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人类皮肤细胞外基质蛋白1(ECm1)的表达随年龄而减少并随紫外线照射而增加

世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 18-19页

作者： Sander C.S. Sercu S. ziemer m. J. merregaert 王琼 Laboratory of molecular Biotechnology Department of Biomedical Sciences University of Antwerp Universiteitsplein 1 2610 Wilrijk Antwerp Belgium Prof.

Background: The extracellular matrix protein 1 (ECm1) is expressed in human skin and plays an important role in its normal structure and function. In the rare genetic skin disease lipoid proteinosis, which is characterized by a loss-of-function mutation in the ECm1 gene, skin areas habitually exposed to the sun may show a more severely scarred and photoaged appearance. However, no data are available on the possible involvement of ECm1 expression in intrinsic and extrinsic skin ageing. Objectives: We hypothesized that ECm1 expression in human skin is regulated by age and ultraviolet (UV) dependent mechanisms. methods: Skin biopsies from 12 patients with histologically confirmed solar elastosis, from non UV exposed sites of 12 age-matched controls and 12 young subjects were analysed. To evaluate the influence of acute UV exposure, buttock skin of 10 healthy subjects was irradiated repetitively on 10 days with a solar simulator and compared intraindividually with non-UV-treated contralateral sites. The expression of ECm1 was investigated by immunohistochemistry using an ECm1 antibody detecting ECm1a and ECm1c isoforms. Semiquantitative analysis of staining intensity was carried out by densitometric image analysis. Results: In normal human skin ECm1a and ECm1c are expressed mainly in the basal cell layers of epidermal keratinocytes and in dermal vessels. For the first time, an expression in the outer root sheath of hair follicles, in sebaceous lobules and epithelium of sweat glands is described. Intrinsically (UV-protec-ted) aged skin shows a significantly reduced expression in basal and upper epidermal cell layers compared with young skin. In photoaged skin, expression is significantly increased within the lower and upper epidermis compared with age-matched UV-protected sites. Importantly, after acute UV exposure in young healthy subjects expression of ECm1 is markedly increased in both lower and upper epidermal cell layers. Conclusions: This is the first study to demo

关键词：遗传性皮肤病细胞外基质蛋白紫外线照射年龄表皮角质形成细胞人类健康受试者 UV照射免疫组化法检测老化现象

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B细胞慢性淋巴细胞白血病在鲜红色单纯疱疹感染部位的特异皮肤浸润

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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 13-13页

作者： ziemer m Bornkessel A Hahnfeld S Weyers W. 刘芯 Department of Dermatology and Allergology Friedrich-Schiller-University Erfurter Strasse 35 07743 Jena Germany.Dr

Background: Specific cutaneous infiltrates in patients with leukemia generally carry a grim prognosis. However, nonneoplastic skin diseases may be associated with recruitment of normal and neoplastic leukocytes circulating in the peripher al blood. In those instances, neoplastic cells may be detected in skin lesions w ithout an adverse effect on prognosis. methods: In a patient with B-cell chroni c lymphocytic leukemia,a specific infiltrate developed at the site of a florid h erpes simplex infection. Clinically, the lesion presented itself as an ulcerated tumor. Results: Histopathologically, the lesion was characterized by a dense, d iffuse infiltrate of small hyperchromatic lymphocytes throughout the entire derm is. Lymphocytes showed an aberrant CD20 +/CD43+/CD5+phenotype of neoplastic B cells, and monoclonal rearrangement of immunoglobulin gamma genes could be demo nstrated by polymerase chain reaction. Although criteria for leukemia cutis were fulfilled, the patient did well. Conclusions: The cutaneous infiltrate of neopl astic cells seemed to be part of a physiologic response to the antigenic stimulu s, rather than indicating an exacerbation of leukemia.

关键词： B细胞皮肤浸润单纯疱疹皮肤白血病免疫球蛋白基因肿瘤性弥漫浸润临床状况组织病理学抗原

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Bioassays to assess drug effects to cells of the microvascular system

Bioassays to assess drug effects to cells of the microvascul...

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2000上海科技论坛BIO-X研讨会暨中德医学生物物理和上海流变学研讨会

作者： O.Stache J.ziemer G.Schneider N.muecke G.m.Artmann Department of Cell Biophysics Fachhochschule Aachen-JuelichGensterweg 152428Germany

Pharmacology performed on isolated cells relates the agent concentration to its biological effect and istherefore a valuable tool to study the complex mechanisms of drug effects on living system. Resultsontained with bioassays can be extremely useful When assessing the actively if natural compounds as thoseused in Chinese traditional medicine. In this context,we would like to introduce three examples of newbioassays:

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化学干燥剂对苜蓿制干草营养物质消化率和奶牛泌乳性能的影响

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国外畜牧学（饲料） 1992年第6期 36-39页

作者： C.J.ziemer 白史且

本文研究了化学干燥剂对苜蓿制的饲草营养物消化率、血液生化指标(PlsmaProfile)、乳牛泌乳性能的影响。两种处理分别是:商品干燥剂(Cm)7.64kg/na和一般干燥剂(m)7.47kg/na,对照是 U。

关键词：奶牛泌乳苜蓿饲料干燥剂

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在抗生素治疗无效的右侧心内膜炎进行三尖瓣切除术

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德国医学 1998年第2期15卷 73-75页

作者： m.H.Hust B.metzler F.Ebermann m.Heinemann G.ziemer 王红 medizinische Klinik KreiskrankenhausSteinenberger Str.31 D-72764 ReutlingenGermany 同济医科大学附属同济医院

近年来,静脉吸毒者日益增多,他们大多使用未经消毒的注射器具,而使得累及三尖瓣的急性心内膜炎也日趋增加,其中又以金黄色葡萄球菌感染最为多见。对此,一般抗生素治疗往往无效,而必须采用外科方法来清除感染病灶。我们报告1例三尖瓣心... 详细信息

近年来,静脉吸毒者日益增多,他们大多使用未经消毒的注射器具,而使得累及三尖瓣的急性心内膜炎也日趋增加,其中又以金黄色葡萄球菌感染最为多见。对此,一般抗生素治疗往往无效,而必须采用外科方法来清除感染病灶。我们报告1例三尖瓣心内膜炎,通过三尖瓣切除术来清除病灶。

关键词：心内膜炎三尖瓣切除术抗生素耐药性

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