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Different bactericidal abilities of plasma-activated saline with various reactive species prepared by surface plasma-activated air and plasma jet combinations

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Plasma Science and Technology 2024年第1期26卷 50-61页

作者：贾怡康李甜会张瑞赵鹏瑜王子丰陈旻郭莉刘定新 State Key Laboratory of Electrical Insulation and Power Equipment Center for Plasma BiomedicineXi’an Jiaotong UniversityXi’an 710049People’s Republic of China School of Life Science and Technology Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China

Plasma-activated water(PAW),as an extended form of cold atmospheric-pressure plasma,greatly expands the application of plasma-based *** biological effects of PAW are closely related to the aqueous reactive species,which can be regulated by the activation *** this study,surface plasma-activated air(SAA)and a He+O_(2)plasma jet(Jet)were parallelly combined(the SAA+Jet combination)or sequentially combined(the SAA→Jet combination and the Jet→SAA combination)to prepare plasma-activated saline(PAS).The PAS activated by the combinations exhibited stronger bactericidal effects than that activated by the SAA or the Jet *** concentrations of H_(2)O_(2)and NO_(2)^(-)were higher in the PAS activated by the Jet→SAA combination,while ONOO^(-)concentrations were close in the three kinds of PAS and^(1)O_(2)concentrations were higher in the PAS activated by the SAA+Jet *** analysis of scavengers also demonstrated that H_(2)O_(2),^(1)O_(2),and ONOO^(-)in the PAS activated by the SAA+Jet combination,and^(1)O_(2)in the PAS activated by the Jet→SAA combination played critical roles in bactericidal ***,the effective placement time of the three PAS varied,and the PAS activated by the Jet→SAA combination could also inactivate 2.6-log_(10)of MRSA cells after placement for more than 60 *** regulation of reactive species in plasma-activated water via different combinations of plasma devices could improve the directional application of plasma-activated water in the biomedical field.

关键词： plasma-activated water surface plasma-activated air plasma jet bactericidal effect reactive species

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等离子体活化介质技术及其生物医学应用

电工技术学报 2024年第12期39卷 3855-3868页

作者：刘定新张基珅王子丰张浩郭莉周仁武王小华荣命哲西安交通大学等离子体生物医学研究中心西安710049

等离子体生物医学兴起20余年来,已有多项技术通过美国食品药品监督管理局(FDA)认证并推广应用,但现有的应用方式主要采用等离子体直接处理生命体,存在处理面积小、作用深度浅、有效时间短、稳定性不足等问题,限制了等离子体生物医学的... 详细信息

等离子体生物医学兴起20余年来,已有多项技术通过美国食品药品监督管理局(FDA)认证并推广应用,但现有的应用方式主要采用等离子体直接处理生命体,存在处理面积小、作用深度浅、有效时间短、稳定性不足等问题,限制了等离子体生物医学的适用范围和应用效果。为此,在近10年研究基础上,发展了等离子体活化介质技术,即:采用等离子体活化处理气体、液体或水凝胶等介质材料,将活性粒子加载到介质材料中再应用,使等离子体生物医学从直接处理变革到间接处理,推动实现“更大面积、更深部位、安全稳定、持续有效”的应用升级。该文总结了等离子体活化介质技术的形成背景与研究现状,分析该技术当前面临的关键科学和技术问题,给出最新研究结果并展望未来发展方向,以期为同行学者和研究生提供参考。

关键词：等离子体生物医学等离子体活化介质活性粒子间接处理

Machine learning method for tight-binding Hamiltonian parameterization from ab-initio band structure

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npj Computational Materials 2021年第1期7卷 79-88页

作者： zifeng wang Shizhuo Ye Hao wang Jin He Qijun Huang Sheng Chang Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education and School of Physics and Technology Wuhan University430072 WuhanHubeiPeople’s Republic of China

The tight-binding(TB)method is an ideal candidate for determining electronic and transport properties for a large-scale *** describes the system as real-space Hamiltonian matrices expressed on a manageable number of parameters,leading to substantially lower computational costs than the ab-initio *** the whole system is defined by the parameterization scheme,the choice of the TB parameters decides the reliability of the TB *** typical empirical TB method uses the TB parameters directly from the existing parameter sets,which hardly reproduces the desired electronic structures quantitatively without specific *** is thus not suitable for quantitative studies like the transport property *** ab-initio TB method derives the TB parameters from the ab-initio results through the transformation of basis functions,which achieves much higher numerical ***,it assumes prior knowledge of the basis and may encompass truncation ***,a machine learning method for TB Hamiltonian parameterization is proposed,within which a neural network(NN)is introduced with its neurons acting as the TB matrix *** method can construct the empirical TB model that reproduces the given ab-initio energy bands with predefined accuracy,which provides a fast and convenient way for TB model construction and gives insights into machine learning applications in physical problems.

