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Melatonin decreases GSDME mediated mesothelial cell pyroptosis and prevents peritoneal fibrosis and ultrafiltration failure

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Science China(Life Sciences) 2024年第2期67卷 360-378页

作者： Hongxia Ruan Xuejuan Li Lina Zhou zihan zheng Rulin Hua Xu Wang Yuan Wang Yujie Fan Shuwen Guo Lihua Wang Shafiq ur Rahman Ziwei Wang Yuyuan Wei Shuangyan Yu Rongzhi Zhang Qian Cheng Jie Sheng Xue Li Xiaoyan Liu Ruqiang Yuan Xiaoyan Zhang Lihong Chen Guowang Xu Youfei Guan Jing Nie Hongqiang Qin Feng zheng Advanced Institute for Medical Sciences Dalian Medical UniversityDalian 116044China Department of Nephrology Second HospitalDalian Medical UniversityDalian 116023China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Chongqing International Institute for Immunology Chongqing 401320China Department of Nephrology Shenzhen HospitalSouthern Medical UniversityShenzhen 518101China Wuhu Hospital and Health Science Center East China Normal UniversityShanghai 200241China Peking University First Hospital Peking UniversityBeijing 100034China

Peritoneal fibrosis together with increased capillaries is the primary cause of peritoneal dialysis failure.Mesothelial cell loss is an initiating event for peritoneal fibrosis.We find that the elevated glucose concentrations in peritoneal dialysate drive mesothelial cell pyroptosis in a manner dependent on caspase-3 and Gasdermin E,driving downstream inflammatory responses,including the activation of macrophages.Moreover,pyroptosis is associated with elevated vascular endothelial growth factor A and C,two key factors in vascular angiogenesis and lymphatic vessel formation.GSDME deficiency mice are protected from high glucose induced peritoneal fibrosis and ultrafiltration failure.Application of melatonin abrogates mesothelial cell pyroptosis through a MT1R-mediated action,and successfully reduces peritoneal fibrosis and angiogenesis in an animal model while preserving dialysis efficacy.Mechanistically,melatonin treatment maintains mitochondrial integrity in mesothelial cells,meanwhile activating m TOR signaling through an increase in the glycolysis product dihydroxyacetone phosphate.These effects together with quenching free radicals by melatonin help mesothelial cells maintain a relatively stable internal environment in the face of high-glucose stress.Thus,Melatonin treatment holds some promise in preserving mesothelium integrity and in decreasing angiogenesis to protect peritoneum function in patients undergoing peritoneal dialysis.

关键词： melatonin mitochondria pyroptosis GSDME peritoneal fibrosis mTOR

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Coupling interface constructions of hollow Co-Mo mixed multiple oxidation states heterostructure for high-performance aprotic Li-O_(2) battery

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Nano Research 2024年第5期17卷 4100-4107页

作者： Xingzi zheng Mengwei Yuan Jingshen Xu zihan Li Caiyun Nan Genban Sun Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing 100875China Center for Advanced Materials Research Beijing Normal UniversityZhuhai 519087China

Constructing interfaces in heterostructures is effective for modulating the electronic properties of electrocatalysts.The hollow CoMoO_(4)-Co_(3)O_(4) heterostructure(HCMCH)was prepared as a bifunctional electrocatalyst for Li-O_(2) battery.The different components in CoMoO_(4)-Co_(3)O_(4) heterostructure presented the efficient coupling and enhanced the electrocatalytic activity for aprotic oxygen reduction reaction(ORR)and oxygen evolution reaction(OER),in which it improved the obviously reduced overpotential of 300 mV(compared with the pure Ketjen black(KB)electrode),enhanced reversibility of 80%capacity retention after 6 full cycles and the superior cyclability of more than 200 cycles with an optimized strategy.The battery performance of the HCMCH was not only associated with the unique hollow structure and rich active sites but also with coupling interface constructions synergetic effects attaching to the improving conductivity and optimized the discharge conversion.These results suggested that this HCMCH electrocatalyst was a promising candidate for the Li-O_(2) battery and it gave a novel insight for high performance electrocatalyst designing.

