检索结果-南通市图书馆

Bone morphogenetic protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling pathway

引用

Genes & Diseases 2021年第4期8卷 531-544页

作者： Liqin An Qiong Shi Ying Zhu Hao Wang Qi Peng Jinghong Wu Yu Cheng Wei Zhang Yanyu Yi zihao bao Hui Zhang Yetao Luo Jiaming Fan Ministry of Education Key Laboratory of Diagnostic Medicine Department of Clinical BiochemistrySchool of Laboratory MedicineChongqing Medical UniversityChongqing400016PR China Department of Clinical Laboratory The Second Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China Clinical Epidemiology and Biostatistics Department Department of Pediatric Research InstituteChildren’s Hospital of Chongqing Medical UniversityChongqing400014PR China

Liver is an important organ for regulating glucose and lipid *** studies have shown that bone morphogenetic proteins(BMPs)may play important roles in regu-lating glucose and lipid *** previous studies,we demonstrated that BMP4 signif-icantly inhibits hepatic steatosis and lowers serum triglycerides,playing a protective role against the progression of non-alcoholic fatty liver disease(NAFLD).However,the direct impact of BMP4 on hepatic glucose metabolism is poorly ***,we investigated the regulatory roles of BMP4 in hepatic glucose *** a comprehensive analysis of the 14 types of BMPs,we found that BMP4 was one of the most potent BMPs in promoting hepatic glycogen accumulation,reducing the level of glucose in hepatocytes and effecting the expression of genes related to glucose ***,we demonstrated that BMP4 reduced the hepatic glucose lewels through the activation of mTORC2 signaling pathway in vitro and in ***,our findings strongly suggest that BMP4 may play an essential role in regulating hepatic glucose *** knowledge should aid us to understand the molecular pathogenesis of NAFLD,and may lead to the development of novel therapeutics by exploiting the inhibitory effects of BMPs on hepatic glucose and lipid metabolism.

关键词： BMP4 Glucose metabolism Glycogen accumulation mTORC2 signaling Non-alcoholic fatty liver disease(NAFLD)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Weighting Function Modification Used for Phase Transform-Based Time Delay Estimation

引用

China Communications 2022年第11期19卷 241-256页

作者： Xue Yang Changchun bao zihao Cui Speech and Audio Signal Processing Laboratory Faculty of Information TechnologyBeijing University of TechnologyBeijing 100124China

Generalized cross-correlation is considered as the most straightforward time delay estimation *** on various weighting function,different methods were derived and a straightforward method,named phase transform(PHAT)has been widely *** is well-known for its robustness to reverberation and its sensitivity to noise,which is partly due to the fact that PHAT distributes same weights to the frequencies dominated by signal or *** alleviate this problem,two weighting functions are proposed in this *** taking a posteriori signal-to-noise ratio(SNR)into account to classify reliable and unreliable frequencies,different weights could be *** first proposed weighting function borrows the idea of binary mask and distributes same weights to frequencies in same set,whereas,the second one assigns weights based on coherence *** showed the robustness of proposed methods to reverberation and noise for improving the performance of time delay estimation through various criteria.

关键词： time delay estimation generalized crosscorrelation PHAT a posteriori SNR coherence function

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

能耗约束下基于预算等级的调度长度最小化算法

引用

湖南工业大学学报 2023年第6期37卷 1-8页

作者：刘丹彤张龙信杨佳暴子豪艾明慧湖南工业大学计算机学院湖南株洲412007

为了解决异构云系统中能耗约束条件下的调度长度最小化问题,提出了一种新颖的预算等级(BL)能耗预分配策略,并设计了一种能耗约束下最小化调度长度算法(BLMSL),BLMSL算法包含任务优先级队列建立、任务能耗约束预分配、最佳处理器与频率... 详细信息

为了解决异构云系统中能耗约束条件下的调度长度最小化问题,提出了一种新颖的预算等级(BL)能耗预分配策略,并设计了一种能耗约束下最小化调度长度算法(BLMSL),BLMSL算法包含任务优先级队列建立、任务能耗约束预分配、最佳处理器与频率组合选择3个阶段。在Epigenomics和LIGO两类科学工作流上进行实验,结果表明,在满足能耗约束的前提下,BLMSL算法相比当前最先进的启发式算法能获得更小的调度长度,具有明显优势。

