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Femoral mechanical performance of precocial and altricial birds:a simulation study

Avian Research 2021年第2期12卷 257-268页

作者： Xinsen Wei zihui Zhang College of Life Sciences Capital Normal UniversityBeijing 100048China

Background:As the major load-bearing structures,bones exhibit various properties related to mechanical perfor-mance to adapt to different locomotor *** habits and ontogenetic changes of locomotion in animals can,thus,be explored by assessing skeletal mechanical ***:In this study,we investigated the growing femoral mechanical performance in an ontogenetic series of Cabot’s Tragopans(Tragopan caboti)and Pigeons(Columba livia domestica).Micro-computed tomography-based finite element analysis was conducted to evaluate the stress,strain,and strain energy density(SED)of femora under axial and radial ***:Femora deflected medio-laterally and dorso-ventrally under axial and radial loading,*** deformed and tensed more severely under radial loading than axial *** adult individuals,Cabot’s Tragopans had lower strain and SED than *** ontogeny,the strain and SED of pigeons decreased sharply,while Cabot’s Tragopans showed moderately *** structural properties of hatchling pigeons are more robust than those of hatchling Cabot’s ***:Limb postures have dominant effect on skeletal *** erect posture is preferred by large mammals and birds to achieve a high safety factor of bones during *** Cabot’s Tragopans have stronger femora than pigeons,reflecting a better bone adaption to the terrestrial locomotion of the studied pheas-ant *** in strain and SED during growth reflect the marked difference in locomotor ability between precocial and altricial *** femora of hatchling Cabot’s Tragopans were built with better energy efficiency than deformation resistance,enabling optimized mechanical *** contrast,although weak in mechani-cal function at the time of hatching,pigeon femora were suggested to be established with a more mature structural design as a prerequisite for rapid *** results will be helpful for studies regarding develop

关键词： Biomechanics Cabot’s Tragopan Femur Finite element analysis Pigeon

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疏肝降逆和胃方治疗肝胃不和型非糜烂性胃食管反流病临床研究

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陕西中医 2021年第11期42卷 1539-1543页

作者：何美君白光李晶孟子惠王天佐陈艺楠 Pawat Thanavachirasin 辽宁中医药大学辽宁沈阳110847 辽宁中医药大学附属医院辽宁沈阳110033 泰国清莱皇太后大学中西医结合医学院泰国清莱57100

目的:评价疏肝降逆和胃方改善肝胃不和型非糜烂性胃食管反流病(NERD)的临床疗效,并探讨治疗前后血清中神经生长因子(NGF)表达量的变化与NERD患者焦虑等症状的相关性。方法:回顾性收集72例NERD患者分为中药组37例和西药组35例,中药组予... 详细信息

目的:评价疏肝降逆和胃方改善肝胃不和型非糜烂性胃食管反流病(NERD)的临床疗效,并探讨治疗前后血清中神经生长因子(NGF)表达量的变化与NERD患者焦虑等症状的相关性。方法:回顾性收集72例NERD患者分为中药组37例和西药组35例,中药组予疏肝降逆和胃方治疗,西药组采用奥美拉唑肠溶片治疗,比较两组中医证候积分,临床疗效以及焦虑、抑郁的得分变化。检测两组治疗前后血清NGF、P物质(SP)的表达水平,并分析NGF表达量与焦虑等症状的相关性。结果:两组中医证候积分组内比较显示,治疗后中药组和西药组的烧心、反酸、腹胀、嗳气症状与治疗前比较差异均有统计学意义(P0.05)。治疗后组间比较显示,中药组的烧心、反酸、嗳气积分均低于西药组(P0.05)。中药组临床总有效率为86.5%,高于对照组的68.6%(χ2=10.68,P0.05)。结论:疏肝降逆和胃方具有较好的临床疗效,且NERD患者血清NGF的表达量与其焦虑状态成正相关。其发挥疗效的机制可能是通过降低了血清NGF、SP的水平,从而改善了NERD食管内脏高敏感。

关键词：非糜烂性胃食管反流病疏肝降逆和胃方焦虑抑郁内脏高敏感神经生长因子

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The t-wise intersection of relative two-weight codes

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Science China Mathematics 2014年第8期57卷 1765-1770页

作者： LIU zihui Department of Mathematics Beijing Institute of Technology

The t-wise intersection of constant-weight codes are *** on the above result,the t-wise intersection of relative two-weight codes are determined by using the finite geometric structure of relative two-weight codes.