关键词： Li-oxygen battery heterostructure electrocatalyst coupling interface

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Capacity Contribution Mechanism of rGO for SnO_(2)/rGO Composite as Anode of Lithium-ion Batteries

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Chinese Journal of Mechanical Engineering 2022年第4期35卷 352-359页

作者： Qi Li Guoju Zhang Yuanduo Qu zihan zheng Junkai Wang Ming Zhu Lianfeng Duan Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Shantou UniversityShantou 515063China Advanced Institute of Materials Science&Department of Materials Science and Engineering Changchun University of TechnologyChangchun 130012China SEU-FEI Nano-Pico Center Key Laboratory of MEMS of Ministry of EducationSoutheast UniversityNanjing 211189China

Compared with ordinary graphite anode,SnO_(2) possesses higher theoretical specifc capacity,rich raw materials and low price.While the severe volume expansion of SnO_(2) during lithium-ion extraction/intercalation limits its further application.To solve this problem,in this work the reduced graphene oxide(rGO)was introduced as volume bufer matrix of SnO_(2).Herein,SnO_(2)/rGO composite is obtained through one-step hydrothermal method.Three-dimensional structure of rGO could efectively hinder the polymerization of SnO_(2) nanoparticles and provide more lithium storage sites attributed to high specifc surface area and density defects.The initial discharge capacity of the composite cathode is 959 mA·h·g^(-1) and the capacity remained at 300 mA·h·g^(-1) after 1000 cycles at 1 C.It proved that the rGO added in the anode has a capacity contribution to the lithium-ion battery.It changes the capacity contribution mechanism from difusion process dominance to surface driven capacitive contribution.Due to the addition of rGO,the anode material gains stable structure and great conductivity.

关键词： SnO_(2)/rGO composite Lithium-ion battery Capacity contribution Difusion coefcients

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基于深度强化学习的SCR脱硝系统协同控制策略研究

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动力工程学报 2024年第5期44卷 802-809页

作者：赵征刘子涵华北电力大学控制与计算机工程学院河北保定071003

针对选择性催化还原(SCR)脱硝系统大惯性、多扰动等特点,提出了一种基于多维状态信息和分段奖励函数优化的深度确定性策略梯度(DDPG)协同比例积分微分(PID)控制器的控制策略。针对SCR脱硝系统中存在部分可观测马尔可夫决策过程(POMDP),... 详细信息

针对选择性催化还原(SCR)脱硝系统大惯性、多扰动等特点,提出了一种基于多维状态信息和分段奖励函数优化的深度确定性策略梯度(DDPG)协同比例积分微分(PID)控制器的控制策略。针对SCR脱硝系统中存在部分可观测马尔可夫决策过程(POMDP),导致DDPG算法策略学习效率较低的问题,首先设计SCR脱硝系统的多维状态信息;其次,设计SCR脱硝系统的分段奖励函数;最后,设计DDPG-PID协同控制策略,以实现SCR脱硝系统的控制。结果表明:所设计的DDPG-PID协同控制策略提高了DDPG算法的策略学习效率,改善了PID的控制效果,同时具有较强的设定值跟踪能力、抗干扰能力和鲁棒性。

关键词： DDPG 强化学习 SCR脱硝系统协同控制多维状态分段奖励函数

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长尾喷管气凝胶隔热层结构设计

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推进技术 2024年第5期45卷 166-175页

作者：高煜航郑健上官子晗南京理工大学机械工程学院江苏南京210094

固体火箭发动机长尾喷管外围通常放置舵机等控制系统,为了满足控制系统的工作温度要求,设计了一种用于长尾喷管段的新型热防护复合结构。长尾段隔热层采用具有低热导率、低密度特点的二氧化硅气凝胶材料。首先建立了气凝胶材料热导率计... 详细信息

固体火箭发动机长尾喷管外围通常放置舵机等控制系统,为了满足控制系统的工作温度要求,设计了一种用于长尾喷管段的新型热防护复合结构。长尾段隔热层采用具有低热导率、低密度特点的二氧化硅气凝胶材料。首先建立了气凝胶材料热导率计算模型,并对高温环境气凝胶材料导热性能进行测试。随后结合气凝胶材料热导率计算,建立了长尾喷管的热防护复合结构模型,并对喷管热防护结构模型进行了瞬态传热分析和力学性能分析。结果表明,喷管热防护结构设计满足材料力学性能。在发动机工作20 s后气凝胶材料可以将喷管的长尾段外壳壁面温度控制在320 K以下。相较于传统的高硅氧酚醛隔热材料,气凝胶材料隔热效果表现更优,且可以有效减少喷管热防护结构的消极质量。

关键词：固体火箭发动机长尾喷管热防护二氧化硅气凝胶传热

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Gas-phase synthesis of Ti_(2)CCl_(2) enables an efficient catalyst for lithiumsulfur batteries

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The Innovation 2024年第1期5卷 33-40页