关键词：异构云系统能耗调度长度并行应用

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tuning the ratio of Bi/Bi_(2)O_(3)in Bi/PNC nanosheet for highefficiency electrosynthesis hydrogen peroxide

引用

Nano Research 2023年第7期16卷 9050-9058页

作者： Zhikang bao Jinyan Zhao Shijie Zhang Xiaoge Peng Yizhen Shao Chenghang Jiang Zaixiang Xu Xing Zhong zihao Yao Jianguo Wang Institute of Industrial Catalysis College of Chemical EngineeringState Key Laboratory Breeding Base of Green-Chemical Synthesis TechnologyZhejiang University of TechnologyHangzhou 310032China

Electrocatalytic two-electron oxygen reduction reaction(2e-ORR)is a promising method for producing green and sustainable H_(2)O_(2)but lacks high selectivity and yields *** it is critical to develop catalysts that meet industrial ***,we report the different ratios of Bi0/Bi^(3+)supported on a phosphorus,nitrogen,and carbon nanosheet(Bi/PNC),which can reduce O_(2) to H_(2)O_(2)with high selectivity(up to 97.75%at 0.4 VRHE)in 0.1 M KOH electrolyte and retain 97%selectivity even after 100 h *** a homemade flow-cell system was built for electrocatalytic production of H_(2)O_(2)under an O_(2) atmosphere using an improved gas diffusion *** Bi/PNC-4 can achieve a high H_(2)O_(2)yield of 2.76 mol·gcatalyst^(-1)·h^(-1)(alkaline),5.29 mol·gcatalyst^(-1)·h^(-1)(neutral),and 3.50 mol·gcatalyst^(-1)·h^(-1)(acid)in universal pH *** in-situ generated H_(2)O_(2)can function as a degradation agent for efficiently degrading pesticides and *** outstanding selectivity and activities are attributed to the synergistic effects of Bi0 and Bi^(3+)that promote proton-coupled reduction of O_(2) to OOH^(*)(ΔGOOH^(*)=4.27 eV),and the formation of H_(2)O_(2).The fast yield of H_(2)O_(2)on Bi/PNC catalysts in flow-cell provides a promising path of electrocatalytic 2e-ORR for practical H_(2)O_(2)production.

关键词： hydrogen peroxide nanosheet Bi_(2)O_(3) Bi degradation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ring-VCO-based phase-locked loops for clock generation–design considerations and state-of-the-art

引用

Chip 2023年第2期2卷 34-43页

作者： Shiheng Yang Jun Yin Yueduo Liu zihao Zhu Rongxin bao Jiahui Lin Haoran Li Qiang Li Pui-In Mak Rui P.Martins School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of China(UESTC)Chengdu 610054China State-Key Laboratory of Analog and Mixed-Signal VLSI/Institute of Microelectronics and the Faculty of Science and TechnologyDepartment of ECEUniversity of MacaoMacao 999078China On leave from Instituto Superior Técnico Universidade de LisboaLisbon 999022Portugal

This article overviews the design considerations and state-of-the-art of the ring voltage-controlled oscillator(VCO)-based phase-locked loops(PLLs)for clock generation in different ***-ularly,the objective of the current work is to evaluate the required PLL performance among the fundamental metrics of power,jitter and *** in-depth treatment of the mainstream PLL architectures and the associated design techniques enables them to be compared analyt-ically and benchmarked with respect to their figure-of-merit(FoM).The paper also summarizes the key concerns on the selection of dif-ferent circuit techniques to optimize the clock performance under dif-ferent scenarios.