关键词： relative two-weight code t-wise intersecting constant-weight code projective subspace value function

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Enantiornithine Birds in China

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Acta Geologica Sinica(English Edition) 2011年第6期85卷 1211-1223页

作者： WANG Xia ZHANG zihui College of Life Sciences Capital Normal University Beijing 100048 China School of Biology and Environmental Science University College Dublin Belfield Dublin 4 Ireland

A brief introduction to the morphology, flight, size, habits, diet, feathers and systematic paleontology of fossil enantiornithine birds known from the Mesozoic of China is provided. Enantiornithine birds were the dominant land birds of the Mesozoic （245-65 Myr）. Although they show great morphological differences from modern birds, their diversification in many respects mimics that of the modern land bird radiation and the reasons for their extinction at the end-Cretaceous remain a mystery.

关键词： enantiornithines distribution diversification Cretaceous China

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Model-based assessment of muscle forces and strain distribution in the femur of Cabot’s Tragopans(Tragopan caboti)

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Avian Research 2023年第4期14卷 706-715页

作者： Xinsen Wei zihui Zhang Institute of Geology and Paleontology Linyi UniversityLinyi276000China College of Life Sciences Capital Normal UniversityBeijing100048China

The hindlimbs play a crucial role in bird locomotion,making the biomechanical properties of the musculoskeletal system in these limbs a focal point for researchers studying avian ***,a comprehensive analysis of the mechanical performance within the long bones of hindlimbs during locomotion remains *** the present study,the strain and deformation of the femur of Cabot’s Tragopans(Tragopan caboti)were *** employed inverse simulation to calculate the force and moment of femoral muscles during mid-stance terrestrial locomotion and conducted finite element analysis to calculate femoral *** showed that during mid-stance,the femur experiences combined deformation primarily characterized by torsion,bending,and *** emphasises the importance of considering the influence of varying loads on bone adaptation when investigating bone form-function *** were found to play a significant role in offsetting joint loads on the femur,subsequently reducing the deformation and overall strain on the *** reduction enhances femoral safety during locomotion,allowing birds to meet mechanical demands while maintaining a lightweight bone ***,the *** caudalis significantly reduces torsional deformation of the proximal femur,protecting the vulnerable femoral neck from high fracture risk induced by rotation *** that the femur torsion during terrestrial locomotion in birds is associated with changes in hindlimb posture due to their adaptation to flight,the characteristics of *** caudalis may provide insight into the locomotor evolution of theropods and the origin of avian flight.

关键词： Cabot’s tragopan Femur Finite element analysis Inverse simulation Muscle force Strain

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Treating peripheral nerve injury-induced spinal cord degeneration and neuropathic pain with peripherally administrated stem cells

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Neural Regeneration Research 2023年第3期18卷 537-538页

作者： zihui Wang Xiaofeng Jia Department of Neurosurgery University of Maryland School of Medicine Department of Orthopedics Anatomy and NeurobiologyUniversity of Maryland School of Medicine Department of Biomedical Engineering Anesthesiology and Critical Care MedicineJohns Hopkins University School of MedicineBaltimoreMDUSA

Peripheral nerve injury(PNI)causes sensory and motor deficits as well as neuropathic pain,which seriously impacts patient quality of life(Jiang et al.,2017).Morphological and molecular changes in the spinal cord and dorsal root ganglia(DRG),such as neuronal cell death,nerve fiber degeneration,and glial activation,are strongly associated with PNI-induced pathological syndromes.

关键词： degeneration pain Morphological

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Optimal slot dimension for skirt support structure of coke drums

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Frontiers of Mechanical Engineering 2018年第4期13卷 554-562页

作者： Edward WANG zihui XIA Department of Mechanical Engineering University of Alberta Edmonton T6G1H9 Canada

The skirt-to-shell junction weld on coke drums is susceptible to fatigue failure due to severe thermal cyclic stresses. One method to decrease junction stress is to add slots near the top of the skirt, thereby reducing the local stiffness close to the weld. The most common skirt slot design is thin relative to its circumferential spacing. A new slot design, which is significantly wider, is proposed. In this study, thermal-mechanical elastoplastic 3-D finite element models of coke drums are created to analyze the effect of different skirt designs on the stress/strain field near the shell-to-skirt junction weld, as well as any other critical stress locations in the overall skirt design. The results confirm that the inclusion of the conventional slot design effectively reduces stress in the junction weld. However, it has also been found that the critical stress location migrates from the shell-to-skirt junction weld to the slot ends. A method is used to estimate the fatigue life near the critical areas of each skirt slot design. It is found that wider skirt slots provide a significant improvement on fatigue life in the weld and slot area.

