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Construction of 3D Shape-Changing Hydrogels via Light-Modulated Internal Stress Fields

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Energy & Environmental Materials 2023年第3期6卷 177-183页

作者： zihan xu Wenxin Fan Jinghua Duan Yanzhi Xia Zhihong Nie Kunyan Sui State Key Laboratory of Bio-Fibers and Eco-Textiles College of Materials Science and EngineeringShandong Collaborative Innovation Center of Marine Biobased Fibers and Ecological TextilesInstitute of Marine Bio-based MaterialsQingdao UniversityQingdao 266071China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

The 3D shape-changing hydrogels are highly pursued for numerous ***,up to now,the construction of complex 3D shape-changing hydrogels remains a *** reported design strategies are mainly applied to fabricate 2D ones by introducing anisotropic microstructures into hydrogel sheets/***,we present a convenient photolithography strategy for constructing complex 3D shape-changing hydrogels by simultaneously modulating anisotropic microstructures and internal stress fields of gel *** the precursor solution containing ultraviolet(UV)absorber is irradiated by single-side UV light,the attenuated polymerization rate can cause the generation of asymmetric internal stress field in the resulting hydrogel *** the meantime,the directional diffusion of unpolymerized monomers allows for the formation of vertical gradient structure within ***,by applying different photomasks to modulate the local gradient structures and internal stress fields of the gel sheets,they can spontaneously transform into various complex 3D shape-changing hydrogels in the *** to the external stimuli,these 3D shape-changing hydrogels(e.g.,fighter plane,birdie,and multi-storey origami lattices)can deform in a novel 3D_(1)-to-3D_(2)-to-3D_(3)*** new design strategy contributes to the development of complex biomedical implants and soft robotics.

关键词： actuators anisotropic microstructure hydrogels internal stress shape transformation

Albumin-based Theranostic Nanosystem for Drug Controlled Release and Magnetic Resonance Imaging Guided Therapy

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Journal of Bionic Engineering 2022年第1期19卷 188-196页

作者： Qiaoying Wang Jiali Cai zihan xu Shihui Huang Ruiping Zhou Zhiyong Wang Leshan Vocational and Technical College Leshan614000China Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education School of Materials Science and EngineeringCenter for Functional BiomaterialsSun Yat-sen UniversityGuangzhou510275China Department of stomatology Shenzhen Yantian District People’s HospitalShenzhen518081China

Chemotherapy is still a kind of important strategy for cancer treatment,but lacking effective delivery system limits the therapeutic *** to the excellent biocompatibility,albumin has been employed as drug vehicle;however,it has to face complicated synthesis procedures and still needs an effective technology for the drug delivery *** this study,a facile method was utilized to prepare a protein-based theranostic system through the self-assembly of albumins with small molecules and drugs;furthermore,the paramagnetic divalent manganese ions were conjugated on the surface of the nanocomposite through a coordination bond and carried out the magnetic resonance *** nanosystem with a stable structure exhibited about 80 nanometer size and 7.7[Mn]mM-1S-1 T1 relaxivity;moreover,the pH-sensitive drug releasing property and the imaging function empower it with theranostic cancer ***,the nanocomposites effectively entered into the cancer cells and showed superior antitumor ability;and these treated cells exhibited significant T1 *** results suggested that the albumin-based nanosystem is a novel chemotherapy drug delivery vehicle and a promising candidate for magnetic resonance imaging.

关键词： Drug delivery system Magnetic resonance imaging Theranostic therapy Self-assembly

不同胃肠减压方式对中度重症急性胰腺炎合并麻痹性肠梗阻患者的作用效果对比

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河南医学研究 2024年第4期33卷 653-656页

作者：廖景徐子涵陈雪贾晓玮河南省直第三人民医院消化病诊疗中心河南郑州450000

目的探讨不同胃肠减压方式在中度重症急性胰腺炎(SAP)合并麻痹性肠梗阻(PI)患者中的应用效果。方法将医院2020年5月至2022年5月收治的96例中度SAP合并PI患者按照随机数字表法分组,对照组(48例)接受传统胃肠减压,观察组(48例)接受改良肠... 详细信息

