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29株食源性志贺氏菌病原学特征和耐药特性分析

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食品安全导刊 2024年第2期 103-107页

作者：王子夫李涛孔凡明临沂市疾病预防控制中心山东临沂276000

目的:分析29株食源性志贺氏菌的病原学特征和耐药特性。方法:利用《食品安全国家标准食品微生物学检验志贺氏菌检验》(GB 4789.5—2012)中的血清学方法对29株食源性志贺氏菌进行分群血清凝集实验;利用高通量测序技术对菌株进行全基因组... 详细信息

目的:分析29株食源性志贺氏菌的病原学特征和耐药特性。方法:利用《食品安全国家标准食品微生物学检验志贺氏菌检验》(GB 4789.5—2012)中的血清学方法对29株食源性志贺氏菌进行分群血清凝集实验;利用高通量测序技术对菌株进行全基因组测序和生物信息学分析,确定其群型和血清型;利用微量肉汤稀释法对菌株进行药敏实验。结果:通过血清学鉴定和wgSNP分析,29株食源性志贺氏菌中仅有2株为福氏志贺氏菌,其余27株均为宋内氏志贺氏菌;29株菌均对氨苄西林、氨苄西林舒巴坦、氯霉素、环丙沙星、头孢噻肟、萘啶酸、复方新诺明和四环素有不同程度的耐药特性,对复方新诺明和萘啶酸耐药率最高(100.00%),对头孢噻肟和环丙沙星的耐药率较低,分别为6.90%和3.45%。结论:临沂市食源性志贺氏菌流行优势菌株为宋内氏志贺氏菌,耐药形势严峻,针对志贺氏菌感染病例应采用更加个性化的治疗方案。

关键词：食源性志贺氏菌基因组病原学特征

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椴叶鼠尾草抗烟草花叶病毒活性成分研究

生物学杂志 2024年第1期41卷 68-72页

作者：王子夫闫俊伊刘洋吴江梅闫晓慧胡世俊西南林业大学生物多样性保护学院云南省森林灾害预警与控制重点实验室昆明650224 西南林业大学林学院昆明650224

为寻找新型植物病毒抑制剂,以烟草花叶病毒(TMV)为供试病毒,研究发现入侵植物椴叶鼠尾草提取物具有抗TMV活性。通过半叶枯斑法不同施药方式筛选发现,在质量浓度为1 mg/mL时,石油醚萃取物的保护作用和钝化作用最强,抑制率为40.95%和52.8... 详细信息

为寻找新型植物病毒抑制剂,以烟草花叶病毒(TMV)为供试病毒,研究发现入侵植物椴叶鼠尾草提取物具有抗TMV活性。通过半叶枯斑法不同施药方式筛选发现,在质量浓度为1 mg/mL时,石油醚萃取物的保护作用和钝化作用最强,抑制率为40.95%和52.85%;乙酸乙酯萃取物的治疗作用最强,抑制率为52.85%,与阳性对照药剂宁南霉素无显著差异。石油醚萃取物各馏分中,Fr7的保护作用和治疗作用最好,抑制率为40.51%和45.52%,Fr6的钝化作用最好,抑制率为74.63%。乙酸乙酯萃取物各馏分中,Fr1′的保护作用最强,抑制率为61.77%,Fr3′的治疗作用最强,抑制率为55.02%,Fr4′的钝化作用最强,抑制率为60.22%。运用现代色谱波谱技术分离鉴定了5个化合物分别为tilifodiolide、eupatoric acid、熊果酸、齐墩果酸和2-甲基-5,7-二羟基色原酮。

关键词：椴叶鼠尾草化学成分分离纯化烟草花叶病毒(TMV) 抗TMV活性

2016—2022年临沂市HIV/AIDS患者抗病毒治疗及时性及影响因素分析

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中国初级卫生保健 2024年第5期38卷 58-61页

作者：李莉杜明庆王子夫王燕李印邦临沂市疾病预防控制中心山东临沂276000

目的:分析山东省临沂市2016—2022年新报告人类免疫缺陷病毒(HIV)/艾滋病(AIDS)患者抗病毒治疗及时性及影响因素,为临沂市抗病毒治疗管理工作提供参考依据。方法:选取临沂市2016—2022年新报告的1764例HIV/AIDS患者。通过艾滋病防治基... 详细信息