关键词： Clock generation IC design Phase-locked loop(PLL) Frequency synthesizer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Trace water triggers high-efficiency photocatalytic hydrogen peroxide production

引用

Journal of Energy Chemistry 2022年第1期31卷 47-54,I0003页

作者： Zaixiang Xu Yang Li Yongyong Cao Renfeng Du Zhikang bao Shijie Zhang Fangjun Shao Wenkai Ji jun Yang Guilin Zhuang Shengwei Deng Zhongzhe Wei zihao Yao Xing Zhong Jianguo Wang Institute of Industrial Catalysis College of Chemical EngineeringState Key Laboratory Breeding Base of Green-Chemical Synthesis TechnologyZhejiang University of TechnologyHangzhou 310032ZhejiangChina Department of Chemistry Zhejiang UniversityHangzhou 310027ZhejiangChina

Photocatalytic production of hydrogen peroxide(H_(2)O_(2))has attracted much attentions as a promising method for sustainable solar ***,we demonstrate that trace water can drastically boost highefficiency photocatalytic production of H_(2)O_(2) with a record-high concentration of 113 mmol L^(-1) using alkali-assisted C_(3)N_(4) as photocatalyst in water/alcohol mixture *** electron paramagnetic resonance(EPR)measurement,the radical species generated during the photocatalytic process of H_(2)O_(2) are *** propose alcohol is used to provide and stabilize-OOH radicals through hydrogen bond,while trace water could trigger photocatalytic production of H_(2)O_(2) via providing and transferring indispensable free protons to completely consume OOH radicals,which breaks the reaction balance of-OOH radical generation from ***-OOH radicals could be supplied by alcohol continuously to serve as a reservoir for high-efficiency production of H_(2)O_(2).These results pave the way towards photocatalytic method on semiconductor catalysts as an outstanding approach for production of hydrogen peroxide.

关键词： Hydrogen peroxide Photocatalysis Carbon nitride Water Radicals

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mitigating fast thermal instability by engineered laser sweep in AlN soliton microcomb generation

引用

Photonics Research 2023年第8期11卷 I0012-I0020页

作者： KEWEI LIU zihao WANG SHUNYU YAO YANAN GUO JIANCHANG YAN JUNXI WANG CHANGXI YANG CHENGYING bao State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentsTsinghua UniversityBeijing 100084China Center for Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Research and Development Center for Solid State Lighting Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

Transient thermal instability represents a significant challenge in generating soliton *** laser sweep can be an efficient method to mitigate thermal instability,but it requires an ultrahigh laser sweep rate for crystalline microresonators with fast thermal ***,we engineer a laser sweep waveform to generate AlNon-sapphire soliton microcombs with an intermediate sweep speed(<30 GHz∕μs).Two laser sweep methods with backward plus forward tuning or two-step backward tuning added after the fast forward laser sweep were demonstrated to stabilize *** the soliton number is found to be useful to stabilize solitons in fast laser *** effectiveness of the methods was numerically *** measurements and simulations also reveal the impacts of different thermal relaxation processes occurring at quite different time scales on thermal *** requirement of the laser sweep protocols is discussed.

关键词： tuning laser sapphire

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

微腔光梳重频调控与光谱应用

引用

科学通报 2024年第12期69卷 1552-1564页

作者：王子皓杨昌喜鲍成英清华大学精密仪器系精密测量技术与仪器国家重点实验室北京100084

利用高品质因子(高Q)微腔中材料的光学非线性可以实现高相干微腔光梳的产生,这为光频梳系统的小型化和片上集成开辟了新的可能性.对于光学频率梳,梳齿间距是光频梳的关键参数,其与产生方式相关,反过来也影响了光梳的应用.芯片化的微腔... 详细信息

利用高品质因子(高Q)微腔中材料的光学非线性可以实现高相干微腔光梳的产生,这为光频梳系统的小型化和片上集成开辟了新的可能性.对于光学频率梳,梳齿间距是光频梳的关键参数,其与产生方式相关,反过来也影响了光梳的应用.芯片化的微腔光梳一般具有高重频的特点,这一特点适用于波分复用光通信、光计算、太赫兹波合成等应用.但对于精密光谱分析等应用,过大的梳齿间隔会带来光谱欠采样等问题,这一问题在中红外波段尤为明显.本文重点介绍了微腔光梳的重频调控,特别是其在光谱测量中的应用;简要分析了不同方式所产生光频梳的重频特点,以及不同应用对光梳重频的要求,特别是对双光梳测量系统;还介绍了微腔光梳与电光梳相结合的间隔光学差频(interleaved difference frequency generation,iDFG)技术,基于此技术可以实现GHz重频的中红外光梳的产生.将iDFG技术与相向传播(counter-propagating,CP)的孤子对相结合,可以实现中红外波段高相干、高分辨率的光谱测量.本文简要介绍了微腔光梳的发展,侧重于微腔光梳在光谱分析上的应用.