目的探讨不同胃肠减压方式在中度重症急性胰腺炎(SAP)合并麻痹性肠梗阻(PI)患者中的应用效果。方法将医院2020年5月至2022年5月收治的96例中度SAP合并PI患者按照随机数字表法分组,对照组(48例)接受传统胃肠减压,观察组(48例)接受改良肠梗阻导管置管技术。观察两组减压效果、胃肠功能恢复、炎症反应程度及不良反应发生情况。结果干预后,观察组腹围减小程度、腹内压降低程度、日平均引流量水平均高于对照组(P<0.05);观察组首次排气、排便、进食及拔管时间均短于对照组(P<0.05);观察组白细胞、红细胞沉降率、C反应蛋白恢复正常水平所需时间均较对照组短(P<0.05);观察组不良反应发生率(6.25%)较对照组(20.83%)低(P<0.05)。结论改良肠梗阻导管置管技术可促进中度SAP合并PI患者胃肠功能恢复,缩短炎症水平恢复正常水平所需时间,提高胃肠减压效果且不良反应少。

关键词：改良肠梗阻导管置管技术重症急性胰腺炎麻痹性肠梗阻胃肠减压

Protective effects of blueberry anthocyanin extracts on hippocampal neuron damage induced by extremely low-frequency electromagnetic field

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Food Science and Human Wellness 2020年第3期9卷 264-271页

作者： Xiyun Sun zihan xu Yuehua Wang Ning Liu College of Food Shenyang Agricultural University120 Dongling RdShenyang City 110866China College of Land and Environment Shenyang Agricultural UniversityChina

The protective effects of blueberry anthocyanin extracts against damage induced by extremely lowfrequency electromagnetic field(ELF-EMF)were investigated in a rat *** rats were exposed to ELF-EMF with or without the administration of blueberry anthocyanin extracts(50,100,and 200 mg/kg per day intragastrically once a day)for 30 *** anthocyanin extracts supplementation inhibited the decrease in Nissl substance levels,cell membrane integrity,and mitochondrial membrane potential induced by ELF-EMF;prevented the increase in nitric oxide,malondialdehyde,and Ca2+concentrations;suppressed superoxide dismutase and glutathione depletion;and enhanced the cognitive ability of the rats exposed to *** protective effects of blueberry anthocyanin extracts against hippocampal neuron injury caused by ELF-EMF were *** results demonstrated that blueberry anthocyanin extracts suppress hippocampal neuron injury caused by ELF-EMF by inhibiting cell membrane damage and oxidative stress pathways,and suggested that blueberry anthocyanin treatment potentially prevents hippocampal neuron injury.

关键词： Blueberry anthocyanin extracts Protective effects Extremely low-frequency electromagnetic field Hippocampal neuron

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更大的泡泡

大学化学 2024年第5期39卷 37-43页

作者：张轩赫徐梓涵孙海楠金剑哈尔滨工业大学(深圳)材料科学与工程学院广东深圳518055 哈尔滨工业大学(深圳)实验与创新实践教育中心广东深圳518055

吹泡泡乐趣无穷,老少皆宜。然而,市售泡泡水成分未知,对皮肤刺激性较大。本作品以居家物品作为原料,用单一变量法开发出绿色安全、接触无毒的泡泡水配方,并吹制巨大泡泡。实验由浅入深,层层递进,具有较强的趣味性、探索性,适合于各个年... 详细信息

吹泡泡乐趣无穷,老少皆宜。然而,市售泡泡水成分未知,对皮肤刺激性较大。本作品以居家物品作为原料,用单一变量法开发出绿色安全、接触无毒的泡泡水配方,并吹制巨大泡泡。实验由浅入深,层层递进,具有较强的趣味性、探索性,适合于各个年龄段人群,有助于激发人们对化学实验的兴趣与热爱。人们可以参与并体验自行配制巨型泡泡水的乐趣。

