Heidelberg 69120 Heidelberg Germany

On September 23, the 2016 Lasker-DeBakey clinical medical research award ceremony was celebrated in New York City. This annual prize has been awarded by the Lasker Foundation for over 71 years, and it is the most prestigious biomedical award in the United States, popu- larly known as ＂America＇s Nobel Prize＂. Indeed, 87 Lasker laureates have received the Nobel Prize, including 41 within the last 30 years （one example is the Chinese pharmaceutical chemist Youyou Tu, who won the 2011 Lasker-DeBakey award and four years later received the Nobel Prize）. This year, the honor went to Ralf F. W. Bartenschlager （Heidelberg University, Germany）, Charles M. Rice （Rockefeller University, NY, USA）, and Michael J. Sofia （Arbutus Biopharma, PA, USA） for the development of cell culture system to study the replication of Hepatitis C virus （HCV） and for the use of this system to develop drugs capable of eliminating Hepatitis C.

关键词：丙型肝炎病毒 Michael 故事治愈诺贝尔奖生物制药开发能力培养系统

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Development of sterically hindered SPOs and enantioselective ni-Al bimetallic catalyzed C-H cyclization of 4-oxoquinazolines with tethered alkenes

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Chinese Chemical Letters 2023年第6期34卷 366-370页

作者： Yaqi Zhang Qiang ni Bendu Pan Long Jiang Liqin Qiu School of Chemistry Guangdong Key Lab of Chiral Molecules and Drug DiscoverySun Yat-sen UniversityGuangzhou 510006China Instrumental Analysis and Research Centre Sun Yat-sen UniversityGuangzhou 510275China

The ni-Al bimetallic catalysis of intramolecular enantioselective and regioselective C-H cyclization of4-oxoquinazolines with tethered alkenes has been successfully *** new secondary phosphine oxides(SPOs)with large steric hindrance(SPO6-11)were designed and successfully synthesized from readily available chiral amines or amino *** developed chiral SPOs as ligands or preligands demonstrate much higher efficiency in the asymmetric catalytic reactions than the reported traditional ones.A new class of chiral tricyclic pyrroloquinazolinones were obtained in up to 95%yield and 99%ee.

关键词： ni-Al bimetallic catalysis Secondary phosphine oxides C-H cyclization Asymmetric catalysis 4-Oxoquinazolines

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