作者： Maoqiao Xiang zihan Shen Jie zheng Miao Song Qiya He Yafeng Yang Jiuyi Zhu Yuqi Geng Fen Yue Qinghua Dong Yu Ge Rui Wang Jiake Wei Weiliang Wang Haiming Huang Huigang Zhang Qingshan Zhu Chuanfang John Zhang State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of the Chinese Academy of SciencesBeijing 100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China China Nuclear Power Engineering Co. Ltd.117 West Third Ring RoadNorth SectionBeijing 100840China College of Materials Science&Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China School of Physics Guangdong Province Key Laboratory of Display Material and TechnologyCenter for Neutron Science and TechnologySun Yat-sen UniversityGuangzhou 510275China Solid State Physics&Material Research Laboratory School of Physics and Materials ScienceGuangzhou UniversityGuangzhou 510006China

MXenes have aroused intensive enthusiasm because of their exotic properties and promising applications.However,to date,they are usually synthesized by etching technologies.Developing synthetic technologies provides more opportunities for innovation and may extend unexplored applications.Here,we report a bottom-up gas-phase synthesis of Cl-terminated MXene(Ti_(2)CCl_(2)).The gas-phase synthesis endows Ti_(2)CCl_(2) with unique surface chemistry,high phase purity,and excellent metallic conductivity,which can be used to accelerate polysulfide conversion kinetics and dramatically prolong the cyclability of Li-S batteries.In-depth mechanistic analysis deciphers the origin of the formation of Ti_(2)CCl_(2) and offers a paradigm for tuning MXene chemical vapor deposition.In brief,the gas-phase synthesis transforms the synthesis of MXenes and unlocks the hardly achieved potentials of MXenes.

关键词： synthesis phase lithium

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The kinase p38αfunctions in dendritic cells to regulate Th2-cell differentiation and allergic inflammation

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Cellular & Molecular Immunology 2022年第7期19卷 805-819页

作者： Miaomiao Han Jingyu Ma Suidong Ouyang Yanyan Wang Tingting zheng Peishan Lu zihan zheng Weiheng Zhao Hongjin Li Yun Wu Baohua Zhang Ran Hu Kinya Otsu Xinguang Liu Ying Wan Huabin Li Gonghua Huang ENT Institute and Department of Otorhinolaryngology Eye&ENT HospitalFudan University200031 ShanghaiChina Shanghai Institute of Immunology Shanghai Jiao Tong University School of Medicine200025 ShanghaiChina Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics Guangdong Medical University523808 DongguanChina Biomedical Analysis Center Army Medical University400038 ChongqingChina Department of Cardiovascular Medicine Graduate School of MedicineOsaka UniversityOsaka 565-0871Japan School of Cardiovascular Medicine and Sciences King’s College LondonLondon SE59NUUK Present address:Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology430030 WuhanChina Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese Medicine200437 ShanghaiChina Department of Clinical Laboratory Medicine Shanghai Tenth People’s Hospital of Tongji University200072 ShanghaiChina Present address:Basic Department of Cancer Center Shanghai Tenth People’s Hospital of Tongji University200072 ShanghaiChina

Dendritic cells(DCs)play a critical role in controlling T helper 2(Th2)cell-dependent diseases,but the signaling mechanism that triggers this function is not fully understood.We showed that p38αactivity in DCs was decreased upon HDM stimulation and dynamically regulated by both extrinsic signals and Th2-instructive cytokines.p38α-specific deletion in cDC1s but not in cDC2s or macrophages promoted Th2 responses under HDM stimulation.Further study showed that p38αin cDC1s regulated Th2-cell differentiation by modulating the MK2−c-FOS−IL-12 axis.Importantly,crosstalk between p38α-dependent DCs and Th2 cells occurred during the sensitization phase,not the effector phase,and was conserved between mice and humans.Our results identify p38αsignaling as a central pathway in DCs that integrates allergic and parasitic instructive signals with Th2-instructive cytokines from the microenvironment to regulate Th2-cell differentiation and function,and this finding may offer a novel strategy for the treatment of allergic diseases and parasitic infection.