关键词：吹泡泡居家物品泡泡水配方巨大泡泡

鄂尔多斯地区医务人员和教师HPV疫苗接种知识与推荐行为分析

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中国公共卫生 2024年第5期40卷 625-631页

作者：丁铭徐子涵雷琪王梦婷张钹杨佳婉蔡紫庭乔友林王宇萍中国医学科学院、北京协和医学院群医学及公共卫生学院北京100021

目的了解内蒙古自治区鄂尔多斯市医务人员和教师人乳头瘤病毒(human papilloma virus,HPV)疫苗接种知识与推荐行为现状及影响因素。方法于2023年7月采用典型抽样方法,在内蒙古自治区鄂尔多斯市东胜区和鄂托克前旗招募415名医务人员和教... 详细信息

目的了解内蒙古自治区鄂尔多斯市医务人员和教师人乳头瘤病毒(human papilloma virus,HPV)疫苗接种知识与推荐行为现状及影响因素。方法于2023年7月采用典型抽样方法,在内蒙古自治区鄂尔多斯市东胜区和鄂托克前旗招募415名医务人员和教师作为研究对象,通过问卷调查社会人口学特征、HPV及其疫苗的知识,以及基于健康信念模型(Health Belief Model,HBM)对HPV疫苗的信念,并采用单因素logistic回归和多因素非条件logistic回归分析HPV疫苗推荐行为的影响因素。结果最终纳入分析的243名医务人员和86名教师中,201名医务人员推荐过HPV疫苗,56名教师推荐过HPV疫苗。在满分11分的知识得分中,医务人员得分中位数为7分,而教师得分中位数为6分。多因素非条件logistic回归模型分析显示,在医务人员中,居住地是鄂托克前旗(OR=17.042,95%CI=2.778~104.544)、与原理相关知识得分较高者(OR=10.194,95%CI=3.076~33.778)、与应用相关知识得分较高(OR=4.510,95%CI=1.451~14.015)、利于推荐HPV疫苗的因素得分高(OR=17.492,95%CI=3.054~100.178)、高感知易感性(OR=100.407,95%CI=15.087~668.239)更有可能推荐HPV疫苗,而已婚者更少推荐(OR=0.050,95%CI=0.006~0.404)。高感知易感性的教师更有可能推荐HPV疫苗(OR=4.947,95%CI=1.322~18.516)。结论鄂尔多斯市医务人员和教师HPV疫苗接种知识掌握较好,所在地、婚姻状况、知识掌握情况、利于推荐HPV疫苗因素和感知易感性是医务人员推荐行为主要影响因素,感知易感性是教师推荐行为的主要影响因素。

关键词：人乳头瘤病毒疫苗接种健康信念模型医务人员教师

基于无人机多源影像数据的灌浆期人工合成小麦抗旱性评价

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中国农业科学 2024年第9期57卷 1674-1686页

作者：燕雯金秀良李龙徐子涵苏悦张跃强景蕊莲毛新国孙黛珍山西农业大学农学院中国农业科学院作物科学研究所/作物基因资源与育种全国重点实验室新疆农业科学院核技术生物技术研究所/农业农村部荒漠绿洲区作物生理生态与耕作重点实验室/新疆作物生物技术重点实验室

【目的】基于无人机多源影像及产量数据评价人工合成小麦种质的抗旱性，优选高通量抗旱性鉴定指标，发掘抗旱人工合成小麦种质资源，为加快拓展小麦抗旱遗传资源、提升旱地小麦育种水平提供技术支撑和种质材料。【方法】以80份人工合成... 详细信息