关键词： Hamiltonian system assume

Validation and Spatiotemporal Distribution of GEOS-5-Based Planetary Boundary Layer Height and Relative Humidity in China

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Advances in Atmospheric Sciences 2018年第4期35卷 479-492页

作者： Yidan SI Shenshen LI Liangfu CHEN Chao YU zifeng wang Yang wang Hongmei wang State Key Laboratory of Remote Sensing Sciences Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

Few studies have specifically focused on the validation and spatiotemporal distribution of planetary boundary layer height （PBLH） and relative humidity （RH） data in China. In this analysis, continuous PBLH and surface-level RH data simulated from GEOS-5 between 2004 and 2012, were validated against ground-based observations. Overall, the simulated RH was consistent with the statistical data from meteorological stations, with a correlation coefficient of 0.78 and a slope of 0.9. However, the simulated PBLH was underestimated compared to LIDAR data by a factor of approximately two, which was primarily because of poor simulation in late summer and early autumn. We further examined the spatiotemporal distribution characteristics of two factors in four regions--North China, South China, Northwest China, and the Tibetan Plateau. The results showed that the annual PBLH trends in all regions were fairly moderate but sensitive to solar radiation and precipitation, which explains why the PBLH values were ranked in order from largest to smallest as follows： Tibetan Plateau, Northwest China, North China, and South China. Strong seasonal variation of the PBLH exhibited high values in summer and low values in winter, which was also consistent with the turbulent vertical exchange. Not surprisingly, the highest RH in South China and the lowest RH in desert areas of Northwest China （less than 30%）. Seasonally, South China exhibited little variation, whereas Northwest China exhibited its highest humidity in winter and lowest humidity in spring, the maximum values in the other regions were obtained from July to September.

关键词： GEOS-5 planetary boundary layer height relative humidity validation spatiotemporal distribution

Systematic screening for potential therapeutic targets in osteosarcoma through a kinome-wide CRISPR-Cas9 library

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Cancer Biology & Medicine 2020年第3期17卷 782-794页

作者： Yuanzhong Wu Liwen Zhou zifeng wang Xin wang Ruhua Zhang Lisi Zheng Tiebang Kang Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China

Objective:Osteosarcoma is the most common primary malignant bone ***,the survival of patients with osteosarcoma has remained unchanged during the past 30 years,owing to a lack of efficient therapeutic ***:We constructed a kinome-targeting CRISPR-Cas9 library containing 507 kinases and 100 nontargeting controls and screened the potential kinase targets in *** CRISPR screening sequencing data were analyzed with the Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout(MAGeCK)Python *** functional data were applied in the 143B cell line through lenti-CRISPR-mediated gene *** clinical significance of kinases in the survival of patients with osteosarcoma was analyzed in the R2:Genomics Analysis and Visualization ***:We identified 53 potential kinase targets in *** these targets,we analyzed 3 kinases,TRRAP,PKMYT1,and TP53RK,to validate their oncogenic functions in ***1 and TP53RK showed higher expression in osteosarcoma than in normal bone tissue,whereas TRRAP showed no significant *** expression of all 3 kinases was associated with relatively poor prognosis in patients with ***:Our results not only offer potential therapeutic kinase targets in osteosarcoma but also provide a paradigm for functional genetic screening by using a CRISPR-Cas9 library,including target design,library construction,screening workflow,data analysis,and functional *** method may also be useful in potentially accelerating drug discovery for other cancer types.

关键词： Osteosarcoma kinase CRISPR-Cas9 library TRRAP PKMYT1 TP53RK

Space view of the decadal variation for typical air pollutants in the Pearl River Delta （PRD） region in China

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Frontiers of Environmental Science & Engineering 2016年第5期10卷 129-142页

作者： zifeng wang Min SHAO Liangfu CHEN Minghui TAO Liuju ZHONG Duohong CHEN Meng FAN Yang wang Xinhui wang State Key Laboratory of Remote Sensing Science Jointly Sponsored by Institute of Remote Sensing and Digital Earth of Chinese Academy of Sciences and Beijing Normal University Beijing 100101 China College of Environmental Sciences and Engineering Peking University Beijing 100876 China Guangdong Environmental Monitoring Center Guangzhou 510308 China

The Pearl River Delta （PRD） is one of the most industrialized, urbanized and populated regions in China, and thus has been long suffering from severe air pollutions. Space data provide a unique perspective for investigating the atmospheric environment at a regional scale. By utilizing multiple satellite retrievals from 2005 to 2013, this study presented, for the first time, the spatial patterns and temporal trends of typical air pollutants over PRD and its vicinity. As viewed from space, aerosol optical depth （AOD）, NO2 and SO2 all had their higher values at the central part of PRD, and showed clear descending gradients as moving to the outskirt of this region. As to the inter-annual variation, all these pollutants had decreasing trends in PRD during the study period, which generally agreed with the relevant in situ measurements. However, the satellite retrievals differed from ground measurements when addressing NO2 and SO2 in the vicinity of PRD. This work also provides the inter-comparison among PRD and three other metropolitan clusters in China： PRD had relatively high AOD, moderate NO2 and low SO2 levels, and it was the only region achieving the effective reduction of NO2 and SO2 during last decade. Unlike the previous three pollutants, HCHO observed by satellite showed very special patterns： it had a relatively homogeneous spatial distribution over both of PRD and its vicinity, and presented an opposite increasing trend from 2005 to 2010. Moreover, PRD had the highest HCHO level among all the metropolitan clusters, hinting a considerable contribution of biogenic origins of HCHO in PRD.