关键词： coke drum stress analysis cyclic stress fatigue life skirt slots

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MR-IDPSO: A Novel Algorithm for Large-Scale Dynamic Service Composition

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Tsinghua Science and Technology 2015年第6期20卷 602-612页

作者： Yanping Zhang zihui Jing Yiwen Zhang School of Computer Science and Technology Key Laboratory of Intelligent Computing and Signal ProcessingMinistry of EducationAnhui University

In the era of big data, data intensive applications have posed new challenges to the field of service composition. How to select the optimal composited service from thousands of functionally equivalent services but different Quality of Service(Qo S) attributes has become a hot research in service computing. As a consequence,in this paper, we propose a novel algorithm MR-IDPSO(Map Reduce based on Improved Discrete Particle Swarm Optimization), which makes use of the improved discrete Particle Swarm Optimization(PSO) with the Map Reduce to solve large-scale dynamic service composition. Experiments show that our algorithm outperforms the parallel genetic algorithm in terms of solution quality and is efficient for large-scale dynamic service composition. In addition,the experimental results also demonstrate that the performance of MR-IDPSO becomes more better with increasing number of candidate services.

关键词： Map Reduce service composition Quality of Service(

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Bivariate association analysis for quantitative traits using generalized estimation equation

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Journal of Genetics and Genomics 2009年第12期36卷 733-743页

作者： Fang Yang zihui Tang Hongwen Deng Laboratory of Molecular and Statistical Genetics College of Life Sciences Hunan Normal University Changsha 410081 China Center of Systematic Biomedical Research Shanghai University of Science and Technology Shanghai 200093 China Departments of Orthopedic Surgery and Basic Medical Sciences University of Missouri-Kansas City Kansas City MO 64108 USA

Quantitative traits often underlie risk for complex diseases. Many studies collect multiple correlated quantitative phenotypes and perform univariate analyses on each of them respectively. However, this strategy may not be powerful and has limitations to detect plei- otropic genes that may underlie correlated quantitative traits. In addition, testing multiple traits individually will exacerbate perplexing problem of multiple testing. In this study, generalized estimating equation 2 （GEE2） is applied to association mapping of two correlated quantitative traits. We suppose that a quantitative trait locus is located in a chromosome region that exerts pleiotropic effects on multiple quantitative traits. In that region, multiple SNPs are genotyped. Genotypes of these SNPs and the two quantitative traits affected by a causal SNP were simulated under various parameter values： residual correlation coefficient between two traits, causal SNP heritability, minor allele frequency of the causal SNP, extent of linkage disequilibrium with the causal SNP, and the test sample size. By power ana- lytical analyses, it is showed that the bivariate method is generally more powerful than the univariate method. This method is robust and yields false-positive rates close to the pre-set nominal significance level. Our real data analyses attested to the usefulness of the method.

关键词： general estimating equation bivariate quantitative trait linkage disequilibrium

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Muscle architecture of the forelimb of the Golden Pheasant(Chrysolophus pictus)(Aves: Phasianidae)and its implications for functional capacity in flight

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Chinese Birds 2015年第1期6卷 6-13页

作者： Yan Yang Huan Wang zihui Zhang College of Life Sciences Capital Normal University

Background: Flight is the central avian adaptation in evolution. Wing muscles form an important anatomical basis for avian flight, affecting wing performance and determine modes of flight. However, the roles of distal muscles in adjusting the wing, as well as their functional specializations, remain largely unknown. The importance of muscle fiber architecture has long been recognized. In this study, we provide quantitative anatomical data on the muscle architecture of the forelimb of the Golden Pheasant(Chrysolophus pictus), with an emphasis on brachial,antebrachial and manual ***: The forelimbs of five Golden Pheasants were dissected and detailed measurements of all muscles were made, including muscle mass, muscle belly length, fascicle length. From these values, muscle volume, physiological cross-sectional area(PCSA) and maximum isometric force were ***: General trends such as the distribution of muscle mass, fascicle length and the ratio of tendon length/belly length are revealed. Comparing PCSAs between antebrachial depressors and elevators and between intrinsics of the alular digit and major digit yielded significant differences(p < 0.05). Pronounced development of the antebrachial depressors suggests that ventral rotation of the distal half of the wing is a pivotal factor in shape change and orientation modulation. Large PCSAs in tandem with the force generation capability of the major digit intrinsics may help stabilize the digits while enhancing support of the primary feathers. The architectural properties of the alular digit confirm that alular adjustment is essential to rapid adduction and ***: These observations illustrate the underlying structural basis for the functional capacities of the distal forelimb muscles and may provide additional information useful in further biomechanical and in vivo investigations.

关键词： Architecture Functional anatomy Golden Pheasant Wing muscles

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