【目的】基于无人机多源影像及产量数据评价人工合成小麦种质的抗旱性，优选高通量抗旱性鉴定指标，发掘抗旱人工合成小麦种质资源，为加快拓展小麦抗旱遗传资源、提升旱地小麦育种水平提供技术支撑和种质材料。【方法】以80份人工合成小麦种质及对照小麦品种新春37为试验材料，在田间进行小区播种，设置干旱和灌溉2种水分处理；利用无人机搭载多光谱及热红外相机采集试验材料灌浆期多源影像进行拼接处理，通过阈值分割等方法提取各试验材料的光谱指数；利用相关性分析和主成分分析鉴选抗旱相关光谱指标，结合单指标及综合评价方法鉴定人工合成小麦种质的抗旱性。【结果】基于无人机多源影像数据提取了80份人工合成小麦种质的19种光谱指数。不同光谱指数抗旱系数与小区产量抗旱指数的相关性分析结果表明，OSAVI的抗旱系数与抗旱指数的关联度最高，NDVI、CIre和NDRE的抗旱系数与抗旱指数的关联度较高。部分光谱指数的抗旱系数间相关性较高，存在冗余信息，通过主成分分析，将19个光谱指数的抗旱系数转换为3个相互独立的综合指标，3个综合指标的贡献度分别为59.6%、12.0%和9.6%。利用加权隶属函数法聚合综合指标，通过公式计算获得各人工合成小麦种质的综合抗旱性度量值。基于抗旱指数鉴定出6份强抗旱人工合成小麦种质，基于综合抗旱性度量值鉴定出5份强抗旱种质，其中，SW004和SW009在2种方法的评价结果中均被评为强抗旱种质。基于OSAVI的抗旱系数对80份人工合成小麦种质进行抗旱性分级，分级结果与基于综合抗旱性度量值的分级结果基本一致。根据OSAVI的抗旱系数鉴定出的6份强抗旱种质中，有5份在基于综合抗旱性度量值分级中也被鉴定为强抗旱种质。【结论】基于无人机多源影像提取的光谱指数NDVI、OSAVI、CIre和NDRE，以及基于光谱指数的综合抗旱性度量值均可用于辅助鉴定小麦种质抗旱性。

关键词：多源影像光谱指数人工合成小麦抗旱性灌浆期

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结构参数对气液下喷式喷射器性能的影响研究

石油化工设备技术 2024年第3期45卷 11-17,I0001页

作者：薄守石徐子涵徐冉桑文蓉张其克孙兰义中国石油大学(华东) 山东青岛266580 山东正诺化工设备有限公司山东淄博255080

喷射环流反应器是一种新型的气液或气液固接触反应装置,其中的喷射器结构会对反应器性能产生重要影响。文章采用计算流体力学方法,建立了文丘里型喷射器的数学模型,分析了吸气室、喉部和扩散段等结构对喷射器吸气量的影响规律。模拟结... 详细信息

喷射环流反应器是一种新型的气液或气液固接触反应装置,其中的喷射器结构会对反应器性能产生重要影响。文章采用计算流体力学方法,建立了文丘里型喷射器的数学模型,分析了吸气室、喉部和扩散段等结构对喷射器吸气量的影响规律。模拟结果表明:吸气室直径和气相入口方式对吸气量影响不大;喷嘴与喉部之间距离越小,喉部长度越短,吸气量越高;扩散段扩散角度在2~4°之间时吸气量存在最大值。

关键词：喷射环流反应器计算流体力学文丘里喷射器

Architectural proteins for the formation and maintenance of the 3D genome

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Science China(Life Sciences) 2020年第6期63卷 795-810页

作者： Mengfan Li Jingbo Gan Yuao Sun zihan xu Junsheng Yang Yujie Sun Cheng Li Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary Studies School of Life Sciences Peking UniversityBeijing 100871China State Key Laboratory of Membrane Biology School of Life Sciences Biomedical Pioneering Innovation Center (BIOPIC) Peking UniversityBeijing 100871China Center for Statistical Science Center for Bioinformatics School of Life Sciences Peking UniversityBejjing 100871China

Eukaryotic genomes are densely packaged into hierarchical three-dimensional(3D) structures that contain information about gene regulation and many other biological processes. With the development of imaging and sequencing-based technologies, 3D genome studies have revealed that the high-order chromatin structure is composed of hierarchical levels, including chromosome territories, A/B compartments, topologically associated domains, and chromatin loops. However, how this chromatin architecture is formed and maintained is not completely clear. In this review, we introduce experimental methods to investigate the 3D genome, review major architectural proteins that regulate 3D chromatin organization in mammalian cells, such as CTCF(CCCTC-binding factor), cohesin, lamins, and transcription factors, and discuss relevant mechanisms such as phase separation.

关键词： 3D genome architectural protein Hi-C