目的:分析山东省临沂市2016—2022年新报告人类免疫缺陷病毒(HIV)/艾滋病(AIDS)患者抗病毒治疗及时性及影响因素,为临沂市抗病毒治疗管理工作提供参考依据。方法:选取临沂市2016—2022年新报告的1764例HIV/AIDS患者。通过艾滋病防治基本信息系统下载病例报告和抗病毒治疗历史卡片,关联后形成数据库;采用多因素logistic回归模型分析抗病毒治疗及时性及影响因素。结果:1764例患者的抗病毒治疗及时率为50.23%,不同年份抗病毒治疗及时率呈增长趋势。多因素logistic回归分析结果显示,年龄、人群分类、样本来源、临沂市发现报告、首次CD4细胞计数是抗病毒治疗及时性的影响因素。结论:临沂市新报告HIV/AIDS患者30 d内启动抗病毒治疗的比例还有待提高,相关部门应重点关注低年龄段人群、首次CD4计数较高人群、羁押人群、商业服务人群和外市报至本市的HIV/AIDS患者的随访和检测工作,完善信息沟通和转介流程,缩短从确诊到治疗的时间间隔,从而进一步提高临沂市HIV/AIDS患者的抗病毒治疗及时性。

关键词：人类免疫缺陷病毒/获得性免疫缺陷综合征患者抗病毒治疗及时性影响因素

Adopting GPU computing to support DL-based Earth science applications

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International Journal of Digital Earth 2023年第1期16卷 2660-2680页

作者： zifu wang Yun Li Kevin wang Jacob Cain Mary Salami Daniel Q.Duffy Michael M.Little Chaowei Yang Department of Geography and Geoinformation Science NSF Spatiotemporal Innovation CenterGeorge Mason UniversityFairfaxVAUSA Department of Electrical Engineering and Computer Science University of CaliforniaBerkeleyCAUSA Department of Geography University of California Santa BarbarGoletaCAUSA NASA Goddard Computational and Information Sciences and Technology OfficeGreenbeltMDUSA

With the advancement of Artificial Intelligence(Al)technologies and accumulation of big Earth data,Deep Learning(DL)has become an important method to discover patterns and understand Earth science processes in the past several *** successful in many Earth science areas,Al/DL applications are often challenging for computing *** recent years,Graphics Processing Unit(GPU)devices have been leveraged to speed up Al/DL applications,yet computational performance still poses a major barrier for DL-based Earth science *** address these computational challenges,we selected five existing sample Earth science Al applications,revised the DL-based models/algorithms,and tested the performance of multiple GPU computing platforms to support the *** softwarepackages,performance comparisonsacross different platforms,along with other results,are *** article can help understand how various Al/ML Earth science applications can be supported by GPU computing and help researchers in the Earth science domain better adopt GPU computing(such as supermicro,GPU clusters,and cloud computing-based)for their Al/ML applications,and to optimize their science applications to better leverage the computing device.

关键词： GPU computing GeoAl open science Earth science artificial intelligence

Unimolecular Self-Assembled Hemicyanine-Oleic Acid Conjugate Acts as a Novel Succinate Dehydrogenase Inhibitor to Amplify Photodynamic Therapy and Eliminate Cancer Stem Cells

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Research 2024年第2期6卷 449-461页

作者： Qiang wang Tian Yang Shiyou Li Chen Xu Chong wang Yuxuan Xiong Xing wang Jiangling Wan Xiangliang Yang zifu Li National Engineering Research Center for Nanomedicine College of Life Science and Technology.Huazhong University of Science and TechnologyWuhan 430074P.R.China Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China .3Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Huazhong University of Science and TechnologyWuhan 430074P.R.China Hubei Bioinformatics and Molecular Imaging Key Laboratory College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074P.R.China

Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells(CSCs).However,the innate drawbacks,including short lifetime and diffusion distance of reactive oxygen species and hypoxia within solid tumors,have become bottlenecks for clinical applications of photodynamic ***,we develop a mitochondria-targeting hemicyanine-oleic acid conjugate(CyOA),which can self-assemble into supramolecular nanoparticles(NPs)without any exogenous *** is also shown for targeting the mitochondrial complex II protein succinate dehydrogenase to inhibit oxidative phosphorylation and reverse tumor hypoxia,resulting in 50.4-fold higher phototoxicity against breast cancer stem cells(BCSCs)compared to SO_(3)-CyOA NPs that cannot target to *** 4T1 and BCSC tumor models,CyOA NPs achieve higher tumor inhibition and less lung metastasis nodules compared to the clinically used photosensitizer *** study develops a self-assembled small molecule that can serve as both oxidative phosphorylation inhibitor and photosensitizer for eradication of CSCs and treatment of solid tumors.

关键词： cyanine oxidative treatment

Study on the green extraction of corncob xylan by deep eutectic solvent

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Grain & Oil Science and Technology 2024年第1期7卷 50-59页

作者： Bingyu Jiao Le wang Haitao Gui zifu Ni Rong Du Yuansen Hu School of Biological Engineering National Engineering Research Center of Wheat and Corn Further ProcessingZhengzhou 450001China

Corn as one of the world's major food crops,its by-product corn cob is also rich in ***,the unreasonable utilization of corn cob often causes the environmental pollution,waste of resources and other *** one of the most abundant polymers in nature,xylan is widely used in food,medicine,materials and other *** cob is rich in xylan,which is an ideal raw material for extracting ***,the intractable lignin is covalently linked to xylan,which increases the difficulty of xylan *** has been reported that the deep eutectic solvent(DES)could preferentially dissolve lignin in biomass,thereby dissolving the ***,the xylan in the extract was separated by ethanol precipitation *** xylan precipitate was obtained after centrifugation,while the supernatant was *** components of the supernatant after ethanol precipitation were separated by the rotary *** ethanol,water and DES were collected for the subsequent extraction of corn cob *** this study,a novel way was provided for the green production of corn cob *** DES was used to extract xylan from corn cob which was used as the raw *** effects of solid-liquid ratio,reaction time,reaction temperature and water content of DES on the extraction rate of corn cob xylan were investigated by the single factor ***,the orthogonal test was designed to optimize the xylan extraction *** structure of corn cob xylan was analyzed and *** results showed that the optimum extraction conditions of corn cob xylan were as follows:the ratio of corn cob to DES was 1:15(g:mL),the extraction time was 3 h,the extraction temperature was 60℃,and the water content of DES was 70%.Under these conditions,the extraction rate of xylan was 16.46%.The extracted corn cob xylan was distinctive triple helix of polysaccharide,which was similar to the structure of commercially available *** was effectively and workably extracted from corn

关键词： Corncob Deep eutectic solvent Xylan Process optimization Extraction

The spatial dynamics of Ukraine air quality impacted by the war and pandemic

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International Journal of Digital Earth 2023年第1期16卷 3680-3705页

作者： vizhi Qian Liu Theodore S.Trefonidesc Sina Hasheminassab Jennifer Smith Thomas Huang Kevin M.Marlis Joe T.Roberts zifu wang Dexuan Sha Ana Beatriz Moura Pereira Heramb Podar Jacob Cain Chaowei Yang Department of Geography and GeoInformation Science George Mason UniversityFairfaxVAUSA Jet Propulsion Laboratory California Institute of TechnologyPasaden1CAUSA Dartmouth College HanoverNHUSA Bayer WashingtonDCUSA Northern Virginia Community College AnnandaleVAUSA Indian Institute of Technology RoorkeeIndia

In recent years,our world has experienced significant disruptions due to the COviD-19 pandemic,and Russia's 2022 invasion of Ukraine,impacting human activities and the global *** paper explored air quality changes in Ukraine due to COVID-19,and Russia's invasion of Ukraine using on-demand with a what-you-see-is-what-you-get *** the cOVID-19 pandemic,strict quarantine policies in Ukraine led to a 2%reduction in tropospheric NO_(2) concentration before the lockdown and 4%during the lockdown *** like Kyiv,Donetsk,and Dnipro exhibited reductions of 5%,11%,and 16%,*** SO_(2) column concentration decreased by 6%before the lockdown and 2.5%during the lockdown period,except in high population density *** showed the highest reduction of 17%in SO_(2) concentration,while Donetsk and Dnipro exhibited an 11%***,during the Russian invasion,there was a significant increase in tropospheric NO_(2) concentration in heavily destroyed Kharkiv while most eastern regions experienced a *** total SO_(2) column was 48%higher before the war but reduced throughout the country after the war,except for in Kyiv and a few central *** findings can contribute to analyzing air pollution and building digital twin simulations for future reconstruction scenarios.