关键词： The Pearl River Delta (PRD) Satellite monitoring Regional air quality Long-term trend HCHO

Stress triggering effect on the 2022 Honghe M_(S)5.0 earthquake with historical strong earthquakes

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Geodesy and Geodynamics 2024年第2期15卷 107-113页

作者： Mingce wang zifeng Liu Ruijie Luo Yunnan Earthquake Agency Kunming 650224China School of Earth Sciences Yunnan UniversityKunming 650504China

The 2022 Honghe M_(S)5.0 seismic event is intriguing due to its occurrence in the south of the Red River Fault,an area historically lacking seismic activities greater than M_(S)*** elucidate the seismogenic mechanism and scrutinize stress-triggered interactions,we calculated co-seismic and post-seismic Coulomb stress alterations induced by nine historical seismic events(M≥6.0).The analysis reveals that these substantial seismic events provoked co-seismic stress augmentations of 1.409 bar and postseismic stress increments of 0.159 *** seismic events,such as the 1833 Songming,1877Shiping,1913 Eshan,and 1970 Tonghai earthquakes,catalyzed the occurrence of the Honghe *** of heightened future seismic risk include the southern region of the Red River Fault and the eastern segments of the Shiping-Jianshui and Qujiang ***,we assessed the correlation between the spatial distribution of aftershocks and the Coulomb stress shift triggered by the mainshock,taking into account the influence of calculation parameter settings.

关键词： Honghe Ms5.0 earthquake Coulomb failurestress Stress triggering Historical strongearthquakes

Large scale fabrication of graphene for oil and organic solvent absorption

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Progress in Natural Science:Materials International 2016年第3期26卷 319-323页

作者： Chenxi Fu zifeng wang Junyi Liu Hongbo Jiang Guangming Li Chunyi Zhi Department of Physics and Materials Science City University of Hong Kong School of Mechanical Electrical & Information Engineering Shandong University

A simple method for synthesizing highly wrinkled and less layered structure of graphene sheets by using a mechano-thermal exfoliation method was developed. During this process, graphite and ammonium chloride（NH;Cl） powders were loaded by milling and followed with heating at a quartz tube under a nitrogen gas flow. The method is facile and easy for scaling up. Consequently, such microstructure merits of structure endowed graphene super strong adsorption ability, which should have great potential for water purification and treatment.

关键词： Graphene Ball-milling Oil absorption

miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer

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Journal of Molecular Cell Biology 2018年第4期10卷 302-315页

作者： Sanhong Liu zifeng wang Zukai Liu Shuo Shi Zhaoran Zhang Jiawei Zhang Haifan Lin Shanghai Institute of Advanced Immunochemical Studies ShanghaiTech University Shanghai China School of Life Science and Technology ShanghaiTech University Shanghai China The Yale Stem Cell Center and Department of Cell Biology Yale University School of Medicine New Haven CT USA

Triple-negative breast cancer （TNBC）, characterized by the lack of expression of the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor 2, is an aggressive form of cancer that conveys unpredictable and poor prognosis due to limited treatment options and lack of effective targeted therapies. Wnt/β-catenin signaling is hyperactivated in TNBC, which promotes the progression of TNBC. However, the molecular mechanism of Wnt/β-catenin activation in TNBC remains unknown. Here, we report the drastic overexpression of miR-221/222 in all of four TNBC cell lines and TNBC primary tumor samples from patients. Furthermore, we demonstrate by both ex vivo and xenograft experiments that inhibiting miR-221/222 expression in a TNBC cell line （MDA-MB-231） suppresses its proliferation, viability, epithelial-to-mesenchymal transition, and migration; whereas expressing miR-221/222 in a non-TNBC line （MCF7） promotes all of the above cancer properties. miR-221/222 achieve so by directly repressing multiple negative regulators of the Wnt/β-catenin signaling pathway, including WIF1, SFRP2, DKK2, and AXIN2, to activate the pathway. Notably, the level of miR-221/222 expression is inversely correlated whereas that of WIF1, DKK2, SFRP2, and AXIN2 expression is positively correlated with the patient survival. Last, we show that anti-miR-221/222 significantly increases apoptotic cells with tamoxifen/Wnt3a treatment but not with cyclophosphamide/Wnt3a treatment. These results demonstrate that miR-221/222 activate the Wnt/β-catenin signaling to promote the aggressiveness and TNBC properties of breast cancers, and thus reveal a new prospect for TNBC treatment.

关键词： miR-221/222 Wnt/β-catenin triple-negative breast cancer