关键词：微腔光梳光学孤子双光梳测量重频

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells

引用

Signal Transduction and Targeted Therapy 2024年第6期9卷 2679-2693页

作者： Junzhi Yi Hui Zhang Fangyuan bao Zhichu Chen Yuliang Zhong Tianning Ye Xuri Chen Jingyi Qian Mengya Tian Min Zhu Zhi Peng Zongyou Pan Jianyou Li zihao Hu Weiliang Shen Jiaqi Xu Xianzhu Zhang Youzhi Cai Mengjie Wu Hua Liu Jing Zhou Hongwei Ouyang Department of Sports Medicine of the Second Affiliated Hospital and Liangzhu LaboratoryZhejiang University School of MedicineHangzhouChina Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cells and Regenerative Medicine Zhejiang University School of MedicineHangzhouChina Stomatology Hospital School of StomatologyZhejiang University School of MedicineZhejiang Provincial Clinical Research Center for Oral DiseasesHangzhouChina The MOE Key Laboratory of Biosystems Homeostasis&Protection The Key Laboratory of Cancer Molecular Cell Biology of Zhejiang ProvinceLife Sciences InstituteZhejiang UniversityHangzhouChina Department of Orthopedics Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhouChina China Orthopedic Regenerative Medicine Group(CORMed) HangzhouChina Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

The knee joint has long been considered a closed *** pathological effects of joint diseases on distant organs have not been ***,our clinical data showed that post-traumatic joint damage,combined with joint bleeding(hemarthrosis),exhibits a worse liver function compared with healthy *** mouse model,hemarthrosis induces both cartilage degeneration and remote liver ***,we found that hemarthrosis induces the upregulation in ratio and differentiation towards Th17 cells of CD4^(+)T cells in peripheral blood and *** of CD4^(+)T cells reverses hemarthrosis-induced liver *** of cartilage matrix induced by hemarthrosis upregulates serological type Ⅱ collagen(COL Ⅱ),which activates CD4^(+)T *** application of a COL Ⅱ antibody blocks the ***,bulk RNAseq and single-cell qPCR analysis revealed that the cartilage Akt pathway is inhibited by blood ***-articular application of Akt activator blocks the cartilage degeneration and thus protects against the liver impairment in mouse and pig *** together,our study revealed a pathological joint-liver axis mediated by matrikine-activated CD4^(+)T cells,which refreshes the organ-crosstalk axis and provides a new treatment target for hemarthrosis-related disease.

关键词： degeneration damage inhibited

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

以RISC-V为目标的动态二进制翻译代码质量优化方法

引用

计算机研究与发展 2023年第10期60卷 2322-2334页

作者：余子濠陈璐孙凝晖包云岗处理器芯片全国重点实验室(中国科学院计算技术研究所) 北京100190 中国科学院大学北京100049

动态二进制翻译是解决一款指令集面临生态系统壁垒问题的主流技术,通过将二进制程序从源指令集翻译成目标指令集,可以在目标指令集的处理器上运行源指令集的应用程序.动态二进制翻译技术的一大挑战是如何生成高质量的目标指令序列,尤其... 详细信息

动态二进制翻译是解决一款指令集面临生态系统壁垒问题的主流技术,通过将二进制程序从源指令集翻译成目标指令集,可以在目标指令集的处理器上运行源指令集的应用程序.动态二进制翻译技术的一大挑战是如何生成高质量的目标指令序列,尤其当源指令集和目标指令集存在差异时.为探究该问题,以RISC-V64指令集为目标指令集,分析了当RISC-V64,RISC-V32,MIPS32,x86分别作为源指令集时,影响动态二进制翻译技术翻译质量的因素.针对这些因素,分别提出相应优化方法,并借助RISC-V B扩展和RISC-V P扩展中的部分指令提升翻译质量.最后,提出一个新的动态二进制翻译程序DBT-FEMU实现优化.在模拟器和FPGA中的评估数据显示,运行SPEC CPU2006的整数基准程序时,优化方法可使目标程序所执行的动态指令数平均减少57%,平均性能达QEMU-i386的4.12倍.

关键词：动态二进制翻译 RISC-V 指令集翻译质量优化

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：