关键词： ukraine war air pollution pandemic climate change environment spatiotemporal computing digital twins

A spatiotemporal data collection of viral cases for COVID-19 rapid response

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Big Earth Data 2021年第1期5卷 90-111页

作者： Dexuan Sha Yi Liu Qian Liu Yun Li Yifei Tian Fayez Beaini Cheng Zhong Tao Hu zifu wang Hai Lan You Zhou Zhiran Zhang Chaowei Yang NSF Spatiotemporal Innovation Center George Mason UniversityFairfaxVAUSA Department of Geography and GeoInformation Science George Mason UniversityFairfaxVAUSA Department of Aerospace and Mechanical Engineering University of Notre DameNotre DameINUSA Center for Geographic Analysis Harvard UniversityCambridgeMAUSA School of Resource and Environmental Sciences Wuhan UniversityWuhanHubeiChina

Under the global health crisis of COVID-19,timely,and accurate epi-demic data are important for observation,monitoring,analyzing,modeling,predicting,and mitigating *** case data can be jointly analyzed with relevant factors for various applications in the context of the *** COVID-19 case data are scattered across a variety of data sources which may consist of low data quality accompanied by inconsistent data *** address this short-coming,a multi-scale spatiotemporal data product is proposed as a public repository platform,based on a spatiotemporal cube,and allows the integration of different data sources by adopting various data *** the spatiotemporal cube,a comprehensive data processing workflow gathers disparate COVID-19 epidemic data-sets at the global,national,provincial/state,county,and city *** proposed framework is supported by an automatic update with a 2-h frequency and the crowdsourcing validation team to produce and update data on a daily time *** rapid-response dataset allows the integration of other relevant socio-economic and environ-mental factors for spatiotemporal *** data is available in Harvard Dataverse platform(https://***/***?persistentId=doi:10.7910/DVN/8HGECN)and GitHub open source repository(https://***/stccenter/COVID-19-Data).

关键词： COVID-19 pandemic public health semi-automatic validation spatiotemporal data set

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硫系集成光频梳(特邀)

红外与激光工程 2022年第5期51卷 43-51页

作者：夏迪赵佳鑫吴家越王自富张斌李朝晖中山大学电子与信息工程学院广东省光电信息处理芯片与系统重点实验室广东广州510275 中山大学光电材料与技术国家重点实验室广东广州510275 南方海洋科学与工程广东省实验室(珠海) 广东珠海519000

硫系玻璃集成光学微腔(硫系微腔)具有高线性折射率和高非线性系数、超宽透光窗口、较低的热光系数,并且可通过常规半导体微纳加工技术实现精确的色散调控,在非线性集成光子学领域备受关注。近年来,来自中山大学的研究者们开发了新型Ge_(... 详细信息

硫系玻璃集成光学微腔(硫系微腔)具有高线性折射率和高非线性系数、超宽透光窗口、较低的热光系数,并且可通过常规半导体微纳加工技术实现精确的色散调控,在非线性集成光子学领域备受关注。近年来,来自中山大学的研究者们开发了新型Ge_(25)Sb_(10)S_(65)硫系材料平台并实现了一系列具有高品质的硫系集成光子器件。主要综述了基于硫系微腔实现集成孤子光频梳产生和调控方面的工作。通过不断优化集成光子器件的加工工艺,实现了具有高品质因子(Q>10^(6))的集成微环谐振腔,进一步通过精确的色散调控分别在该硫系集成微腔内实现了低泵浦功率的锁模光孤子频梳和宽带可调谐的拉曼-克尔光频梳。

关键词：硫系玻璃集成光学微腔非线性集成光子学孤子微腔光梳