关键词： Allergy p38α dendritic cell Th2

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Improving constraint on Ωfrom SDSS using marked correlation functions

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Limin Lai Jiacheng Ding Xiaolin Luo Yizhao Yang zihan Wang Keshi Liu Guanfu Liu Xin Wang Yi zheng Zhaoyu Li Le Zhang Xiaodong Li School of Physics and Astronomy Sun Yat-sen University Zhuhai Campus Department of Astronomy Shanghai Jiao Tong University Department of Astronomy Tsinghua University CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area SYSU Peng Cheng Laboratory

Large-scale structure （LSS） surveys will increasingly provide stringent constraints on our cosmological models.Recently,the density-marked correlation function （MCF） has been introduced,offering an easily computable density-correlation statistic.Simulations have demonstrated that MCFs offer additional,independent constraints on cosmological models beyond the standard two-point correlation （2PCF）.In this study,we apply MCFs for the first time to SDSS CMASS data,aiming to investigate the statistical information regarding clustering and anisotropy properties in the Universe and assess the performance of various weighting schemes in MCFs,and finally obtain constraints on Ωm.Upon analyzing the CMASS data,we observe that,by combining different weights （α=[-0.2,0,0.2,0.6]）,the MCFs provide a tight and independent constraint on the cosmological parameter Ωm,yielding Ωm=0.293±0.006 at the 1σlevel,which represents a significant reduction in the statistical error by a factor of 3.4compared to that from 2PCF.Our constraint is consistent with recent findings from the small-scale clustering of BOSS galaxies(Zhai et al.Astronphys.J.948,99 （2023）) within the 1σlevel.However,we also find that our estimate is lower than the Planck measurements by about 2.6σ,indicating the potential presence of new physics beyond the standard cosmological model if all the systematics are fully corrected.The method outlined in this study can be extended to other surveys and datasets,allowing for the constraint of other cosmological parameters.Additionally,it serves as a valuable tool for forthcoming emulator analysis on the Chinese Space Station Telescope （CSST）.

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广义多边形凸包弹性线递支模拟算法

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北京航空航天大学学报 2024年第1期50卷 216-223页

作者：崔钰萍李子涵郑国磊北京航空航天大学机械工程及自动化学院北京100191

针对诸多领域涉及的平面弯曲图形的凸包计算,提出弹性线递支模拟算法用于计算简单闭广义多边形的弹性包络线。所提算法基于物理模型,通过判断各支点是否受力平衡来判别其是否为弹性包络线上的平衡支点,并据此分别进行前进、回弹和跳跃... 详细信息

针对诸多领域涉及的平面弯曲图形的凸包计算,提出弹性线递支模拟算法用于计算简单闭广义多边形的弹性包络线。所提算法基于物理模型,通过判断各支点是否受力平衡来判别其是否为弹性包络线上的平衡支点,并据此分别进行前进、回弹和跳跃等操作,直至计算出所有平衡支点进而求出其弹性包络线。3种典型的简单闭广义多边形的对比测算表明:所提算法可实时稳健地求解平面任意简单闭广义多边形的弹性包络线,具有高效性和普遍适用性。

关键词：广义多边形曲边形凸包弹性包络线支撑线

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基于记忆驱动的多模态医学影像报告自动生成研究

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生物医学工程学杂志 2024年第1期41卷 60-69页

作者：邢素霞方俊泽鞠子涵郭正王瑜北京工商大学人工智能学院北京100048

医学影像报告自动生成任务面临疾病类型多样、报告描述缺乏专业性和流畅性等多重挑战。为解决以上问题,本文提出一种基于记忆驱动的多模态医学影像报告自动生成方法(mMIRmd),首先使用基于移位窗口的层次视觉转换器(Swin-Transformer)提... 详细信息

医学影像报告自动生成任务面临疾病类型多样、报告描述缺乏专业性和流畅性等多重挑战。为解决以上问题,本文提出一种基于记忆驱动的多模态医学影像报告自动生成方法(mMIRmd),首先使用基于移位窗口的层次视觉转换器(Swin-Transformer)提取患者医学影像的多视角视觉特征,通过基于转换器的双向编码模型(BERT)提取病史信息的语义特征,然后将多模态特征进行融合,提高模型对不同疾病类型的识别能力。其次,使用医学文本预训练的词向量词典对视觉特征标签进行编码,以提高生成报告的专业性。最后,在解码器中引入记忆驱动模块,解决医学影像数据中的长距离依赖关系。本研究在印第安纳大学收集的胸部X光数据集(IU X-Ray)和麻省理工学院联合马萨诸塞州总医院发布的重症监护X光医疗数据集(MIMIC-CXR)上进行验证。实验结果表明,本文所提方法能更好地关注患病区域,提高生成报告的准确性与流畅性,可以辅助放射科医生快速完成医学影像报告的撰写。

关键词：多模态特征融合记忆驱动报告自动生成医学影像

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